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한병원의 외래를 이용한고혈압혹은 심장질환 환자대상 복약상담 실태조사
안성심,최고운,김순주,방준석,나현오 한국병원약사회 2009 병원약사회지 Vol.26 No.3
Abstract: The medication counseling to the patients with hypertension or cardiovascular dis-eases influences affirmative events for the treatment. In general, this kinds of education is pro-vided by the medical caregivers and is needed to evaluate the efficacy if fulfill the demands of the patients. The aims of this study are to analyze the actual condition and to present adequate methodological directions for developing effective counseling programs. The study subject was eighty-five out-patients who suffering with hypertension or cardiovascular diseases. The ques-tionnaire was developed and the face-to-face interviews were conducted by trained clinical pharmacists. About 74% of the patients recognized the dosage of their prescribed medications, 30% recognized the name, side effects, interaction, and precautions of the medications. Only 45.9% of patients(n=39) recognized their late blood pressure, 30%(n=18) recognized their thera-peutic target number of the blood pressure. Around 40% answered the medication counseling is necessary. Thirty-two percent of patients(31.8%) necessitated the knowledge of drug-drug inter-actions, or the adequate count-actions to manage the un-wanted side effects(29.4%, n=25). In conclusion, for the patients with hypertension or cardiovascular disease, well-designed medica-tion-counseling or education programs are essential to lessen the possibilities of the side effects and to increase the pharmacotherapeutic outcomes.
The Inhibitory Effect of Quercetin on the Agonist-Induced Regulation of Vascular Contractility
( Hyen Oh La ),( Hyun Dong Je ),( Ji Hoon Jeong ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.4
The present study was undertaken to investigate the infl uence of quercetin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Quercetin at a low concentration (0.01-0.03 mM) directly and more signifi cantly relaxed fl uoride or thromboxane A2-induced vascular contraction than phorbol ester-induced contraction suggesting as a possible antihypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, quercetin more signifi cantly inhibited thromboxane A2-induced increases in pMYPT1 levels than phorbol ester-induced increases. It also more signifi cantly inhibited thromboxane A2-induced increases in pMYPT1 levels than pERK1/2 levels suggesting the mechanism involving the primarily inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1. This study provides evidence regarding the mechanism underlying the relaxation effect of quercetin on agonist-induced vascular contraction regardless of endothelial function.
( Hyen Oh La ),( Hyun Dong Je ),( Hyeong Dong Kim ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.2
Apigenin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. Thepresent study was undertaken to investigate the influence of apigenin on vascular smooth muscle contractility and to determinethe mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combinedwith molecular experiments. Apigenin significantly relaxed fluoride-, thromboxane A2 mimetic- or phorbol ester-induced vascularcontraction, which suggests that apigenin could be an anti-hypertensive that reduces agonist-induced vascular contraction regardlessof endothelial nitric oxide synthesis. Furthermore, apigenin significantly inhibited fluoride-induced increases in pMYPT1 levelsand phorbol ester-induced increases in pERK1/2 levels, which suggests the mechanism involving the inhibition of Rho-kinase andMEK activity and the subsequent phosphorylation of MYPT1 and ERK1/2. This study provides evidence regarding the mechanismunderlying the relaxation effect of apigenin on agonist-induced vascular contraction regardless of endothelial function.
