타석증 3 예

장현선,김수관 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.4

The sialolithiasis is one of the most common disease that is found in the submandibular gland and they can be usually observed in the extra glandular area. As the lumen of Wharton's duct is larger and more expandable than that of Stensen's duct, the symptom of them is initially painless. Obstruction of salivary secretion by a sialolith can result in sudden swelling and pain, as well as infection of the gland It can be observed with clinical exam and the scintigraphy. After removal of sialoliths, the majority of them can get the recovery of function. Our department performed the transoral sialolithotomy. One of three cases was recurred sialolithiasis with sialadenitis and was performed by the re-sialolithotomy and extraoral sialoadenectomy.

건축설계실무와 의사결정에 관한 사례 연구 : 공공프로젝트의 경우 Case of Buchon Welfare center and Yonsu Sub-municipal Office

장성준,서윤영,이현창,하종수 명지대학교 대학원 1997 대학원논문집 Vol.1 No.-

The study analyzes a series of decisions made by Building Construction Review Committee on public building construction project. Several government authorities are engaged on the review and required the building client authority to revise the design according to revise items suggested by the committee members ranging from Architectural Planning to other Building Engineering fields. The study delves the legal and design aspects of the review, the meaning of private, semi-public and public function of building, and the construction policy. Two Public building projects were analyzed in terms of revise items. We found some patterns of problem and the current review system works to promote technical aspect of the building and to keep public entity of the projects.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

외상성신경종 4례

장현선,김수관 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.4

The traumatic neuroma is uncommon in the mouth. Clinically, the majority of traumatic neuromas are painless, but may give rise to neuralgic pain. The traumatic neuroma is most often diagnosed in the adult of life. They are found as small nodules in the tissues and surgical excision is curative. Four cases of traumatic neuroma was found from the files of the Department of Oral Pathology at Chosun University School of Dentistry by a 20-year retrospective study. 3 cases were male and one was female. The chief complaint of the four patients was facial asymmetry, numbness, sharp pain, and masticatory difficulty, respectively, Of the our patients, 3 cases were 55, 56, and 65 years old, respectively and one was 7 years old. Our patients were treated by surgical excision. No recurrences have been found.

치유가 지연된 발치창에서 발생한 질환에 대한 임상적, 방사선학적, 조직병리학적 분석

장현선,김수관 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

For the earlier diagnosis and treatment of delayed wound healing in extraction socket, we investigated the clinical, radiographic and histopathologic features of 106 patients with delayed wound healing diagnosed by biopsy. The patients were enrolled at the Department of Oral Pathology, Chosun University Dental Hospital. Among 106 delayed wound healing diagnosed by biopsy, cysts showed most significant 25 cases (23%), osteomyelitis showed 13 cases (12%), chronic maxillary sinusitis and squamous cell carcinoma showed 12 (11%) and 11 (10%) cases, respectively. We have analyzed these lesions through relevant literatures.

법랑아세포성 섬유치아종

장현선,기근홍,김수관 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

Ameloblastic fibro-odontoma consists of ameloblastic fibroma combined with an odontoma. Ameloblastic fibro-odontoma affects somewhat younger patients than ameloblastic fibroma and 62% of patients are younger than 10 years. Clinical, radiologic, and histologic studies were performed in 9-year-old child of ameloblastic fibro-odontoma. Location of the lesion was the upper molar area. Radiographically, the opaque odontomatous tissues was observed in a circumscribed, but otherwise radiolucent area. Histologically, typical ameloblastic fibro-odontoma was associated with the calcifying or calcified dental tissues of an odontoma. In this paper, a case of ameloblastic fibro-odontoma of the maxilla and a review of the literature is presented.

점액표피종 : 증례보고

장현선,김수관 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3

Mucoepidermid tumors are usually indistinquishable from benign tumors clinically, and accounts for approximately 6% to 8% of all salivary gland tumors. Although rare in children, it is the most common "malignant" salivary gland tumor, haying been reported in major and minor (intraortal) salivary gland sites as well as in the maxilla and the mandible. In children, as in adults, it most often occurs in the parotid gland, but a significant percentage is found in the palate. Presently, there is no unanimity of opinion about whether to consider all mucoepidermoid tumors malignant or what the most appropriate treatment regimen is. The importance of submitting, for microscopic diagnosis, all tissue removed during surgical procedure is illustrated in this case report and a review of the literature is presented.

우췌성암종 : 증례보고

장현선,김수관 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3

Verrucous carcinoma is a distinctive, extremely well-differentiated, slow-growing variant of the squamous cell carcinoma. Verrucous carcinoma of the oral cavity is relatively rare. McCoy reported about 49 verrucous carcinomas of the oral cavity. McCoy reported that the most common site of occurrence was the buccal mucosa, followed by the mandibular alveolar ridge and gingiva, and that The majority of the patients were between the ages of 50 and 80 years. Although most other series of oral verrucous carcinoma show a male predominence, our case occurred in female. The role of radiation therapy in treatment of oral verrucous carcinoma is controversial, and adequate surgical excision appears to be the treatment of choice. In this paper a case of verrucous carcinoma of the buccal mucosa and a review of the literature is presented.

초경 드릴의 절삭 성능에 관한 실험적 평가 연구

장성규,변상기,이승수,김현수,전언찬 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.1

Among the cutting process, recently hole processing in one of extensive using. This study, we made use of the 3 point edge drill. Regarding the cutting efficiency, we investigated the shape of cutting hole and studied cutting hole, a slope of center shaft, roundness and surface roughness. By using carbide 3 point cutting edge, compare with 2 cutting edge, it is possible that high precision drill processing and near the hole, at extremely limited area, quantity of magnification is a little big. After 15m cutting distance, a gradient of center shaft values was fixed 22㎛. It is necessary that a sufficient consideration concerned with jig intensity of workpiece, cutting conditions etc.

치아종의 임상적, 방사선학적, 조직병리학적 분석

장현선,김수관 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.4

An odontoma is a slow growing and nonaggressive odontogenic tumor composed of enamel, dentin, cementum, and pulp tissue. The etiology of odontomas is unknown, although local trauma, infection, and genetic factors have been suggested. Odontomas are classified as compound odontoma or complex. A 20-year retrospective study was performed on 36 odontomas from the files of the Department of Oral Pathology at Chosun University School of Dentistry. Fifty-six percent of the patients were compound odontoma and 44% were complex odontoma. 56 percent of the patients were female and 44% were male. The odontoma is most often diagnosed in the second decade of life, during routine radiographic examination. The usual presenting symptoms are an impacted or and unerupted tooth, a retained primary tooth. Other less frequent signs and symptoms are pain, swelling, suppuration, foul odor, tooth mobility. In our patients were treated by enucleation of the tumor, and related teeth were treated by surgical extraction or ortho-dontically assisted eruption.