복강경하 대장절제술을 시행 받는 환자에서 라모세트론과 온단세트론외 술 후 오심 및 구토 예방 효과 비교

김효중;어전영;어근무;어정한;엄세훈;조광래;김명훈 인제대학교 2011 仁濟醫學 Vol.32 No.-

Objectives : We evaluated the efficacy of ramosetron and ondansetron for preventing postoperative nausea and vomiting (PONV) in laparoscopic colectomy. Methods and Materials : Eighty patients who received laparoscopic colectomy were randomly divided into two groups: R group (ramosetron 0.1mg PO) and O group (ondansetron 4mg twice IV). Injection or oral medication was administered before the induction of anesthesia in each group. Injection was administered at the end of surgery in O group. General anesthesia was induced using propofol and rocuronium, and maintained with sevoflurane, remifentanil and air (FiO2 0.5), We investigated the incidences of PONV in each group by the Rhodes index of nausea, vomiting and retching (RINVR) at postoperative 6 and 24 hours. Results : The incidence of PONV was not different between group at each time points after surgery (at postoperative 6 hours: 20% in group R, 17.5% in group 0, at postoperative 24 hours; 12.5% in group R, 7.5% in group 0). There was no difference in the severity of PONV, satisfaction, rescue drug usage. Conclusion : Prophylactic therapy with ramosetron is as effective as conventional prophylactic therapy with ondansetron for preventing PONV in general anesthesia for laparoscopic colectomy.

전치태반의 임상적 고찰

정갑인,이해혁,이효환,유정완,남계현,이임순,이권해 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Objective : Our purpose was to make preparations of what for proper emergency care and delivery in order to improve maternal and fetal well-being. Methods : The study was undertaken for the clinical evaluation and statistical analysis on the patients with placenta previa who had been admitted and delivered at Soonchunhyang University Hospital from January, 1994 to May, 1998, retrospectively. Results : The incidence of placenta previa was 2.0%. Placenta previa has occurred more often in multigravida(92%) than primigravida(8%). Vaginal bleeding was most frequent(37.3%) presentation. The mean gestational age at the first bleeding episode was 31~35 weeks(46.4%). The type of placenta previa was totalis (31.3%), Partialis(18%), marginalis(32.7%), low lying(18%). Conclusion . This study indicates that the obstetrician and the pediatrician should be prepared for emergency care and delivery of the placenta previa patients, with the improvement of delivery room and neonatal intensive care unit.

Cognitive training이 알츠하이머 치매의 인지, 실행에 미치는 영향

이효정 忠州大學校 2008 한국교통대학교 논문집 Vol.43 No.-

This study was performed for effects of intervention of attention training, general cognitive training which influenced on the change of cognitive and performance with patients caused by Alzheimer's dementia. The cognitive training program was provided to experimental groups for 4 weeks(5 times a week) and no intervention was provided to control group. Measurements of pre, 2wks, post(4wks) and follow up(2wks, 4wks and 8wks) experiment were K-MMSE and ACL. The results of this study showed that in comparison of pre, 2wks, post and follow up(2wks, 4wks and 8wks) changes, A group noticeable changes in cognitive. B group noticeable changes in cognitive and performance(ACL). These results mean cognitive training provides cognitive and performance with Alzheimer's dementia. Comprehensive research is required about a point of time and duration for intervention and severity degree in clinical approach for Alzheimer's dementia.

플라보노이드의 세포 신호전달 조절

이응룡,강근호,강용진,김우열,최혜연,김봉우,정효순,조쌍구 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

Many studies revealed the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. The plausible mechanistic interpretation of the various effects of flavonoids was concentrated on the anti-oxidant or free radical-scavenging properties of these phytochernicals, both in model systems and under in vivo conditions. While there has been a major focus on the anti-oxidant properties. there is an emerging view that flavonoids and their in vivo metabolites. do not act as conventional hydrogen-donating anti-oxidants. but they may exert regulatory functions in cells through actions at protein kinase or lipid kinase signaling pathways. Flavonoids and more recently their metabolites. have been reported to act at phosphoinositide 3-kinase(PI 3-kinase). Akt/protein kinase B(Akt/PKB), protein kinase C (PKC), mitogen activated protein kinase(MAP kinase), and various tyrosine kinases signaling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as anti-oxidants or modulators of cellular signaling pathways, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anti-cancer agents, cardio-protectants, and inhibitors of neurodegeneration.

