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김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2
Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.
Yoon, Hyoung Kyu,Park, Yong-Bum,Rhee, Chin Kook,Lee, Jin Hwa,Oh, Yeon-Mok,Committee of the Korean COPD Guideline 2014 The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3
Chronic obstructive pulmonary disease (COPD) results in high morbidity and mortality among patients both domestically and globally. The Korean clinical practice guideline for COPD was revised in 2014. It was drafted by the members of the Korean Academy of Tuberculosis and Respiratory Diseases, as well as participating members of the Health Insurance Review and Assessment Service, Korean Physicians' Association, and Korea Respiration Trouble Association. This revised guideline covers a wide range of topics, including the epidemiology, diagnosis, assessment, monitoring, management, exacerbation, and comorbidities of COPD in Korea. We drafted a guideline on COPD management by performing systematic reviews on the topic of management with the help of a meta-analysis expert. We expect this guideline will be helpful medical doctors treating patients with respiratory conditions, other health care professionals, and government personnel in South Korea.
Effects of Pravastatin on Murine Chronic Graft-Versus-Host Disease
Yoon, Hyoung-Kyu,Lim, Ji-Young,Kim, Tae-Jung,Cho, Chul-Soo,Min, Chang-Ki Lippincott Williams Wilkins, Inc. 2010 Transplantation Vol.90 No.8
BACKGROUND.: Chronic graft-versus-host disease (CGVHD) is a serious and increasingly common complication after allogeneic (allo) hematopoietic stem-cell transplantation, but currently available therapies have demonstrated limited efficacy. Furthermore, the statins have been reported to be effective in various immune-mediated disease models, but their therapeutic potentials versus CGVHD have not been determined. METHODS.: We used a B10.D2→BALB/c model of CGVHD, which differs at minor histocompatibility loci, to address the therapeutic effect of statins on the development of CGVHD. Pravastatin (PST, 30 mg/kg/day) was intraperitoneally injected for 5 days per week from the day of transplantation until 4 weeks after allo hematopoietic stem-cell transplantation. RESULTS.: The onset of clinical cutaneous GVHD was significantly slower in PST-treated recipients than in allo-controls (36 days vs. 25 days, respectively, P<0.05), and pathologic changes in skin disease confirmed this clinical result. Animals injected with PST showed less submucosal fibrosis in lungs than allo-controls. In addition, collagen deposition in skin and lungs was markedly attenuated by PST treatment. PST also significantly reduced protein concentrations and numbers of inflammatory and epithelial cells in bronchoalveolar lavage fluid. Significantly lower numbers of donor CD11b and CD4, but not CD8 cells, were observed in skin and bronchoalveolar lavage fluid after PST treatment. The protein concentrations of monocyte chemoattractant protein-1 (MCP-1) and regulated on activation normal T cell expressed and secreted (RANTES) in skin and lungs were substantially reduced in PST-treated animals when compared with allo-controls. CONCLUSIONS.: This study suggests that the CGVHD-protecting effect of PST involves the down-regulation of chemokines and the reduction of collagen synthesis.
Polymorphisms in <i>PDE4D</i> are Associated with a Risk of COPD in Non-Emphysematous Koreans
Yoon, Hyoung-Kyu,Hu, Hae-Jin,Rhee, Chin-Kook,Shin, Seung-Hoon,Oh, Yeon-Mok,Lee, Sang-Do,Jung, Seung-Hyun,Yim, Seon-Hee,Kim, Tae-Min,Chung, Yeun-Jun Informa Healthcare 2014 COPD Vol.11 No.6
<P>Despite extensive effort, only a few chronic obstructive pulmonary disease (COPD)-associated genes have been suggested, indicating that there must be additional risk-associated loci. Here we aimed to identify additional COPD-associated SNPs and to explore the potential relationship between COPD subgroups and the SNPs in the Korean population. We performed a genome-wide association study (GWAS) with 990 Korean individuals; 102 COPD cases and 544 controls for GWAS using Affymetrix SNP array 5.0, and 173 COPD cases and 171 controls for replication. After validating the candidate single nucleotide polymorphisms (SNP), we performed subgroup analysis by disease phenotype. Through GWAS, we identified a novel SNP in the <I>phosphodiesterase-4D</I> (<I>PDE4D</I>) gene [rs16878037 (C>T), <I>p</I> = 1.66 ◊ 10<SUP>−6</SUP>] that was significantly associated with COPD. This signal in <I>PDE4D</I> was successfully replicated in the independent set (<I>p</I> = 0.041). When we combined the discovery and replication data, the association signal became more significant (<I>p</I> = 5.69 ◊ 10<SUP>−7</SUP>). In the COPD subgroup analysis, the T allele of rs16878037 was significantly more frequent in COPD patients without severe diffusion capacity impairment (mild mixed and obstruction-dominant group) than in patients with severe impairment (severe mixed and emphysema-dominant groups). This result supports that <I>PDE4D</I> polymorphisms might be involved in the susceptibility to COPD especially in non-emphysematous individuals and that they could also affect the responsiveness of the PDE4 inhibitor treatment.</P>
