질소 기체의 다분자층 흡착을 이용한 BN, Alumina 및 Silica-Gel의 동공 크기 분포

안운선,조현우,곽현태,김영진 성균관대학교 기초과학연구소 1988 論文集 Vol.39 No.1

Multilayer adsorption isotherms of nitrogen on hexagonal boron nitride, γ-alumina, and silicagel powders are determined at the liquid nitrogen temperature using a gravimetric adsorption apparatus. The volume(V) of the adsorbed gas are plotted against the statistical thickness(t) of the adsorbed layer, and the t-method area are calculated from the slope of these V-t plots to compare with the BET area. The Frenkel-Halsey-Hill equation are used in calculating the statistical thickness. Pore-size distribution of the adsorbents are determined by using the improved method of pore-size distribution analysis proposed by Ahn et al. The cumulative surface area calculated from the results of these pore-size distribution analysis agrees very well with the BET area and the t-method area.

연골외막세포가 포함된 alginate beads를 이용한 토끼에서의 골연골결손 치료

안현정,김은미,정미현,조현철,이인범,성상철,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

한국인의 아동학대에 대한 태도

박현선,이현정,안동현 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

목 적 : 아동학대에 관한 연구가 활발하게 진행되어 왔으나, 학대의 개념과 정의를 규정함에 있어서 혼란이 초래되고 있다. 이에 저자들은 일반 인구 집단과 전문가 집단을 광범위하게 표집하고, 학대 행위뿐 아니라 행위의 주체자, 피학자 특성, 동기, 결과, 행위의 정당성 등을 포함하는 사례를 개발하여 이들을 다차원적으로 고려한 구정을 마련하고자 하였다. 방 법 : 저자들이 고안한 사례를 제시하는 형태의 설문지를 405명의 일반 인구 집단, 125명의 전문가 집단을 대상으로 조사하였다. 사례는 6개의 신체학대, 3개의 방임, 5개의 정서 학대를 제시하였고, 각 사례에 대해 학대 여부, 허용 여부, 판단 근거의 세 차원을 측정하였다. 결 과 : 첫째, 대체적으로 학대로 규정하는 비율은 높았는데 전문가 집단이 좀 더 높은 비율을 나타내었다. 둘째, 혼육이 동기가 되었던 사례에서는 두 집단이 거의 동일하게 낮은 비율로 학대로 규정하였다. 세째, 허용도에 있어서는 덜 일관된 경향을 보이는데, 앞에서와 마찬가지로 훈육이 목적일 때는 비교적 허용적이었으며, 전문가 집단에서 일반 인구 집단보다 더 높게 허용되고 있다고 응답하였다. 네째, 방임과 정서적 학대가 비교적 높게 학대로 규정되고 있고, 또한 허용될 수 없다고 보는 견해가 매우 높았다. 토 의 : 기존의 연구들이 주로 신체 학대에 한정된 경향이 높았는데 앞으로는 적극적으로 방임과 정서 학대를 포함할 필요가 있다. 또한 신체 학대에서 훈육=체벌=학대의 관점에서 체벌 금지와 같은 주장은 더욱 설득력이 없을 것으로 여겨진다. 따라서 학대 행위를 규정함에 있어서 행위의 결과나 행위 자체뿐 아니라, 동기, 정당성 등이 매우 중요하게 고려되어야 할 것이다. 마지막으로 학대의 규정과 혀용적인 태도의 이중성인데, 이는 실제 학대의 예방과 대책에서 매우 중요한 문제가 되므로 이 같은 이중적인 태도에 대한 더 많은 연구와 이해가 필요하겠다. Objective : Child abuse is not an uncommon occurrence in Korea. Despite the significant progression the child abuse study suffers from methodological difficultes including that child abuse has never been adequately or reliably defined. Therefore, authors surveyed the attitudes toward child abuse and defined the concept of child abuse more reliably. Methods : We used the survey questionnaire with the vignette based on clinical cases. The survey included 405 persons in general population living in Seoul and 125 professional personnel engaged in child welfare business. The survey was done by trained university students of social welfare. Questionnaire composed of 14 vignettes(6 physical abuse cases ; 3 neglect cases ; five emotional abuse cases). Each vignette contained 3 items composed of decisiveness and permissiveness of child abuse and the rationale about the determination of the abuse. Results : First, the irrational rationale for parental behavior or very serious inflictions and injury on child were usually considered as abusive behavior. However, parents or teacher may be often allowed to inflict abuse upon the children for the correction or discipline. Second, neglect in considered as an unaccepatable serious child abuse at a high rate. Third, the most important factor determining the criteria of the abuse, was the motivation for discipline. At that times procedure or injury can be ignored. Fourth, some vignettes were considered as abusive but permissible. This discrepancy between concept and acceptance were not unpredictied but notable. Professional group had higher rates of abuse, but was permissive than general population group. Both of general population and professional groups showed similar patterns in other parts. Conclusion : We suggests that the definition of child abuse should include the neglect and emotional abuse as well as physical abuse or battering(or corporal punishment) despite of the methodological difficulties. Several factors including the motivation for discipline should be considered in the definition, and the discrepancy between concept and acceptance of child abuse also need to be considered.

