Comparison of clinical characteristics and prognosis of pneumocystis jirovecii pneumonia in patients with immunocompromised and non-immunocompromised conditions

( Hong-joon Shin ),( Min-seok Kim ),( Bo Gun Kho ),( Ha Young Park ),( Tae-ok Kim ),( Cheol-kyu Park ),( Yong-soo Kwon ),( In-jae Oh ),( Yu-il Kim ),( Sung-chul Lim ),( Young- Chul Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Pneumocystis jirovecii pneumonia (PCP) is a fatal respiratory infection frequently associated with immunocompromised (IC) conditions. Although PCP has been reported in non-immunocompromised (non-IC) patients, however, few studies have been conducted. This study was aimed to compare the clinical characteristics and prognosis of PCP in IC and non-IC patients. Methods: We retrospectively analyzed patients who were suspected of having PCP with polymerase chain reaction (PCR) test positive for Pneumocystis jirovecii from January 2013 to May 2019. IC group was classified into human immunodeficiency virus (HIV), hematologic, solid organ tumor, rheumatologic and immunosuppressive agent group. Results: A total 192 PCP cases including 176 IC cases and 16 non-IC cases were analyzed. Patients were older in the non-IC group compared with the IC group (72.5 vs. 62.0, P=0.002). Hematologic malignancy was the most common (47.2%), followed by HIV (14.8%) in the IC group. The interval between test for PCP-PCR and PCP treatment was shorter in the IC group compared with non-IC group (0 [0-3] vs. 4.0 [2.2-7.7] days, P=0.001). In-hospital mortality was not significantly different between IC and non-IC groups (43.2% vs. 62.5%, P=0.189). Age (odds ratio [OR] 1.05; 95% confidence interval [CI] 1.02-1.09; P=0.002) and PaO₂/FiO₂ (OR 0.99; 95% CI 0.98-1.00; P=0.039) were the prognostic factors for in-hospital mortality in the multivariate logistic regression analysis. There was no significant difference between IC and non-IC group in 6-month survival. However, HIV group had better 6-month survival compared with non- IC group in the subgroup analysis (Hazard ratio 0.16; 95% CI 0.05-0.53; P=0.003]. Conclusion: Patients with PCP in non-IC group were older than IC group, and had similar prognosis as other IC group except HIV group.

