제1형 Trichorhinophalangeal 증후군

손효성,오창근,김문범,이재봉,장호선,권경술 대한피부과학회 2003 대한피부과학회지 Vol.41 No.6

Trichorhinophalangeal syndrome(TRPS) typeⅠis characterized by sparse and slow-growing hairs, pear-shaped nose, elongated philtrum, thin upper lip, and bone deformities, especially, cone-shaped epiphyses of the phalanges. The syndrome is inherited in an autosomal dominant manner. We report a case of TRPS typeⅠ with alopecia like male pattern baldness and Perthes-like changes on the right hip joint. (Korean J Dermatol 2003;41(6) : 801~804)

전력시스템의 부하주파수 제어를 위한 뉴로-퍼지제어기 설계

손태훈,김상효 동의공업대학 2000 論文集 Vol.26 No.1

The load frequency control of power system is one of important subjects in view of system operation and control. That is, even though the rapid load disturbances were applied to the given power system, the stable and reliable power should be supplied to the users, converging unconditionally and rapidly the frequency deviations and the tie-line power flow ones of each area into allowable boundary limits. Nonetheless of such needs, if the internal parameter perturbation and the sudden load variation were given, the unstable phenomena of power system can be often brought out because of the large frequency deviation and the unsuppressible power line one. Therefore, it is desirable to design the robust power system controller which can stabilize effectively the given power system as soon as possible, In this paper the robust neuro-fuzzy controller was proposed and applied to control of load frequency over multi-area power system. The architecture and algorithm of a designed NFC(Neuro-Fuzzy Controller) were consist of fuzzy controller and neural network for auto tuning of fuzzy controller. The adaptively learned antecedent and consequent parameters of membership functions in fuzzy controller were acquired from the steepest gradient method for error-back propagation algorithm.

맹출장애가 있는 하악대구치의 임상적 관리

손우성,이해경,남형진,강상욱,송효경,김성식 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

비소세포폐암에서 Microsatellite Instability

전효성,김정란,손지웅,박선하,박태인,김창호,김인산,정태훈,박재용 경북대학교 병원 2001 경북대학교병원의학연구소논문집 Vol.5 No.1

연구베경:MMR 유전자의 불활성화에 의해 야기되는 뮤전적 불안정성은 발암기전의 한 부류로 인정되고 있다.저자들은 비소세포폐암의 발암과정에서의 MSI의 역할을 규명하기 위해 비소세포폐암에서 MSI의 빈도 및 MSI 유무에 따른 임상상의 차이를 조사하였다. 대상 및 방법:근치적 절제술을 받은 비소세포폐암 20예를 대상으로 하였다.동결된 폐암조직과 환자의 림프구에서 DNA를 추출한 후 3P와 9p의 15개의 marker들을 대상으로 PCR을 시행하고 7% polyacrylamide gel에서 전기영동한 후 silver 염색을 시행하였다. 암조직과 림프구 DNA의 PCR product의 band를 비교하여 MSI와 LOH를 판정하였다. 결과:1)대상환자들은 남자 19예,여자 1예였으며 모두 흡연자였고 평균 흠연력은 47 갑년이었다. 폐암의 조직형은 편평상피암 15예, 선암 4예,대세포암 1예였고, 술 후 병리학적 병기는 Ⅰ기 6예,Ⅱ기 5예, ⅢA기 7예,ⅢB기 2예였다. 2)20예 가운데 8예(40%)에서 MSI가 관찰되었으며 3예는 한 개의 marker에서,5예는 2개 이상의 marker에서 MSI가 관찰되었다. 3)LOH는 10예(50%)에서 있었으며,LOH유무에 따른 병가 및 흡연력의 차이가 없었다. 4)분석한 marker의 10% 이상에서 MSI가 관찰된 MSI-L종양은 5예였으며, 대부분의 marker에서 MSI양성인 MSI-H종양은 없었다.MSS종양과 MSI-L종양은 흡연력, 병기, 폐암 조직형 및 LOH 빈도의 유의한 차이가 없었다. 결론:비소세포폐암에서 MSI는 비교적 흔히 관찰되지만 MMR 유전자의 불활성화에 의한 MMP pathway 는 비소세포폐암의 주요 발생기전은 아닐 것으로 생각된다.향 후 비소세포폐암의 발암과정에 있어서 MMP pathway의 역할을 규명하기 위해서는 보다 많은 예를 대상으로 한 연구가 필요할 것으로 생각되며, MSI 발생기전에 관한 추가적인 연구가 필요할 것으로 생각된다. Purpose: Microsatellite instability(MSI) is frequently used as an indicator of microsatellite mutator phenotype (MMP) tumors.MSI has been observed in a percentage of non-small cell lung cancer(NSCLC).However, its role in tumorigenesis of NSCLC remains unknown.The frequency and partten of MSI in NSCLC were evaluted and clinical parameters of MSI-positive tumors with those of MSS(microsatellite stable) tumors were compared. Materials and Methods: Twenty surgically resected NSCLCs were analyzed for 15 microsatellite markers located at chromosomes 3p and 9p.The peripheral blood lymphocytes of patients were used as the source of the normal DNA. Results:1) of 20 cases, 8(40%) demonstrated MSI. 2) Instability was observed more frequently in tri- and tetra-nucleotide repeats that in dinucleotide repeats. In all cases, instability appeared as a shift of individual allelic bands. 3) LOH was observed in 10(50%) of 20 tumors analyzed. 4) Of 20 cases, MSI-H tumor(showing MSI in the majority of markers) was absent. There were 5 MSI-L tumors( showing MSI in a greater than 10% of markers). 5) No significant difference was observed between MSI-L tumors and MSI negative tumors in terms of clinicopathologic features such as pack-year history of smoking, histologic subtype, and (delete) stage of disease.There was also no significant difference in the incidence of LOH in relation to the status of MSI. Conclusion: These data strongly suggest that MSI plays different roles in lung and colon cancer.MMP pathway appears to be far less important in the tumorigenesis of NSCLC, caused mainly by cigarette smoke, with little familial tendency.(tuberculosis and Respiratory Diseases 2000,48:24-32)

