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김혜원,이선희,임수정,박형진,김태신,송은식,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1
A 10-year-old, male, poodle dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University because of continuous cough and cardiomegaly. Weight gain, lethargy, unwillingness to exercise and decreased activity was revealed on history. Obesty and alopecia was also observed on physical examination. Hypercholesterolemia and increased ALP was revealed on blood exam. So, evaluation of thyroid gland function was performed and cTSH concentration was increased. tT4 and fT4 concentrations was decreased. Results of a history, physical examination, blood exam, and thyroid gland fuction test support a diagnosis of hypothyroidism. Initial therapy with sodium levothyroxine was indicated. On 32 days after treatment of hypothyroidism, clinical signs was relieved and cTSH concentration was decreased, tT4 and fT4 concenctrations was increased.
신혜숙,박혜자,박명희,연기순,김훈교,문한림,송혜향 가톨릭대학교 가톨릭대학교 간호대학 호스피스 교육연구소 1999 호스피스논집 Vol.4 No.-
The purpose of this study was to assess the changes in quality of life wish elapse of chemotherapy in head and neck cancer patients. This study was a longitudinal descriptive design. The subjects were 9 patients who had stage III and stage IV head and neck cancer and received neoadjuvant cisplatin and 5-fluorouracil chemotherapy. Linear Analogue Self Assessment Scale (LASA) of the QOL which it includes eleven items(seven physical items appetite, nausea/vomiting, physical well-being, vigor activity, energy, sleepiness, fatigue and four mental items anger, anxiety, depression & vital power) were used to assess the quality of life eleven times(once in the prechemotherapy period and from the 1st day to 10th day postchemotherapy). The means of scores at each time were analyzed by repealed measures of ANOVA and Bonferroni multiple comparison method. The results are as follows : 1. The degree of appetites decreased significantly on the period between third and sixth day compared with that of appetites on the prechemotherapy day (p<0.001). 2. The degree of physical well-being decreased significantly on the period between first and fifth day compared with that of physical well-being on the prechemotherapy day (p<0.001). 3. The degree of nausea/vomiting decreased significantly on the period between first and fourth day compared with that of appetites on the prechemotherapy day (p<0.001). 4. The degree of anger decreased significantly on the second, fourth, eighth and ninth day after chemotherapy compared with that of anger on the prechemotherapy day(p<0.001). 5. The degree of fatigue decreased significantly on the fourth day compared with that of fatigue on the prechemotherapy day(p<0.001). 6. The increment of nausea/vomiting and poor appetite started on the 2.89th day and 3.67th day after chemotherapy, respectively. 7. The increment of sleepiness started on the 2.56th day after chemotherapy. 8. The increment of depression and anxiety started on the 2.33th day and 3.33th day after chemotherapy, respectively. 9. The lowest degrees of nausea/vomiting and poor appetite were 37.00±17.9 % and 28.64±14.94 % after chemotherapy compared with those of nausea/vomiting and poor appetite on the prechemotherapy day, respectively. 10. The lowest degrees of anger and vigor activity were 48.12±28.3 % and 39.83±24.9 % after chemotherapy compared with those of anger and vigor activity on the prechemotherapy day, respectively. 11. The recovery rates of eight items of quality of life (appetite, vigor activity, energy, fatigue, anger, anxiety, depression & vital power) were shown to reach a peak on the tenth day after chemotherapy and be reached to almost 84 % compared with those of quality of life on the prechemotherapy day. 12. The recovery rates of physical well-being and sleepiness were shown to reach to 67.75 % and 95.68 % on the 10th day after chemotherapy compared with those of physical well-belong and sleepiness on the prechemotherapy day. 13. The recovery rates of seven physical items were faster than those of four mental items on the 10th day after chemotherapy. In conclusion, it is suggested that nursing care strategies to improve the quality of life in patients with chemotherapy would be established both physically and mentally, and be extended at least ten days when patients stayed their home after chemotherapy.