주의력결핍 과잉운동장애 환아에서 주의력 과제와 관련된 대뇌의 기능적 국소화

신동원,송동호,전덕인,남궁기,이만홍,이홍식,민성길 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 주의력결핍 과잉운동장애는 주의력에 결함이 있는 장애이다. 주의력에 주로 관여하는 부위는 전두엽과 두정엽으로서 이전 연구에서 주의력결핍 과잉운동장애 환자의 전두엽과 두정엽의 이상에 대하여 보고되어 왔으나, 대부분 안정상태에서 정상인과 비교한 연구들이다. 이에 본 연구는 주의력결핍 과잉운동장애 환자가 주의를 요하는 과제를 실행하는 동안 활성화되는 뇌의 양상을 정량화 뇌파를 이용하여 파악하고, 활성화 양상에 있어 정상인과의 차이점을 확인해 주의력결핍 과잉운동장애 환자의 주의력 결함과 관계된 뇌의 국소적 병태를 밝히고자 하였다. 또한 주의력결핍 과잉운동장애 환자의 주의력 결함과 관계된 뇌의 국소적 병태를 밝히고자 하였다. 또한 주의력결핍 과잉운동장애의 치료제인 methylphenidate를 주의력결핍 과잉운동장애 환자에게 투여하여 주의력 과제 중에 활성화되는 뇌 양상의 변화를 알아보고, 치료제가 주의력을 높이는 기전에 대한 이해를 넓히고자 하였다. 방 법 : 연구 대상자는 환자 20명, 정상인 20명으로 총 40명이었다. 두 군은 성별, 나이, 손잡이, 지능에 있어서 차이가 없도록 선발되었다. 정상인은 안정 상태와 주의력 과제를 실행하는 동안 정량화 뇌파를 측정하였다. 환자군은 methylphenidate를 투여한 상태와 투여하지 않은 상태에서 각각 안정 상태와 주의력 과제를 실행하는 동안 정량화 뇌파를 측정하였다. 결 과 : 본 연구의 결과는 다음과 같다. 1) 집중력 검사상, 정상대조군이 투약 전 환자군에 비해 목표자극에 대한 정반응 시간과 목표 자극에 대한 정반응 시간의 표준편차에 있어 유의하게 낮은 점수를 보여 집중력이 좋음을 알 수 있었다. 환자군은 누락 오류, 목표 자극에 대한 평균 정반응 시간, 표준편차에 있어 투약 전에 비해 투약 후에 유의하게 낮은 점수를 얻어, 투약 후 집중력이 유의하게 호전됨을 확인하였다. 정상 대조군과 투약 후 환자군 사이에 집중력 검사상 차이는 없었다. 2) 안정상태에서 얻은 정량화 뇌파의 모든 파 영역에서 환자군은 정상군에 비해 유의하게 뇌파의 전위가 증가해 있었다. 3) 정량화 뇌파의 delta 파 영역에서 뇌파를 분석한 결과, 정상 대조군의 경우, 주의력 과제 중에는 안정상태에 비하여 두정-후두엽 부위의 전위가 유의하게 증가하였으나, 환자군에서는 주의력 과제 중에 유의하게 전위가 증가하는 부위가 없어, 국소화한 뇌 활성 변화를 관찰할 수 없었다. 4) Theta 파 영역에서, 정상 대조군의 경우, 주의력 과제 중에는 안정상태에 비해 우측 전두엽, 우측 측두엽, 양측 두정-후두엽 부위에서 전위가 유의하게 증가하였다. 그러나 환자군에서 투약하기 전에는 유의하게 증가하는 부위가 없었다. 환자군에서 투약 후에는 우측 전두엽, 우측 측두엽, 양측 두정-후두엽 부위에서 유의하게 전위가 증가해, 정상 대조군과 유사한 뇌활성도의 변화 양상을 보였다. 5) Alpha 파 영역에서, 정상 대조군의 경우, 주의력 과제 중에는 안정상태와 비교해 두정-후두엽 부위만이 유의하게 뇌파가 증가하는 반면, 투약하지 않은 환자군의 경우 광범위한 부위에서 유의하게 뇌파가 증가하여 뇌 활성 변화 부위가 국소화되지 않았다. 6) Beta 파 영역에서, 정상 대조군의 경우 안정상태에 비해 주의력 과제 중에는 좌측 전두엽과 Cz 부위만이 유의하게 전위가 증가하는 반면, 투약 하지 않은 환자군의 경우 거의 모든 뇌부위에서 전위가 유의하게 증가해 뇌의 활성 변화 부위가 국소화되지 않았다. 투약한 후에는 좌측 전두엽과 양측 측두엽의 뇌파가 유의하게 증가해 국소화한 뇌 활성 변화 양상을 보였다. 결 론 : 주의력결핍 과잉운동장애 환자는 안정상태에서 정상인과 비교해 뇌파상 비정상적으로 활성화되어 있다. 정상인의 경우, 공간 자극에 관계된 주의력 과제 실행시 주로 전두엽과 두정-후두엽이 활성화되었으나 주의력결핍 과잉운동장애 환자는 국소적인 뇌활성화에 실패하였다. 주의력결핍 과잉운동장애 환자의 주의력 결함은 전두엽과 두정-후두엽 부위의 병태와 관련이 있을 것으로 사료된다. Objectives : The attentional deficit is a core symptom in attention deficit hyperactivity disorder. The major brain areas related to attention are frontal and parietal lobes. Abnormalities of frontal and parietal lobes in attention deficit hyperactivity disorder have been reported in previous researches. But, most of the researches are based on comparing patients and controls while they are in resting condition. Further research on functional changes related to performance of attentional task is needed to understand the attentional dysfunction in attention deficit hyperactivity disorder. In this study, the localized functional changes of the brains related to attentional task in patients with attention deficit hyperactivity disorder and the differences of them between patients and normal controls were examined. Also the effect of the methylphenidate on functional changes related to attentional task in patients with attention deficit hyperactivity disorder was examined. Method : Quantitative electroencephalography(QEEG) was applied to examine the fuctional changes related to attentional task. Subjects of this study consisted of 20 patients with attention deficit hyperactivity disorder and 20 controls who were matched age, sex, handedness, intelligence. QEEG was recorded on eye open resting condition, and on performing computerized attentional task. In cases of patients, after taking of methylphenidate, QEEG was recorded on both conditions. Results : 1) In attention test, normal controls had better scores in response time and variabilities of response time than those of patients with attention deficit hyperactivity disorder without taking methylphenidate. After taking medication, scores of omission, response time and variabilities of response time were significantly improved, comparing to scores without taking medication. No differences were recognized between the controls and patients with taking medication in scores of attention test. 2) In resting condition, spectral EEG revealed baseline activity levels of patients were significantly increased comparing to those of controls. 3) Analysis of delta wave revealed that amplitudes of controls were significantly elevated in parieto-occipital area during performance of attentional task. But in patients, localized activated area related to attentional task was not remarkable. 4) Theta activity of controls were significantly elevated in right frontal, right temporal, and both parieto-occipital areas during performance of attentional task. But in patients without taking medication, localized activated area related to attentional work was not remarkable. After taking medication, right frontal, right temporal, and both parieto-occipital areas were significantly activated. 5) Alpha activities of controls were significantly increased in parieto-occipital area during performance of attentional task, but those of patient without taking medication were increased in broad area. 6) Beta activities of controls were significantly increased in frontal area during attentional performance, but those of patients without taking medication were significantly increased in most of the brain areas. After taking medication, significantly increased activities related to attentional task were recognized in left frontal, and both temporal areas. Localized activated patterns similar to those of controls were recognized. Conclusion : Based on the results of this research, it is suggested that patients with attention deficit hyperactivity disorder have increased baseline brain activity. In controls, brains showed localized response to a attentional stimuli, and functional changes related to attentional stimuli were recognized in frontal, and parieto-occipital areas. But, patients failed in showing appropriate localized activated response to attentional stimuli. It is concluded that frontal and parieto-occipital areas have some deficit responsible for the attentional dysfunction of attention deficit hyperactivity disorder.

