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- 저자 : ( Hyoun-ah Kim ) (검색결과 104 건)
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Kim, Hyoun-Ah,Choi, Bunsoon,Suh, Chang-Hee,Han, Mi Hwa,Jung, Ju-Yang,Sayeed, Hasan M.,Kim, Ye Won,Sohn, Seonghyang MDPI AG 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.1
<P>Background: We investigated the potential role of several pattern-recognition receptors (PRRs; CD11b, CD11c, CD32, CD206, CD209, and dectin-1) in adult-onset Still’s disease (AOSD). Methods: The study included 13 untreated AOSD patients, 19 rheumatoid arthritis (RA) patients (as a disease control), and 19 healthy controls (HCs). The PRRs were quantified in peripheral blood using flow cytometry. The serum levels of interleukin-17 (IL-17), IL-18, and IL-23 were measured by enzyme-linked immunosorbent assay. Results: Significantly higher mean frequencies of cells presenting CD11b and CD32 from whole blood were observed in patients with AOSD than in patients with RA or HC. The levels of IL-17, IL-18, and IL-23 were elevated in AOSD patients compared to HCs. CD11b frequencies from whole cells correlated with systemic scores, lactate dehydrogenase (LDH) levels, aspartate transaminase levels, interleukin-23 (IL-23) levels, and IL-18. Frequencies of CD209 from granulocytes were significantly correlated with systemic scores, and the erythrocyte sedimentation rate and levels of C-reactive protein, ferritin, LDH, IL-23, and interleukin-18 (IL-18). Conclusions: Elevated frequencies of circulating CD11b-positive cells and positive correlations with disease activity markers suggest that circulating CD11b-positive cells contribute to the pathogenesis of AOSD.</P>
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Kim, Hyoun-Ah,Baek, Wook-Young,Han, Mi-Hwa,Jung, Ju-Yang,Suh, Chang-Hee Hindawi 2019 MEDIATORS OF INFLAMMATION Vol.2019 No.-
<P>Liver X receptors (LXRs) have emerged as important regulators of inflammatory gene expression. Previously, we had reported that an LXR<I>α</I> gene promoter polymorphism (-1830 T > C) is associated with systemic lupus erythematosus (SLE). Therefore, we assessed cytokine expression in relation to LXR<I>α</I> polymorphism in monocyte-derived macrophages from patients with SLE. Macrophages were obtained after 72 hours of culture of human monocytes supplemented with phorbol 12-myristate 13-acetate. Cells were transfected with LXR<I>α</I> promoter constructs. Additionally, peripheral blood mononuclear cell- (PBMC-) derived macrophages from the patients were evaluated for proinflammatory cytokines in relation to the genotypes of LXR<I>α</I> -1830 T > C. The expression of LXR<I>α</I> was increased in macrophages; levels of proinflammatory cytokines were decreased with LXR<I>α</I> expression. Production of proinflammatory cytokines varied depending on LXR<I>α</I> -1830 T > C genotype. In particular, expression of LXR<I>α</I> was decreased and that of proinflammatory cytokines was increased for LXR<I>α</I> -1830 TC genotype compared to that for TT genotype. The data were consistent in PBMC-derived macrophages from patients with SLE. Increased proinflammatory cytokines is related to TLR7 and TLR9 expression. These data suggest that the expression levels of LXR<I>α</I>, according to LXR<I>α</I> -1830 T > C genotype, may contribute to the inflammatory response by induction of inflammatory cytokines in SLE.</P>
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Therapeutic responses and prognosis in adult-onset Still's disease.
