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        ORiginal Article : The Risk Factors and Quality of Life in Patients with Overlapping Functional Dyspepsia or Peptic Ulcer Disease with Gastroesophageal Reflux Disease

        ( Shou Wu Lee ),( Teng Yu Lee ),( Han Chung Lien ),( Hong Zen Yeh ),( Chi Sen Chang ),( Chung Wang Ko ) The Editorial Office of Gut and Liver 2014 Gut and Liver Vol.8 No.2

        Background/Aims: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and peptic ulcer disease (PUD) impact the daily lives of affected individuals. The aim of this study was to compare the risk factors and impacts on life quality of overlapping FD or PUD in patients with GERD. Methods: Data from patients diagnosed with GERD were collected between January and November 2009. FD was defined using the Rome III diagnostic criteria. The overlap-ping GERD-FD or GERD-PUD groups were classified as con-comitant GERD and FD or peptic ulcers. The characteristics of these individuals were analyzed. Results: There were 63, 48, and 60 patients in the GERD only, overlapping GERD-FD, and overlapping GERD-PUD groups, respectively. Significantly younger age, female gender, lower body weight and body mass index, and higher rates of tea consumption were noted in the GERD-FD group. Patients in the GERD-FD group ex-hibited the lowest quality of life scores, both with respect to physical and mental health, on the Short Form 36 domains. Conclusions: Patients with concomitant GERD and FD were more likely to be younger and female. Overlapping GERD and FD had the worst impact on the quality of life of the affected individuals. (Gut Liver 2014;8:160-164)

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        Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett`s Esophagus

        ( Shou-wu Lee ),( Han-chung Lien ),( Teng-yu Lee ),( Chun-fang Tung ),( Hong-zen Yeh ),( Chi-sen Chang ) 대한간학회 2017 Gut and Liver Vol.11 No.3

        Background/Aims: The aim of this study was to investigate the associations between obesity and erosive esophagitis (EE) or Barrett`s esophagus (BE) in a Chinese population. Methods: Data from subjects were retrospectively collected from 2006 to 2009. Individuals with BE were identified and age- and sex-matched at a 1:2 ratio with normal esophagocardial junction and EE patients. The subjects were stratified into two groups: the normal weight group and overweight/ obesity group (body mass index ≥25 mg/m2) or the normal waist group and abdominal obesity group (waist circumference ≥90 cm for men and ≥80 cm for women). Results: Overall, 45%, 72%, and 52% were overweight/obese and 23%, 65%, and 18% had abdominal obesity in the normal, EE, and BE groups, respectively. Positive associations were identified between EE and overweight/obesity (odds ratio [OR], 3.14; 95% confidence interval [CI], 1.75 to 5.66) and abdominal obesity (OR, 6.22; 95% CI, 3.34 to 11.57); however, the associations were nonsignificant between BE and overweight/obesity (OR, 1.32; 95% CI, 0.67 to 2.61) or abdominal obesity (OR, 0.73; 95% CI, 0.31 to 1.73). Female BE patients had a significantly increased rate of being overweight/obese. Conclusions: Obesity is a contributing factor in EE. The association of BE and obesity was not significant, with the exception of female BE cases. (Gut Liver 2017;11:377-382)

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