사회적 네트워크 유형 별 내향 중심성이 직무 스트레스에 미치는 차별적 영향

신인용(In Yoing Shin),이기현(Ki Hyun Lee),오홍석(Hong Seok Oh) 한국경영학회 2013 經營學硏究 Vol.42 No.4

As interdependent tasks have been increasing and the necessity of smooth communication among employees has been emphasized in organizations, scholars and practitioners are interested in the effects of social support from social relationships on job stress. Drawing on a social network perspective, we examined that social ties among organizational members influenced the level of job stress which they experience. We especially expected that the types of social networks in which employees were embedded (task-advice networks, friendship networks, and negative affect networks) were respectively linked to the provision, reception, and absence of social support, which in turn led to differently affecting individual job stress. According to the results of this study based on the survey data from employees in two organizations, the persons who occupied in-degree centrality in friendship networks were more likely to receive social support from the other employees and then their levels of job stress reduced, whereas the employees who were located in in-degree centrality in negative affect networks were less likely to receive social support from the other members, resulting in increasing the level of job stress they experienced. In addition, we hypothesized the U-shaped relationship between in-degree centrality in task-advice networks and individual job stress. In other words, we anticipated that the central persons in task-advice networks to the certain level tended to experience lower levels of job stress by the increased sense of control and self-esteem about themselves, and beyond the optimum level they were likely to experience higher levels of job stress because they were excessively granted the role of providing social support to the others. However, this hypothesis was not supported. This study suggests that the extent of centrality by the types of social networks differently influences the levels of job stress which organizational membersexperience.

