티로파 정(염산티로프라미드 100 mg) 에 대한 안티모딕정의 생물학적 동등성

곽손혁,구선회,린팜두안,강종성,황성주 충남대학교 약학대학 의약품개발연구소 2000 藥學論文集 Vol.16 No.-

Bioequivalence of two tiropramide tablets, test drug (Antimodic® tablet: Chong Kun Dang Pharm. Co.) and reference drug (Tiropa® tablet: Dae Woong Pharm. Co.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty healthy male volunteers were divided randomly into two groups and administered the drug orally at the dose of 100 mg as tiropramide hydrochloride in a 2×2 crossover study. There was a week washout period between administrations. Blood samples were taken at predetermined time intervals for 10 hr and the plasma concentration of tiropramide HCl was determined by a GC/MS method. AUC_0-10hr (area under the plasma concentration-time curve from time zero to 10 hr), C_max (maximum plasma drug concentration) and T_max (time to reach C_max) were estimated from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed no difference in AUC_(0-10hr), C_max and T_max between two products. The apparent differences of these parameters between two products were less than 20% (i.e., 0.043, 6.430 and 8.929% for AUC_(0-10hr), C_max and T_max, respectively). The powers (1-β) for AUC_(0-10hr) and C_max were over 0.9. Minimal detectable differences (Δ) at α=0.05, 1-β=0.8 were less than 20% (i.e. 15.71 and 12.53% for AUC_(0-10hr) and C_max, respectively). The 90% confidence intervals (δ) for these parameters were also within ±20% (i.e. -9.15≤δ≤9.24 and -0.90≤δ≤13.77 for AUC_(0-10hr) and C_max, respectively). These results satisfied the criteria of KFDA guidelines for bioequivalence, indicating the two tablets of tiropramide were bioequivalent.

선인장 양심실 보조장치의 설계 및 임상적용을 위한 평가

민병구,박찬영,최재순,이혁수,황창모,김삼성,윤걸중,김종원,선경,이경갑,정종태,김원곤 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1

현재 개발되고 있는 맥동형 이식형 인공심장은 완전이식형 인공심장과 좌심실보조장치 뿐이다. 좌심실보조장치를 장착한 환자의 10~15%가 우심실의 보조를 필요로하고 완전이식형 인공심장의 장착을 위해서는 자연심장을 제거해야하는 상황에서 이식형 양심실보조장치에 대한 필요성이 대두되고 있다. 본 연구진은 완전이식형 인공심장으로 개발된 한국형 인공심장을 개선하여 양심 실 보조장치를 개발하였다. 양심실보조장치는 이동형 작동기식 미케니즘을 이용하고 있으며 에너지 변환장치와 감속기로 구성된 작동기와 혈액주머니, 그리고 내장형 제어기로 구성되어 있다. 선인장 펌프로 명명된 KAH350은 캐뉼라의 연결을 위한 커넥터를 포함하여 길이 177mm, 폭 164mm, 높이 67 이고 무게 780g이며 최대 심박출량은 5L/min 이다. 양심실보조장치로 개발된 선인장펌프는 좌심실보조장치로도 응용이 가능하다. 이식적합성과 생체적합성을 평가하기 위하여 좌심실보조장치로 5회, 양싱실보조장치로 6회의 동물실험을 수행하였다. 각각 최장 28일간 생존하였으며 11회의 동물실험중 장치의 결함에 의한 것이 3회 있었는데 이들은 모두 전자장치의 결함과 방수처리문제였다. 현재 이식적합성과 일박출량을 향상시킨 KAH400모델이 개발중이다. The types of pulsatile implantable artificial hearts that are on the way of development and have been developed are totally implantable artificial heart and implantable left ventricular assist device (LVAD). Approximately 10% to 15% of all patients Implanted with wearable VADs have required right heart support with another device. And it is reluctant to patient who should remove his or her own heart to be implanted with total artificial heart. These situations drive the development of implantable bi-ventricular assist device (BVAD). The Korean BVAD was develophed by modifying the moving actuator type Korean artificial heart. This electro-mechanical BVAD comprises actuator including energy converter and reduction gear train, blood sacs, and internal motor and energy controllers. The KAH350 which is named as 'Cactus Pump' is 177mm in length, 164mm in width, and 67mm in thickness including connectors and nuts. The weight and maximum cardiac output of Cactus Pump is 780g and 5L/min, respectively. The Cactus Pump that was developed as BVAD could be used as LVAD by attaching compliance caps on the 2 ports of one ventricle. The animal experiments were undergone 5 times for LVAD, and 6 times for BVAD. The best records were 28 days survival in both applications. There were 3 times of device failure and they were all associated with electrical connection and hermetic sealing. The KAH400 that has improved anatomical fitting characterisitcs and stroke volume is on development.

