췌장염에 의한 가성낭종내에 생긴 가성동맥류 : 1례 보고

오연희,이채경,김승현,이성우,양창현,이정호,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

만성 췌장염의 합병증으로 생긴 가성동맥류는 드문질환으로, 반복적으로 다량의 출혈을 일으킬 수 있으며, 치료를 하지 않을 경우 사망율이 높기 때문에, 조기 진단과 치료가 필수적이다. 저자들은 38세 남자 환자에서 췌장염의 합병증으로 생긴 가성낭종내에서 발생한 가성동맥류 1예를 경험하였기에 보고하는 바이다. 가성 동맥류의 색혈류도플러상 낭종내에 양방향 흐름의 와류를 볼 수 있었다. Pancreatic Pseudoaneurysm within Pseudocyst from Pancreatitis: 1 Case Department of Diagnostic Radiology and Internal Medicine, College of Medicine,DongGuk University Yeon Hee OH M.D., Chae Kyeong Lee M.D., Seoung Hyeon Kim M.D., Sung Woo Lee M.D., Chang Heon Yang M.D., Jung Ho Lee M.D., Young Hyun Lee M.D. Pseudoaneurysm from pancreatitis is uncommon, but it can cause recurrent and massive hemorrhage. Because of high morbidity and mortality, early detection and treatment of the pseudoaneurysm is needed. We report a case of pseudoaneurysm within pseudocyst from pancreatitis. Color-flow Doppler sonography shows bidirectional flow and turbulent arterial flow, within anechoic mass.

日本 價格破壞 |店의 營體系에 關한 硏究

채희용 ; 이현기 김천대학교 1998 김천대학교 논문집 Vol.19 No.-

In 1990's, it is often supposed that the new trend of various distribution business is price destruction. The meaning of price destruction, here is not a price sale selling a discounted material during regular terms but the form of selling as a dramatically discounted price everyday and no holiday. Such new store types as discount stores of price destruction have begun to appear in Korean retailing market since November 1993. Since then, they have been growing very rapidly. Having led by a few department stores, supermarkets and conventional markets, the domestic retail arena met a meaningful turning-point with the rising number of discount stores. Cashing on their cutting edge. "so-good' price, to the extent of destructing the existing price structure and marketing structure as well, the discount stores are forecast to gain a rapid growth in coming years, leading the distribution industry expansion. This study focuses on the "low-cost operations” since the factor is the very reason for the creation and survival of discount stores and plays a decisive role in their success and failure. The competitiveness of discount stores will depend on how they effectively combine the low-cost operations and the marketing strategies, and give much satisfaction to consumers. The domestic retail picture will be re-drawn by a few strong play living up to these qualifications.

