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이호준,양효식,전영문,정흥락,강재구,방제용 建國大學校基礎科學硏究所 1996 理學論集 Vol.21 No.-
영광원자력발전소 주변의 식생에 대한 식물사회학적 조사를 실시하였으며, 순 1차 생산량과 식물현존량을 추정하였다. 또한 상관에 의해 현존식생도 및 녹지자연도를 작성하였다(1:50,000). Z-M 방식에 의한 삼림식생은 소나무군락과 곰솔군락으로 구분되었다. 전체적으로 교목층에 소나무와 곰솔, 아교목층에 졸참나무와 곰솔, 관목층에 털진달래와 신갈나무, 초본층에 털대사초와 그늘사초 등의 피복지수가 우세하게 나타났다. 토양의 pH는 4.65∼4.67, 유기물 함량은 7.28∼7.53%의 범위였다. 현존식생도에 의한 분포비율은 경작지(67%), 소나무(21.9%) 및 곰솔군락(9.1%)의 순으로 나타났으며, 녹지자연도는 등급 2가 67%(경작지), 7등급(이차림(A))과 6등급(조림지)이 각각 29.2%와 1.8%로 나타났다. Montreal model에의한 소나무림과 곰솔림의 식물현존량은 657,817.2와 177,367.0ton으로 각각 산정되었다. The forest vegetation and estimation of phytomass and net primary production in the vicinity of Yonggwang Atomic Power Plant were analyzed on the basis of the phytosociological data. Depending on physiognomy, the actual vegetation map and the degree of green naturality(DGN) were also drawn in the scale of 1:50,000. According to Z-M method, the forest vegetation was classified into two communities; Pinus densiflora and Pinus thunbergii communities. It was generally shown that Pinus densiflora and Pirus thunbergii in tree-1 layer, Quercus serrata and Pinus thunbergii in tree-2 layer, Rhododendron mucronulatum var. ciliatum and Quercus serrata in shrub layer, and Carex ciliato-marginata and Carex lanceolata in herb layer had high coverage index. The pHs and contents of organic matter of the forest soils collected in each sites were in the 4.64 to 4.67 and 7.28% to 7.53% in average, respectively. The distribution area of each vegetationindex. The pHs and contents of organic matter of the forest soils collected in each sites were in the 4.64 to 4.67 and 7.28% to 7.53% in average, respectively. The distribution area of each vegetation type in the actual vegetation map was 67% cultivated land, 21.9% in Pinus densiflora community and 9.1% in pinus thunbergii community. The distribution of the degree of green naturality(DGN) was 67% in the second-grade (cultivated land), 29.2% in 7th grade (second forest(A)) and 1.8% in 6th grade (plantation). It was estimated that phytomass of Pinus densiflora and Pinus thunbergii in the study sites, which was calculated by Montreal model, was 657,817.2 and 177,367.0 ton, respectively.
우리 나라에서 재해방지를 위한 개선안 생활변화단위 모형 개발 및 응용
강영식,함효준,양성환 대한설비관리학회 2003 대한설비관리학회지 Vol.8 No.2
The major cause of the industrial accidents is often induced by the human error. It brings about all kind of accidents. Moreover, the more the information and system complicates, the more the human error brings about. So the active accident prevention policy by human behavior, life style, culture, and psychology should develop at this time. Especially, the behavior models have provided the accident proneness concept through the life change unit factors. According to the existing studies on the life change unit models, the oriental behavior models differs from the western model in the life style and ideas. Therefore, the purpose of this paper is to develop the proposed life change unit model by the improved life change unit factors, and to evaluate its application in real fields. The proposed model can be simply applied in real fields in order to minimize the industrial accidents
Hyo-Joon Yang,정혜경,Seung Joo Kang,이용찬,Seon-Young Park,Cheol Min Shin,Sung Eun Kim,임현철,Jie-Hyun Kim,Su Youn Nam,Woon Geon Shin,Jae Myung Park,Il Ju Choi,김재규,Miyoung Choi,Korean College of Helicobacter a 대한상부위장관ㆍ헬리코박터학회 2021 Korean Journal of Helicobacter Upper Gastrointesti Vol.21 No.1
Background/Aims: As antibiotic resistance increases and new first-line therapies emerge, salvage therapies for Helicobacter pylori (H. pylori) eradication failures are becoming more common and complicated. This study aimed to systematically review overall salvage regimens after previous failure of H. pylori eradication. Materials and Methods: A systematic review of randomized clinical trials evaluating salvage therapies after previous H. pylori eradication failure was performed. A meta-analysis was conducted when an adequate number of studies suitable for grouping was found. Results: Overall, 36 studies with 77 treatment arms were identified, and they were highly heterogeneous regarding previously failed regimens and salvage regimens under comparison. Bismuth quadruple therapy after failure of standard triple therapy showed a pooled intention-to-treat (ITT) eradication rate of 75.5% (95% CI, 71.6~79.1%), and the rates were significantly higher with 14-day therapy than 7-day therapy by 9% (95% CI, 2~15%). Levofloxacin