麻黃의 사람 비점막 섬유아세포 monocyte chemotactic protein 중 MCP - 1 , MCP - 2 , 및 MCP - 3 분비에 대한 효과

김현미,이향숙,김정선,조정제,유영천,안현종,최훈,임강현 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

Recent reports have proposed that Ephedrae Herba may modulate the immune response on allergy or asthma. Human nasal mucosal fibroblasts are a rich source cytokines, inflammatory mediators, and chemokines. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. Objectives : The objective of this study was to investigate the effect of Ephedrae Herba on the release of the chemokines such as monocyte chemotactic protein(MCP)-1, MCP-2, and MCP-3 in human nasal mucosal fibroblasts after stimulation with cytokines like tumor necrosis factor -α(TNF-α), interferon-γ(IFN-γ), and interleukin -1β(IL-1β).

뉴로-퍼지 논리를 이용한 12경락의 양도락진단 시스템의 구현

김병화,한권상,이우철,김성현,최해성,안현식,김도현 대한전자공학회 1997 秋季綜合學術大會 論文集 Vol.20 No.2

Alginate 배양내에서 Transglutaminase가 연골막세포에 미치는 영향

박정선,공차배,김충현,안현정,정미현,성상철,김희중,조현철,이상훈,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

대학생 흡연자의 금연경험에 따른 건강신념차이

구정일,김민정,김동희,백정희,안현실,은가희,우혜령,이명희,이수현,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

