노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

두경부 편평상피암에서의 MIB-1, p53, bcl-2와 apoptosis의 발현 및 상호 연관성

손용준,한지용,윤형기,장수원,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Squamous cell carcinoma of the head and neck represents approximately 2.0∼4.0% of all malignant tumors, with an etiology closely associated with smoking, drinking and various genetic alterations. The purpose of this study was to investigate the correlation of MIB-1, p53, bcl-2 and apoptosis according to degree of differentitation of squamous cell carcinoma. Methods and Material : forty-eight cases of squamous cell carcinoma of the head and neck were selected for this study. MIB-1, p53, bc1-2 expression rate were studied by iromunogistochemical staining and the number of apoptosis observed by TUNEL method. Results : The expressioins of MIB-1, p53, bcl-2 and apoptosis were found in 56.3%, 50.0%, 14.6%, 85.4%, of 48 cases of squamous cell carcinoma, respectively. The expression of MIB-1, p53 and apoptosis were more higher in poorly differentiated cases than well differentiated cases. MIB-1 expression was related with p53 mutation (p<0.05) and apoptosis rate(p<0.05). Conclusion : From these results. the expressions of MIB-1, bcl-2 and apoptosis were related with degree of differentiation of squamous cell carcinoma and correlation among these parameters.

Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice

Yoon, Hye Eun,Kim, Eun Nim,Kim, Min Young,Lim, Ji Hee,Jang, In-Ae,Ban, Tae Hyun,Shin, Seok Joon,Park, Cheol Whee,Chang, Yoon Sik,Choi, Bum Soon Hindawi Publishing Corporation 2016 Oxidative medicine and cellular longevity Vol.2016 No.-

<P><I>Background</I>. This study evaluated whether the change in the renin-angiotensin system (RAS) is associated with arterial aging in mice.<I> Methods</I>. Histologic changes and expressions of transforming growth factor-<I>β</I> (TGF-<I>β</I>), collagen IV,<I> fibronectin</I>, angiotensin II (Ang II), angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), prorenin receptor (PRR), Mas receptor (MasR), endothelial nitric oxide synthase (eNOS), NADPH oxidase 2 and oxidase 4 (Nox2 and Nox4), 8-hydroxy-2′-deoxyguanosine (8-OHdG),<I> 3-nitrotyrosine</I>, and superoxide dismutase 1 and dismutase 2 (SOD1 and SOD2) were measured in the thoracic aortas from 2-month-old, 12-month-old, and 24-month-old C57/BL6 mice.<I> Results</I>. Twenty-four-month-old mice showed significantly increased aortic media thickness and expressions of TGF-<I>β</I>, collagen IV, and fibronectin, compared to 2-month-old and 12-month-old mice. The expressions of PRR, ACE, and Ang II, and AT1R-positive area significantly increased, whereas expressions of ACE2 and MasR and AT2R-positive area decreased with age. The expressions of phosphorylated serine<SUP>1177</SUP>-eNOS, SOD1, and SOD2 decreased, and the 8-OHdG-positive area and the 3-nitrotyrosine-positive area increased with age. The expression of Nox2 significantly increased with age, but that of Nox4 did not change.<I> Conclusions</I>. The enhanced PRR-ACE-Ang II-AT1R axis and reduced ACE2-MasR axis were associated with arterial aging in mice. </P>

