김동리 연구

김혜미(Kim, Hyemi) 전남대학교 한국어문학연구소 2014 전남대학교 한국어문학연구소 학술지 어문논총 Vol.- No.25

본 논문은 김동리에 관한 단순한 작품 창작의 부분적 해명에서 벗어나, 작가의 체험과 문학 작품의 상호 긴밀한 관계를 해명하려는 시도였다. 그러기 위해 정신분석적 방법을 통하여 원형적 체험의 문학적 형상화 과정을 살펴보았다. 먼저, 부모 밑에서 상처받은 주체가 상징계로 진입하는 과정이 김동리의 작품에 어떻게 영향을 미쳤는지를 보았다. 아버지와 어머니의 부재는 사회적 금기와 관련하여 작품으로 형상화되었다. 다음으로, ‘선이’의 죽음 이후 이어지는 일련의 죽음에의 체험이 문학적 형상화와 어떤 관계를 맺는가를 확인했다. 역설적이게도 의도하지 않은 죽음에 대한 직・간접적인 반복이 작가를 ‘글쓰기’의 주체적인 위치에 설 수 있게 해준 것이다. 마지막으로, 위의 부정적인 경험들이 친형 ‘범부’의 영향 하에 작품으로 승화될 수 있었던 기반을 살펴보았다. ‘결핍’과 ‘소외’를 불러일으키던 원형적 체험들이 한학자였던 범부의 정신적, 물질적 영향을 받아 문학적으로 승화될 수 있었다. 즉, 김동리의 원형적 체험들은 스스로 의식하는 부분과 의식하지 못하는 부분에 복합적으로 자리 잡고 있었다. 작가로서 그가 끊임없이 원형적 체험을 진술하고 문학적으로 형상화하는 지점들은 자신의 욕망을 대리적으로 해소하는 일종의 자기 정화(catharsis) 과정일 뿐만 아니라 작가의 치열한 자기 치료의 과정이었음을 보여준 것이었다. This thesis attempts to elucidate the close interrelationship between experiences of an author and literature works, beyond the partial explication of simple creation of works related with Kim Dongli. Therefore, the literary formation of archetypal experience was examined through psychoanalytical method. At first, it examines how the process in which a subject afflicted by his/her parents shifted into the symbolic has an effect on the works of Kim Dongli. The lack of father and mother was formalized as the work related with social taboo. Next, it verifies what relations a series of deaths which were induced following the death of ‘Seon-I’ make with literary formation. Paradoxically, direct/indirect repetitions of unintended death allowed tor the author to stand at subjective position of "writing". Finally, it examines the basis on which such negative experiences can be sublimated into a work under his older brother, ‘Beombu’: The archetypal experiences giving rise to ‘lack’ and ‘alienation’ can be literally sublimated through the psychological and material effects of Beombu, a scholar of the Chinese classics. Thus, the archetypal experiences of Kim Dongli are complicatedly placed in intended and unintended part. The points where the author continuously states and literally formalizes the archetypal experiences seems to be not only a kind of catharsis process in which his own desire is vicariously satisfied, but also an another process of intense self-therapy of the author.

Profiling of remote skeletal muscle gene changes resulting from stimulation of atopic dermatitis disease in NC/Nga mouse model

Lee, Donghee,Seo, Yelim,Kim, Young-Won,Kim, Seongtae,Choi, Jeongyoon,Moon, Sung-Hee,Bae, Hyemi,Kim, Hui-sok,Kim, Hangyeol,Kim, Jae-Hyun,Kim, Tae-Young,Kim, Eunho,Yim, Suemin,Lim, Inja,Bang, Hyoweon,Ki The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5

Although atopic dermatitis (AD) is known to be a representative skin disorder, it also affects the systemic immune response. In a recent study, myoblasts were shown to be involved in the immune regulation, but the roles of muscle cells in AD are poorly understood. We aimed to identify the relationship between mitochondria and atopy by genome-wide analysis of skeletal muscles in mice. We induced AD-like symptoms using house dust mite (HDM) extract in NC/Nga mice. The transcriptional profiles of the untreated group and HDM-induced AD-like group were analyzed and compared using microarray, differentially expressed gene and functional pathway analyses, and protein interaction network construction. Our microarray analysis demonstrated that immune response-, calcium handling-, and mitochondrial metabolism-related genes were differentially expressed. In the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology pathway analyses, immune response pathways involved in cytokine interaction, nuclear factor-kappa B, and T-cell receptor signaling, calcium handling pathways, and mitochondria metabolism pathways involved in the citrate cycle were significantly upregulated. In protein interaction network analysis, chemokine family-, muscle contraction process-, and immune response-related genes were identified as hub genes with many interactions. In addition, mitochondrial pathways involved in calcium signaling, cardiac muscle contraction, tricarboxylic acid cycle, oxidation-reduction process, and calcium-mediated signaling were significantly stimulated in KEGG and Gene Ontology analyses. Our results provide a comprehensive understanding of the genome-wide transcriptional changes of HDM-induced AD-like symptoms and the indicated genes that could be used as AD clinical biomarkers.

