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Park, Kyung-Jae,Yu, Mi Ok,Song, Na-Hyun,Kong, Doo-Sik,Park, Dong-Hyuk,Chae, Yang-Seok,Chung, Yong-Gu,Kang, Shin-Hyuk M. Nijhoff ; Kluwer Academic Publishers 2015 Journal of neuro-oncology Vol.121 No.1
<P>Astrocyte elevated gene-1 (AEG-1) has recently been proposed to be involved in tumor development, invasion, and metastasis in several human cancers. However, the functional importance of AEG-1 expression in human meningioma has not been determined. We investigate the level of AEG-1 expression by quantitative reverse transcription PCR, immunohistochemistry analysis, and western blotting in various human meningioma tissues and cells. To determine the suppressive effect of AEG-1 on meningioma progression, we inhibited AEG-1 expression using small interfering RNA and examined cell proliferation, apoptosis, colony formation and tumorigenicity in a mouse xenograft model. AEG-1 expression was frequently elevated at both mRNA and protein levels in meningioma tumor tissues and in meningioma-derived cells as well. This elevation was more commonly observed in high-grade tumors than in benign ones. The knockdown of AEG-1 led to a decrease in overall cell proliferation, as well as anchorage-independent growth of malignant meningioma. In addition, apoptotic cell death occurred in AEG-1 depleted meningioma cells through p-Akt and Bcl-2 suppression. Furthermore, a mouse xenograft meningioma model showed that inhibition of AEG-1 expression significantly decreased tumor growth. Altogether, these data show that the elevation of AEG-1 contributes to the malignant progression of meningiomas, suggesting that AEG-1 could be a novel therapeutic target against human meningiomas.</P>
Prognostic Factors of Clinical Outcomes in Patients with Spontaneous Thalamic Hemorrhage
Lee, Sang-Hoon,Park, Kyung-Jae,Kang, Shin-Hyuk,Jung, Yong-Gu,Park, Jung-Yul,Park, Dong-Hyuk International Scientific Literature, Inc. 2015 Medical science monitor Vol.21 No.-
<P><B>Background</B></P><P>Intracerebral hemorrhage (ICH) is a well-known condition, but ICH restricted to the thalamus is less widely studied. We investigated the prognostic factors of thalamic ICHs.</P><P><B>Material/Methods</B></P><P>Seventy patients from January 2009 to November 2014 were retrospectively reviewed. Patients who demonstrated spontaneous ICH primarily affecting the thalamus on initial brain computed tomography (CT) were enrolled. Patients were categorized into 2 groups based on their Glasgow Outcome Scale (GOS) scores. Various presumptive prognostic factors were analyzed to investigate relationships between various clinical characteristics and outcomes.</P><P><B>Results</B></P><P>Of the enrolled patients, 39 showed a GOS of 4–5, and were categorized as the good outcome group, while another 31 patients showed a GOS of 1–3 and were categorized as the poor outcome group. Initial GCS score, calculated volume of hematoma, presence of intraventricular hemorrhage (IVH), coexisting complications, hydrocephalus, performance of external ventricular drainage, and modified Graeb’s scores of patients with IVH were significantly different between the 2 groups. In multivariate analysis, among the factors above, initial GCS score (P=0.002, Odds ratio [OR]=1.761, Confidence interval [CI]=1.223–2.536) and the existence of systemic complications (P=0.015, OR=0.059, CI=0.006–0.573) were independently associated with clinical outcomes. Calculated hematoma volume showed a borderline relationship with outcomes (P=0.079, OR=0.920, CI=0.839–1.010).</P><P><B>Conclusions</B></P><P>Initial GCS score and the existence of systemic complications were strong predictive factors for prognosis of thalamic ICH. Calculated hematoma volume also had predictive value for clinical outcomes.</P>