Methylphenidate 투약에 따른 주의력결핍 과잉운동장애 아동의 정량화 뇌파의 변화

이병대,정성훈,이만기,장수민,백지령,임효덕 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

인공신경망 이론을 이용한 충주호의 수질예측

정효준,이소진,이홍근 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

This study was carried out to evaluate the artificial neural network algorithm for water quality forecasting in Chungju lake, north Chungcheong province. Multi-layer perceptron(MLP) was used to train artificial neural networks. MLP was composed of one input layer, two hidden layers and one output layer. Transfer functions of the hidden layer were sigmoid and linear function. The number of node in the hidden layer was decided by trial and error method. It showed that appropriate node number in the hidden layer is 10 for pH training, 15 for DO and BOD, respectively. Reliability index was used to verify for the forecasting power. Considering some outlying data, artificial neural network fitted well between actual water quality data and computed data by artificial neural networks.

항고형암제의 활성평가를 위한 in vitro 삼차원 암세포 배양계의 확립

이상학,이주호,구효정 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

For the efficient determination of activity against solid tumors, an in vitro tumor model that resembles the condition of in vivo solid tumors, is required. The purpose of this study was to establish a rapid culture method and viability assay for an in vitro 3-dimensional tumor model, multicellular spheroid (MCS). Among 12 human cancer cell lines, a few cell lines including DUD-1 (human colorectal carcinoma cells) formed fully compact MCS which was adequate for in vitro viability assay. DLD-1 MCS showed steady growth reaching 700 pm diameter after 11 day culture. DUD-1 cells grown as MCS showed significant increase in G_(0)/G₁ phase compared to the monolayer cells (73.9% vs 45.7%). but necrotic regions or apoptotic cells were not observed. The cells cultured as MCS showed resistance to 5-FU (10.3 fold higher IC_(50)) compared to monolayers. however, tirapazamine (a hypotoxin) showed similar activity in both culture systems. In summary, MCS may be a valid in vitro model for activity screening of anticancer agents against human solid tumors and also exploitable for studying molecular markers of drug resistance in human solid tumors.

노부모의 성인자녀와의 갈등 및 우울에 관한 연구

이윤정,이신숙,신효식 全南大學校家政科學硏究所 1994 生活科學硏究 Vol.4 No.-

This study was to investigate the depression of the aged parents perceived through the conflicts between the aged parents and their adult children. The subjects of the study were 469 old parents, consisted of 234 male and 235 female over 60 years old lives in Kwangju. The datas were analysed by frequency, percentage, mean, standard deviation, oneway ANOVA, t test, Duncan's test and multiple regression using SAS program and the results are as follows. 1) In the conflict between the aged parents and their adult children which the aged parents perceive, the mean values are 32.54 in the case of old father and 34.26 in old mother from the average point. The average values of the depression the aged parents perceive are 26.03 and 28.35 each in old father and old mother and show the level of depression over the middle value. 2) The background variables which show the significant differences of the conflict between the aged parents and their adult children are marital status, age, education, pocket money, health and activity of the aged parents. 3) The background variables which show the significant difference in the depression the aged parents perceive are marital atatus, education, pocket money, health, activity, support type and occupation of the aged parents. 4) The depression and conflict between the aged parents and their adult children show high correlations and the greatest variable as the effect of conflict on the depression is emotional conflict. In addition, significant difference is shown depending on health, value and economic conflict and its explanatory power is 50%.

태양 추적 장치를 갖는 집광 시스템의 집열 특성

이용훈,최석천,지명국,이상철,정효민,정한식 경상대학교 해양산업연구소 2002 해양산업연구소보 Vol.15 No.-

The purpose of this research is to obtain the heat transfer characteristics of the absorber type solar collector. This new system moving by time and degree. The second system had the solar tracking system. The x-y axis were designed at intervals of 0.33˚/min and 0.16˚/min respectively. In this system the absorber specification was 1OOLX80Φ1.4t. This experiment was conducted from July to August. 2002. The temperature of solar collector was reached about mean temperature 250℃.

Compound Poisson 수요를 갖는 CONWIP 시스템의 근사적 분석

이정은,이효성 한국경영과학회 1998 韓國經營科學會誌 Vol.23 No.3

In this study we consider a CONWIP system in which the processing times at each station follow an exponential distribution and the demands for the finished products arrive according to a compound Poisson process. The demands that are not satisfied instantaneously are assumed to be backordered. For this system we develop an approximation method to obtain the performance measures such as steady state probabilities of the number of parts at each station, the proportion of backordered demand. For the analysis of the proposed CONWIP system, we model the CONWIP system as a closed queueing network with a synchronization station and analyze the closed queueing network using a product form approximation method. A matrix geometric method is used to solve the subnetwork in the application of the product-form approximation method. To test the accuracy of the approximation method, the results obtained from the approximation method were compared with those obtained by simulation. Comparisons with simulation have shown that the approximate method provides fairly good results.