배우자 지지가 미취학아동 어머니의 양육스트레스와 삶의 질에 미치는 영향

채선미,강희선,이한주,신현숙 한국모자보건학회 1999 한국모자보건학회지 Vol.3 No.2

비알콜성 지방간 : 임상소견과 초음파소견의 비교

채희복,김미성,박선미,성노현,윤세진 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.1

연구목적 : 최근 건강검진이 널리 시행됨에 따라서 지방간 환자가 많이 발견되고 있으며 이에 대한 사람들의 관심이 증대되고 있다. 본 논문에서는 지방간 환자의 임상적인 특징을 살펴보고 위험요인과 예후에 관련된 인자들을 규명해 보고자 하였다. 연구대상 및 방법: 1998년 2월부터 2000년 3월까지 충북대학교 병원에 내원한 환자 중 초음파로 지방간을 진단받은 65명의 환자를 대상으로 하였다. 후향적으로 진료기록을 검토하였으며, 전화로 체중, 키, 음주력, 약물복용력, 관련증상 유무를 확인하였다. 초음파상 지방간의 중증도와 대상환자들의 체질량지수, 혈청 ALT치의 상승, 기저질환, 관련 임상 증상들간에 상관성이 있는지를 비교분석 하였다. 결과: 체질량지수와 초음파상 지방간의 중증도간에는 유의한 상관관계가 관찰되었다. 혈청 ALT치를 80 IU/L를 기준으로 두 군으로 나누어 지방간의 중증도와 비교하여 본 결과 중증도가 심할수록 혈청 ALT치의 이상소견이 더 높은 빈도로 관찰되었다. (P < 0.01) AST/ALT비는 초음파상 중증도와 역의 상관관계를 나타내었다. (P < 0.01) 소량음주군과 비음주군의 두 군으로 나누었을 때 지방간의 중증도가 심한 군에서 소량음주군이 보다 더 많이 포함되는 경향을 보였다 (P = 0.052) 첫 초음파 검사 시행 시점부터 평균 32개월의 기간이 경과한 뒤 추적검사가 가능하였던 9명의 환자 중 6명에서 무변, 3명에서 호전이 관찰되었다. 결론: 본 연구의 결과 초음파상 지방간 중증도가 심한 환자에서 더 자주 혈청 ALT치의 상승이 관찰되었다. 지방간 환자 중에서 간내 지방축적이 심할수록 염증을 동반할 기회가 많아진다고 생각된다. 이러한 간내 염증괴사소견의 동반은 좋지 않는 예후를 시사하므로 간조직검사등의 적극적인 진단과 비 알콜성지방간염에 대한 조기대응이 필요하다고 생각된다 아울러 지방간 이환기간과 간내 염증과의 상관성을 증명하기 위한 후속연구가 더 필요하다고 생각된다. Background/purpose : Nonalcoholic fatty liver disease can be found more frequently than before due to a high fat diet and a sedentary life style. The aim of this study was to compare clinical characteristics and outcomes of patients with different sonographical grade of the nonalcoholic fatty liver. Methods : 65 patients were diagnosed as nonalcoholic fatty limier patients by abdominal solography from Feb. 1998 to Mar. 2000. We reviewed medical records and confirmed the clinical data by phone. We compared the sonographical grade of the fatty liver with such clinical data as BMI, serum ALT level, underlying diseases and associated symptoms. Results: 1) There was a significant correlation between the BMI and the sonographical grade of the fatty liver . 2) The more severe the sonographical grade of the fatty liver, the higher the serum ALT level was. 3) There were significant inverse correlations between the AST/ALT ratio and the sonographical grade of the fatty liver. 4) Out of the 9 patients whose status could be assessed by sonography or biochemical tests after about 3 years, 3 patients improved and the other 6 patients showed no interval change. Conclusion : Both the amount of excessive fat and the duration of the fatty liver are considered to be the risk factors of nonalcoholic steatohepatitis. We confirmed the association between the sonographical grade of the fatty liver and the serum ALT level by this study, but the association between the duration of the fatty liver diesease and the nonalcoholic steatohepatitis needs to be studied more in the future. The nonalcoholic steatohepatitis showing necrosis or a Mallory body may take an aggressive course leading to cirrhosis and liver related death. Therefore, a liver biopsy and active therapeutic intervention is necessary, early and properly

갑상선 세포에서 전사보조활성인자인 CBP와 CIITA의 인터페론-감마 활성 부위에 대한 조절 : CBP and CIITA on GAS(Interferon- γ Activated Site)-Mediated Transcription in Thyroid Cells

채수흥,홍우정,김군순,조영석,김도희,김현진,구본정,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : In the previous stuides, we identified that the interferon-r activated sequence (GAS) in the 5-flanking region of rat ICAM-1 gene is major element for interferon-r-inducible expression of the gene in rat thyroid cells, FRTL-5. We here, investigated the role of transcriptional coactivators, CBP(CREB binding protein) and CⅡTA (class Ⅱ transactivator) in the modulation of the activity of GAS which could interacts with signal transducers and activators of transcription-1 and 3 (STAT1 and STAT3). Methods : The expression of CBP RNA and protein were quantitated in FRTL-5 after stimulation with interferon-r (IFN-r), thyroid stimulating hormone (TSH), forskolin and methimazole. Direct association of CBP with STAT were analyzed by immunoprecipitation. The transcriptional roles of CBP and CⅡTA in the regulation of GAS were assessed by the cotransfection with their expression vectors with reporters; 5-deletion constructs of rat ICAM-1 promoter or 8xGAS-luc constructs, into FRTL-5 thyroid cells. Results : The level of CBP RNA and protein were not changed by the treatment with TSH, IFN-r, forskolin and methimazole in FRTL-5, FRT and BRL liver cells. The CBP could be directly associated with STAT1. Furthermore, the overexpression of CBP significantly increases the both promoter activities; rat ICAM-1 gene promoter which has GAS element and 8xGAS-luc cassette constructs. However, the cotransfection of CⅡTA decreased the constitutive and CBP-mediated transactivation of rat ICAM-1 promoter and 8xGAS-luc cassette constructs. Conclusion : We identified that the two tanscriptional coactivators; CBP and CⅡTA has differential roles in the regulation of transcriptional activity of GAS drived promoter. CBP increases the GAS activity through the direct binding with STAT1, but CⅡTA inhibited the CBP-mediated transactivation of GAS activity.

