2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

치근관 내 편성 혐기성 세균에 대한 서양산 고추냉이 뿌리 추출물의 항균효과

이원주,박호원,신일식,이주현,서현우 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.2

치근단 감염 시 물리적인 작용으로 증상이 완화되지 않을 때, 근관 내 세균을 제거하기 위해 항균성을 지닌 소독제나 세척제가 필요하다. 천연항균제에 대한 관심이 증가하면서 여러 연구들에 의해 고추냉이 추출물의 구성 성분 중 하나인 allyl isothiocyanate에 대한 항균성이 밝혀졌다. 이에 본 연구에서는 근관내 감염시 자주 발견되는 세균들 중 편성혐기성 세균인 Fusobacterium nucleatum, Prevotella nigrescence, 그리고 항생제에 내성이 커서 항균 작용 실험 시 대조균으로 자주 사용되는 Clostidial perfringens에 대한 서양산 고추냉이 뿌리 추출물의 항균효과를 알아보고, 대표적인 항균제인 클로르헥시딘과 비교하여 다음과 같은 결과를 얻었다. 1. 본 연구에 사용된 3종의 편성 혐기성 세균에 대한 서양산 고추냉이 뿌리 추출물의 최소 억제 농도는 평균 87-470 ppm, 최소 살균 농도는 평균 156-625 ppm으로 F.nucleatum에 대해 가장 강한 항균효과를 나타내었으며, 항균제에 저항성이 큰 C. perfringens에도 항균효과를 나타내었다. 2. 본 연구에 사용된 3종의 편성 혐기성 세균에 대한 클로르헥시딘의 최소억제 농도는 평균 3.12-6.25 ppm, 최소 살균 농도는 평균 10.94 ppm이었다. 3. 서양산 고추냉이 뿌리 추출물은 87-470 ppm의 농도에서 3.12-6.25 ppm의 클로르헥시딘과 비슷한 세균성장 억제 효과를 가지며 156-625 ppm의 서양산 고추냉이 뿌리 추출물은 10.94 ppm의 클로르헥시딘과 비슷한 살균 효과를 보였다. When the symptom of periapical infection is not released by mechanical instrumentation, anti-microbial agents including antibiosis become necessary in order to remove microorganisms from the root canal. Since anti-microbial agents of natural origins are currently popular, more natural remedies are being sought out. As it turns out, it is welll known isothiocyanates (ITCs) in horseradish root extract have anti-microbial activity from many studies. In this research, anti-microbial effects of horseradish root extract and chlorhexidine, a typical anti-microbial agent, were investigated and compared against two kinds of obligate anaerobes, Fusobacterium nucleatum and Prevotella nigrescens, that are often discovered in infected root canal, and Clostridium perfringens, which is resistant to antibiotics and frequently used as a control strain for antibacterial studies. 1. The MIC and MBC of horseradish root extract were ranged from 87 to 470 ppm and from 156 to 625 ppm against three kinds of obligate anaerobes, respectively. Horseradish root extract showed the strongest anti-bacterial activity (MBC, 156 ppm) against F. nucleatum and also showed anti-bacterial activity against antibiotic resistant obligate anaerobes, C. perfringens. 2. The MIC and MBC of chlorhexidine were ranged from 3.12 to 6.25 ppm and 10.94 ppm aginst three kinds of obligate anaerobes, respectively. 3. The MIC with 87-470 ppm of horseradish root exact has the same growth inhibiting effect as the one of 3.12-6.25 ppm of chlorhexidine. Likewise, the MBC with 156-625 ppm of horseradish has the similar bactericidal effect as 10.94 ppm of chlorhexidine.

폐암과 동반되어 나타난 기관기관지병증 골연골형성증 1예

이영진,전현수,박시형,김모세,김현주,이승헌,이영민,이현욱,이현경 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

Tracheobronchopathia osteochondroplastica (TPO) is a rare benign disease of unknown etiology characterized by multiple cartilaginous or bony submucosal nodules, which project into the tracheobronchial lumen. Although some disorders were reported combined with TPO, these seemed to be considered casual. We report a case of TPO that combined with adenocarcinoma of lung. She was 50-year-old non smoking woman presented with chronic cough with right chest pain. Lung mass on right lower lobe was found on chest x-ray, so lung cancer was suspected. Multiple scattered whitish small elevations from trachea to bronchial trees were found on bronchoscopic exam. We mistook these lesions for metastases from lung cancer and biopsies of these lesions were done. Transbronchial biopsy for right lower lobe mass lesion was also done. But biopsies from trachea and bronchus revealed TPO rather than lung cancer. Transbronchial lung biopsy of right lower lobe mass was diagnosed adenocarcinoma of lung. So TPO combined with adenocarcinoma of lung was diagnosed.