It has been generally known that smoking is one of the worst factor increasing disease and mortality in human health since in 1950's and nowadays. But regardless of various proofs about social or economical problems due to smoking, current smoking rate has not been decreased in our country. Until now, most of tobacco use and its addiction researches have been focused on the adolescent or adult women smokers not on the university students. Therefore, the purpose of this study was to investigate smoking cessation of university smokers and analyze the health belief-perceived sensitivity, severity, benefits and barriers- difference, then to provide basic data for effective smoking cessation strategy for university smokers. The subjects were comprised of 181 university smokers from 15 universities in Seoul. The data were collected by structured questionaires. The questionaires were designed to measure general characteristics, smoking cessation and health belief, based on Ahn(2003)'s result on the Study of Smoking attitude, Behavior and Smoking Cessation of Adult Male and Lee(1987)'s result on Relationships Between the Health Belief Model and Smoking Habits. The data were collected from May 5 to 16. The collected data were analyzed by SPSS program. The actual number, percentiles, means, standard deviation, t-test and ANOVA were done. The result of this study were as follows; 1. The general characteristics of the subjects of this study The range of age was from 18 to 34 and the averaging age was 23. The subjects of this study were 141 males and 40 females. The religions were Christianity 25.4%(46), Buddhism 12.7%(23), Catholic 23.2%(42), no religion 37.0%(67). The residential forms were living with family 59.1%(107), cooking food for oneself 28.7%(52), dormitory 5.0%(9), boarding house 1.7%(3). Smoking starting age were university 43.1 %(78), high school 29.8%(54), middle school 14.9%(27), in the army 6.1 %(11), elementary school 1.1 %(2). 2. The smoking cessation of the subjects 80% of current smokers showed quitting smoking decision and 20% have not tried. The frequency of quitting smoking decision were from 1 to above 8 and mean was 3.06. As for smoking cessation plan, 54.7%(99) current smokers answered yes, 3.9%(7) said no, 35.4%(64) had no idea and 6.1 %(11) didn't answer. As for the reason of never quitting smoking decision, 71.42%(25 among total 35) have no need to quit smoking and the others said difficulty of smoking cessation. As for the main reason of smoking cessation decision, 54.7%(99) answered for the health, 7.2%(13) family advice, 15.5%(28) girl/boy friend's advice, 1.7%(3) to save money. As for the reason to fail smoking cessation, 56.7%(68) were will-lack, 17.5%(21) stress, 15%(18) smoking mood, 10%(12) withdrawl symptom. As for the smoking cessation method, 85.0%(125) were oneself-will, 2.7%(4) way acquired by mass-media, 2%(3) doctor's prescription, 2%(3) religion's help, 0.7%(1) smoking cessation school. As for the difficulty in smoking cessation, 42.2%(62) were drinking meeting, 23.1 %(34) no alternative of stress release, 12.2%(18) withdrawl symptom, 11.6%(17) having nothing to do, 7.5%(11) friend's encouragement. As for the most difficult cigarette to quit, 67.8%(99) were all-day smoking except the first smoking in the morning, 32.2%(47) the first smoking in the morning. 3. Health belief as for general characteristics Gender - The total point in benefits showed higher in male(28.5177) than female(26.6750). There was significant difference(t=.778, p<.05). The total point in health belief showed higher in male (105.8298) than female(l00.5000). So there was significant difference(t=.345, p<.05). Age - There was significant difference in benefits between age(10's-25.83, 20's-28.39, 30's-32.00)(F=3.73, p<.05). Smoking starting age - There was significant difference in total point of sensitivity and health belief(sensitivity F=4.00, p<.Ol, health belief F=2.843, p<.05). As for sensitivity, subjects who started smoking in the army showed the highest(33.36) and ones in high school showed the lowest(26.96). The total point in health belief showed the highest in elementary school(l19.00) and the lowest in high school(100.98). 4. Health belief as for smoking cessation There was significant difference in health belief as for smoking cessation(t=0.189, p=0.OO2). Sensitivity point showed higher in smoking quitting trial smokers(29.2) than non-trial smoker (26.9). Severity point showed higher in trial smokers (30.7) than non-trial smokers(28.9). Benefit point showed higher in trial smokers(28.6) than non-trial smokers(26.2). There was no significant difference in barriers point.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

智異山國立公園의 登山路 毁損

安鉉哲,趙顯瑞,秋甲喆 진주산업대학교 농업기술연구소 1998 農業技術硏究所報 Vol.11 No.-

지리산국립공원의 주요 등산로에 대해 이용강도에 따른 등산로 훼손상태를 조사하였다. 총 37.15km, 111개 지점에서 등산로 상태를 조사한 바, 등산로폭과 나지노출폭 및 최대침식깊이는 다른 국립공원의 등산로보다 크게 나타났다. 훼손유형의 출현빈도는 뿌리노출, 노폭확대, 암석노출, 분기 등의 순으로 나타났으며, 이들 지점의 등산로상태는 건전한 지점과 뚜렸한 차이를 보였다. Major trails of Chirisan National Park were selected to investigate the use impacts on trail according to the different amount of use. The entire width, bare width and maximum depth of trail as the trail condition surveyed at the total of 111 points were greater on the other National Parks. Major deterioration types of trail were rock-exposure, deeping, root-exposure, widening, in order of frequency. And trail conditions of deteriorated points were significantly different from those of non-deteriorated points.