Risk Factors Associated with Poor Outcomes in Patients with Brain Abscesses
Ko, Seok-Jin,Park, Kyung-Jae,Park, Dong-Hyuk,Kang, Shin-Hyuk,Park, Jung-Yul,Chung, Yong-Gu The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.56 No.1
Objective : The purpose of this study was to describe the clinical characteristics, treatment outcomes, and prognostic factors in patients with brain abscesses treated in a single institute during a recent 10-year period. Methods : Fifty-one patients with brain abscesses who underwent navigation-assisted abscess aspiration with antibiotic treatment were included in this study. Variable parameters were collected from the patients' medical records and radiological data. A comparison was made between patients with favorable [Glasgow Outcome Scale (GOS) ${\geq}4$] and unfavorable (GOS <4) outcomes at discharge. Additionally, we investigated the factors influencing the duration of antibiotic administration. Results : The study included 41 male and 10 female patients with a mean age of 53 years. At admission, 42 patients (82%) showed either clear or mildly disturbed consciousness (GCS ${\geq}13$) and 24 patients (47%) had predisposing factors. The offending microorganisms were identified in 25 patients (49%), and Streptococcus species were the most commonly isolated bacteria (27%). The mean duration of antibiotic administration was 42 days. At discharge, 41 patients had a favorable outcome and 10 had an unfavorable outcome including 8 deaths. The decreased level of consciousness (GCS <13) on admission was likely associated with an unfavorable outcome (p=0.052), and initial hyperglycemia (${\geq}140mg/dL$) was an independent risk factor for prolonged antibiotic therapy (p=0.032). Conclusion : We found that the level of consciousness at admission was associated with treatment outcomes in patients with brain abscesses. Furthermore, initial hyperglycemia was closely related to the long-term use of antibiotic agents.
충청남도 지역의 농경지 토지이용에 따른 깊이별 용적밀도 조사
박성용(Seong-Yong Park),이재한(Jae-Han Lee),천진혁(Jin-Hyuk Chun),강윤구(Yun-gu Kang),유준혁(Jun-Hyuk Yoo),박성진(Seong-Jin Park),윤여욱(Yeo-Uk Yun),이기범(Gi-bum Yi),오택근(Taek-Keun Oh) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11
용적밀도는 토양의 물리적 특성 중 중요한 요소로 탄소함량 및 유기물 함량과 관련이 깊어 작물 생육에 영향을 미친다. 본 연구에서는 농촌진흥청의 농업환경변동조사 지점을 기준으로 충청남도 지역의 농경지 총 152 지점을 선정하였으며, 이를 농경지 이용 형태(논 91지점, 밭 38지점, 과수원 23지점)에 따른 깊이별 용적밀도를 조사하였다. 토양 시료는 코어 시료 채취기를 이용하여, 깊이 60 cm까지 10 cm를 간격(0-10, 10-20, 20-30, 30-40, 40-50, 50-60 cm)으로 구분하여 채취하였다. 그 결과, 충청남도 시료 채취 지역의 깊이 별 토양 용적밀도 평균은 0-10, 10-20, 20-30, 30-40, 40-50, 50-60 cm에서 각각 1.40, 1.50, 1.60, 1.63, 1.59, 1.59 g cm<SUP>-3</SUP>로 40 cm 지점까지는 깊이가 깊어짐에 따라 높아지는 경향을 나타내었으며, 40 cm 이상의 깊이에서는 다시 낮아지는 경향을 나타내었다. 농경지 이용 형태별 토양의 용적밀도는 논토양, 밭토양, 과수원토양의 깊이 0-10 cm에서 각각 1.37, 1.47, 1.40 g cm<SUP>-3</SUP>으로 가장 낮았으며, 30-40 cm에서 각각 1.66, 1.40, 1.57 g cm<SUP>-3</SUP>로 가장 높았다. 농경지 이용 형태별 전체 깊이(0-60 cm)의 용적밀도 평균값은 밭토양이 1.59 g cm<SUP>-3</SUP>로 가장 높았으며, 과수원 토양이 1.51 g cm<SUP>-3</SUP>로 가장 낮았다. 본 조사 결과는 충청남도 지역 농경지 토양의 깊이별 유기물 함량 추정을 위한 기초자료로 활용 가능할 것으로 판단된다.