안식향산 함유 식품 섭취가 톨루엔 폭로 근로자들의 요중 마뇨산 농도에 미치는 영향

심상효,손정일,박정일 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.3

This study was performed to investigate the effect of foods containing benzoic acid on the urinary hippuric acid concentration in the toluene exposed workers. The urinary hippuric acid concentration were measured at 0, 30, 60, 90, 120 and 150 minute after intake of soft drink and bread containing benzoic acid in volunteers, who did not have been exposed toluene occupationally. After that urinary hippuric acids were measured at the end of shift in toluene exposed workers. And also the concentration of toluene in air were analysed by gas chromatography. So the relationships between urinary hippuric acid concentration and age, work duration, concentration of toluene in air and intake of benzoic acid containing food were observed. The results were as follows: 1. The urinary hippuric acid concentration reached the highest level at 30 minute after intake of soft drink with bread at a level of 1.41g/g creatinine and soft drink alone at a level of 1.04g/g creatinine which contained benzoic acid among unexposed toluene, and then gradually decreased. 2. In toluene exposed group to significant effect of general characteristics such as gender, age, work duration, drinking and smoking on urinary hippuric acid concentration was showed in toluene exposed group. 3. The mean value of urinary hippuric acid concentration of group taking benzoic acid containing foods was significantly higher than that of group not taking. 4. Multiple regression analysis showed that toluene concentration in air and benzoic acid containing foods were together significantly influence on urinary hippuric acid concentration. And the function between variables is Y=0.014Toluene+0.489Benzoic acid+0.745 and the contribution rates were 31%. In conclusion, it was suggested that the information on intake of benzoic acid containing foods should be considered in measurement of urinary hippuric acid for the more accurate toluene exposure evaluation.

急性 骨髓性 白血病 患者 1例에 對한 臨床報告

조정효,유화승,최우진,이용연,서상훈,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

AML is the most common type of leukemia in adults. AML(acute myeloid leukaemia) is characterised by a rapid accumulation of abnormal white blood cells in the blood and bone marrow, resulting in severe anemia, and possibly infection, and hemorrhage during the course of the disease. In general the prognosis of patient with relapsed AML is poor. At this time, however, the only potentially curative therapy for relapsed patients is allogeneic BMT(bone marrow transplantation). This clinical study were carried out 1 case of female patient aged 44 with relapsed AML treated by herb medicine. At the time of admission, she complained of mild fever, nausea, vomitting, abdominal pain, anorexia and no sign of bleeding. For the 10 days of admission, she was treated with Oriental-Western medicine and all the symptoms were disappeared. After that, the syptoms were aggravated because of secondary infection. Anyway, above result showed the possibility of Oriental therapy as Supportive Care in AML.

抗癌丹을 投與한 大腸癌 患者 83例에 대한 臨床報告

이용연,서상훈,유화승,최우진,조정효,이연월,손창규,조종관 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