대형물의 RP 작업을 위한 절단 알고리즘의 개발

채희창,강희용,유상훈,이승현,문홍렬 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.2

Nowadays, as the development period of new products becomes shorter and consumer's requirement is more various, the importance of Rapid Prototyping Technology has been rapidly increased. Rapid Prototyping makes prototypes or functional parts directly using the 3D CAD data. But RP machines can make protypes in limit size. For making large size prototype, we slice solid, which is made of STL file, and then glue sliced solid. And if contact area of part is small, union solid will be easily destroyed for going down of adhesion. So we need to expand contact area, I suggest making a section into stair shape. This paper is concerned with slicing solid on STL file and improving on adhesion.

소아에서의 Nd : YAG Laser를 이용한 치은착색제거술 YAG Laser in children

모경희,박헌동,박종휘,김효석,정현구,설재헌,이병채 조선대학교 구강생물학연구소 2003 口腔生物學硏究 Vol.27 No.1

Melanin is normally found in the skin of all people, and normal pigmentation of the intraoral tissues is a relative frequent finding. Gingival hyperpigmentation may cause esthetic problems and embarrassment, especially in patients with a gummy smile. Melanin pigmentation is related to etiologic factor such as hormon, systemic factor, drug, smoking and gingival inflamation. Depigmentation procedure can be Performed by gingival epithelium removing procedure, gingivectomy, free gingival graft, laser therapy, dry ice, Vitamin C and phenol-alcohol method. We could obtain favorable esthetic results by procedures such as Nd: YAG laser. The Nd:YAG laser was set at 4 watt, 50mJ, 80 pulse per second. The procedures were performed with contact mode in all pigmented areas by using a handpiece with a 320㎛ diameter fiber optic. Ablation of the gingival hyperpigmented gingiva appeared healthy, pink, and firm. No recurrence of hyperpigmentation had been found in 6 months of follow-up.

우관상동맥 개구부 완전 폐쇄가 동반된 대동맥 판상부 협착증 1례

임상현,김종진,김희열,진승원,전희경,노태호,채장성,김재형,홍순조,최규보,윤정섭,김치경 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

국부 불안정성을 고려한 트러스의 기하학적 비선형해석

정명채,최현희 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

The purpose of this study is to perform geometrically nonlinear analysis of a truss system affected by the member failure(yielding or buckling). The geometric effect is considered by B matrix that links the variation of strain to displacement variations. And member behaviors are modeled through a stress-strain relationship. Solution strategy used in this study is arc-length method. The element routine and material models are implemented based on FEAP Instability behavior of the toggle truss is evaluated when member failure progressively occurs. The generated results show that a substantial reduction in truss limit loads when both geometric non-linearity and member failure are considered and the member failure leads to overall instability or failure of the truss system.

사람 갑상선자극호르몬 수용체를 발현하는 Chinese Hamster Ovary(hTSHR-CHO)세포를 이용한 자극형 갑상선자극호르몬 수용체 항체 활성 측정의 임상적 유용성

한희정,원진호,채수홍,김현진,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

Detection of thyroid stimulating hormone receptor(TSHR) autoantibodies has clinical value in establishing the diagnosis of Graves ' disease, and in predicting its clinical course with high sensitivity and high specificity. Especially, TBII using radioreceptor assay has been widely used. Recently, for detecting thyroid stimulating antibody(TSAb), a sensitive method using human TSH receptor-transfected Chinese Hamster Ovary(CHO) cells has been developed and clinically used. The aims of this study are to determine the change and discrepancy of 2 TSHR autoantibodics in clinical course and to evaluate the correlation between 2 autoantibodies. We measured TSAb and TBII in 30 newly diagnosed and untreated patients and in 73 previously diagnosed as Graves ' disease and treated with antithyroid drug. Also we compared the changes of the antibodies in clinical course and correlation between 2 antibodies. Thes results are summarized follows. 1. In newly diagnosed patients, all of the 30 patients had positive TBII and/or TSAb. None of them had negative TBII and negative TSAb. And in newly diagnosed patients, mean TBII and mean TSAb values are 46.8% and 361%, respectively. In 73 treated patients mean values are 18. 7% and 196% each other. Therefore, newly diagnosed group has significant greater TBII and TSAb than antithyroid drug-treated group. 2. TBII was significantly different between euthyroid group and thyrotoxic group in antithyroid drug-treated patients, but TSAb was not. 3. TBII was sequentially decreased as increased medication duration, but TSAb was not shown sequential decrease as increased medication duration. 4. There was significant negative correlation between cumulative doses of antithyroid drug and TBII, but no significant correlation between cumulative doses and TSAb. 6. There was significant positive correlation between TBII and TSAb in total patients group and in antithyroid drug medication group, but not in newly diagnosed group. In conclusion, in Graves ' disease patients, detection of TSHR antibodies are clinical values in establishing the diagnosis and prediction of clinical course. A method detecting TSAb using hTSHR-CHO cells should be further studied for standardization of measurement, and for detecting the changes of TSAb in clinical course, long-term follow-up of patients are important.