지방자치단체 문화예산 효율성에 관한 연구 : 불용액을 중심으로

장혜윤(Jang, Hye-yoon) 경기연구원 2020 GRI 연구논총 Vol.22 No.2

지방의회 입법성과의 영향요인에 대한 연구: 경기도 의회의 연정 전후의 비교를 중심으로

장혜윤 ( Jang Hye Yoon ),조경훈 ( Cho Kyunghoon ) 한국지방행정연구원 2018 地方行政硏究 Vol.32 No.1

지방의회 입법기능은 주민의 의사를 실현시킬 수 있는 제도적 기반을 마련한다는 점에서 중요하다. 본 연구는 지방의회의 입법성과에 대한 영향요인들의 상호 결합조건을 분석하는 것을 목적으로 한다. 경기도의 경우, 9대 의회부터 연정이 시행되었으며, 이는 의회 내 우호적인 입법환경을 제공하게 된다. 이를 고려하여 본 연구에서는 연정의 시행 이전과 이후의 의원발의 법안을 분석대상으로 퍼지셋 2단계 분석방법을 적용하였다. 분석결과, 재분배정책과 상임위원회 일치 여부는 입법성과에 일관된 영향력을 보이는 것으로 나타났다. 또한 연정의 시행 이전과 이후에서 모두 원내 다수당인 야당의원들의 발의법안이 입법성과의 주요 요인으로 기능하는 것으로 나타났다. 이는 연정이 분점정부 상황을 타개하기 위한 목적으로 시행되었으나 이를 달성하였다고는 보기 어려운 것으로 해석할 수 있다. The legislative performance of the local council is closely related to its essential function. In this context, it is necessary to examine the effect of the combination of influence factors on the legislative performance of local councils. In particular, the legislative process of the local councils is affected by the political environment. Considering Gyeonggido provincial council started the execution of the coalition in 2014 to clear ideological conflict among the major parties, the political environment would be stable after that. Thus, this study has two purposes: verification a combination of influence factors, comparing influence factors before and after the execution of the coalition. To accomplish these purpose of the study, we focused on ordinance bill of the 8th and 9th parliaments of Gyeonggido and used the fuzzy set two - step analysis method. As a result of the analysis, redistributive policy and the standing committee shows that it has a consistent influence on legislative performance. Moreover, it was found that the initiative of opposition lawmakers, who are in the majority of the party, functions as a major factor after the coalition. This result implies that the coalition failed to achieve its original purpose, although it was implemented as a means to overcome the divided government.

Renal Infarction Concurrent with Multiple Venous Thrombosis in Association with Inherited Antithrombin Deficiency

( Sun Hye Ko ),( Hong Seok Lee ),( Ji Hye Jang ),( Ji Hyun Kim ),( Hye Eun Yoon ),( Hyun Hwa Chung ),( Seok Joon Shin ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.5

Antithrombin deficiency is a rare condition among the numerous conditions that can lead to a hypercoagulable state, and can manifest as deep vein thrombosis, portal or mesenteric venous thrombosis, pulmonary thromboembolism and cerebrovascular accidents. In this report, we present a case of acute renal infarction and multiple venous thrombosis in a 36-year-old man with a family history of thromboembolism. He presented with a sudden onset of pain in the right flank and was admitted to the emergency room for evaluation. On computed tomography and renal angiography, the diagnosis of acute renal infarction concurrent with portal, splenic and superior mesenteric venous thrombosis was made. Laboratory data revealed parallel decreases in activity and antigen concentration of antithrombin despite normal liver and renal functions. He was treated with intravenous heparin and fresh frozen plasma followed by concomitant warfarin therapy. Taken together, the etiology of acute renal infarction and multiple venous thrombosis was considered to be associated with type I inherited antithrombin deficiency.

성과관리제도 운영과 보상 간의 디커플링에 관한 연구:

장혜윤(Jang, Hye-Yoon),최정우(Choi, Jung-Woo),박해육(Park, Hae-Yug) 한국지방정부학회 2017 지방정부연구 Vol.21 No.3

