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Fosfomycin의 항균효과 및 capillary electrophoresis에 의한 측정법에 관한 연구
윤효인,박승춘,이규승,권진욱,조준형,신광순,김무열,허강준,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
Fosfomycin, a low molecular antibiotic, is to be easily synthesized, therefore to be possibly used in veterinary sectors due to econimic reasons. In this study, we determined the antibacterial activities of fosfomycin against some domestic animal-origin pathogens, and its combined effects with some important antibacterials available. We also compared detection methods of fosfomycin from various measuring instruments. The results obtained through this experiment were as follows: 1. Antibacterial activities of fosfomycin against the pathogens used in this experiment were appeared fairly low. We found the antobacterial activities depanded on the kinds of media and the addition of some material thereins, which suggests the importance of appropriate medium so as to judge the antibacterial activity of fosfomycin. 2. Fosfomycin showed varying antibacterial effects in combination with other antibacterials, which should be taken into consideration when combining other antobacterials especially in the clinical settings. Of the combined antivacterials, fosfomycin had synergistic effects in combination with amoxicillin but antagonistic effects with oxytetracyline. 3. Conventional detection methods using HPLC, GC and spectrophotometer were not appropriate to measure fosfomycin. Capillary electrophoresis by the way of the indirect ultraviolet detection method was good enough to detect fosfomycin in the range of expected concentration in tissues, with the limit of quantitation (LOQ) of 1.25 ㎍/㎖. We recommend the eletrophoresis method could be used to detect fosfomycin, thereby being able to set the optimal dosage for animals and providing the measures in relation with the residual concentration in the meat.
공동주택의 범죄발생 실태 및 범죄불안감에 관한 연구 : 부산진구 사례 중심으로 The Case Studies of Busan Jin-Gu
최열,김효숙,임하경 釜山大學校 都市問題硏究所 2003 都市硏究報 Vol.15 No.-
Security of residential environment is a basic desire as well as a necessary condition to make happy home. Specially a security from the crime is an important matter at the large scale and high density dwelling complex in the industrialized city. The concept of defensible space is the living environment for crime prevention and reduction in fear of crime, based on recognition that crime occurrences have influenced on the quality of residential environment. Recently Crime Prevention Through Environment Design (CPTED) is used a variety fields including housing, commerce, education and recreation facilities. So it became important factors to construct a good city. It means that possibility of a CPTED's application is very diverse. This study intended to understand the place where produces crime and affects the uneasiness and to propose the design's guideline of defensible space to residential site. Therefore this paper analyzed the differences of the case among the apartments, the mixed-use residential buildings, the multiplex houses.
돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학
윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.
박효열,진광수,유병길,주정진,김중환 동의대학교 기초과학연구소 1994 基礎科學硏究論文集 Vol.4 No.1
Cd_1-xMn_xTe single crystals were grown by vertical Bridgman method and Mn mole fraction x was determined by the X-ray diffraction. Band gap and optical transition energies E₁, E₁+ △₁, E₂, △₁as Mn mole fraction x were obtained by measuring optical absorption and reflection at UV-visible region respectively. The change of the valence band spin-orbit splitting △₁at △ point of the Brillouin zone was discussed.
오상우,김윤희,고효선,이상열,노승호 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2
배경: 본 연구는 SCL-90-R에서 9개 증상차원의 요인구조가 어떻게 나타나는지를 알아보는 데 목적이 있다. 방법: SAS 프로그램을 이용하여 정신과적 장애로 진단받은 환자 188명이 수행한 SCL-90-R 자료의 요인구조를 분석하였다. 결과: 요인분석 결과 SCL-90-R의 9개 증상차원은 단일요인으로 나타났다. 결론: SCL-90-R의 요인분석 결과 단일 요인 모형이 탐색되었다. 추후 연구에서는 SCL-90-R의 9개 척도에 대한 확인적 요인분석이 필요할 것으로 생각된다. Background: To find of this study was to find exploratory factor analysis of the nine scales of the Symptom Checklist-90-Revision(SCL-90-R). Methods: This study was investigated the factor structures of nine scales of the SCL-90-R in 188 patients with psychiatric disorders using SAS 8.02 software. Results: The factor structure showed that the factor structures of nine scales of the SCL-90-R had one factor. Conclusion: The factor structures showed that the factor structures of the SCL-90-R had one factor. Further research is nedeed about confirmatory factor analysis of the nine scales of the SCL-90-R.
Peter Eisenman의 해체주의이론과 작품에 관한 연구
鄭鎭洙,金孝烈 嶺南大學校工業技術硏究所 1992 연구보고 Vol.20 No.2
Deconstruction in relatively short time gained currency and public prominence. It created a stir on the main stream of 20th century architecture, which reflected changes in the literature and philosophy. Jacques Derrida's notions of critical 'deconstruction and difference' have been translated into the architectural substances. The movement in architecture has been developed by several architects such as Peter Eisenman et al. Peter Eisenman is the architect who develops logical theories that change idealogical selection. He seeks most logical essential qualities in architecture. His architectural works are expressed in two types. The one is that the performance of conceptual theories is one of his type of architectural work. The pther is the endowment of suitable theories to the circumstances after converting classical vocabulary into that of contemporary architecture.
Comparative proteome analysis for Wheat Processing Property
Jong-Yeol Lee,Yeong-Tae Kim,Hyo-Jeung Kim,Sun-Hyung Lim,Sun-Hwa Ha,Young-Mi Kim 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Although it is known that the composition of high-molecular weight glutenin subunits (HMW-GSs) and low-molecular weight glutenin subunits (LMW-GSs) are important factor for bread, noodle and cookie, it is still not clear which HMW-GSs and LMW-GSs confer improved processing properties and how those HMW-GSs and LMW-GSs interact each other. In this study, to investigate distinctive glutenin proteins for characteristic processing properties for noodle, glutenins extracted from seeds of several Korean and Chinese wheat cultivars were focused in IPG gel strip and subjected to SDS-polyacrylamide gel electrophoresis. Differential protein expression level was analyzed using image master platinum 6. Then to characterize the HMW-GSs of Korean cultivar Uri, extracted glutenin proteins were separated by two dimensional gel electrophoresis. Nine spots digested with trypsin resulting peptide fragmentation were identified by LC ESI-MS/MS and MASCOT database. We also separated HMW-GSs from wheat cultivar Uri by fast protein liquid chromatography (FPLC) withResource Phe column using gradient buffer condition with 4M Urea and 0.45M ammonium sulfate.Each single band of 1Dx 2.2, 1Bx7 and double bands of 1Dy8 and 1By12 were separated.
Isolation of mesenchymal stem-like cells in meningioma specimens
LIM, HYO-YEOL,KIM, KYUNG MIN,KIM, BO KYUNG,SHIM, JIN-KYOUNG,LEE, JI-HYUN,HUH, YONG-MIN,KIM, SE-HOON,KIM, EUI-HYUN,PARK, EUN-KYUNG,SHIM, KYU-WON,CHANG, JONG HEE,KIM, DONG-SEOK,KIM, SUN HO,HONG, YONG-KI Spandidos Publications 2013 International journal of oncology Vol.43 No.4