대형 화재로 인한 사상자의 손상 유형과 합병증 : 동인천 라이브호프 화재를 중심으로

신중호,김재광,염석란,신종환,민순식,임용수,양혁준,이근,황성연 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: High risks of fire alway exist for buildings in urban areas, especially those in downtown. Crowds, as well as more complex and larger structures, may cause more victims in the event of fire; therefore, emergency medical service plans must be established for such disastrous events. Methods: On the evening of October 30,1999, a fire broke out in downtown, Dong-Incheon Live-Hof restaurant; 56 people were killed and 76 were injured. Most of them were teenagers. We retrospectively reviewed the medical records of the victims, Results: 1) Among the 56 dead, 54 died from smoke inhalation, one from extensive burns, and one from sepsis during treatment. 2) Among the 76 injured, 70 patients suffered from smoke inhalation, 53 from burns, and 9 from several types of trauma (sprains, contusions, lacerations, abrasions, fractures, etc.). 3) Later complications were laryngeal edema, pulmonary edema, scar contracture, and hypoxic brain damage, and so forth. 4) Post traumatic stress syndrome was unexpectedly more prevalent in mildly to moderately injured survivors and witnesses than in seriously injured survivors. Conclusion: Many complications exist after a fire. Some may be resolved in time, but others may result in permanent sequelae. Early rescue, early triage, and early management during transport by emergency medical service (EMS) personnel can result in fewer complications and a lower mortality rate. Therefore, we propose the establishment of plans to be followed during various major disasters.

The pepper pathogen-inducible, receptor-Like cytoplasmic protein kinase CaPIK1 gene modulates the defense signaling in a SA-dependent manner and induces cell death with defense-responsive phenotypes

In Sun Hwang,Dae Sung Kim,Byung Kook Hwang,Hyong Woo Choi,Du Seok Choi,Nak Hyun Kim,Dong Hyuk Lee 한국육종학회 2009 한국육종학회 학술발표회 발표요지 Vol.41 No.1

Nonalcoholic Fatty Liver Disease as a Sentinel Marker for the Development of Diabetes Mellitus in Non-Obese Subjects

( Soon Sun Kim ),( Hyun Ji Kim ),( Dae Ryong Kang ),( Jin Hong Kim ),( Min-jae Yang ),( Sun Gyo Lim ),( Hyo Jung Cho ),( Jong Ik Park ),( Sun Hyuk Hwang ),( Jae Youn Cheong ),( Sung Won Cho ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: To evaluate and compare the long-term clinical outcomes in non-obese subjects with nonalcoholic fatty liver disease (NAFLD) and non-obese individuals with metabolic syndrome. Methods: A total of 2,920 participants were retrospectively selected from health check-up center in 2000 and were followed through December 2010. NAFLD was diagnosed using ultrasonography. Study subjects were stratified according to body mass index, NAFLD, and metabolic syndrome status. Results: The prevalence of non-obese subjects without NAFLD, non-obese subjects with NAFLD, obese subjects without NAFLD, and obese subjects with NAFLD was 58.2%, 14.4%, 10.2%, and 17.2%, respectively. The prevalence of metabolically healthy non-obese subjects, metabolically unhealthy non-obese subjects, metabolically healthy obese subjects, and metabolically unhealthy obese subjects was 63.9%, 8.7%, 14.0%, and 13.4%, respectively. In the multivariate analysis, non-obese subjects with NAFLD had a significantly higher risk for diabetes mellitus (DM) compared with non-obese subjects without NAFLD (HR 2.69, 95% CI 1.72-4.20, P<0.001); they did not have a significantly higher risk for hypertension or cardiovascular disease. Metabolically unhealthy non-obese subjects had a significantly higher risk for hypertension (HR 2.75, 95% CI 2.02- 3.74, P<0.001), DM (HR 5.72, 95% CI 3.68-8.89, P<0.001), and cardiovascular disease (HR 2.93, 95% CI 1.53-5.63, P=0.001). In a subgroup analysis with non-obese subjects, non-obese subjects with NAFLD, even without metabolic syndrome, had a higher risk for DM compared to control (HR 3.60, 95% CI 2.03-6.39, P<0.001). Conclusions: Non-obese subjects with NAFLD are at a higher risk for DM independent of whether they have metabolic syndrome.

