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      • 초등 사회과 3학년 지역화 교수·학습자료개발 연구

        홍기대,손정선,김언식,김용조,이광성,김경운 光州敎育大學校 初等敎育硏究所 2002 初等敎育硏究 Vol.17 No.-

        The purpose of this study is in developing locally-oriented teaching-learning materials to motivate students to effectively take part in activities using map and in improving the field work of social studies to plan a map learning and to give them the ability of practice. It represents the right order involved in teaching the activities using map after doing preceding learning : classroom, playground, and the environs of the school including to some learning methods such as a puzzle map, a correlative of learning. Field trip study planning and lesson-plan are designed in case of Sewage disposal plant, Duknam filtration plant, Bonchon industrial complex relating to field trip study. There are some effects expected which follow through this study. First, teachers are able to draw learner's interest in finding learning sources directly through the community where they live. Second, learners have active participation in class, motivation, drawing their interests through map learning by doing preceding study of learner-centered. Third, teachers can make use of it as useful tools to get high achievement goal with self-direct learning.

      • 鉛暴露 作業者의 鉛中毒 早期發見을 위한 集團檢診法 改善方案에 관한 硏究

        홍대용,김장락,정주화,최현림,윤형렬 慶尙大學校 1995 論文集 Vol.34 No.1

        This study was carried out to evaluate the feasibility of current lead indicators used in screening lead who were sspeted to have been exposed to lead were selected as 'case'and 207 female workers from non-lead industry were selected for 'control'. The results obtained were as follows: 1. The mean values of blood lead for case and control were 31.4㎍/dl, 22.2㎍/dl,respectively. The difference observed in the mean concentration between case and control was statistically signifi-ant(P<0.01) 2. The mean values for blood ZPP by hematofluorometer for case and control were 31.3㎍/dl, 25.4㎍/dl,respectiely. And difference between two groups was statistically significant(P<0.01). 3. No statistically significant correlation was found between working duation and blood lead, blood ZPPlovel. 4. According to the simple correlation analysis,ZPPand urine lead were found to be statistically correlated with blood lead(P<0.01) 5. According to the discriminant analysis using blood lead as a dependent variable, it showed 89.1% predictability when using 40㎍/dl as a cutting value which is used as a screenig cutting value for industry workers health examination, while 81.8% for 30㎍/dl,77.54% for 20㎍/dl, respectively. 6. Lead related simptons which is used for screening the lead ntoxicated patients were used as a dependent variables in multiple regression analysis to find useful lead indicator. And significant independent variables were found to be ZPP, Age, and Hct. 7. Above results suggest that objective evalution of feasibbility of several lead indicators should be developed to correct the disutility of current lead screeng system in Korea.

      • KCI등재

        Caco-2 세포 단층막 투과 실험시 교반이 약물의 투과계수에 미치는 영향

        홍순선,유호정,이홍,정석재,김대덕,심창구 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2

        The unstirred water layer (UWL), which has been known to exist in the boundary of the intestinal lumen and intestinal wall, often behaves as an absorption barrier especially for lipophilic drugs. The intestinal absorption of drugs is often characterized using Caco-2 cell monolayers grown on Transwell polycarbonate membranes. The permeability (Pare) of drugs across the cell monolayer might be influenced by the agitation of the donor compartment, since the width of UWL on the surface of the cell monolayer would be reduced by the agitation. In this study, the effect of agitation of the donor compartment with 60 rpm on the permeability was measured for 12 drugs with a wide range of lipophilicity and permeability. The of mannitol, tributylmethyl ammonium, cimetidine, ranitidine, hydrocortisone, benzylpenicillin and loxoprofen was not influenced by the agitation, while the P_(app) of theophylline, propranolol, YH439, phenylpropanolarnine and testosterone was increased by the agitation. There was a significant correlation between the increase of P_(app) by agitation and the lipophilicity for the compounds having P_(app) > 2 x 10^(-5) cm/sec. No correlation was observed for the difference in P_(app) by agitation and the molecular weight, or lipophilicity of the drugs. Therefore, the agitation rate of the donor compartment in the Caco-2 cell monolayer study should be carefully controlled in order to estimate Pap, reproducibly especially for iipophilic drugs.

      • 백서에서 동종 신경이식시 항 T임파구 단일클론항체 분포에 관한 조직화학적 연구

        홍창섭,김경욱,임창준,정대현 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

        Nerve allografts as a bridge through which lost nerve can regenerate is useful in the repair of peripheral nerve defect resulting from trauma, neoplasm and leprosy. But immunological rejection and complicated scar formation is an unaboidable problem in the application of allogenic nerves. This article is intended to study histopathological and immunohistochemical response after fresh allogenic sciatic nerve grafts in rats. 12 male Sprague- Dawley rats were used as the experimental animals. A 2cm skin incision was made on the lateral aspects of limb, parallel to the femur. 1cm-long sciatic nerve trunk taken from the one rat was resected at the middle of the to high, and it was transplanted to the same area of the other rat with perineural suture method. Observation was made at the postoperative 1, 3, 8, 16 day. The results were as follows. 1. Histopathologically, destruction of the perineural sheath was observed only in 1-day group. 2. Mild degenerative changes of the nucleus and cytoplasm of Schwann cells were ovserved in the 1-day and 3-day groups. These changes gradually resolved. 3. Hollow space phenomena of the nucleus and cytoplasm of schwann cells were observed. The response was mild in the 1 day and 3 day groups, and moderate in the 8 day group. The phenomena were not identified in the 16 day group. 4. Immunohistochemical studies revealed pan T cells and cytotoxic T cells in the 1 day group. Increased numbers of cytotoxic T Cells and helper T cells were observed in the 3 and 8 day groups. 5. According to these results, after transplantation of fresh allogenic sciatic nerve an inflammatory response was observed up to 8 days and then gradually resolved. Degenerative changes were more severe up to 8 days, but an the 16th day they had resolved histopathologically and immunopathologically.