공공부문에서 시행하고 있는 성과중심 보상제도는 성과에 따른 인센티브를 차등 지급하여 조직구성원들의 동기를 고취하고 궁극적으로 조직성과를 증진하는 것을 목적으로 한다. 이러한 목적을 달성하기 위해서는 체계적인 성과관리 시스템이 구축･운영되어 조직구성원들이 성과와 보상 간 연계에 대한 높은 수용성이 수반될 필요가 있다. 이러한 관점에서 BSC는 재무적 관점과 비재무적 관점을 포함하여 체계적 성과관리를 가능하게 하여 다수의 지방자치단체에서 도입･운영하고 있다. 특히, BSC제도는 성과를 측정･평가한 결과를 보상 및 인사에 활용하고 있어성과중심 보상제도와 연계되어 운영될 것이 요구된다. 그러나 실제 제도의 운영과정에 있어서 평가결과와 보상 간 연계성이 미흡하거나 더 나아가서 평가결과에 따른 보상이 이루어지지 않는 디커플링 현상이 나타나고 있다. 이에 본 연구는 지방자치단체를 중심으로 BSC 도입 지역과미도입 지역의 디커플링 현상을 t-test를 통해 분석하였다. 분석결과에 따르면, BSC 도입 지역은 미도입 지역에 비해 객관적 성과와 보상체계 간 연계성이 높은 것으로 나타났으나 보상의 차등지급에는 차이가 없는 것으로 나타났다. The performance-based incentive system, which is being implemented in the public sector, aims to motivate the members of an organization. In the long run, this seeks to enhance organizational performance by providing a differential rate of incentives based on performance. In order to achieve this objective, a systematic performance management system needs to be constructed and operated while the organizational members must have high acceptance of connections between performance and incentives. Therefore, the Balanced Scorecard(BSC) is being implemented by a number of local governments because it enables systematic performance management, with both financial and non-financial perspectives. The BSC system in particular requires implementation in conjunction with the performance-based incentive system by using the measurement and evaluation of performance in rewards or promotions. However, in the process of system operation, the link between evaluation and incentive weakens and often leads to decoupling which is a phenomenon where rewards are not given accordingly. This study analyzes the decoupling phenomenon of BSC in implemented and non-implemented regions through the t-test, by placing emphasis on local autonomous entities. According to the analysis, BSC implemented municipalities showed higher correlation between objective performance and incentive system compared to municipalities where it has not been implemented. There was, however, no distinction among the municipalities regarding differential rates of reward payments.

지방공무원의 성과관리제도 인식이 직무몰입에 미치는 영향

장혜윤(Jang, Hye-Yoon),최정우(Choi, Jung-Woo),박해육(Park, Hae-Yug) 한국지방정부학회 2016 지방정부연구 Vol.20 No.3

본 연구는 지방공무원의 성과관리제도에 대한 인식이 직무몰입에 미치는 영향을 분석하였다. 직무몰입의 영향요인에 관한 선행연구들은 주로 직무특성과 개인적 특성에 초점을 맞추어 분석하고 있다. 그러나 성과관리제도의 확산으로 인하여 성과를 측정하고 평가받는 과정이 반복적으로 이루어지면서 지방공무원의 성과관리제도에 대한 인식은 직무와 관련된 태도에 영향을 미칠 수 있다. 일반적으로 조직구성원이 성과관리제도에 대해 긍정적으로 인식할 때 보다 자신의 직무에 헌신하고 더 많은 노력을 기울이게 된다. 이를 분석하기 위해 선행연구의 검토를 통해 성과관리제도의 인식을 분배공정성, 절차공정성, 조직운영 기여도, 성과중심 평가체계 구축, 성과중심 조직문화 조성으로 세분화하였으며, 통제변수로 직무특성과 개인적 특성을 분석모형에 포함하였다. 분석결과에 따르면, 성과관리제도의 분배공정성을 높게 인식하고, 성과관리제도가 조직 운영에 기여하는 수준이 높다고 인식할 때 공무원의 직무몰입이 높아지는 것으로 나타났다. The objective of this research is to analyze the effect that the local public officials perception on the performance management system(PMS) has related to the job commitment. The past literatures and studies have mainly focused on analyzing the job characteristics and personal traits as Job Commitment’s key factors. However, the local public employees perception on the PMS revealed that it impacts their attitudes relating to job activities, due to the proliferation of the performance management system and its cyclical processes in performance-related job assessments. In general, it is said that organization members dedicate and endeavor more to fulfill their duties when they have positive perception to the PMS. To analyze this statement, our study divided the perception on PMS into five categories drawn from the previous research findings: distributive justice, procedural justice, level of contribution in organizational operation, establishment of performance-oriented evaluation system and development of performance-oriented organizational culture. Furthermore, the controllable variables like job characteristics and personal traits are included in our analysis model. According to the analytic results, it is perceived that the higher the local public officials’ job commitment when they perceived that the distributive justice and the level of contribution are assured higher and. also, the PMS’s contribution level in organizational operation is to be higher level in organization.

