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단기간의 저용량 Cytosine arabinoside 치료에 반응하였던 Down 증후군에 병발한 급성골수성백혈병 1례
김현수,이정호,이정찬,강정현,곽상혁,김철희,배광봉,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
The incidence of hematologic disorders in patients with Down's syndrome is significantly increased, about 14∼30 - fold higher than in general population and includes neonatal transient abnormal myelopoieis and acute leukemias. The age of onset of leukemia in Down's syndrome is peaking first in the newborn period and then under 4 years of age. Down's syndrome with acute leukemia above the age of 20 is very rare and it's treatment oucome is unclear. The treatment of Down's syndrome with leukemia has been controversial because of toxicity and associated congenital cardiac and other abnormalities. But if treated adequately, children with Down's syndrome show a favorable response to anti-leukemia therapy. A 24-year-old man with Down's syndrome was first seen for the evaluation of anemia and thrombocytopenia. The peripheral blood morphology and bone marrow study revealed acute myelogenous leukemia, cytogenetic study of bone marrow showed trisomy 21. Beacuse of his sicioeconomic condition and medical abnormalities including deafness, visual loss, he was treated with low dose subcutaneous cytosine arabinoside(Ara-C) for 11 days. Complete remission was obtained after 37 days. The complete remission lasted for 5 months. He subsequently relapsed, and died 6 months later.
중증 재생불량성 빈혈 환자에서 신우신염에 대한 광범위항생제치료 중에 속발한 Saccharomyces cerevisiae 진균감염 1예
김철희,이정호,이정찬,강정현,곽상혁,배광봉,김현수,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
Most patients with aplastic anemia who do not respond to immunosuppressive treatment or are not candidates for bone marrow transplantation die of infection or bleeding. The neutropenia in acute leukemia, aplastic anemia, or occurring subsequently to chemotherapy and bone marrow transplantation increases susceptibility to infection. In general, the number of infectious episodes correlate with the degree and duration of neutropenia. Global immunosuppression produced by conditioning for bone marrow transplantation or graft-versus-host disease, is associated with unusual bacterial and fungal pathogens, or serious viral and protozoan infections. In addition, repeated treatment with broad-spectrum antibiotics is associated with the emergence of resistant organisms and fungal diseases because of the altered microbial microenvironment of the host. The incidence of invasive fungal infection caused by Saccharomycetes eerevisiae in immunosuppressed patients is very rare, compared with that of infection by candida or aspcrgillus species. Cases of Saccharomycetes cerevisiae fungemia occurring in the course of treatment with broad-spectrum antibiotics are reported in patients with extensive burn or with prosthetic valve endocarditis. We experienced a case of urinary tract infection by Saccharomycetes cerevisiae in a 27-year old female patient with severe aplastic anemia. We report the case with a review of relevant literatures.
Azathioprine에 반응을 보인 류마티양 관절염에 의한 경막염(Pachymeningitis)1예
배광봉,이정호,이정찬,곽상혁,강정현,김철희,김현수,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
Rheumatoid arthritis frequently involves the cervical spine and may lead to neurologic impairement. However, direct involvement of CNS structures by inflammatory cells has been reported infrequently. The prevalence of this complication of rheumatoid arthritis is unknown. Inflammatory CNS involvement in rheumatoid arthritis reportedly occurs in the setting of longstanding, active, erosive articular disease and is accompanied by extracranial and extraspinal nodules and vasculitis. This is diagnosed by radiologic finding of CNS nodules or meningeal thickening and by biopsy or autopsy. Treatment with corticosteroid, cytotoxic agent or surgical decompression is helpful. But the majority of patients die within several months of onset of neurologic symptom. Recently, we experienced a case of pachymeningitis caused by rheumatoid arthritis, which resolved repeatedly with azathioprine treatment.
Jo Hyeong Ho,Kim Nayoung,Oh Hyeon Jeong,Song Du Hyun,Choi Yonghoon,Park Jaehyung,Lee Jongchan,Yoon Hyuk,Shin Cheol Min,Park Young Soo,Lee Dong Ho,Lee Hye Seung,Park Young Suk,Ahn Sang-Hoon,Suh Yun-Suh 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.5
Background/Aims: There are few reports regarding mixed carcinoma, defined as a mixture of glandular and poorly cohesive components, in patients with gastric cancer (GC). The aim of this study was to evaluate the proportion and characteristics of mixed carcinoma in GC patients. Methods: A total of 7,215 patients diagnosed with GC at Seoul National University Bundang Hospital were enrolled from March 2011 to February 2020. GC was divided into four groups (wellmoderately differentiated GC, poorly differentiated GC, poorly cohesive carcinoma, and mixed carcinoma). The proportion of each GC type and the clinicopathological features were analyzed and divided into early GC and advanced GC. Results: The proportion of mixed carcinoma was 10.9% (n=787). In early GC, submucosal invasion was the most common in poorly differentiated (53.7%), and mixed carcinoma ranked second (41.1%). Mixed carcinoma showed the highest proportion of lymph node metastasis in early GC (23.0%) and advanced GC (78.3%). In advanced GC, the rate of distant metastasis was 3.6% and 3.9% in well-moderately differentiated GC and mixed carcinoma, respectively, lower than that in poorly differentiated GC (6.4%) and poorly cohesive carcinoma (5.7%), without statistical significance. Conclusions: Mixed carcinoma was associated with lymph node metastasis compared to other histological GC subtypes. And it showed relatively common submucosal invasion in early GC, but the rates of venous invasion and distant metastasis were lower in advanced GC. Further research is needed to uncover the mechanism underlying these characteristics of mixed carcinoma (Trial registration number: NCT04973631).