파골세포 활성에 있어 gp130과 PTH의 연관성

김영준,류현모,김신윤,신홍인 경북대학교 병원 2002 경북대학교병원의학연구소논문집 Vol.6 No.1

gp130,a subunit for serveral cytokine signal transducing receptors, mediates diverse activities including osteoclastogenesis. In vitro obaervations suggest that PTH also triggers the gp130-mediated signal for bone resorption by stimulating secretion of IL-6,IL-11 and LIF from osteoblast/stromal cells. Though this gp130 signaling is required for full activation of bone resporption by PTH in vitro, the relationship between PTH and gp130 signaling pathway in vitro is not yet clanified. To address the importance of gp130 as a mediator of PTH action in osteoclast activation, the blood ionized calium and blood serum PTH level was investigated in gp130-/- and wild type mice at E18.5 using a CIBA/Coming 634 Ca^+2/pH analyzer and rat intact PTH Kit, respectively.In addition, calium transport efficiency was assessed from gp130 mice at E17.5. The resorptive activity of osteoclasts from intact calvariae by a ^45Ca release assay and the osteoclastic developmental condition in tibiae were also analyzed, respectively.The gp130-/- micerevealed significantly lower ionized calcium level(1.44±0.03 vs1.77±0.03 mmol/ℓ, p<0.001)and significantly higher blood serum PTH(251.8±5.3 VS 20.5±5.3 pg/㎖,p<0.001) compared to wild type littermates.There was no remarkable pathologic change of placenta in gp130-/- and the ^45Ca transport though placenta was accelerated in gp130-/- compared to wild type littermates(%to Het 83%in -/- vs 148% in +/+).The gp130-/- embryos had small skeletons with bones containing little primary spongiosa, and large multinucleated TRAP+ cells along the lower border of the growth plate. Release of ^45Ca from prelableled calvarial bone(E18.5)in response to either 10^-7 M hpTH(1-34)or 20 ng/㎖ sRANKL was lower in gp130-/-calvarial bone compared to gp130+/+ calvarial bone (PTH 1.83±0.6 fold over basal in-/- vs 2.79±0.6 in +/+and sRANKL1.3±0.4 in -/- vs 2.79±0.6 in +/+ and sRANKL1.3±0.4 in -/- vs 2.0±0.4 in +/+,p<0.5). These result strongly support the hypothesis that PTH activates bone resortion,in part, by stimulating ostedtrophic cytokine secretiom from osteoblast/stromal cells, which tirggers gp130-mediated signaling for osteoclastic activation.

Ownership Structure of Northeast Asian Countries

Seung Rok Park,Peter Drysdale,Shin Il Kang,In kie Hong 한국경제연구원 2004 한국경제연구원 연구보고서 Vol.2004-02 No.-