Complete chloroplast genome of Codonopsis lanceolata and Platycodon grandiflorus: insight into evolution of the Asterales and development of molecular marker.

Jin-hyuk Kim,Sun-Goo Hwang,Cheol-Seong Jang 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Asterales are dicotyledonous flowering plants and are one of the Asterid clade, incuding many species as well as Codonopsis and Platycodon. Here, we have determined the complete chloroplast genome sequences of C. lanceolata and P. grandiflorus by using the targeted denovo assembly method of short reads derived from whole genome resequencing. The total lengths of each chloroplast genome sequence are 156,180 bp for C. lanceolata and 155,453 bp for P. grandiflorus. In their chloroplast genomes, 106 genes (75 protein-coding genes, 4 rRNA genes, 23 tRNA genes, and 4 hypothetical chloroplast open reading frames [ycfs]) exhibited the relatively similar positions. Also, 7 protein-coding genes commonly showed to contain introns in both C. lanceolata and P. grandiflorus chloroplast genome, while psaA gene contain intragenic regions only in P. grandiflorus chloroplast genome. In further analysis, we identified the codon usage bias to A or T and found the different simple sequence repeat (SSR) loci of each chloroplast genome (18 SSR loci of C. lanceolata and 16 SSR loci of P. grandiflorus). In the phylogenetic trees based on 72 protein-coding genes, C. lanceolata is more closely related to P. grandiflorus than the other plant species order Asterales. Also, we found the highest sequence diversities of 12 protein-coding genes in small single copy (SSC) region than in the inverted repeat (IRs) and large single copy (LSC) region, and 3 genes such as rpoC2 (LSC region), ndhB (IRs region), and ndhF (SSC region) showed the highest number of segregating sites in each region. Additionally, we developed the molecular markers for phylogenetic applications of C. lanceolata and P. grandiflorus chloroplast genome.

Role of pepper DC1 domain-containing CCCH-type zinc finger protein CaDC1 in defense responses to microbial pathogens

In Sun Hwang,Du Seok Choi,Dae Sung Kim,Nak Hyun Kim,Dong Hyuk Lee,Byung Kook Hwang 한국육종학회 2011 한국육종학회 학술발표회 발표요지 Vol.43 No.-

전대장에 걸쳐 침범한 해면 혈관종 1례

황선혁 ( Sun Hyuk Hwang ),박선영 ( Sun Young Park ),김기찬 ( Ki Chan Kim ),박주한 ( Joo Han Park ),김시연 ( Si Yeon Kim ),송가원 ( Ga Won Song ),정숙희 ( Jun Goo Kang ),임선교 ( Sook Hee Chung ),이기명 ( Sun Gyo Lim ),이광재 ( Kwa 전북대학교 의과학연구소 2013 全北醫大論文集 Vol.37 No.2

Cavernous hemangioma of the colon is a rare disease. It mostly affects young patients with recurrent painless rectal bleeding. Complete surgical excision with a sphincter saving procedure is the best therapeutic option. A 25-year-old man referred to our hospital because of a chronic anemia and recurrent painless rectal bleeding. In esophagogastroduodenoscopy, there was gastric erosion. In colonoscopy, there were multiple submucosal vessel dilatations on whole colon. Prominent submucosal vessel was noted on cecum and rectum suspicious for cavernous hemangioma. Biopsy was not performed because of the risk of bleeding. Abdomen computer tomography (CT) showed bowel wall thickening in rectum and colon. Multiple small aggregated cystic lesions in omentum and mesentery were seen. Multiple calcifications in the rectum were noted, a finding compatible with phleboliths. We recommended surgery but patient refused and now he is followed up in our outpainet clinic without complication. Cavernous hemangioma is a rare disease but clinicians should be cautious about the occurrence of this malformation in young patients with recurrent rectal bleeding. Suspicion and knowledge of this disease would reduce the misdiagnosis and mismanagement.