The etiology of potential small-bowel bleeding depending on patient’s age and gender
Song, Joo Hye,Hong, Sung Noh,Kyung Chang, Dong,Ran Jeon, Seong,Kim, Jin-Oh,Kim, Jinsu,Lee, Bo-In,Choi, Myung-Gyu,Kim, Kyeong Ok,Yang, Dong-Hoon,Song, Hyun Joo,Hyuk Do, Jae,Jeong Lim, Yun,Shim, Ki-Nam SAGE Publications 2018 United European gastroenterology journal Vol.6 No.8
<B>Background</B><P> Whether the etiology of potential small-bowel bleeding depends on the age and gender of the patient is not yet fully understood. </P><B>Methods</B><P> A total of 1953 patients who underwent video capsule endoscopy (VCE) to evaluate potential small-bowel bleeding and were registered in the Capsule Endoscopy Nationwide Database Registry from 2003 to 2014 were eligible for this study. VCE findings and the etiology of small-bowel bleeding were analyzed by age and gender. </P><B>Results</B><P> The diagnostic yield of VCE was 48.4% (95% CI: 46.2%-50.6%) and the diagnosis rate of etiology of potential small-bowel bleeding was 61.4% (95% CI: 59.2%-63.6%). The etiology of potential small-bowel bleeding depends on the age and gender of the patient. Crohn's disease and small-bowel diverticular diseases were more prevalent etiology of potential small-bowel bleeding in the young adults group (@@<@@ 40 years) whereas angiodysplasia was revealed to be a most common etiology in elderly group (≥ 60 years), reaching statistical significance ( p@@<@@0.00152) by Bonferroni correction. </P><B>Conclusions</B><P> The etiology of potential small-bowel bleeding depends on the age of the patient. Thus, an individualized lesion-specific diagnostic approach based on age might be needed for patients with potential small-bowel bleeding. </P>
Song, Suk-Won,Chang, Woochul,Song, Byeong-Wook,Song, Heesang,Lim, Soyeon,Kim, Hye-Jung,Cha, Min-Ji,Choi, Eunju,Im, Sin-Hyeog,Chang, Byung-Chul,Chung, Namsik,Jang, Yangsoo,Hwang, Ki-Chul Wiley (John WileySons) 2009 Stem Cells Vol.27 No.6
<P>Mesenchymal stem cells (MSCs) therapy has limitations due to the poor viability of MSCs after cell transplantation. Integrin-mediated adhesion is a prerequisite for cell survival. As a novel anti-death strategy to improve cell survival in the infarcted heart, MSCs were genetically modified to overexpress integrin-linked kinase (ILK). The survival rate of ILK-transfected MSCs (ILK-MSCs) was augmented by about 1.5-fold and the phosphorylation of ERK1/2 and Akt in ILK-MSCs were increased by about three and twofold, respectively. ILK-MSCs demonstrated an increase of twofold in the ratio of Bcl-2/Bax and inhibited caspase-3 activation, compared with hypoxic MSCs. The adhesion rate of ILK-MSCs also had a 32.2% increase on the cardiac fibroblast-derived three-dimensional matrix and ILK-MSCs showed higher retention by about fourfold compared to unmodified MSCs. Six animals per group were used for the in vivo experiments analyzed at 1 week after occlusion of the left coronary artery. ILK-MSC transplanted rats had a 12.0% +/- 3.1% smaller infarct size than MSC-treated rats after ligation of left anterior descending coronary artery. Transplantation of ILK-MSCs not only led to a 16.0% +/- 0.4% decrease in the fibrotic heart area, but also significantly reduced the apoptotic positive index by two-thirds when compared with ligation only. The mean microvessel count per field in the infarcted myocardium of ILK-MSCs group was increased relative to the sham group and MSCs group. In conclusion, the ILK gene transduction of MSCs further assisted cell survival and adhesion, and improved myocardial damage when compared with MSC only after transplantation.</P>
Production of Poly(3-hydroxybutyrate) from Glucose in Pseudomonas putida KT2440
Hye Min SONG,Hye Jin LIM,Si Jae PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Pseudomonas putida is a saprotrophic soil bacterium and widely employed platform strain in a bioprocess for the production of value-added materials. Recently, social interests and responsibilities on the production and consumption of biodegradable polymers have been considered important more than ever. Polyhydroxyalkanoates (PHAs) are biodegradable biopolymers, accumulated in numerous bacteria as their carbon and energy storage compounds, and P. putida is also the native producer of PHAs, especially with medium-chain lengths. Among various PHAs, poly(3-hydroxybutyrate) [P(3HB)] is the most characterized member and the key precursor for P(3HB) biosynthesis is acetyl-CoA, the metabolite produced through glycolysis. However, P. putida KT2440 cannot consume glucose well and produce P(3HB) neither. In order to develop P. putida KT2440 to be a more versatile platform strain in biotechnology, it is important to engineer P. putida KT2440 capable of producing nonnatural compounds as well as consuming unpreferable carbon sources. Toward this goal, we aimed to develop the recombinant P. putida KT2440 strain that can produce P(3HB) from glucose. Here, we present the metabolic engineering strategies devised for the production of P(3HB) from glucose in P. putida KT2440.
공동주택 세대의 추계 난방 에너지사용량 원단위·대표 원단위 예비 도출
진혜선(Hye Sun Jin),임수현(Su Hyun Lim),임한영(Han Young Lim),이수진(Soo Jin Lee),김성임(Sung Im Kim),임재한(Jae Han Lim),송승영(Seung Yeong Song) 대한설비공학회 2017 대한설비공학회 학술발표대회논문집 Vol.2017 No.6
The purpose of this study is to preliminarily derive the energy use intensity(EUI) and reference EU I of apartments’ heating energy consumption in the autumn season. 45 sample units were selected for analysis in this study. The installation of energy consumption measuring equipments for the sample units(40 complexes with 200 units) is scheduled to be phased in over the 4 years starting from 2015. A reference EUI database for apartments and a benchmarking tool based on this database will be available after 2020, and similar systems for office buildings are now being established.
Simultaneous Analysis of Diuretic Drugs in Food and Dietary Supplements Using LC/PDA and LC/MS/MS
Moo-Song Lim,Hyung Il Kim,Hye Soon Kang,Eun Ju Kim,Mi Ok Kim,Ki Mi No,Yong Woo Shin,Min Seok Kim,Ji-Yong Yang,Eun Jung Jang,Joong-Hoon Cho,Chul-Joo Lim,Sun-Ok Choi 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10