1 In the first paper “Determinants of Corporate Ownership Structure and their effects on Corporate Governance in South Korea” by Shin-Il Kang, Korea’s unique characteristics, specifically the ownership structure and corporate governance are examined. The author takes a broad perspective by incorporating corporate culture, business leadership, and ownership structure in Korean corporation. Furthermore, he discusses the substitutability of Korean specific features given the rapidly changing economic environment. Under the Korea’s Chaebol structure, controlling shareholders, who are the real owner of firms, have exercised ownership rights while having a large proportion of shares aided by cross shareholdings. This has been possible through the pyramid ownership control structure as well as cross-shareholding among subsidiaries. Market circumstances related to management costs are not favorable to the firm with a dispersed ownership structure. In Korea, that’s the reason why ownership is concentrated. Given such a structure, the owners minimize costs related to management’s risks. Furthermore it proposes that leadership(firm culture) and ownership are substitutes. Concentrated ownership is needed when the leadership is not mature like Korean Chaebol. 2 The second paper “Issues in Japanese Corporate Governance” by Peter Drysdale examines some of the major issues of Japanese corporate governance today. The role of that main bank in corporate governance and inter corporate shareholding has been well documented. Although Japanese banks have rigorously monitored firms and have had an enormous influence on firms’ decisions and strategies through the owning of shares, firm performance under such a main bank system has not always been positive. Opposing views and their rationale regarding the pessimism behind the performance of firms in the main bank system are also explained in this paper. 3 The paper “Corporate Governance in China” by In Kie Hong discusses the current status and the restructuring efforts of China’s corporate governance. In China, state shareholders possess strong control rights over listed companies allowing them to exercise control even beyond their proportion of shareholding. Various governmental organizations(under the Communist Party) acting as representatives of the state as shareholders have influenced firms enormously, particularly regarding matters of organizing the board of directors as well as electing management. However since they have little incentives to manage state(national) assets and have insufficient capacity to monitor a large number of firms of which they are in charge, the principal-agent problem tends to prevail, which adds to the difficulties in preserving the value of state assets as well. 4 The last paper “Ownership Concentration and Corporate Performances in the Northeast Asian Countries” by Seung-Rok Park compares the relationship between corporate governance structure and corporate performance in Korea, Japan, and China by empirically examining the accounting corporate performances and technical efficiency measures. In the case of Korea, ownership concentration was shown to have positively affected all corporate accounting performance variables such as profit margin, return on shareholders’ funds, return on total assets, and return on capital employed. Furthermore, it was also found that ownership concentration positively affected corporate performance by helping improve the technical efficiency of firms. Unlike Korea, in Japan, there was no sign of a positive effect of ownership concentration on the accounting corporate performance and technical efficiency. Moreover, in the case of China, ownership concentration positively affected profit margin and return on total assets, while no positive effects of ownership concentration were found on return on capital employed and return on shareholders’ funds. It is shown in this study that the difference in the rel

혈액 내 구리, 아연 및 ceruloplasmin 농도에 흡연, 음주 및 신체적 활동이 미치는 영향

홍연표,강은용,신인철,최병선,박정덕,장임원,박진완 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : To investigate the influence of smoking, alcohol ingestion, and physical activity on copper and zinc in RBC and serum and serum ceruloplasmin, this study was performed in a cross-sectional study in 113 healthy men aged 20 to 40 years who had no symptomatic liver, heart, gastrointestinal, and other chronic diseases. Methods : At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of copper, zinc, iron, ceruloplasmin, total cholesterol, and hematocrit. Each man completed a questionnaire that provided information on smoking, amount of alcohol intake, and physical activity. Partial regression analysis was performed on confounding variables such as age, body mass index, hematocrit, serum cholesterol, and serum iron. Results : In general linear models, adjustment for confounding variables did not show statistical differences, and there was only an increasing tendency in serum copper in heavy smoker(P=0.0678). There was no difference between high physical activity with mild smokers and lower physical with heavy smokers. Conclusions : This study suggested that copper, zinc and ceruloplasmin were not good biomarker for early effect by smoking, alcohol intake and physical activity in young adult. However, selection bias should be considered in evaluation of this result, and a large prospective study will be needed in advance on usefulness of copper, zinc and ceruloplasmin as a marker for risk factors and early change of atherosclerosis.

