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참당귀묘의 (當歸苗) 생육진전 (生育進展) 양상 및 파종량에 따른 묘생육 특성
유홍섭(Hong Seob Yu),강병화(Byeung Hoa Kang),장영희(Yeong Hee Chang),김충국(Chung Guk Kim),김영국(Young Guk Kim),이승택(Seoung Tack Lee) 한국약용작물학회 1995 한국약용작물학회지 Vol.3 No.2
These experiment were conducted to know the seedling growth pattern and to determine the appropriate seeding amount for producing the small and middle sized uniform seedlings of which known to have low bolting in the cultivation of Angelica gigas. Cotyledons of seedling were emerged by 18 days after seeding and the first and the second leaf appeared at 5.0 days and 9.8 days respectively after the anterior leaf emergence. Leaf development from the 3rd to the 6th in order needs about 13 days respectively after the emergence of anterior leaf. Growth of small and middle sized seedling of which required 60∼87days were 3.0 to 7.0㎜ in root head diameter, 63 to 10.3㎝ in root length, 0.4 to 1.3g in fresh root weight per plant with 3.9 to 5.0 leaves. The highest production ratio of small and middle sized seedlings was showers in 15,000seeds/㎡ of seeding amount as 52.8% respectively.
온도, 광, GA₃ 및 저장방법이 참당귀 발아에 미치는 영향
유홍섭(Hong Seob Yu),강병화(Byeung Hoa Kang),임대준(Dae Joon Im),김충국(Chung Guk Kim),김영국(Young Guk Kim),이승택(Seoung Tack Lee),장영희(Yeong Hee Chang) 한국약용작물학회 1995 한국약용작물학회지 Vol.3 No.1
Theses studies were conducted to clarify the germinating characteristics of seed treated with different temperature, light, and Gibberellin(GA₃) to produce the homogeneous seedlings Angelicagigas NAKAI. The results obtained are summarized as follows : Rate and speed of germinating at 25℃ were higher than 15℃ and 20℃ by 87.3% and 68.9% and also the required day for germination at 25℃ was shortest by 14.1 days. Germination rate at the light condition was 90.7% and that at the dark was 65.7%. Germinating ability of seed stored at 4℃ and -10℃ for 165 days as dried states was 92.0% and 91.3% while that at room temperature was 50.3%, but the longer storage of seed than 165 days decreased the ability. Gibberellin treatment by 10ppm to seed stored at 4℃ and by 6ppm to seed stored at -10℃ increased the germination rate more by 20.9% and 31.7% than nontreated seed.
유홍섭(Hong Seob Yu),성낙술(Nak Sul Seong),박춘근(Chun Geon Park),김영국(Young Guk Kim),박충현(Chung Heon Park),박희운(Hee Woon Park),이봉호(Bong Ho Lee),권오혼(Oh Heun Kwon) 한국약용작물학회 2002 한국약용작물학회지 Vol.10 No.5
Korean angelica(Angelica gigas Nakai), a oriental medicinal plants is important and in great demand in Korea. This crop is a biennial which is to die after flower, so as could not harvest the root. A new variety Anpung was developed from the selection of the local collecting population by medicinal crop team at NCES in 2001. This showed stable bolting during its cropping year and have high quality and yield potential. The color is greenish purple in stem and red purple in flower. It was longer in plant height and root length, thicker in root diameter, more leave and latheral roots comparing with the check variety manchu. The dry root was 72 g/plant showing heavier than check variety of 65 g/plant. It showed such low bolting rate s 0.5%, on the other hand 49.3% in landrace when it cultured by transplanting with heating nursery seedlings, and 0∼15% with field nursery seedlings. The dry root yield of the variety was averaged 3,630 ㎏/㏊ out yielding the check variety by 11% at the three regional yield test from 1999 to 2001. Finally, “Anpung” showed higher content of extracts up to 46.3% in “Anpung”and 45% in check variety, decursin and decursinol contents was 3.48% and 2.79%, showing slightly than check variety.
참당귀 꽃대발생 년차에 따른 종자의 발아 및 묘생육 특성
유홍섭(Hong Seob Yu),이승택(Seung Tack Lee),장영희(Yeong Hee Chang),김관수(Kwan Su Kim),김영국(Young Guk Kim) 한국약용작물학회 1996 한국약용작물학회지 Vol.4 No.3
To establish appropriate seed production system in Angelica gigas. Germination of seeds with different bolting years and the growth characters of plants originated from these seeds were investigated. Seed weight from 1st year bolting plant was highest. In germinability according to seeds with different bolting years, seeds from 1st year bolting plant were higher than seeds from 2nd. 3rd years bolting one. In growth characters of plants originated from seeds with different bolting years, as the bolting years became late, root growth increased and top growth decreased, therefore T/R ratio decreased.
식도 편평상피암 및 식도 이형성증에서 돌연변이 p53 단백 및 p16 단백의 발현
홍수진 ( Hong Su Jin ),권계원 ( Kwon Gye Won ),김성환 ( Kim Seong Hwan ),정인섭 ( Jeong In Seob ),고봉민 ( Go Bong Min ),유창범 ( Yu Chang Beom ),김진오 ( Kim Jin O ),조주영 ( Jo Ju Yeong ),김연수 ( Kim Yeon Su ),이준성 ( Lee Jun 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> p53 유전자는 대표적인 종양억제유전자로 세포분열 조절과 사멸에 관여하여 세포의 증식과 관련이 깊으며 유전자의 돌연변이로 불활성화되어 종양을 유발하는 것으로 알려져 있다. 또한 p16 유전자는 세포분열을 억제하는 종양억제유전자의 일종으로 CDK (cyclin-dependent kinases)를 억제하여 세포주기를 조절하며 메틸화나 LOH (loss of heterozygosity)로 유전자의 발현이 소실되면서 종양이 발생하는 것으로 여겨진다.