서혜부에 발생한 골화성 지방종

황선철(Sun-Chul Hwang),김동희(Dong-Hee Kim),이상혁(Sang-Hyuk Lee),남대철(Dae-Cheol Nam),고경혁(Gyung-Hyuk Ko),나재범(Jae-Boem Na),정순택(Soon-Taek Jeong) 대한정형외과학회 2012 대한정형외과학회지 Vol.47 No.6

서혜부에서 골조직과 분리되어 독립적으로 발생한 골화성 지방종은 아주 드물다. 저자들은 좌측 서혜부에서 어른 주먹 크기의 단단하고, 움직임이 없는 무통성 종괴를 주소로 내원한 환자를 종양 변연 절제술로 치료하였으며, 병리조직 소견으로 골화성 지방종으로 확진되었다. 골 조직을 동반한 많은 지방종의 아형들이 문헌에 보고되고 있으나 저자들의 증례처럼 골화성 지방종이 서혜부에서 발견된 문헌 보고는 거의 없는 실정이다. 이에 저자들은 골조직과 분리되어 발생한 골화성 지방종의 치료 시에 석회화 병변을 동반하는 다른 종양과 감별 진단함이 중요하기에 영상의학적 소견 및 조직병리학적 소견과 연관시켜 문헌 고찰과 함께 보고하고자 한다. It is extremely rare to observe ossifying lipoma that developes separately from bone tissues in the groin. A patient with an adult fist-sized, firm, non-movable and painless mass in the left groin area, had been treated with marginal excision, which turned out to be ossifying lipoma. Although many different variants of lipoma with bone tissue have been reported, a case like this has never previously been reported. It is important to distinguish ossifying lipoma, from tumors with calcific lesions. We report its uniqueness in radiologic and pathologic ways, with specific findings of ossifying lipoma.

Short-Term Outcomes of Laparoscopic Proximal Gastrectomy With Double-Tract Reconstruction Versus Laparoscopic Total Gastrectomy for Upper Early Gastric Cancer: A KLASS 05 Randomized Clinical Trial

Hwang, Sun-Hwi,Park, Do Joong,Kim, Hyung-Ho,Hyung, Woo Jin,Hur, Hoon,Yang, Han-Kwang,Lee, Hyuk-Joon,Kim, Hyoung-Il,Kong, Seong-Ho,Kim, Young Woo,Lee, Han Hong,Kim, Beom Su,Park, Young-Kyu,Lee, Young-J The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.2

Purpose: Laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) is a function-preserving procedure performed for treating upper early gastric cancer (EGC). However, few studies have compared the outcomes of LPG-DTR with those of laparoscopic total gastrectomy (LTG). This study aimed at comparing the short-term outcomes of LPG-DTR between LTG and upper EGC. Materials and Methods: For upper-third EGC, a multicenter, prospective, randomized trial was performed to compare those who underwent LPG-DTR with those who underwent LTG. Short-term outcomes, including clinicopathologic results, morbidity, mortality, and postoperative courses, were evaluated using a full analysis set based on the intention-to-treat principle and the per-protocol set. Results: Of the patients, 138 who fulfilled the criteria were randomized to each group. One patient in the LPG-DTR group withdrew consent. Sixty-eight patients underwent LPG-DTR and 69 underwent LTG. The operative time (LPG-DTR=219.4 minutes; LTG=201.8 minutes; P=0.085), estimated blood loss (LPG-DTR=76.0 mL; LTG=66.1 mL; P=0.413), and the morbidity rate (LPG-DTR=23.5%; LTG=17.4%; P=0.373) between the groups were not significantly different. No mortality occurred in either of the study groups. Two weeks post operation, the Visick scores for postprandial symptoms, including reflux symptoms, were not significantly different between the groups (P=0.749). Laboratory findings on postoperative day 5 were not significantly different between the groups. Conclusions: The short-term outcomes of LPG-DTR for upper EGC were comparable to those of LTG.