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Sophora flavescens의 뿌리에서 유래한 Cholinesterase 저해 화합물
장원희, 트란홍광, 김장훈, 양서영, 김영호 충남대학교 약학대학 의약품개발연구소 2021 藥學論文集 Vol.36 No.-
Searching for cholinesterase inhibitory compounds from natural products is important to de- velop therapeutic agents for Alzheimer’s disease. Our previous research on the chemical components of Sophora flavescens roots resulted in the isolation of twelve flavonoids, kushenol E (1), maackiain (2), 8-prenylkaemperol (3), 8-prenylnaringenin (4), kushenol L (5), kushenol A (6), kushenol C (7), kushenol B (8), sophoraflavanone G (9), kushenol H (10), isoxanthohumol (11) and kurarinone (12) and their structures were elucidated by spectroscopic methods. Inhibitory effect of cholinesterase were tested using the Ellman's method. Most flavonoid compounds showed good inhibitory activities on cholinesterases. Kushenol E (1) and sophoraflavanone G (9) showed good inhibitory activities on acetylcholinesterase with IC50 values of 3.75 and 4.14 μM and butyrylcholinesterase with IC50 values of 2.00 and 0.75 μM, respectively. In addition, a kinetic analysis revealed that kushenol E (1) was non-competitive inhibitor with Ki value of 0.77 μM on acetylcholinesterase and 0.16 μM on butyrylcholinesterase, whereas sophoraflavanone G (9) was mixed type inhibitior with Ki value of 9.42 μM on acetylcholinesterase and 0.81 μM on butyrylcholinesterase. These findings suggest that flavonoid compounds from S. flavescens roots are potential cholinesterase inhibitors.
위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예
김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.
[PB-0073] 무(Raphanus sativus L.) 품종의 표현형적 특성과 heterozygosity 간의 상관관계 분석
Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
[PB-0071] GBS 분석을 통한 국내 무(Raphanus sativus L.) 품종의 유전적 유연관계 분석
Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-