심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

과량의 불소가 함유된 상수도에 의한 반점치의 발생 : 증례보고

이원주,박호원,이주현,서현우 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

불소는 치아 우식증을 예방할 수 있는 물질로 여러 가지 방법으로 사용되고 있으며 그 중 가장 효과적이고 경제적인 방법은 수돗물에 불소를 첨가하는 수돗물불소농도조정사업이다. 그러나 정기적인 수질 검사를 통해 음용수의 불소농도를 검사하지 않으면 불소증과 같은 부작용이 생길 수 있다. 이에 음용수에 불소가 과다하게 포함되어 있는 경우 나타날 수 있는 심각한 불소증에 대해 보고하고자 하는 바이다. Fluoride is a very effective element that can help prevent dental caries. The most economical and safest way of using fluoride is to add fluoride to the tap water. However, care must be taken to maintain the adequate con centration of fluoride in drinking water by regular check-up. Unless, dental fluorosis may occur. We are presenting a case of concurrent occurrence of fluorosis in people living in the same village in Korea, where drinking water contained high concentration of fluoride.

In situ 고상 에피택시 방법에 의한 CoSi₂/Si(111)구조의 형성

이정주,강민성,김현수,최치규,이운환,이종덕,이영백,김건호,이정용 濟州大學校 基礎科學硏究所 1996 基礎科學硏究 Vol.9 No.2

초고진공에서 공상에피택시(solid-phase epiyaxy, SPE) 방법으로 CoSi₂를 Si(111)기판 위에 에피택시 성장시켰다. 2MeV⁴He++ ion후방산란 분광기와 사중결정 x-선 회절기 및 고분해 투과전자 현미경을 이용하여 성장된 CoSi₂의 상과 조성, 결정성, 그리고 계면의 미시구조를 조사하였다. 초고진공상태의 실온에서 Si(111)-7X7기판에 Co를 약 20 ~50 ?? 중착한 후 SPE에 의하여 실리사이드를 형성시키는 경우 600℃에서는 B-형의 CoSi₂가, 그리고 700℃에서는 A형의 CoSi₂가 선택적으로 에피택시 성장하였으며, 정합성은 B-CoSi₂[110]//Si[110] and CoSi₂(111)//Si(111)이, 그리고 700℃에서는 A-CoSi₂[110]//Si[110], CoSi₂(002)//Si(002)을 나타내었다. Epitaxial films of CoSi₂were grown on Si(111) substrates by in situ solid-phase epitaxy in a ultrahigh vacuum. The phase, the chemical composition, the crystallinity, and the microstructure of the Silicide/Si interface were investigated by 2-MeV⁴He++ ion-backscattering spectrometry, quadruple crystal X-ray diffractometry, and high-resolution transmission eletron micorscopy. High-quality films of either B-type or A-type CoSi₂ could be grown selectively on Si(111) substrates by depositing ~ 20 ~ 50 ?? of Co on a Si(111)-7X7 substrate followed by in situ annealing at 600℃ or 700℃ for 10 min. The matching face relationships are CoSi₂[110]//Si[110] and CoSi₂(111)//Si(111) by B-type CoSi₂ and CoSi₂[110]//Si[110]//Si[110] and CoSi₂(002)//Si(002) for A-type CoSi₂.