Kim, Hyoun-Ah,Sung, Jun-Mo,Suh, Chang-Hee Springer International 2012 Rheumatology international Vol.32 No.5
<P>To date, the treatment of adult-onset Still's disease (AOSD) has been largely empirical; therefore, this study was conducted to investigate the response to therapy and prognostic factors of AOSD. Fifty-four Korean patients with AOSD were enrolled based on Yamaguchi's criteria. We retrospectively analyzed the treatments and prognosis. Thirty-nine patients (72.2%) were female, and the average age at disease onset was 37.3 years. Twenty-nine patients had a monocyclic disease (53.7%), five had a polycyclic (9.3%) and fifteen had a chronic articular disease (27.7%) and five died (9.3%). The elevated ESR and corticosteroids refractoriness were associated with poor prognosis (P = 0.023 and P = 0.009, respectively). The patients that died were older than those survived (49.2 ± 11.8 vs. 42.2 ± 14 year old, P = 0.024). Forty-two patients were treated with non-steroidal anti-inflammatory drugs; however, they also needed corticosteroids and intravenous immunoglobulin (IVIG). Among 50 patients treated with high-dose corticosteroids, 21 patients (42%) were resistant to corticosteroids and treated with IVIG or anti-tumor necrosis factor (TNF) agents. Of the 23 patients medicated with IVIG, the prognosis was better in IVIG-responsive patients, indicating a therapeutic effect. Methotrexate was the most commonly used disease modifying anti-rheumatic drugs (27 patients, 50%), and the corticosteroid requirements were lower in the methotrexate-responsive patients. Approximately half of AOSD patients had a poor prognosis and were corticosteroids resistance. An elevated ESR and non-response to corticosteroids were associated with poor prognosis. Patients who died were older than those survived.</P>
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( Hyoun Ah Kim ),( Young Sil An ),( Ju Yang Jung ),( Chang Hee Suh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Previous studies have reported the results of bone scan in infi ammatory myositis patients; however, they are not consistent. Therefore, in this study, we investigated the clinical signifi cance of bone scan with a quantitative method for the global assessment of uptake in the proximal muscles in KoreanPM/DM patients. Methods: The 26 PM/DM patients fulfi lled the previously proposed criteria for either defi nite or probable PM/DM. The patients had undergone bone scan. The results were retrospectively analyzed visually and quantitatively using uptake ratios. The correlation between clinical parameters (laboratory and manual muscle test [MMT]) representing disease activity and fi nding of bone scan was assessed. Results: Visual analysis determined that 10 (71. 5%) active PM/DM patients had abnormal muscle uptake in bone scan. Visual grade of bone scan gave a sensitivity and specifi city value of 74% and 90. 9%, respectively in assessing infi ammation of muscle. Maximal proximal muscle uptake ratios of bone scan weresignificantly greater in active PM/DM patients than inactive patients (median 1. 97 vs 1. 02, p=0. 046). Maximal proximal uptake ratio signifi cantly correlated with creatine kinase (r=0. 394, p=0. 046), lactate dehydrogenase (LDH, r=0. 473, p=0. 015), aldolase (r=. 0428, p=0. 029), erythrocyte sedimentation rate (r=0. 412, p=0. 036), C reactive protein (r=0. 454, p=0. 002), and corresponding MMT (r=-0. 399, p=0. 044). Mean proximal muscle uptake ratio signifi - cantly correlated with LDH (r=0. 438, p=0. 025) and aldolase (r=0. 572, p=0. 002). Conclusions: Visual grade and maximal proximal uptake ratio on bone scan signifi cant correlated with known disease activity markers. The data suggest that bone scan may be a useful imaging technique for evaluation of PM/DM patients.
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Hyoun Oak Kim,Won Lee,Yoon-Ah Kook,Yoonji Kim 대한치과교정학회 2013 대한치과교정학회지 Vol.43 No.5
Objective: This study investigated whether temporomandibular joint (TMJ) condyle-fossa relationships are bilaterally symmetric in class III malocclusion patients with and without asymmetry and compared to those with normal occlusion. The hypothesis was a difference in condyle-fossa relationships exists in asymmetric patients. Methods: Group 1 comprised 40 Korean normal occlusion subjects. Groups 2 and 3 comprised patients diagnosed with skeletal class III malocclusion, who were grouped according to the presence of mandibular asymmetry: Group 2 included symmetric mandibles, while group 3 included asymmetric mandibles. Pretreatment three-dimensional cone-beam computed tomography (3D CBCT) images were obtained. Right- and left-sided TMJ spaces in groups 1 and 2 or deviated and non-deviated sides in group 3 were evaluated, and the axial condylar angle was compared. Results: The TMJ spaces demonstrated no significant bilateral differences in any group. Only group 3 had slightly narrower superior spaces (p < 0.001). The axial condylar angles between group 1 and 2 were not significant. However, group 3 showed a statistically significant bilateral difference (p < 0.001); toward the deviated side, the axial condylar angle was steeper. Conclusions: Even in the asymmetric group, the TMJ spaces were similar between deviated and non-deviated sides, indicating a bilateral condyle-fossa relationship in patients with asymmetry that may be as symmetrical as that in patients with symmetry. However, the axial condylar angle had bilateral differences only in asymmetric groups. The mean TMJ space value and the bilateral difference may be used for evaluating condyle-fossa relationships with CBCT.