The Inhibitory Effect of Eupatilin on the Intestinal Contraction Induced by Carbachol
( Jong Min Lee ),( Hyen Oh La ),( Hyun Dong Je ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.4
This study was conducted to determine whether treatment with the anti-inflammatory eupatilin influences intestinal smooth muscle contraction stimulated by carbachol and, if so, to investigate the related mechanism. Denuded ileal or colonic muscles from Sprague-Dawley rats were used for the study and measurements of isometric contractions were obtained using a computerized data acquisition system; this data was also combined with results from molecular experiments. Eupatilin from Artemisia asiatica Nakai significantly decreased carbachol-induced contractions in both ileal and colonic muscles. Interestingly, eupatilin decreased carbachol-induced phosphorylation of ERK1/2 more significantly than that of MYPT1 at Thr855 in ileal and colonic muscles. However, eupatilin significantly decreased phosphorylation of MYPT1 at Thr855, but only in ileal muscle. Therefore, thin filament regulation, including MEK inactivation and related phospho-ERK1/2 decrease, is mainly involved in the eupatilin-induced decrease of intestinal contraction induced by carbachol. In conclusion, this study provides the evidence and a possible related mechanism concerning the inhibitory effect of the flavonoid as an antispasmodic on the agonist-induced contractions in rat ileum and colonic muscles.
Hypothermia Inhibits Endothelium-Independent Vascular Contractility via Rho-kinase Inhibition
Chung, Yoon Hee,Oh, Keon Woong,Kim, Sung Tae,Park, Eon Sub,Je, Hyun Dong,Yoon, Hyuk-Jun,Sohn, Uy Dong,Jeong, Ji Hoon,La, Hyen-Oh The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2
The present study was undertaken to investigate the influence of hypothermia on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Hypothermia significantly inhibited fluoride-, thromboxane $A_{2-}$, phenylephrine-, and phorbol ester-induced vascular contractions regardless of endothelial nitric oxide synthesis, suggesting that another pathway had a direct effect on vascular smooth muscle. Hypothermia significantly inhibited the fluoride-induced increase in pMYPT1 level and phorbol ester-induced increase in pERK1/2 level, suggesting inhibition of Rho-kinase and MEK activity and subsequent phosphorylation of MYPT1 and ERK1/2. These results suggest that the relaxing effect of moderate hypothermia on agonist-induced vascular contraction regardless of endothelial function involves inhibition of Rho-kinase and MEK activities.
Je, Hyun Dong,Sohn, Uy Dong,La, Hyen-Oh The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.1
Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of fisetin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Fisetin significantly relaxed fluoride-, thromboxane $A_2$- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, fisetin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of fisetin on agonist-induced vascular contraction regardless of endothelial function.
Hypothermia Inhibits Endothelium-Independent Vascular Contractility via Rho-kinase Inhibition
( Yoon Hee Chung ),( Keon Woong Oh ),( Sung Tae Kim ),( Eon Sub Park ),( Hyun Dong Je ),( Hyuk-jun Yoon ),( Uy Dong Sohn ),( Ji Hoon Jeong ),( Hyen-oh La ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2
The present study was undertaken to investigate the influence of hypothermia on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Hypothermia significantly inhibited fluoride-, thromboxane A<sub>2-</sub>, phenylephrine-, and phorbol ester-induced vascular contractions regardless of endothelial nitric oxide synthesis, suggesting that another pathway had a direct effect on vascular smooth muscle. Hypothermia significantly inhibited the fluorideinduced increase in pMYPT1 level and phorbol ester-induced increase in pERK1/2 level, suggesting inhibition of Rho-kinase and MEK activity and subsequent phosphorylation of MYPT1 and ERK1/2. These results suggest that the relaxing effect of moderate hypothermia on agonist-induced vascular contraction regardless of endothelial function involves inhibition of Rho-kinase and MEK activities.
( Hyun Dong Je ),( Uy Dong Sohn ),( Hyen Oh La ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.1
Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of fisetin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Fisetin significantly relaxed fluoride-, thromboxane A2- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, fisetin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of fisetin on agonist-induced vascular contraction regardless of endothelial function.
The Inhibitory Effect of Shikonin on the Agonist-Induced Regulation of Vascular Contractility
( Hyun Dong Je ),( Hyeong Dong Kim ),( Hyen Oh La ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.3
Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Shikonin significantly relaxed fluoride-, thromboxane A2- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, shikonin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol esterinduced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and the inhibition of MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of shikonin on agonist-induced vascular contraction regardless of endothelial function.