1936년, 『조광』, 이효석의 "고향"

이현주 ( Hyun Ju Lee ) 한국문학언어학회( 구- 경북어문학회) 2006 어문론총 Vol.44 No.-

영재 학생들을 위한 과학사-CPS 수업 모형을 활용한 분자생물 영역 수업 프로그램의 개발 및 적용

이주현 ( Ju Hyun Lee ),이미숙 ( Mi Sook Lee ),주희영 ( Hee Young Ju ),이길재 ( Kil Jae Lee3 ) 경북대학교 과학교육연구소 2011 科學敎育硏究誌 Vol.35 No.2

This research was aimed to develop and apply the molecular genetics teaching program based on the history of science and creative problem solving model (HS-CPS model) for gifted students. Based on the strategies of creative problem solving and scientific theory development, the HS-CPS teaching program were developed. This program was applied to 8 first and second graders of the special class for invention activity in a high school. Creative problem solving ability in science and the understanding of DNA and gene concept were tested in pre and post of 12 lessons. The results were as follows: First, creative problem solving ability in science was improved meaningfully. Second, HS-CPS teaching program was effective in the understanding of DNA and gene concepts. Third, the students responded positively to the program evaluation questionnaire.

기(氣)현상에 대한 철학적 고찰

이현주 ( Hyun Ju Lee ) 경희대학교 동서간호학연구소 1998 동서간호학연구지 Vol.3 No.1

When recognition of the Ghi(氣) which exist in all things, is changed on the aspects of the science of nursing, the view of health and nursing well be more efficient and can be developed as the proper concept for Korean culture. I think it is nessary to confirm which philosophical basis of the well be applicable to nursing and how to it has to be developed. Therefore I can for the research of the Ghi phenomena to attain the Thoughts of philosophy that is appropriate to expound those phenomena. And I attempt to induct the fusion of horizons to unify the view of the world between Korea and the West. The Ghi is very energetic and omnipresent among the universe, Nature, and the human being. So it can organize all the primary elements of mental and physical function of human as like life, mind, breath, feeling, energy, etc, A feneral concept of the Ghi is described as follows; ① The Ghi is the origin and essence to organize the universe, Nature, and the human being. ② It is the perpetually movable thing. ③ And there are continuous transmission between the Ghi of the universe and the human through body, mind, and soul. For review on the philosophic basis of the Ghi, I studied out the identity of the doctrine of Li and Chi리(理氣論) in the field of philosophy of Korea and the West, In Korea the concept of the Vigor is based on Ch`i mongolism(기일원론) and Li Ch`I dualism (이기이원론) of Yul-gok Lee`s, Hwa-dam`s, and/or Hekang`s, These are indispensable for the view of the world of Korea as Metaphysical ideology, Conerete science, Materialism, Ontology, and Epistemology. From the viewpoint of the philosophy of the West, the doctrine of Li and Ch`i(이기론) of Korea is identical with the doctrine of Joo-ja, Idea of Plato, Metaphysics of Aristotle, World Spirit(Weltgeist) of Hegel, and Existentialism of Heidegger. In the nursing theory of the West, some of them referred to the Ghi as like Energy field theory of Rogers and Energy exchange of Neuman. Though there are different in terminlolgy, energy and the Ghi are induced comparable therapeutic action between the human and the environments. With the nursing theory of Korea, I have made an attempt to compare the Ghi with metaparadigm of nursing-the human being, the environment, the health, and the nursing. For the most part, the alternative therapy is reasonable to the frame of the nursing theory of Korea. It is easy to apply alternative therapy on the every spot of nursing, So this therapy could be a kind of forms as nursing therapy in the nursing centers In result, independent nursing intervention will be activated by the nurse who puts up with the major parts, It is available to apply this therapy to palliation of pain, insomnia of infant, Sanhujori(산후조리), pain of menstruation, arthritis. And the alternative therapy makes it possible to propose the nursing model which represent originality, tradition, and history of the nursing of Korea. Additionally, in the field of the nursing, it is indispensable to choose a suitable methodology which is considered whether it is matched with a theory of philosophy in the boundary and object of the research. Because there are many to get the knowledge of nursing related to the Ghi. In the science of nursing, context of sociocultural background and frame are required to understand the person who need to take care of (nursing client). But the value systems of the West and the East are distinctive each other as well as the behavior of health pursuance. Therefore it is the basic research data of great worth to review philosophical the Ghi phenomena which is well known to Korean.