Jo Hyeong Ho,Kim Nayoung,Jang Jieun,Choi Yonghoon,Park Jaehyung,Park Young Mi,Ahn Soyeon,Yoon Hyuk,Shin Cheol Min,Park Young Soo,Lee Dong Ho,Oh Hyeon Jeong,Lee Hye Seung,Park Young Suk,Ahn Sang-Hoon,S 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: The incidence and prognosis of gastric cancer (GC) shows sex difference. This study aimed to evaluate the effect of body mass index (BMI) on GC survival depending on sex. Methods: The sex, age, location, histology, TNM stages, BMI, and survival were analyzed in GC patients from May 2003 to February 2020 at the Seoul National University Bundang Hospital. Results: Among 14,688 patients, there were twice as many males (66.6%) as females (33.4%). However, under age 40 years, females (8.6%) were more prevalent than males (3.1%). Cardia GC in males showed a U-shaped distribution for underweight (9.6%), normal (6.4%), overweight (6.1%), obesity (5.6%), and severe obesity (9.3%) but not in females (p=0.003). Females showed decreased proportion of diffuse-type GC regarding BMI (underweight [59.9%], normal [56.8%], overweight [49.5%], obesity [44.8%], and severe obesity [41.7%]), but males did not (p<0.001). Both sexes had the worst prognosis in the underweight group (p<0.001), and the higher BMI, the better prognosis in males, but not females. Sex differences in prognosis according to BMI tended to be more prominent in males than in females in subgroup analysis of TNM stages I, II, and III and the operative treatment group. Conclusions: GC-specific survival was affected by BMI in a sex-dependent manner. These differences may be related to genetic, and environmental, hormonal factors; body composition; and muscle mass (Trial registration number: NCT04973631).
상부위장관내시경검사 중 관상동맥 혈관경축으로 심정지를 일으킨 후 회복되었던
조대현 ( Jo Dae Hyeon ),박정호 ( Park Jeong Ho ),권정훈 ( Kwon Jeong Hun ),김현서 ( Kim Hyeon Seo ),김재희 ( Kim Jae Hui ),오주현 ( O Ju Hyeon ),심상군 ( Sim Sang Gun ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
The incidence of serious cardiac complications associated with esophagogastro-duodenoscopic examination is very rare. An episode of cardiac arrest developed in 49-year-old during endoscopic examination. The patient had no history of pulmonary or ischemic
현일식 ( Hyeon Il Sig ),조경란 ( Jo Gyeong Lan ),백상현 ( Baeg Sang Hyeon ),김진배 ( Kim Jin Bae ),최호순 ( Choe Ho Sun ),이오영 ( Lee O Yeong ),한동수 ( Han Dong Su ),손주현 ( Son Ju Hyeon ),함준수 ( Ham Jun Su ),이민호 ( Lee Min 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
원발성 간세포암종은 간 외로 전이하는 경우가 드문 암이다. 전이가 있는 경우 주로 폐, 복부 임파선, 뼈, 뇌 순으로 전이된다. 그러나, 전이성인 경우라도, 간 종물 없이 전이 병변만 발견된 경우는 보고된 바가 없었다. 이에 간 종물 없이 흉벽에서만 발견된 전이성 간세포암종을 경험하였기에 보고하는 바이다. 51세 남자로, 좌상부 흉벽에 약 12×10㎝ 크기로 단단한 종물이 촉지되고 8개월 전부터 크기가 증가되어 내원하였다. 환자는 10년 전 만성 B형
지붕형 태양광발전 패널의 공장 지붕 설치에 따른 냉방 및 난방 부하 변화량 연구
조호현(Ho-Hyeon Jo),김정민(Jung-Min Kim),김영일(Young Il Kim) 한국지열·수열에너지학회 2020 한국지열에너지학회논문집 Vol.16 No.4
In this study, effect of reinforced insulation on heating and cooling loads were studied due to installation of PV panels on factory building roof with a floor area of 12,960 m². For PV panel installation, combination of aluminum, polyurethane, air, polystyrene and steel materials were added to the original roof, which increased thermal insulation performance. Half of the roof were covered with PV panel and the other half without. Temperature and relative humidity were measured for 8 days during summer season for both indoor spaces. PV panel showed the effect of lowering the indoor space temperature by 0.6℃. TRNSYS dynamic simulation showed that with PV panel, cooling load per area is reduced by 1.7 W/m² and heating by 10.0 W/m². PV panels installed on building roof not only generate electricity but also can save energy by reducing cooling and heating loads.