triple therapy after failure of standard triple therapy demonstrated a pooled ITT eradication rate of 73.3% (95% CI, 68.4~77.3%). In direct comparison, the two regimens were not significantly different in eradication rates. No study evaluated salvage regimens after the failure of bismuth or non-bismuth quadruple therapy. Conclusions: The current studies regarding salvage regimens are highly heterogeneous. Bismuth quadruple therapy and levofloxacin triple therapy may be a reliable option after failure of standard triple therapy, but the regional profile of antibiotic resistance should be considered. Further studies are needed for salvage regimens after failure of non-bismuth or bismuth quadruple therapy.
Yang Hyo-Joon,Kim Young-Il,Ahn Ji Yong,Choi Kee Don,Kim Sang Gyun,Jeon Seong Woo,Kim Jie-Hyun,Shin Sung Kwan,Lee Hyuk,Lee Wan-Sik,Kim Gwang Ha,Park Jae Myung,Shin Woon Geon,Choi Il Ju 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.4
Background/Aims: The eCura system, a scoring model for stratifying the lymph node metastasis risk after noncurative endoscopic resection for early gastric cancer (EGC), has been internally validated, primarily for differentiated-type EGC. We aimed to externally validate this model for undifferentiated-type EGC. Methods: This multicenter, retrospective cohort study included 634 patients who underwent additional surgery (radical surgery group, n=270) or were followed up without additional treatment (no additional treatment group, n=364) after noncurative endoscopic resection for undifferentiated- type EGC between 2005 and 2015. The lymph node metastasis and survival rates were compared according to the risk categories. Results: For the radical surgery group, the lymph node metastasis rates were 2.6%, 10.9%, and 14.8% for the low-, intermediate-, and high-risk eCura categories, respectively (p for trend=0.003). For the low-, intermediate-, and high-risk categories in the no additional treatment group, the overall survival (92.7%, 68.9%, and 80.0% at 5 years, respectively, p<0.001) and cancer-specific survival rates (99.7%, 94.7%, and 80.0% at 5 years, respectively, p<0.001) differed significantly. In the multivariate analysis, the hazard ratios (95% confidence interval) in the no additional treatment group relative to the radical surgery group were 3.18 (1.41 to 7.17; p=0.005) for overall mortality and 2.60 (0.46 to 14.66; p=0.280) for cancer-specific mortality in the intermediate-tohigh risk category. No such differences were noted in the low-risk category. Conclusions: The eCura system can be applied to undifferentiated-type EGC. Close follow-up without additional treatment might be considered for low-risk patients, while additional surgery is recommended for intermediate- and high-risk patients.
( Hyo-joon Yang ),( Chang Woo Cho ),( Jongha Jang ),( Sang Soo Kim ),( Kwang-sung Ahn ),( Soo-kyung Park ),( Dong Il Park ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.4
Background/Aims: We aimed to develop a deep learning model for the prediction of the risk of advanced colorectal neoplasia (ACRN) in asymptomatic adults, based on which colorectal cancer screening could be customized. Methods: We collected data on 26 clinical and laboratory parameters, including age, sex, smoking status, body mass index, complete blood count, blood chemistry, and tumor marker, from 70,336 first-time colonoscopy screening recipients. For reference, we used a logistic regression (LR) model with nine variables manually selected from the 26 variables. A deep neural network (DNN) model was developed using all 26 variables. The area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of the models were compared in a randomly split validation group. Results: In comparison with the LR model (AUC, 0.724; 95% confidence interval [CI], 0.684 to 0.765), the DNN model (AUC, 0.760; 95% CI, 0.724 to 0.795) demonstrated significantly improved performance with respect to the prediction of ACRN (p < 0.001). At a sensitivity of 90%, the specificity significantly increased with the application of the DNN model (41.0%) in comparison with the LR model (26.5%) (p < 0.001), indicating that the colonoscopy workload required to detect the same number of ACRNs could be reduced by 20%. Conclusions: The application of DNN to big clinical data could significantly improve the prediction of ACRNs in comparison with the LR model, potentially realizing further customization by utilizing large quantities and various types of biomedical information.
