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강성원,조한래,한설해,박현주,정인성,홍선미,김성걸,이헌영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
In 58 patients who were admitted to department of internal medicine, ChungNam national university hospital from January 1989 to March, 1993. We evaluated for medical treatments and the following results were obtained. 1) The ratio of male and female was 1 : 1 and mean age of the patients was 57.4 years. 2) At arrival on hospital, the most common clinical symptom was pain in right upper quadrant and epigastrium(93.1%), the remainders were fever and chill(79.3%), nausea(51.7%) and vomiting(36.2 %) in order of frequency. 3) The most common physical findings was tenderness on the right upper quadrant and epaigastrium(98%), the remainders were jaundice(50%) and palpable gall bladder(13.8%) in order of freguency. 4) In laboratory examination, elevated levels of ESR(82.8%), leukocytosis(67.2%), elevated levels of AST(62.0%), ALT(50.0%), serum total bilirubin(51.7%) and alkaline phosphatase (43.1%) were noted. 5) The mean period of NPO was 3.9 days and the mean hospital period was 13.5 days. 6) The rates of combined complications in patients with acute cholecystitis were 17.2%; these are gall bladder empyema(5.2%), hydrops(5.2%), perforation(3.4%), sepsis(3.4%) and intestinal obstruction (1.7%). 7) In 96.6 percent of 58 cases, the symptoms of acute cholecystitis were improved by conservative management. 8) The mean follow-up period was 25.5 months and the recurrence rate was 10% during this period.
열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
설혜원 ( Hye Won Seol ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2013 人口醫學硏究論集 Vol.26 No.-
Pluripotency and proliferative capacity of pluripotent stem cells such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) make them a promising source for basic and applied research as well as therapeutic medicine. However, pluripotent stem cells have a tendency to acquire chromosomal aberrations during prolonged culture in vitro. Maintaining the genetic stability of stem cells is a big concern for researchers. The genetic stability of human pluripotent stem cells is commonly monitored by karyotyping (G-banding). We investigated the high resolution technique including FISH, CGH and MLPA for detecting of genetic instability in stem cells. The monitoring of genetic instability by high resolution technique as well as karyotyping would facilitate us to maintain the genetic stability of pluripotent stem cells.
설혜원 ( Hye Won Seol ),오선경 ( Sun Kyung Oh ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2010 人口醫學硏究論集 Vol.23 No.-
In 2003, the International Stem Cell Forum (ISCF) started work to develop a set of agreed global criteria for the derivation, characterization and maintenance of human stem cell lines. As part of this work, the Forum has invited research groups worldwide to submit stem cell lines from their laboratories for inclusion in a large-scale characterization project using ISCF criteria. ISCE membership comprises 21 medical research funders from around the world that are committed to advancing stem cell research including Stem Cell Research Center (SCRC) of South Korea. The ISCF is currently working on several projects aimed at addressing key issues for stem cell scientists and funders: Ethics Working Party (EWP), Intellectual Property Rights (IPR), the international Stem Cell Initiative (ISCI), and the international Stem Cell Banking Initiative (ISCBI). Particularly, ISCI does not aim to impose any views on researchers in the field, but rather to facilitate the development of consensus views where that is possible. Also, ISCBI will aid the development of international efforts on harmonization and best practice for preparation of high quality cells for research. It will also provide a key forum for rigorously evaluating some of the requirements for the clinical application of stem cell lines. The project should also stimulate further international initiatives to deliver safe and reliable stem cell therapies for the future. Well-characterized, stable stem cell lines that grow and reproduce predictably are essential for successful stem cell research.
착상 전 유전진단으로 획득된 비정상 배아를 이용한 유전질환 인간 배아줄기세포 수립 연구 동향
설혜원 ( Hye Won Seol ),이지영 ( Ji Young Lee ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2015 人口醫學硏究論集 Vol.28 No.-
Human embryonic stem cells (hESCs) are derived from the inner cell mass (rCM) of blastocyst embryos. They are established from surplus embryos that have been obtained by in vitro fertilization (IVF) and donated for research purposes. The rCM-derived cell lines have two unique properties, they can be propagated indefinitely in culture and have the potential to develop into any cell type in vivo and in vitro. Human ESCs carrying specific mutations can be used as a powerful tool for studying genetic disorders in human. One preferable approach for obtaining these cell lines is their derivation from affected preimplanration genetic diagnosed (PGD) embryos. These unique cells are important for modeling human genetic disorders for which there are no suitable research models. They can be further used to gain new insights into developmentally regulated events that occur during human embryo development and that are responsible for the manifestation of genetically inherited disorders. In this review, we will introduce a current state of the studies for PGD-derived hESCs carrying mutation for genetic disorders that have great potential for the investigation of new therapeutic protocols, including gene-therapy-based treatments and disease-oriented drug screening and discovery.
정상과 비정상핵형을 가진 인간 배아줄기세포의 비교 분석
설혜원 ( Hye Won Seol ),백진아 ( Jin Ah Baek ),정주원 ( Ju Won Jung ),윤보애 ( Bo Ae Yoon ),김희선 ( Hee Sun Kim ),오선경 ( Sun Kyung Oh ),구승엽 ( Seung Yup Ku ),김석현 ( Seok Hyun Kim ),문신용 ( Shin Yong Moon ),최영민 ( Young M 서울대학교 인구의학연구소 2011 人口醫學硏究論集 Vol.24 No.-
Human embryonic stem cells (hESCs) are a useful source for biological research fields and applications in regenerative medicine. The maintenance and distribution of the undifferentiated hESCs of normal karyotypes are very important. The changes of colony morphology were observed during the culturing of hESCs, and chromosomal analysis was performed in this study. Abnormal karyotypes were identified in the cells which have the changes of the colony morphology. Attachment ratio and the spontaneous differentiation ratio of abnormal cells were compared to those of normal cells. High cell attachment ratio and low spontaneous differentiation ratio were confirmed in karyotypically abnormal cells. HESCs showed chromosomal anomaly if the colony morphology changed, and high attachment ratio and low spontaneous differentiation ratio have been observed during the cell culture. Our results suggest that the morphology of the colonies would play a ro1e as a criterion for chromosomal anomaly.