Climical studies were carried out 83 cases of patients with colorectal cancer treated bv Hangamdan(抗癌丹) from January lth 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by colorectal cancer, by sex, showed that Male is more then Female, by age, showed that the numbber of fifties is majorith. 2. distribution of diagnostic stage, in descending order; stage Ⅲ(53%, top), stagew Ⅵ(45.8%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(83.3%) and combined treatment of westem and oriental therapy(92.1%)were boserved. The effects of the symptoms were as folows: diarrhea(37.3%),abdominal pain (25.3%), general body weakness(22.9%), nausea(20.5%) and etc. in orders. 4. Analysis of hematology attached by colorectal cancer, maintenance and increasing of WBC(89.9%), RBC(74.7%), Hgb(81.1%), Platelet(92.4%) were Observed. After taken Hangamdan, the satety of the liver and kidney were as follows; maintenance and decreasting of AST(85.9%), ALT(94.8%) , GTP(87.5%), Creatinine(90.9%) were observed. 5. of IL-12 and IFN-λ attached by colorectal cancer, increasing of IL-12(53.3%), IFN-λ(80%) were observedl. 6. Analysis of QOL attached by colorectal cancer, maintenance and improvement of combined treatment of western and oniental therapy(89.6%), traditional oriental therapy(83.3%) were observed. 7. Analysis of survival in patients with Ⅳ stage of colorectal cancer, above 7 months(18.4%), 12 months(65.8%). 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(83.3%) and maintenance and improvement of combined treatment of western and oriental therapy(80.5%) were observed. Analysis of tumor marker attached by colorectal cancer, maintenance and decreasing of CEA(78.8%) were boserved 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(83.3%), combined treatment of westem and oriental therapy(72.7%) were observed.

압력용기의 설계기준 및 손상 평가

오환섭,정효진,박상필,손두익 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

The damage of the pressure courage by degradation can become the reason of unexpected break down or failure accident and it is very important because safety accident, the production loss, environmental pollution, social problems are occur. Consequently The result to investigat of failure accident for domestic pressure vessel, the factor of degradation is SCC, Sorrosion, Cavity, Crack

冬蟲夏草의 抗轉移와 免疫增進에 關한 硏究

최우진,유화승,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

This experimental study was carried out to evaluate the effects of Cordiceps sinensis on the antimetastasis and immune activity. In order to investigate the effect of Cordiceps sinensis, the followings were performed; Cytotoxicity, inhibition of MMP-2 & MMP-9 gene expression, fraction of CD4+, CD8+, CD19+ in splenic cell, the moprphological change of splenic cells, gene expression of IL-12(p35), IL-12(p40), IFN-?? and splenic cell proliferation by CS-E. The results were obtained as follows. 1. CS-E did not present cytotoxic effect on L+14, B16-F10 melanoma cells and HMCB. 2. CS-E inhibited MMP-2 and MMP-9 gene expression more effectively compared with control group. 3. CS-E inhibited invasion of B16-F10 melanoma cells more effectively compared with control group. 4. CS-E helped CD4+, CD8+, CD19+ expression more effectively compared with control group. 5. CS-E activated phagocytic cells in spleen more effectively compared with control group. 6. CS-E helped IL-12(p35), IL-12(p40), IFN-?? gene expression in splenic cell more effectively compared with control group. 7. CS-E activated splenic cell proliferation more effectively compared with control group. From above findings, it is suggested that CS-E is able to inhibit metastasis of cancer and activate immune response system.

抗癌丹을 投與한 胃癌 患者 105例에 對한 臨床報告

유화승,최우진,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

Clinical studies were carried out 105 cases of patients with stomach cancer treated by Hangamdan(抗癌丹) from January 1th 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by stomach cancer, by sex, showed that Male is more then Female, by age, showed that the number of forties, fifties, sixties are majority. 2. Distribution of diagnostic stage, in descending order; stage Ⅲ(45.1%, top), stage Ⅳ(40.2%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(77.8%) and combined treatment of western and oriental therapy(92.3%) were observed. The effects of the symptoms were as follows; abdominal pain (16.3%), general body weakness(10.5%), nausea&vomiting (8.6%), diarrhea(6.7%) and etc, in orders. 4. Analysis of hematology attached by stomach cancer, maintenance and increasing of WBC(89.4%), RBC(63.6%), Hgb(62.3%), Platelet(95.6%) were observed. After taken Hangamdan, the safety of the liver and kidney were as follows; maintenance and decreasing of AST(85.3%), ALT(91.6%), BUN(84.8%), Creatinine(92.4%) were observed. 5. Analysis of IL-12 and IFN-γ attached by stomach cancer, increasing of IL-12(39.1%), IFN-γ(69.6%) were observed. 6. Analysis of QOL attached by stomach cancer, maintenance and improvement of combined treatment of western and oriental therapy(91%), traditional oriental therapy(85.2%) were observed. 7. Analysis of survival in patients with Ⅳ stage of stomach cancer, above 6 months(17.1%), 12 months(85.2%) were observed. 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(81.5%) and maintenance and improvement of combined treatment of western and oriental therapy(89.7%) were observed. Analysis of tumor marker attached by stomach cancer, maintenance of CEA(85.7%) were observed. 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(77.7%), combined treatment of western and oriental therapy(82.1%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for stomach cancer patients by combination with western therapy or alone.