중학교 과학과 수업 개선을 위한 학급수업과정 분석

박행신,정충덕,오홍식,노인화 濟州大學校 師範大學 科學敎育硏究所 1992 科學敎育 Vol.9 No.1

The purpose of this study is to find ways for the improvement of science instruction by describing and analyzing the schooling process in the class-room of the middle school through the participant observation. Four differ-ent middle schools and four different science teachers were selected. And intensive participant observations were made about total 18 hours' school-ing process concerned to the instruction of ' Photosynthesis' and 'Digestion' which are two units in the science textbook of the middle school. The documentary records of the results of field research on schooling the classroom were made. On the basis of these data analytical diagrams of each hour's schooling process were made and each teacher's teaching type, instrucion process type and teaching method about the same teaching contents were comparatively analyzed. Through this analysis, the following conclusions could be obtained. 1. Teaching type was divided largely into two different kinds, such as laboratory lessons in the laboratory and lecture lessons in the classroom. Laboratory lessons were conspicuously grouping lessons, and the lessons in the classroom were lecture lessons practiced by the lead of the teacher. 2. Instrucion process model stood out as an 'Inquiring Model' in the the-oritical model in case of laboratory grouping lessons, that is, in which 'inquiry learning process' was dominant, and stood out as 'Concept Model' explained by the teacher or 'Discovery Model' by suggesting teaching materials in case of lecture lessons. 3. Teaching method, even in case of the same teaching contents, showed various styles according to the different teachers. such as structur-izing lesson, providing instructional cues, questioning and reacting to stu-dents 'response, explanation and writing on the blackboard, student con-trol in class. But in case of the' same teacher the same styles were found in suggesting teaching aims, teaching arrangements, turning over in teach-ing. explanation and writing on the blackboard, of every class hour. 4. In order to make a qualitative improvement for the science instruc-tion, the inquiring instruction process, that is the greatest aim of science education, should necessarily be practiced in each class, and through this teaching process the present limits of science instruction should be over come. Therefore, the exploring attitude of each teachers own to renew the instruction stratege, Comparing the existing instruction process model, and teaching methods of individual teacher's, is thought to be nessessary. For this, through the teacher's training program or the teacher's retrain-ing course, the various ways to improve the science instruction quality should be provided by using ethnographic data on schooling as a tool for the indirect experience about other's schooling process.

초등학교 아동들의 신체질량지수에 의한 비만 평가

이신언,김홍인,윤우상 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The prevalence of overweight and obesity in elementary school has increased in several surveys. also obesity is increasingly recognised as a health problem by many countries. body mass index is widely used as a measure of %body at in clinical practice. for adults there are internationally recognised. however, in childhood and adolescence, there has been a lack of agreement about the definition of overweight and obesity. So the purpose is to apply and provide basic data of BMI cutoff points in elementary school and adolescence. the present study evaluated body mass index in 404(3grades; aged 10years) and 392(6grades aged 13years)boys and girls attending in 12 elementary schools. the method to evaluate overweight and obesity in elementary boys and girls is body mass index(BMI ; weight in ㎏/㎡). The mean height in 10 years elementary boys and girls were 132.2±5.48㎠, 130.9±5.54㎠, respectively. the mean height in 13 years elementary boys and girls were 149.7±7.34㎠, 149.9± 6.24㎠, respectively. the mean height was significant difference(p<0.05) between 10 and 13 years school boys and girls. The mean weight in 10 years elementary boys and girls were 32.3±7.15㎏, 30.2±5.68㎏, respectively. The mean weight in 13 years elementary boys and girls were 46.8±11.34㎏, 44.3±9.16㎏, respectively. The mean weight was significant difference(p<0.05) between 10 and 13 years school boys and girls. as the result of BMI evaluation, the mean BMI in 10 years elementary boys and girls were 18.34±3.21 ㎏/㎡, 17.52±2.55㎏/㎡, respectively. The mean BMl is significantly greater (p<.05) for 10 years elementary boys than 10 years elementary girls. the mean BM in 13 years elementary boys and girls were 20.69±3.70㎏ /㎡, 19.57±3.21㎏/㎡,respectively. The mean BMI is significantly greater(p<.05) for 13 years elementary boys than 13 years elementary girls. and the prevalence of obesity when evaluated BM were as follows mild obesity is 6.78%, moderate obesity 12.94%, and severe obesity 6.03%.

