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( Hyoung Yoel Park ),( Dae Hwan Kang ),( Sun Mi Lee ),( Tae Oh Kim ),( Gwang Ha Kim ),( Geun Am Song ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Self-expandable metal stents (SEMS) are a safe and efficacious method for palliating malignant gastric outlet obstruction. But few reports assess clinical outcome after SEMS insertion for malignant gastric outlet obstruction caused by stomach cancer only. The aim of this study was to assess the usefulness of uncovered SEMS in patients with malignant gastric outlet obstruction caused by stomach cancer only. Methods: We report our experience of 62 patients with gastric outlet obstruction caused by stomach cancer treated by implantation of uncovered SEMS. 62 patients (43 male, 19 female) were treated between August, 2000 and March, 2007. A scoring system was used to grade the ability to eat. Results: Stent implantation was successful in 61 (98.4%) patients. Relief of obstructive symptoms was achieved in 49 (80.3%) patients. Mean survival duration was 143 days. Mean stent patency time was 103.5 days. The improvement in ability to eat using the scoring system was statistically significant (p<0.05). Conclusions: Endoscopic placement of uncovered SEMS is a safe and effective treatment for the palliation of patients with inoperable malignant gastric outlet obstruction caused by stomach cancer.
인두구와 쉰 목소리 환자의 위식도 및 위후두 역류 빈도
박찬원 ( Chan Won Park ),최철웅 ( Cheol Woong Choi ),김광하 ( Gwang Ha Kim ),김경엽 ( Kyung Yeob Kim ),하태인 ( Tae In Ha ),박형열 ( Hyoung Yoel Park ),엄재섭 ( Jae Sup Eum ),박찬호 ( Chan Ho Park ),이선미 ( Sun Mi Lee ),강대환 ( 대한소화기기능성질환·운동학회 2008 Journal of Neurogastroenterology and Motility (JNM Vol.14 No.1
목적 : 인두구 및 쉰 목소리 같은 만성 인후두 증상이 위식도 역류 질환 및 식도 운동성 질환과 관련이 있다고 알려져 있다. 인두구와 쉰 목소리를 호소하는 환자에서 위식도 역류 및 위인두 역류와의 관계를 후향적으로 조사하고자 하였다. 대상 및 방법 : 인두구와 쉰 목소리를 호소하는 290명의 환자(남자 122명, 여자 168명)를 대상으로 하여, 위내시경검사, 24시간 보행성 식도산도검사 및 식도내압검사를 시행하였다. 내시경 소견, 24시간 보행성 식도산도검사 및 식도 내압 검사 소견을 분석하였다. 결과 : 1) 위산 역류의 전형적인 증상은 51.7% (150/290)에서 관찰되었다. 2) 내시경 검사에서 역류성 식도염은 12.2% (29/236), 식도열공탈장은 5.9% (14/236)에서 관찰되었다. 3) 식도내압 검사에서 비정상 소견을 보이는 경우는 64.8%였으며, 이중 비효과적 식도운동이 가장 많았다. 4) 24시간 보행성 식도산도검사에서 정상 소견은 34.2% (91/266), 위식도역류질 환으로만 진단된 경우는 14.3% (38/266), 위후두역류질환으로만 진단된 경우는 15.0% (40/266), 위식도역류질환과 위후두역류질환 모두로 진단된 경우는 36.5% (97/266)이었다. 결론 : 인두구와 쉰 목소리를 호소하는 환자에서 위식도 역류질환 및 위후두 역류질환의 빈도가 높게 나타났다. 그러므로, 후두경 검사상 정상인 인두구 및 쉰 목소리를 호소하는 환자에서 위식도 역류 및 식도운동질환에 대한 검사를 시행하고 이에 따라 치료적 접근을 하는 것이 바람직 하다고 사료된다. Background/Aims: Globus pharyngeus and hoarseness are common extraesophageal manifestations in the patients with astroesophageal reflux disease. The aim of this study was to evaluate the frequency of gastroesophageal and gastropharyngeal reflux in the patients with globus and/or hoarseness. Methods: From July 2004 to December 2006, we retrospectively analyzed the medical records and the findings from endoscopy, esophageal manometry and ambulatory 24-hour pH monitoring of patients with symptoms of globuspharyngeus or hoarseness. Results: One hundred fifty patients (51.7%, 150/290) complained typical reflux symptoms such as heartburn or acid regurgitation. Two hundred thirty-six patients underwent endoscopy. Reflux esophagitis and hiatal hernia were found in 12.2% (29/236) cases and 5.9% (14/236) cases, respectively. Abnormal esophageal motilities were found on 64.8% of patients showed abnormal esophageal motilitiy tests. Ineffective esophageal motility was the most frequent finding. Two hundred sixty-six patients underwent ambulatory 24-hour dual probe pH monitoring. Of them, normal PH monitoring , GERD only, GPRD only and both GERD and GPRD were 34.2% (91/266), 14.3% (38/266), 15.0% (40/266) and 36.5% (97/266), respectively. Conclusions: In a high proportion of the patients with globus pharygeus and hoarseness, gastroesophageal reflux disease and gastropharyngeal reflux disease were observed.
Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor
( Hyoung-min Park ),( Huisu Kim ),( Dong Wook Kim ),( Jong-hyuk Yoon ),( Byung-gyu Kim ),( Je-yoel Cho ) 생화학분자생물학회(구 한국생화학분자생물학회) 2020 BMB Reports Vol.53 No.12
Breast cancer is one of the most frequently diagnosed cancers. Although biomarkers are continuously being discovered, few specific markers, rather than classification markers, representing the aggressiveness and invasiveness of breast cancer are known. In this study, we used samples from canine mammary tumors in a comparative approach. We subjected 36 fractions of both canine normal and mammary tumor plasmas to highperformance quantitative proteomics analysis. Among the identified proteins, LCAT was selectively expressed in mixed tumor samples. With further MRM and Western blot validation, we discovered that the LCAT protein is an indicator of aggressive mammary tumors, an advanced stage of cancer, possibly highly metastatic. Interestingly, we also found that LCAT is overexpressed in high-grade and lymph-node-positive breast cancer in silico data. We also demonstrated that LCAT is highly expressed in the sera of advanced-stage human breast cancers within the same classification. In conclusion, we identified a possible common plasma protein biomarker, LCAT, that is highly expressed in aggressive human breast cancer and canine mammary tumor. [BMB Reports 2020; 53(12): 664-669]
급성 하부 위장관 출혈 진단에 대한 다검출기 전산화단층촬영의 역할
이선미 ( Sun Mi Lee ),김태오 ( Tae Oh Kim ),박형열 ( Hyoung Yoel Park ),김경엽 ( Kyung Yeob Kim ),김광하 ( Gwang Ha Kim ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),김석 ( Suk Kim ) 대한소화기학회 2008 대한소화기학회지 Vol.51 No.5
Background/Aims: Recent studies have shown good performance for the detection of sources of gastrointestinal bleeding using multi-detector row computed tomography (MDCT). However, there are limited reports about the role of MDCT for localization of acute lower gastrointestinal (GI) bleeding. The purpose of this study was to evaluate the role of MDCT for detection and localization of acute lower gastrointestinal bleeding. Methods: A total of 49 patients underwent MDCT examination for the evaluation of acute lower GI bleeding were investigated prospectively. Sensitivity, specificity, positive and negative predictive values of MDCT for the detection of acute lower GI bleeding were assessed. Colonoscopy, angiography, RBC scan or postoperative results were adopted as the reference standard. Results: Sensitivity, specificity, positive and negative predictive values of MDCT for the detection of acute lower GI bleeding were 72.7%, 80%, 93.9% and 25%, respectively. Eighteen patients experienced massive bleeding and 5 of them could not undergo the colonoscopic examination due to massive bleeding. MDCT detected the bleeding focuses in all of 5 patients. Conclusions: MDCT is useful for the localization of acute lower GI bleeding. The procedure is brief, less invasive, and relatively accurate diagnostic method. Moreover, positive finding will allow directed therapeutic procedure such as angiography. (Korean J Gastroenterol 2008;51:298-304)
( Kyung Yeob Kim ),( Gwang Ha Kim ),( Tae In Ha ),( Hyoung Yoel Park ),( Sun Mi Lee ),( Tae Oh Kim ),( Dae Hwan Kang ),( Geun Am Song ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background Aims: The endoscopic grading of the gastro-esophageal flap valve (GEFV) has been suggested to be a good predictor of the reflux status. Atrophic gastritis is inversely associated with reflux esophagitis. The aim of this study was to investigate the association between GEFV, atrophic gastritis, and gastroesophageal reflux. Methods: A total of 608 patients (252 men and 356 women; mean age 51.1 years) who underwent endoscopy, esophageal manometry, and ambulatory 24-hour pH monitoring were included. GEFV was graded I through IV using Hill`s classification; the GEFV was largely classified into 2 groups: the normal GEFV group (grade I and II) and the abnormal GEFV group (grade III and IV). Atrophic gastritis was classified into 2 groups by endoscopic atrophic border; closed-type (C-type) and open-type (O-type). Findings of endoscopy, esophageal manometry, and ambulatory pH monitoring were compared among the groups. Results: The incidence of reflux esophagitis and gastro-esophageal reflux disease was associated with an abnormal GEFV grade and was inversely associated with open-type of atrophic gastritis. The patients with a coexisting abnormal GEFV and closed-type atrophic gastritis showed a significantly higher incidence of reflux esophagitis and gastroesophageal reflux disease than the patients with a coexisting normal GEFV and open-type atrophic gastritis (OR, 20.6 [95% CI, 6.2-68.4], 11.4 [95% CI, 6.3-20.7], respectively). Conclusions: Endoscopic grading of the GEFV and the atrophic gastritis is simple and provides useful information on the status of gastroesophageal reflux.