Profiling of remote skeletal muscle gene changes resulting from stimulation of atopic dermatitis disease in NC/Nga mouse model

Donghee Lee,Yelim Seo,Young-Won Kim,Seongtae Kim,Jeongyoon Choi,Sung-Hee Moon,Hyemi Bae,Hui-sok Kim,Hangyeol Kim,Jae-Hyun Kim,Tae-Young Kim,Eunho Kim,Suemin Yim,Inja Lim,Hyoweon Bang,Jung-Ha Kim,Jae-H 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5

Although atopic dermatitis (AD) is known to be a representative skin disorder, it also affects the systemic immune response. In a recent study, myoblasts were shown to be involved in the immune regulation, but the roles of muscle cells in AD are poorly understood. We aimed to identify the relationship between mitochondria and atopy by genome-wide analysis of skeletal muscles in mice. We induced AD-like symptoms using house dust mite (HDM) extract in NC/Nga mice. The transcriptional profiles of the untreated group and HDM-induced AD-like group were analyzed and compared using microarray, differentially expressed gene and functional pathway analyses, and protein interaction network construction. Our microarray analysis demonstrated that immune response-, calcium handling-, and mitochondrial metabolism-related genes were differentially expressed. In the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology pathway analyses, immune response pathways involved in cytokine interaction, nuclear factor-kappa B, and T-cell receptor signaling, calcium handling pathways, and mitochondria metabolism pathways involved in the citrate cycle were significantly upregulated. In protein interaction network analysis, chemokine family-, muscle contraction process-, and immune response-related genes were identified as hub genes with many interactions. In addition, mitochondrial pathways involved in calcium signaling, cardiac muscle contraction, tricarboxylic acid cycle, oxidation-reduction process, and calcium-mediated signaling were significantly stimulated in KEGG and Gene Ontology analyses. Our results provide a comprehensive understanding of the genome-wide transcriptional changes of HDM-induced AD-like symptoms and the indicated genes that could be used as AD clinical biomarkers.

Growth Kinetics of Macronodular Lung Metastases and Survival in Differentiated Thyroid Carcinoma

Kim, Mijin,Kim, Won Gu,Park, Suyeon,Kwon, Hyemi,Jeon, Min Ji,Lee, Sang Min,Lee, Jeong Hyun,Kim, Tae Yong,Shong, Young Kee,Kim, Won Bae Mary Ann Liebert 2017 Thyroid Vol.27 No.7

<P>Conclusions: This is the first study to demonstrate objectively that tumor growth kinetics within the first year are an independent predictor of CSS in patients with macronodular lung metastases. Performing chest computed tomography at least twice a year in the early phase of the disease in patients with macronodular lung metastases may be helpful for identifying high-risk patients who are eligible for treatment with tyrosine kinase inhibitors.</P>

Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes

Kim, Hyemi,Yang, Eunjung,Lee, Jeonggi,Kim, Se-Hoon,Shin, Jeon-Soo,Park, Joo Young,Choi, Sun Ju,Kim, Se Jong,Choi, In-Hong Blackwell Publishing Ltd 2008 Immunology Vol.124 No.4

<P>Summary</P><P>Toll-like receptor 3 (TLR3) participates in the innate immune response by recognizing viral pathogens. In this study, human brain astrocytes were found to constitutively express TLR3, and this expression was increased by interferon-&ggr; (IFN-&ggr;) or double-stranded RNA (dsRNA). Treatment employing dsRNA in astrocytes induced IFN regulatory factor 3 (IRF3) phosphorylation, dimer formation and nuclear translocation followed by STAT1 activation. This treatment also activated nuclear factor-&kgr;B, p38 and c-Jun N-terminal kinase significantly, while activating extracellular signal-regulated kinase to a lesser extent. Treatment with anti-TLR3 antibody inhibited dsRNA-mediated interleukin-6 (IL-6) production. In the presence of mitogen-activated protein kinase inhibitors, astrocytes failed to secrete IL-6 in response to dsRNA treatment. Therefore, dsRNA-induced IL-6 production is dependent on mitogen-activated protein kinases and type I IFN production is dependent on IRF3 in brain astrocytes. These results suggest that brain inflammation, which produces inflammatory cytokines and type I IFNs, may enhance TLR3 expression in astrocytes. Additionally, upregulated TLR3 might modulate inflammatory processes by producing proinflammatory cytokines.</P>

Initial Size of Metastatic Lesions Is Best Prognostic Factor in Patients with Metastatic Differentiated Thyroid Carcinoma Confined to the Lung

Kim, Mijin,Kim, Won Gu,Park, Suyeon,Kwon, Hyemi,Jeon, Min Ji,Lee, Jong Jin,Ryu, Jin-Sook,Kim, Tae Yong,Shong, Young Kee,Kim, Won Bae Mary Ann Liebert 2017 Thyroid Vol.27 No.1

Evaluation of photon-counting spectral mammography for classification of breast microcalcifications