( Hyo Joon Yang ),( Chang Hyun Lee ),( Seon Hee Lim ),( Jong In Yang ),( Seung Joo Kang ),( Min Jung Park ),( Su Jin Chung ),( Jong Pil Im ),( Sang Gyun Kim ),( Joo Sung Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: This study aimed to identify the clinical characteristics and prognosis of primary gastric lymphoma detected by screening upper endoscopy in high prevalence area of Helicobacter pylori ( H. pylori) infection. Methods: Between October 2003 and May 2013, consecutive subjects who were diagnosed with primary gastric lymphoma by screening upper endoscopy were retrospectively enrolled at Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea. Results: During the study period, a total of 101,103 subjects received 207,114 screening upper endoscopy. Among them, primary gastric lymphoma was detected in 49subjects. They were 53.0 ± 10.5 years of age, and 72.9% (35/49) were female. Histologic type of primary gastric lymphoma was predominantly (98.0%, 48/49) extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), and one remaining case (2.0%) was diffuse large B-cell lymphoma. Initial stage was IEa in 95.9% (47/49), and H. pylori was positive in 91.8% (43/49). Among 41 H. pylori-positive patients with gastric MALT lymphoma stage IEa, H. pylori eradication achieved complete remission in 95.1% (39/41). There were three cases of recurrence with (n = 2) or without (n = 1) reinfection of H. pylori. Conclusions: Upper endoscopy as a screening for upper gastrointestinal malignancymay detect gastric MALT lymphoma in early stage, which can be successfully treated with H. pylori eradication, especially in H. pylori endemic area. For those who achieved complete remission, it is needed to undertake surveillance for recurrence.
( Hyo-Joon Yang ),( Wan-Sik Lee ),( Bong Eun Lee ),( Ji Yong Ahn ),( Jae-Young Jang ),( Joo Hyun Lim ),( Su Youn Nam ),( Jie-Hyun Kim ),( Byung-Hoon Min ),( Moon Kyung Joo ),( Jae Myung Park ),( Woon 대한소화기학회 2021 Gut and Liver Vol.15 No.5
Background/Aims: This study examined the long-term outcomes of undifferentiated-type early gastric cancer (UD EGC) with positive horizontal margins (HMs) after endoscopic resection (ER) and compared them between additional surgery and nonsurgical management. Methods: From 2005 to 2015, a total of 1,124 patients with UD EGC underwent ER at 18 tertiary hospitals in Korea. Of them, 92 patients with positive HMs as the only noncurative factor (n=25) or with both positive HMs and tumor size >2 cm (n=67) were included. These patients underwent additional surgery (n=40), underwent additional endoscopic treatment (n=6), or were followed up without further treatment (n=46). Results: No lymph node (LN) metastasis was found in patients who underwent additional surgery. During a median follow-up of 57.7 months (interquartile range, 27.6 to 68.8 months), no LN or distant metastases or gastric cancer-related deaths occurred in the overall cohort. At baseline, the residual cancer rate was 57.8% (26/45) after additional surgery or ER. The 5-year local recurrence rate was 33.6% among patients who were followed up without additional treatment. The 5-year overall survival rates were 95.0% and 87.8% after additional surgery and nonsurgical management (endoscopic treatment or close follow-up), respectively (log-rank p=0.224). In the multivariate Cox regression analysis, nonsurgical management was not associated with an increased risk of mortality. Conclusions: UD EGC with positive HMs after ER may have favorable long-term outcomes and a very low risk of LN metastasis. Nonsurgical management may be suggested as an alternative, particularly for patients with old age or chronic illness. (Gut Liver 2021;15:723-731)