α-클로로-α-(메틸티오)아세톤을 이용한 벤조푸란 유도체의 합성

崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1

Benzofuran ring을 포함하는 다수의 화합물이 생리활성을 발현하는 의약품으로 개발되어있고 아울러 Benzofuran ring의 모핵 구조를 가진 천연물로서 천식, 위궤양 및 고혈압 등에 유용한 물질도 알려져 있다. Benzofuran ring의 합성법 중 대표적인 예로는 고온에서 arylalkyl ether의 cyclodehydration, aryloxyacetone의 탈수제에 의한 cyclization 및 o-allylphenol 류의 오존분해와 cyclization을 경유하는 방법과 (2-methoxyphenyl)ethynes을 2,4,6-trimethylpyrideine 중 lithium iodide로 처리하는 방법이 보고된바 잇다 .이들 제법은 출발물질의 합성이 용이하지 않고, 고온과 강산성의 격렬한 방응조건을 요구하고 있다.

성인 천식환자에서 도메난(염산 오자그렐)의 임상적 효과와 안전성

최인선,고영일,임호,명보현,홍서나,오봉석,이삼용 최신의학사 2000 最新醫學 Vol.43 No.9-10

폐모세포종 : 1례보고 A Case Report

최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.

저압간선의 전압강하 계산 알고리즘

崔洪圭,趙啓術,徐梵寬 홍익대학교 산업기술연구소 2002 産業技術 Vol.12 No.-

A size of low-voltage conductor cables is determined by the voltage drop of a system, the cable impedance and the cable ampacity based on temperature correction factor in accordance with the condition of cable installation. Therefore, the proper temperature correction factor according to the condition of cable installation should be applied to determining the cable ampacity and also the skin effect and proximity effect, along with the kind and size of conductor and the condition of cable installation, should be properly considered to analyze the proper value of resistance and the reactance of the conductors. This paper addresses the systematic design flow for determining the size of low voltage level conductor cables in calculating the voltage drop of a power system and proposes a new improved the calculating formula where error should be minimized in comparison with the general formula and which can be applied in design work for determining the size of conductor cables.

2-Chloro-2-(methylthio)acetophenone을 이용한 2-페닐벤조[b]퓨란 유도체의 합성

崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

It is well known that 2-arylbenzo[b]furan derivatives are occured in natural products such as Styrax obassia, Sophora tomentosa, and Krameria ramosissima. In the course of our search on the carbon-carbon bond formation utilizing 1-acyl-l-thiocarbocationic intermediates, we showed that the reaction of substituted phenols with α-chloro-α-(methylthio)acetone (1) in the presence of Lewis acid provided a convenient method for the 2-methylbenzo[b]furans (3) through the reductive desulfurization of the resulting products (2) (Scheme 1). The present paper describes the one-step synthesis for 2-phenylbenzo[b]furan derivatives from the reaction of phenol or cresol isomers with 2-chloro-2-(methylthio) acetophenone in the presence of zinc chloride. Many procedures have been reported for the preparation of 2-phenylbenzofuran ring. Among them, the most frequently employed method is based upon the cyclodehydration reaction of aryloxyacetone moiety with standard dehydrating reagents(H₂SO₄, ZnCl₂, POCl₃, KOH or PPA).

Copper(Ⅱ) Acetate Amide 착물의 합성 및 분석

徐弼子,崔洪大 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

地衣類의 脂質과 蛋白質 含量

徐信惠,李鴻善,崔璟姬,崔正渼 효성여자대학교 가정대학 학도호국단 1984 家政大論集 Vol.3 No.-

地衣類의 영양학적 가치를 조사하기 위하여 地衣類(지붕, 바위, 나무)와 석이의 總脂質 含量, 脂質 분포, 脂肪酸 조성, 蛋白質 含量을 측정하였다. 그 결과 총지질 함량은 100g당 석이는 3.47g, 바위에 地衣類는 3.40g, 지붕의 地衣類는 3.17g, 나무의 地衣類는 2.73g 이었고 TLC法에 의한 脂質의 분포는 석이와 地衣類 모두 cholesterol ester와 phospholipid 등이 있었고 나무 地衣類에는 TG 및 cholesterol의 흔적을 보였다. 지방산 조성은 대부분 C_12~C_18 fatty acid였고 그 중 C_18 : 1 C_18 : 2인 것이 50% 정도로 높게 나타났다. 나무의 地衣類에는 C_18 이상의 fatty acid도 상당량 분포되어 있었으며 C_20.4 fatty acid는 18.9%였다. 단백질 함량은 석이 6.60g, 地衣類는 8.22g이었다. To investigate the nutritional value of lichens, contents of total lipid, compositions of fatty acids, distributions of lipids and contents of total proteins in lichens (on the rock, roof and tree) and sogi were examined. The results were summarized as follow. The contents of total lipid in sogi, rock, roof, and tree lichens were 3.47±0.05%, 3.40±0.09%, 3.17±0.02%, 2.73±0.04% respectively. Lipids in all them were cholestrol ester and phospholidpid, and TG and cholesterol were existed only the lichen on the tree. Fatty acids were composed of that of carbon number 12-18; C_18:1 and C_18:2 were about 50%, Contents of total protein in sogi and lichen (roof) were 6.60% and 8.22% respectively.

개심술(開心術)의 임상적 고찰 : 치험 200예 200 Cases

최형호,서홍주,임영혁,김정중,배대양,이석기,임진수 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2

Background and Objectives: Two hundred cases of the open heart surgery due to congenital and acquired heart disease were done using the cardiopulmonary bypass in the Department of Thoracic and Cardiovascular surgery, Chosun University Hospital from November, 1980 to June, 2001. Material and Methods: The number of congenital heart disease was 132 cases. 68 cases were acquired heart disease. 'The age of the congenital heart disease was from 22 days to 45 years. In the acquired heart disease, the age was from 14 to 72 years. Result: Congenital heart disease consisted of 113 congenital acyanotic heart disease, 19 congenital cyanotic heart disease. Corrective operation was done for congenital heart disease with 4. 5 % operative mortality. Of 68 cases acquired heart disease, 44 patients were valvular heart disease, 3 cardiac tumors, 9 ischemic heart diseases, 12 aortic dissections and etc. The operative mortality was 13%. Conclusion: The postoperative complications were appeared in 68 cases and the complications were wound infection, occipital alopecia, low cardiac output syndrome, arrhythmia, septicemia etc. The mortality after open heart surgery was 15 cases and the causes of death were low cardiac output syndrome, septicemia, respiratory failure and left ventricle rupture.

서울 서남부지역 노인 인구에서 비만증 유병률과 고지혈증과의 상관성

최경묵,조영직,김경오,김동림,김난희,백세현,안정천,서홍석,오동주,최동섭 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3