Factors Associated with Clinical Outcomes in Patients with Primary Intraventricular Hemorrhage
Lee, Sang-Hoon,Park, Kyung-Jae,Park, Dong-Hyuk,Kang, Shin-Hyuk,Park, Jung-Yul,Jung, Yong-Gu International Scientific Literature, Inc. 2017 Medical science monitor Vol.23 No.-
<P><B>Background</B></P><P>Primary intraventricular hemorrhage (PIVH) is an uncommon type of intracerebral hemorrhage. Owing to its rarity, the clinical and radiological factors affecting outcomes in patients with PIVH have not been widely studied.</P><P><B>Material/Methods</B></P><P>We retrospectively reviewed 112 patients (mean age 53 years) treated for PIVH at our institution from January 2004 to December 2014. Clinical and radiological parameters were analyzed 3 months after initial presentation to identify factors associated with clinical outcomes, as assessed by the Glasgow Outcome Scale (favorable ≥4, unfavorable <4).</P><P><B>Results</B></P><P>Of the 99 patients who underwent angiography, causative vascular abnormalities were found in 46%, and included Moyamoya disease, arteriovenous malformation, and cerebral aneurysm. At 3 months after initial presentation, 64% and 36% of patients were in the favorable and unfavorable outcome groups, respectively. The mortality rate was 19%. However, most survivors had no or mild deficits. Age, initial Glasgow Coma Scale (GCS) score, simplified acute physiology score (SAPS II), modified Graeb score, and various radiological parameters reflecting ventricular dilatation were significantly different between the groups. Specifically, a GCS score of less than 13 (<I>p</I>=0.015), a SAPS II score of less than 33 (<I>p</I>=0.039), and a dilated fourth ventricle (<I>p</I>=0.043) were demonstrated to be independent predictors of an unfavorable clinical outcome.</P><P><B>Conclusions</B></P><P>In this study we reveal independent predictors of poor outcome in primary intraventricular hemorrhage patients, and show that nearly half of the patients in our study had predisposing vascular abnormalities. Routine angiography is recommended in the evaluation of PIVH to identify potentially treatable etiologies, which may enhance long-term prognosis.</P>
Romo1 is associated with ROS production and cellular growth in human gliomas.
Yu, Mi Ok,Song, Na-Hyun,Park, Kyung-Jae,Park, Dong-Hyuk,Kim, Se-Hyuk,Chae, Yang-Seok,Chung, Yong-Gu,Chi, Sung-Gil,Kang, Shin-Hyuk M. Nijhoff ; Kluwer Academic Publishers 2015 Journal of neuro-oncology Vol.121 No.1
<P>Romo1 is a mitochondrial protein whose elevated expression is commonly observed in various types of human cancers. However, the expression status of Romo1 and its implication in the pathogenesis of human glioblastoma (GBM) remain largely undefined. To understand the role of Romo1 in the progression of GBM, we explored its expression in a series of GBM tissues and cell lines and determined its effect on ROS production, cell proliferation, and tumor growth. Romo1 was frequently overexpressed at the mRNA level in both primary tumors and cell lines and its elevation was more commonly observed in high grade tumors versus low grade tumors. Romo1 expression was associated with ROS production and its knockdown led to a marked reduction of in vitro cellular growth and anchorage-independent growth of GBM. Consistently, Romo1 depletion induced a G2/M arrest of the cell cycle that was accompanied with accumulation of phospho-cdc2. Furthermore, a mouse xenograft assay revealed that Romo1 depletion significantly decreased tumor formation and growth. Therefore, our data demonstrate that Romo1 upregulation is a common event in human GBMs and contributes to the malignant tumor progression, suggesting that Romo1 could be a new therapeutic target for human GBM.</P>