제주도의 주요 습지에 도래하는 도요·물떼새류의 현황

오홍식,임인추,김병수,김완병,박행신 경희대학교 한국조류연구소 2002 연구보고 Vol.8 No.1

본 연구는 제주도 주요 습지에 도래하는 도요ㆍ물떼새류의 지소적인 연구의 일환으로, 1998년 3월부터 2000년 2월까지 2년간 매월 2회씩, 1) 동부지역(하도리 양어장, 종달리 해안 및 성산포 양어장)과, 2)서부지역(용수리 저수지, 금등리 해안 및 대정읍 일과리 해안)으로 나누어 조사하였다. 조사기간 중 2개 지역에서 관찰된 도요ㆍ물떼새류는 총 45종 5,117개체였으며, 지역별로는 동부지역에서 40종 4,910개체, 서부지역에서 38종 927개체로 나타났다. 계절별로는 봄철 2,821개체, 가을철 1,229개체로 봄철에 도래하는 개체수가 가을철보다 많았다. 우점종은 제1차 조사기간인 봄철에는 민물도요 Calidris alpina 2,024개체(88.5%), 흰물떼새 Charadrius alexandrinus 84개체(3.7%), 흰목물떼새 Charadrius placidus 11개체(2.4%)의 순으로 나타났으며, 가을철에도 민물도요 384개체(82.9%), 흰물떼새 20개체(4.3%), 흰목물떼새 11개체(2.4%)의 순으로 나타났다. 제2차 조사기간에는 봄철에 좀도요 Calidria ruficollis 116개체(21.8%), 민물도요 67개체(12.6%), 청다리도요 Tringa nebularia 58개체(10.9%)의 순으로, 가을철에는 민물도요 191개체(24.9%), 노랑발도요 T. brevipes 156개체(20.4%), 삑삑도요 T. ochropus 104개체(13.6%)의 순으로 나타났다. 동부지역은 서부지역에 비하여 우점도는 높았으나, 종다양도와 균등도는 낮게 나타났다. 동부지역과 서부지역간의 유사도는 0.85였다. 본 연구를 통해 물꿩 Hydrophasianus chirurgus, 검은머리물떼새 Haematopus ostralegus, 바늘꼬리도요 Gallinago stenura, 흰꼬리좀도요 Calidrius temminckii 등 4종의 제주도 미기록종과, 검은머리물떼새, 흰목물떼새, 넓적부리도요 Eurynorhynchus pygmeus, 알락꼬리마도요 Numenius madagascariensis 등 3종의 환경부 지정 보호조류가 관찰되었다. This study was part of a continuous research project on the status of migrating shorebirds on major wetlands in Cheju Island. This study was conducted twice every month for two years, from March 1998 to February 2000. The investigated location are mainly two areas. The first census areas were Hado-ri fishfarm and the coast of Jongdal-ri in Kujaw-up and Sungsan-po fishfarm in Sungsan-up, all located in the eastern part of Cheju Island. The second census areas were Yongsu-ri reservoir and the coast of Kumdung-ri in Hangyoung-myon and the coast of Ilgwa-ri in Dejong-up, all located in the western part of Cheju Island. In total, 45 species consisting 5,117 individuals were observed during the census period. There were 40 species and 4,910 individuals in the eastern area, 38 species and 927 individuals in the western area. The number of individuals of shorebirds in the spring migratory season was greater than in the autumn. The dominant species researched during the first census period were 2,024 individuals of Calidrius alpina (88.5%), 84 individuals of Charadrius alexandrinus (3.7%), 59 individuals of Charadrius placidus (2.6%) in spring and 384 individuals of Calidrius alpina (82.9%), 20 individuals of Charadrius alexandrinus (4.3%), 11 individuals of Charadrius placidus (2.4%) in autumn. The dominant species researched during the second census period were 116 individuals of Calidrius ruficolis (21.8%), 67 individuals of Calidrius alpina (12.6%), 58 individuals of Tringa nebularia (10.9%) in spring and 191 individuals of Calidrius alpina (24.9%), 156 individuals of Tringa brebipes (20.4%), 104 individuals of Tringa ochropus (13.6%) in autumn. Dominance index were recorded better in the eastern area than the western area, but species diversity and evenness index were recorded lower in the eastern area than the western area. Similarity index were 0.85 between the eastern area and the western area. Hydrophasianus chirurgus, Haematopus ostralegus, Gallinago stenura and Calidrius temminuckii, which are observed during the census period are previously unrecorded species on Cheju Island. Rare and endangered species were observed such as Haematopus ostralegus, Charadrius placidus, Numenius madagascariensis, and Eurynorhynchus pygmeus.

