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일측성 질폐쇄 및 동측 신장 무발생을 동반한 중복자궁 2예
윤일영,여소진,김형문,김정식,김태희,이해혁,남계현,이권해,김준모,김민의 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Uterus didelphys with unilateral obstructed hemivagina and ipsilateral renal agenesis usually presents after menarch with progressive abdominal pain during menses secondary to hematocolpos, and indeed a very rare congenital anomaly due to Mullerian duct malformation. An accurate and prompt diagnosis is of importance to permit treatment and to assure the future fertility of the patient. Pelvic ultrasound, physical examination and pelvic MRI established a diagnosis of hematometracolpos secondary to uterus didelphys with unilateral imperforate hemivagina. An incision in the vaginal septum allowed drainage of the hematocolpos, providing relief of the patients symptoms. We report two case of uterus didelphys with obstructed hemivagina with brief review of the literature.
Yun, Hyung-Mun,Jin, Peng,Han, Jin-Yi,Lee, Moon-Soon,Han, Sang-Bae,Oh, Ki-Wan,Hong, Sung-Han,Jung, Eun-Yong,Hong, Jin Tae Humana Press 2013 Molecular Neurobiology Vol.48 No.3
<P>The amyloid beta (Aβ) peptide in the brains of patients with Alzheimer's disease (AD) is cytotoxic to neurons and has a central role in the pathogenesis of the disease. Peroxiredoxin 6 (Prdx6) is an antioxidant protein and could act as a cytoprotective protein. However, the role of Prdx6 in neurodegenerative disease has not been studied. Thus, the roles and action mechanisms in the development of AD were examined. Aβ1-42-induced memory impairment in Prdx6 transgenic mice was worse than C57BL/6 mice, and the expression of amyloid precursor protein cleavage, C99, β-site APP-cleaving enzyme 1, inducible nitric oxide synthase, and cyclooxygenase-2 was greatly increased. In addition, the astrocytes and microglia cells of Aβ-infused Prdx6 transgenic mice were more activated, and Aβ also significantly increased lipid peroxidation and protein carbonyl levels, but decreased glutathione levels. Furthermore, we found that translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) to the nucleus was increased in Aβ-infused Prdx6 transgenic mice. These results suggest that the overexpression of Prdx6 could accelerate the development of AD through increased amyloidogenesis through independent PLA2 activation and Nrf2 transcription.</P>
The Serotonin-6 Receptor as a Novel Therapeutic Target
Yun, Hyung-Mun,Rhim, Hyewhon The Korean Society for Brain and Neural Science 2011 Experimental Neurobiology Vol.20 No.4
<P>Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that is found in both the central and peripheral nervous systems. 5-HT mediates its diverse physiological responses through 7 different 5-HT receptor families: 5-HT<SUB>1</SUB>, 5-HT<SUB>2</SUB>, 5-HT<SUB>3</SUB>, 5-HT<SUB>4</SUB>, 5-HT<SUB>5</SUB>, 5-HT<SUB>6</SUB>, and 5-HT<SUB>7</SUB> receptors. Among them, the 5-HT<SUB>6</SUB> receptor (5-HT<SUB>6</SUB>R) is the most recently cloned serotonin receptor and plays important roles in the central nervous system (CNS) and in the etiology of neurological diseases. Compared to other 5-HT receptors, the 5-HT<SUB>6</SUB>R has been considered as an attractive CNS therapeutic target because it is expressed exclusively in the CNS and has no known isoforms. This review evaluates in detail the role of the 5-HT<SUB>6</SUB>R in the physiology and pathophysiology of the CNS and the potential usefulness of 5-HT<SUB>6</SUB>R ligands in the development of therapeutic strategies for the treatment of CNS disorders. Preclinical studies provide support for the use of 5-HT<SUB>6</SUB>R ligands as promising medications to treat the cognitive dysfunction associated with Alzheimer's disease, obesity, depression, and anxiety.</P>