『蓬萊酬唱錄』 (「附東萊府治圖」)에 관한 일고찰

이현주 ( Lee Hyun-ju ) 동아시아문물연구학술재단 2016 文物硏究 Vol.- No.30

『蓬萊酬唱錄』은 1725년 음력 3월 동래부사 趙錫命이 주관하여 여러 智人 들과 동래부에서 수창한 시문을 그림과 함께 장황한 총 35장의 서화첩이다. 서화첩 구성은 권두에 접위관 洪晟이 大字로 蓬萊, 酬唱이라 題名을 쓰고 다음 장에는 「東萊府治圖」를 배치하였으며, 다음으로 星州의 문사 鄭錫儒가 지은 <蓬萊酬唱錄序>가 있다. 그 뒤로 당시의 동래부사 조석명이 지은 책 제목 에 가늠하는 권두사에 해당되는 <題詞>를 두었고, 이어 본문에 해당되는 조석 명, 정석유, 洪晟, 趙駿命, 범어사 승려 存覺이 지은 시문 55수를 李仲寬이 행 서로 필사하였다. 卷末은 홍성이 짓고 쓴 <後記>가 장황되어 있다. 1725년(영조 1)년 당시의 동래부사 조석명은 나이가 52세로 이 벼슬을 마지막 으로 관직에서 물러날 뜻을 이미 갖고 있었는데, 여러 날에 걸친 酬唱詩를 서화 첩으로 묶어 후일 동래에서의 일을 回憶하고 破寂하기 위하여 제작한 것이며 또한 네 집안의 자제들이 뒷날 볼 수 있기를 희망하였다. 『봉래수창록』에서 특히 주목되는 것은「동래부치도」이다. 현재 알려진 대부분 의 동래부 관련 그림들이 후기동래읍성을 배경으로 제작된 반면 이 그림은 1731 년 정언섭의 후기읍성 축조 이전의 모습을 반영하고 있기 때문이다. 더욱이 묘사 된 관아시설과 주변지형의 공간배치는 상당히 정확하고 사실적이다. 묘사된 동래 부 내의 관아시설이 아주 상세하고 화풍에서도 18세기 동래부 무임화사계열의 화풍이 엿보이고 있을 뿐 아니라 그 그림의 주문자가 동래부사였다는 점을 감안 해볼 때 이 그림의 제작자는 동래부 무임화사일 가능성이 크다. 『봉래수창록』의 전반적인 내용에 관해서는 해제를 덧붙여 고찰하였다. 이 작품 은 18세기 동래지역에서의 수창교유와 시화첩의 제작배경을 확인할 수 있을 뿐 아니라 새로운 동래부 화사를 발굴할 중요한 사료이다. Bongraesuchangrok is a collection of poems and paintings containing 35 sheets of paper. It was arranged by Dongraebu Magistrate Seokmyeong Cho in March of the lunar calendar, 1725 and includes poetry with paintings the Magistrate and his acquaintances recited in Dongraebu. On the opening page of the collection are large characters, Bongrae and Suchang by Diplomat Seong Hong, which is followed by Dongraebuchido, preface by Seokyou Cheong from Seongju and J aesa, introductory remarks whose title is known by. In the body part of the collection, 55 poems by Seokmyeong Cho, Seokyou Cheong, Seong Hong, Junmyeong Cho and Monk Jonggak of Boemeo Temple were transcribed in the semicursive style of writing by JungGwan Lee. At the end was a postface by Seong Hong. In 1725 (King Youngjo 1st year), Dongraebu Magistrate Seokmyeong Cho was thinking of withdrawing from his office of Dongrae. He made the collection for recalling the experiences in Dongrae later and hoping that offsprings of 4 families involved would read it. Dongraebichido is especially noticeable in Bongraesuchangrok. While most known pictures of Dongraebu at this time are with the latter part settings of Dongrae Eupsung, this picture in Bongraesuchangrok reflects the time before EonSeop Cheong built the latter part settings of Dongrae Eupsung in 1731. Moreover, it was verified that governmental facilities and space arrangement in the picture are considerably accurate and realistic. There is a very strong possibility that the picture Dongraebuchido was produced by Muimhwasa in Dongraebu, given the fact that described governmental facilities are in great detail; the painting style of Muimwhasa in Dongraebu in the 18th century is shown; its orderer is Dongraebu Magistrate. This paper covers overall contents of Bongraesuchangrok with a bibliography. This collection is a very historical source not only for checking a poem recitation in Dongrae and the background of producing the collections of poems and paintings, but also for discovering new Dongrabuhwasa.