휴대폰 케이스 가공업체에서 발생한 은피증 1예

탁기홍,윤석환,이미영,신동훈,정인성 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

배경: 은피증은 은의 피부 침착에 의해서 생기는 질환으로, 만성적인 노출에 의해 생기며, 치료법이 없는 영구적인 질병이다. 은의 흡입에 의한 은피증의 보고는 아주 드물며, 우리나라에는 현재까지 관련 보고가 없었다. 이에 휴대폰 도장제의 은 흡입에 의한 은피증을 보고하고자 한다. 증례: 30세 남자근로자로 5년 전부터 휴대폰 부품조립 및 도장업체에서 EMI부서와 가스켓부서에서 전자기파 차단제를 스프레이 도장하는 작업을 하였고, 3년 전부터 서서히 발생한 얼굴과 몸의 회색 및 회청색 피부색 변화를 주소로 내원하였다. 전자기파 차단제는 은, 구리, 용제들로 구성되어 있었다. 피부 조직 검사에서 에크린 한선 기저판(basal lamina)에 미세하고 둥근 흑갈색 과립들이 관찰되어 은피증의 소견을 보였으며, 작업중 노출된 은 흡입에 의한 직업성 은피증으로 진단하였다. 킬레이트 치료는 도움 되지 않으며, 노출 중단 및 자외선 차단 등의 보존적인 방법을 사용하고 있다. 고찰: 은피증은 은의 복용, 흡입, 접촉에 의해 발생한다. 본 증례에서는 은피증을 원인으로 작업시의 은 노출 이외의 은 노출을 발견할 수 없었다. 그러므로, 직업성 은피증으로 사료되며, 은의 첨가제에 의해 은피증이 발생 할 수 있음을 보여준다. 현재 전자기파 차단의 용도로 은과 은 화합물의 사용이 계속되고 있으므로, 이에 대한 대책이 필요하다고 본다. 적절한 치료법이 없기 때문에, 예 방이 가장 중요하며, 보호구 착용, 작업환경 개선, 산업 안전보건교육이 필요하다. Background: Skin contact with, and the breathing in of air containing silver compounds can occur in the workplace. Occupational exposure to silver and its compounds is mainly via airborne dust, metal fumes, and mists of solutions containing silver compounds. Argyria results from increased serum silver levels and the deposition of silver-containing particles in the dermis and mucous membranes. The author reports a patient with generalized argyria, who worked on the manufacture of cellular phone cases. Case report: The patient was a 30 year-old male, with extensive blue-gray discoloration of the whole body, especially sun-exposed area, of 3 years duration. He had been exposed to silver in the processing of EMI for the past 4 years and gaskets for 1 year. EMI is the process by which the internal electromagnetic wave in cellular phone cases are shielded, and gaskets play an important role in shielding the electric clashes between electronic circuits, as well as increasing the durability of cellular phone cases to impact. EMI had been processed manually but this was changed to automatic spraying by robots in 2003. On physical examination, the patient had diffuse blue-gray discoloration of the skin, which was most prominent in the sun-exposed areas of his face, neck and V of the chest. Histopathological examination of a punch biopsy specimen from the posterior neck revealed fine, minute, round, and brown-black granules deposited in the basement membrane zone surrounding the eccrine glands. The laboratory findings were positive for hepatitis B antigen, with a serum silver concentration of 150.3 ppb. From this evidence, he was diagnosed with argyria due to silver exposure. Discussion: The author reports a case of occupational systemic argyria due to inhalation exposure of silver compounds.