Kim, Hyemi,Lee, Minjae,Kim, Dohyeon,Lee, Donghoon,Kim, Hee-Joung Pergamon 2019 Radiation physics and chemistry Vol.162 No.-

A comparison of lobectomy and total thyroidectomy in patients with papillary thyroid microcarcinoma: a retrospective individual risk factor-matched cohort study

Kwon, Hyemi,Jeon, Min Ji,Kim, Won Gu,Park, Suyeon,Kim, Mijin,Song, Dong Eun,Sung, Tae-Yon,Yoon, Jong Ho,Hong, Suck Joon,Kim, Tae Yong,Shong, Young Kee,Kim, Won Bae Bioscientifica 2017 European journal of endocrinology Vol.176 No.4

<B>Objective</B><P>Papillary thyroid microcarcinoma (PTMC) accounts for most of the increase in thyroid cancer in recent decades. We compared clinical outcomes and surgical complications of lobectomy and total thyroidectomy (TT) in PTMC patients.</P><B>Design and methods</B><P>In this retrospective individual risk factor-matched cohort study, 2031 patients with PTMC were initially included. Patients who underwent lobectomy or TT were one-to-one matched according to individual risk factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality and cervical lymph node (LN) metastasis.</P><B>Results</B><P>In total, 688 patients were assigned to each group. During the median 8.5 years of follow-up, 26 patients (3.8%) in the lobectomy group and 11 patients (1.6%) in the TT group had recurrences. The relative risk of recurrence was significantly less in the TT than that in the lobectomy group (hazard ratio (HR) 0.41; 95% confidence interval (CI) 0.21-0.81; <I>P</I> = 0.01). Most recurrences (84.6%) in the lobectomy group occurred in the contralateral lobe, and all patients were disease-free after completion of thyroidectomy. There were no significant differences in recurrence-free survival between the two groups after exclusion of contralateral lobe recurrences (HR, 2.75; 95% CI, 0.08-8.79; <I>P</I> = 0.08). There were significantly more patients with transient and permanent hypoparathyroidism in the TT than that in the lobectomy group (<I>P</I> < 0.001).</P><B>Conclusions</B><P>Lobectomy could be appropriate for most patients with PTMC when there is no evidence of extrathyroidal disease in the preoperative work-up. Preoperative and postoperative imaging studies are important for patients who undergo lobectomy for PTMC, because most recurrences are in the contralateral lobe.</P>

지시 위치 예측을 위한 직관적 자동 캘리브레이션 사용자 인터페이스

김혜미(Hyemi Kim),김대환(Daehwan Kim),김기홍(Ki-Hong Kim) 한국HCI학회 2013 한국HCI학회 학술대회 Vol.2013 No.1

행동 변화를 유도하는 사회적 실험

김혜미(Hyemi Kim),김아람(Aram Kim),송세준(Sejun Song),문정현(Junghyun Moon),백한나(Hannah Baek),김진우(Jinwoo Kim) 한국HCI학회 2016 한국HCI학회 학술대회 Vol.2016 No.1

본 연구는 짧은 시간 동안 혼잡한 지하철 계단을 이동하는 보행자 집단을 노인을 중심으로 한 교통약자와 비교통약자로 구분하고, 그들의 충돌위험을 줄이기 위해 계단 위 경로를 구분하는 사회적 실험을 통해 비교통약자의 행동 변화를 유도할 수 있을지 확인하고자 하였다. 고정된 시각 자극과 유동적인 시각 자극, 청각 자극을 통해 경로의 구분을 안내한 결과 비교통약자의 행동 변화가 관찰되었다. 자극을 인지하고 경로를 변경한 비교통약자를 대상으로 행동변화를 가능하게 한 이유를 인터뷰한 결과, 실험자극에 대한 반사적인 반응으로 관찰된 경로 변경행동과는 별개로 교통약자에 대한 배려의 필요성이나, 배려행위를 하는 스스로에 대한 만족감과 같은 내재적 동기를 이야기하는 것을 확인할 수 있었다. 따라서 단시간 내에 혼잡한 환경에서 보행자의 주의를 보행환경으로 환기하는 행동변화를 공간 디자인을 통해 끌어냈다는 점과 행동 변화가 사회적 규칙으로 자리매김하는 데 필요한 내재적 동기와 외부 자극의 관계에 대한 향후 연구의 방향성을 제시했다는 점에서 본 연구의 의의를 찾을 수 있다. In our study, we attempt to understand the pedestrians’ behavioral change by conducting a social experiment. Using a simple design that consists of fixed visual stimulation, interactive visual stimulation, and interactive audio stimulation, we set a proprietary lane for elder citizens on subway stairways. Through the experiment we found that the stimuli were effective, as it changed the non-elder pedestrians’ behavior in relatively short time. Also through post-experiment interviews of those who displayed changes in their behavior, we found possible relationship between these short-term behavior changes and an individual’s intrinsic motivations, such as self-satisfaction. However, due to limited time and the scope of the study, we keep this finding to be further researched in the future.