증례 : 순환기; 베체트병 환자의 복부 가성 대동맥류 혈관 내 스텐트 그라프트 치료

장혜윤 ( Hye Yoon Jang ),최종현 ( Jong Hyun Choi ),남윤정 ( Yoon Jeong Nam ),전무송 ( Moo Song Jeon ),이혜원 ( Hye Won Lee ),김상필 ( Sang Pil Kim ),이한철 ( Han Cheol Lee ) 대한내과학회 2014 대한내과학회지 Vol.86 No.4

베체트병에서 발생하는 복부 가성 대동맥류는 그 빈도는드물지만 주요 사망 원인 중의 하나로 임상적 중요도가 높은혈관염 합병증이다. 만성적인 혈관의 염증상태로 인하여 수술적 치료 후 재발 및 가성 대동맥류의 형성 빈도가 높아 스텐트 이식편을 이용한 비침습적 방법이 대안으로 제시되고있다. 저자들은 베체트병으로 진단받은 46세 남자 환자에서발생한 거대 복부 가성 대동맥류를 수술 위험도와 재발의위험을 고려하여 스텐트 이식편 삽입으로 3년간 효과적으로치료된 1예를 경험하였기에 이를 문헌고찰과 함께 보고하는바이다. Behcet`s disease shows systemic involvement, including mucocutaneus, ophthalmical, neurological, pulmonary, gastrointestinal, urogenital, mucoskeletal, and cardiovascular disorders. Aneurysmal changes develop in 65% of patients with arterial involvement and are associated with a poor prognosis. Although many attempts have been made to surgically manage these serious arterial lesions, several reports have shown a high recurrence rate and operation-related complications. Stent-graft placement has been indicated for the treatment of pseudoaneurysms and aneurysms in patients with a high surgical risk, including those with Behcet`s disease. We herein describe an abdominal aortic pseudoaneurysm in a patient with Behcet`s disease that was successfully treated with stent-graft insertion without an endoleak after 36 months of follow-up. (Korean J Med 2014;86:494-499)

효모변이주 Saccharomyces cerevisiae Sa59에 의한 glutathione 생성

장혜윤(Hye-Yoon Jang),오철환(Chul-Hwan Oh),오남순(Nam-Soon Oh) 한국식품과학회 2013 한국식품과학회지 Vol.45 No.6

Glutathione 생성능이 우수한 효모균주의 획득을 목적으로 Saccharomyces cerevisiae 균주를 변이처리 하였다. 선발된 변이주들의 전체적인 glutathione 함유량은 6.1-15.8 mg/g이었으며, glutathione 함유량과 항산화활성은 비교적 양호한 양의 상관관계(R2 =0.488)를 보였다. 특히, 변이주 S. cerevisiae Sa59의 glutathione 함유량이 wild type에 비해 약 38% 증가되었으며, 환원력 또한 0.40으로 가장 높아 glutathione 생성을 위한 변이주로 선발하였다. 배양방법에 따른 gluthathione의 부피당 생산성은 진탕배양이 정치배양에 비해 약 70% 증가하였으며, 단위균체량당 glutathione 함유량 또한 진탕배양 했을 때 약 19% 증가하였다. Glucose 농도가 증가함에 따라 건조균체량과 발효에 의한 에탄올 함량은 증가하였으나, glutathione 함유량과 환원력은 감소하는 경향을 나타냈다. Glutamate, cysteine 및 glycine을 각각 0.04% 첨가하였을 때 단위부피 및 단위균체량당 glutathione 함유량이 각각 16%, 66% 증가하였으며, 환원력 또한 0.52로 가장 우수하였다. The glutathione contents of the selected mutants were investigated and found to be 6.1-15.8 mg/g-DCW. The glutathione content positively correlated with the antioxidant activity of the mutant strains (R2=0.488). Furthermore, the glutathione content of the mutant S. cerevisiae Sa-59 was approximately 38% greater than that of the wild type strain and, therefore, this mutant strain was selected for glutathione production. The volumetric glutathione content in a shaking culture was increased by about 70% compared to the static culture. In addition, the specific glutathione content was increased by ~19%. The volumetric glutathione content and specific glutathione content were increased by approximately 16% and 66%, respectively, when 0.04% glutamate, 0.04% cysteine and 0.04% glycine were added. Furthermore, the highest antioxidant activity was 0.52 as absorbance unit at 700 nm.