( Hyoung Kyu Yoon ),( Yong-bum Park ),( Chin Kook Rhee ),( Jin Hwa Lee ),( Yeon-mok ) 대한결핵 및 호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3
Chronic obstructive pulmonary disease (COPD) results in high morbidity and mortality among patients both domestically and globally. The Korean clinical practice guideline for COPD was revised in 2014. It was drafted by the members of the Korean Academy of Tuberculosis and Respiratory Diseases, as well as participating members of the Health Insurance Review and Assessment Service, Korean Physicians` Association, and Korea Respiration Trouble Association. This revised guideline covers a wide range of topics, including the epidemiology, diagnosis, assessment, monitoring, management, exacerbation, and comorbidities of COPD in Korea. We drafted a guideline on COPD management by performing systematic reviews on the topic of management with the help of a meta-analysis expert. We expect this guideline will be helpful medical doctors treating patients with respiratory conditions, other health care professionals, and government personnel in South Korea.
Humidifier Disinfectant (HD) and Bronchial Asthma
( Hyoung-kyu Yoon ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Humidifier disinfectant (HD) lung damage was terrible environmental chemical damage that happened in only South Korea, and it is estimated that there are 2.27 million people who have experienced potential health damage from humidifier disinfectants, and 230 people have died so far. Currently only pulmonary fibrosis (severe lung injury), asthma, fetal damage, toxic hepatitis, and interstitial lung disease in children are recognized for relief benefit. As a result of synthesizing the results of studies on adults and children, it was confirmed that all humidifier disinfectants, regardless of the type (ingredient), can cause asthma. In addition, the reduction of FEF25-75% among the lung functions of the group recognized as harmed by the humidifier disinfectant was significant, and the FEF25-75% did not improve well after the exposure was stopped or even after treatment. More than 80% (169 people) of the asthma-damaged group were new asthma patients caused by exposure to humidifier disinfectant, and the death rate was significantly higher in exacerbated asthma patients than in new asthma patients. Pneumonia was common in patients with exacerbated asthma and bronchitis was common in patients with new asthma. About 97% of those admitted suffering from asthma used asthma medications during treatment, and about 80% of them used inhaled steroids and inhaled long-acting beta-2 agonists (ICS + LABA) together. The prognosis is poor compared to the non-exposed asthma patient group due to damage to the small airways, and it is believed that it can cause continuous damage for a long time, so follow-up through health monitoring is necessary.
Hyoung Kyu Yoon,Tai Joon An,Ji Hye Kim,Chan Kwon Park 대한결핵및호흡기학회 2022 Tuberculosis and Respiratory Diseases Vol.85 No.1
Background: Neutrophilic asthma (NeuA) is usually resistant to corticosteroids. Tiotropium bromide (TIO) is abronchodilator that is used as an add-on therapy to inhaled corticosteroid and long-acting β2 agonist in asthmatreatment. However, the role of TIO in NeuA is not fully known. Thus, the aim of this study was to evaluate the effect ofTIO on NeuA compared to that of corticosteroids. Methods: C57BL/6 female mice were sensitized with ovalbumin and lipopolysaccharide to induce neutrophilicinflammation. Dexamethasone (DEX) was administered on days 14, 17, 20, and 23. TIO was inhaled on days 21, 21, and23. On day 24, mice were sacrificed. Airway hyper-responsiveness, levels of cytokines in bronchoalveolar lavage (BAL)and lung homogenates, and lung tissue histopathology were compared between the two groups. Results: Neutrophil counts, T helper 2 cells (TH2)/TH17 cytokines, and pro-inflammatory cytokine in BAL fluids wereelevated in the NeuA group. TIO group showed lower total cells, neutrophil counts, and eosinophil counts in BAL fluidsthan the DEX group (p<0.001, p<0.05, and p<0.001, respectively). Airway resistance was attenuated in the TIO group butelevated in the NeuA group (p<0.001). Total protein, interleukin (IL)-5, and IL-17A levels in BAL fluids were lower in theTIO group than in the NeuA group (all p<0.05). Conclusion: TIO showed more potent effects than DEX in improving airway inflammation and attenuating airwayresistance in NeuA.