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Kim, Hyoun-Ah,Han, Jae Ho,Kim, Woo-Jung,Noh, Hyun Jin,An, Jeong-Mi,Yim, Hyunee,Jung, Ju-Yang,Kim, You-Sun,Suh, Chang-Hee MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.8
<P>S100A8/A9 has been suggested as a marker of disease activity in patients with adult-onset Still’s disease (AOSD). We evaluated the clinical significance of S100A8/A9 as a biomarker and its pathogenic role in AOSD. Blood samples were collected prospectively from 20 AOSD patients and 20 healthy controls (HCs). Furthermore, skin and lymph node biopsy specimens of AOSD patients were investigated for S100A8/A9 expression levels via immunohistochemistry. Peripheral blood mononuclear cells (PBMCs) of active AOSD patients and HCs were investigated for S100A8/A9 cell signals. S100A8/A9, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) levels in active AOSD patients were higher than those of HCs. S100A8/A9 levels correlated positively with IL-1β, TNF-α and C-reactive protein. The inflammatory cells expressing S100A8/A9 were graded from one to three in skin and lymph node biopsies of AOSD patients. The grading for S100A8/A9 was more intense in the skin lesions with karyorrhexis, mucin deposition, and neutrophil infiltration. Like lipopolysaccharide (LPS), S100A8/A9 induced phosphorylation of p38 and c-Jun amino-terminal kinase (JNK) in PBMCs, suggesting that S100A8/A9 activates Toll-like receptor 4 signaling pathways. These findings suggest that S100A8/A9 may be involved in the inflammatory response with induction of proinflammatory cytokines and may serve as a clinicopathological marker for disease activity in AOSD.</P>
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Kim Hyoun-Ah,Lee Eunyoung,Park So Young,Lee Shin-Seok,Shin Kichul 대한의학회 2022 Journal of Korean medical science Vol.37 No.33
Background: Clinical characteristics and manifestations of psoriatic arthritis (PsA) have been extensively studied in western countries, yet data of Korean patients with PsA are very limited. We aimed to investigate the clinical traits of patients with PsA and dissect the characteristics of those with axial involvement. Methods: In this observational study, we analyzed clinical data of 109 patients with PsA who were enrolled in the Korean College of Rheumatology Biologics and Targeted Therapy registry between December 2012 and March 2022 at the time point of initiating or switching to a biologic agent. Data from 2,221 patients with ankylosing spondylitis (AS) registered during the same period were also analyzed. We divided patients with PsA into patients with or without axial involvement and then added AS patients with psoriasis (total three subgroups) for comparative analyses. Results: Asymmetric oligoarthritis was the most common clinical manifestation in patients with PsA, followed by symmetric polyarthritis and spondylitis. Our analysis indicated that methotrexate and sulfasalazine were the two most prescribed disease-modifying antirheumatic drugs for patients with PsA before starting biologic therapy. The patients with psoriatic spondylitis had more peripheral joint involvement (P = 0.016), less prior uveitis (P < 0.001), and lower human leukocyte antigen B27 (HLA-B27) positivity (P < 0.001) than the AS patients with psoriasis. Furthermore, syndesmophytes and radiographic sacroiliitis were prevalent among patients with PsA and AS patients with psoriasis who had the HLA-B27 gene. Conclusion: Our study shows that the degree of peripheral arthritis is less severe in Korean patients with PsA who require biologics and reestablishes that psoriatic spondylitis is a common and important clinical pattern in Korean patients with PsA.
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Kim, Hyoun Oak,Lee, Won,Kook, Yoon-Ah,Kim, Yoonji The Korean Association Of Orthodontists 2013 대한치과교정학회지 Vol.43 No.5
Objective: This study investigated whether temporomandibular joint (TMJ) condyle-fossa relationships are bilaterally symmetric in class III malocclusion patients with and without asymmetry and compared to those with normal occlusion. The hypothesis was a difference in condyle-fossa relationships exists in asymmetric patients. Methods: Group 1 comprised 40 Korean normal occlusion subjects. Groups 2 and 3 comprised patients diagnosed with skeletal class III malocclusion, who were grouped according to the presence of mandibular asymmetry: Group 2 included symmetric mandibles, while group 3 included asymmetric mandibles. Pretreatment three-dimensional cone-beam computed tomography (3D CBCT) images were obtained. Right- and left-sided TMJ spaces in groups 1 and 2 or deviated and non-deviated sides in group 3 were evaluated, and the axial condylar angle was compared. Results: The TMJ spaces demonstrated no significant bilateral differences in any group. Only group 3 had slightly narrower superior spaces (p < 0.001). The axial condylar angles between group 1 and 2 were not significant. However, group 3 showed a statistically significant bilateral difference (p < 0.001); toward the deviated side, the axial condylar angle was steeper. Conclusions: Even in the asymmetric group, the TMJ spaces were similar between deviated and non-deviated sides, indicating a bilateral condyle-fossa relationship in patients with asymmetry that may be as symmetrical as that in patients with symmetry. However, the axial condylar angle had bilateral differences only in asymmetric groups. The mean TMJ space value and the bilateral difference may be used for evaluating condyle-fossa relationships with CBCT.
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