( Hyung Mun Yun ),( Dong Young Choi ),( Ki Wan Oh ),( Jin Tae Hong ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase (GPx) and calciumindependent phospholipase A2 (iPLA2) activities. Expression of PRDX6 has been detected in human Parkinson’s disease (PD) and dementia patients. However, no study has described PRDX6 function in the dopaminergic neurodegeneration in PD. Herein, we investigated the effects of PRDX6 on 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration using PRDX6 transgenic (Tg) mice. Immunohistochemistry (IHC) and Western blot data for tyrosine hydroxylase (TH) showed that PRDX6 Tg mice had much higher loss of dopaminergic neurons by MPTP administration compared to non-Tg mice, as well as there was much higher behavioral impairment and astrocyte activation in PRDX6 Tg mice. MPTP-induced GPx activity was not different between PRDX6 Tg mice and non-Tg mice, which is accompanied by hyperoxidation of PRDX6. While iPLA2 activity was increased in PRDX6 Tg mice followed by an increase in the level of ROS and 4-hydroxynonenal (4- HNE). Intriguingly, the expression pattern of PRDX6 showed similar distribution and co-localization with astrocytes, but not neuron in the mouse and human brain. Furthermore, we demonstrated that iPLA2 activity of PRDX6 induced astrocytic activation followed by increased proinflammatory cytokines (TNF-α and IL1-β) , 4-HNE, and PRDX6 hyperoxidation in primary cultured astrocytes. Our findings provide novel insights for PRDX6 function on nigrostriatal dopaminergic neuronal system, and we suggest that PRDX6 has an important role in dopaminergic neurodegeneration of PD.
Yun, Jin‐,Mun,Yeo, Jun‐,Seok,Kim, Juhwan,Jeong, Hyung‐,Gu,Kim, Dong‐,Yu,Noh, Yong‐,Jin,Kim, Seok‐,Soon,Ku, Bon‐,Cheol,Na, Seok‐,In WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.42
<P>Solution‐processable reduced graphene oxide as a hole‐transporting layer for highly efficient and stable organic solar cells is reported on page 4923 by Dong‐Yu Kim, Seok‐In Na, and co‐workers. Introduction of a newly reduced graphene oxide by simple solution processing into solar cells dramatically raises the cell efficiency and cell life‐time. The results will allow full use of chemically reduced graphene and will advance the realization of carbon‐based printable optoelectronic devices. </P>
Yun, Jin‐,Mun,Yeo, Jun‐,Seok,Kim, Juhwan,Jeong, Hyung‐,Gu,Kim, Dong‐,Yu,Noh, Yong‐,Jin,Kim, Seok‐,Soon,Ku, Bon‐,Cheol,Na, Seok‐,In WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.42
<P><B>The preparation of a reduced graphene oxide (pr‐Go) is with a novel p‐TosNHNH2 reductant</B> is demonstrated for use as an efficient anode interfacial layer for high‐performance and highstability organic solar cells (OSCs). The efficiency of the cells with pr‐GO is highly comparable to those of the PEDOT:PSSbased devices. Furthermore, the pr‐GO based OSCs show a much longer cell life time in air stability tests in comparison with PEDOT:PSS‐based cells.</P>
Yun Sok Ha,Chang Doo Jang,Jong Tae Kim,Hyung Suk Mun 한국정밀공학회 2007 International Journal of Precision Engineering and Vol.8 No.4
An analytical method to predict the post-weld deformation at the heat-affected zone (HAZ.) is presented in this paper. The method was based on the assumption that the post-weld deformation is caused by external forces resulting from the inherent strain, which is defined as the irrecoverable strain after removing structural restraints and loadings. In general, the equivalent loading method can be used to analyze distortions in welding areas because it is efficient and effective. However, if additional loads are applied after welding, it is difficult to determine the final strain on a welded structure. To determine the final strain of a welded structure at the HAZ. more accurately, we developed a modified equivalent loading method based on the inherent strain that incorporated hardening effects. The proposed method was applied to calculate the residual stress at the HAZ. Experiments were also conducted on welded plates to evaluate the validity of the proposed method.