      • 재활용 폐페인트를 이용한 방청페인트 개발연구

        한대상,정재헌,조홍식,조창제,이종무,장상목 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.2

        In this study, The method to produce anticorrosive paint using reproductive wastepaint was investigated. The liquid-phase resin, BHO-500 and powder-phase paint BHO-300 were produced through wastepaint reproductive process. BHO-500 and BHO-300 could be replaced respectively polyvinylchloride resin and filler, which are thr components of anticorrosive paint. The properties of the anticorrosive paint produced through this process were excellent in comparison with the existing anticorrosive paint.

      • 건설 클레임의 예측모델에 관한 연구 : 턴키프로젝트 중심으로

        윤대중,윤준선,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

        The purpose of this study is to identify those attributes that affect a construction project, and to construct a model to predict construction claim in Turn-key construction projects. Data for the model development were collected using forty questionnaire surveys. This study developed a model and the likelihood of construction claims was modeled using logistic regression. People, process, and project issues play a role in predicting the likelihood of Turn-key construction claims. In this paper, the theoretical framework for predictable factors is first presented. This is followed by the research methodology. The results of the relevance of the attributes as tested in the fieldwork are then presented and discussed. Next, the Logistic regression model development is described, followed by model validation. The final section discusses the limitations of this paper and concludes the study. The essence of this study is that claims in Turn-key construction projects can be predicted by using variables.

      • 친환경 방염액의 연구

        이순홍,김병량,문명욱,이대정,정영호 안양대학교 산업기술연구소 2004 自然科學硏究 Vol.11 No.1

        대구 지하철 참사 이후 사회 전반적으로 방염에 대한 관심이 증대되어 방염제에 대한 연구가 활발하게 진행되고 있는 실정이다. 기존의 할로겐화 방염제는 방염제 자체의 독성으로 인해 인간의 건강과 환경에 유해성이 확인됨에 따라 이를 대체할 친환경 방염제의 연구가 부각되고 있는 시점이다. 본 연구에서는 친환경 대체 방염제의 일환으로 인계와 무기계 방염제를 혼합 사용하여 우수한 방염성능 및 연소시 유독가스가 발생되지 않는 친환경 방염제의 조성을 설계하고자 하였다. 인계 방염제로서 제1인산암모늄, 제2인산암모늄을 사용하였으며, 무기계 방염제로서 붕산과 붕사를 사용하여 각 조성 배합비의 함량 변화 실험을 통한 방염 특성 평가를 수행하였다. 이와 더불어 방염제의 부착률에 따라서 방염효과가 달라지는데, 최적의 조성으로 부착률을 달리하여 경제성과 법적인 측면을 고려하여 가장 효율적인 부착률을 알아보았다. The purpose of this research is to make a non toxic flame retardants as a substitute material for toxic halogen type, and to evaluate burning area, adhesion rate and flammability of non toxic flame retardants. The non toxic flame retardants were prepared by mixing processes of ammonium phosphate monobasic, ammonium phosphate dibasic, boric acid and borax under the various preparation conditions. Flammability of polyester fabrics treated with these mixed flame retardants was investigated through measurement of burning area and adhesion rate. The burning area values were decreased with increase of the Ammonium phosphate monobasic and ammonium phosphate dibasic content of flame retardants. For economic and legal reasons, the optimum adhesion rate of flame retardants on the polyester fabrics was 50%.

      • 장기투석을 받은 만성 신부전 환자에서 발생한 종양에 관한 고찰

        황정화,이혜경,홍현숙,박재성,김대호,권귀향,최득린,황승덕,이희발 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

        The authors tried to evaluate tumor occurrence in long-term dialysis patients with chronic renal failure. Among 359 patients, 20 patients (about 5.6%) were diagnosed with malignancy during long-term dialysis from the period of 1983 to 1995 at our nephrology department. The ultrasonographic and computed tomographic findings including the clinical features of 20 patients that were retrospectively reviewed. The mean age of the patients was 53 (37-75)years old and the ratio of male to female was 9:1. Among the 20 cases, 7 cases of hepatoma (35%) were developed. Among them, urinary tract tumors such as renal and bladder cancer were developed in 4 (20%) and 2 (10%) of the cases. Other malignant tumors were lymphoma, stomach cancer, uterine cervical cancer, cholangiocarcinoma, lung cancer, meningioma, and acoustic neuroma one case of each (each of 5.3%). The most common tumor in patients with chronic renal failure, who were receiving long-term dialysis, was hepatoma and the second most common tumor was cancer of the urinary tract such as kidney and bladder.

      • Au를 공침한 SnO₂후막센서의 가스 감응 특성

        성정훈,강대원,이윤수,임준우,홍영호,이덕동 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

        High selective and sensitive thick film type methane gas sensors were fabricated and their sensing characteristics for various hydrocarbon gases were investigated. Raw material, SnO_(2)/Au, prepared by coprecipitation was even grain size. SEM, TEM, BET and XRD analyses were carried out for investigation of surface morphology and crystalline structure. The thick film devices using the above materials exhibited high sensitivity to methane gas at the operating temperature of 400°C. The sensitivity of SnO_(2)/Au+Pd thick film devices to methane gas was higher than that to the other hydrocarbon gases such as iso-butane and propane. The optimal adding amounts of Au and Pd were 1wt.% and 3wt.%, respectively. The sensitivity, S, is defined as {(R_(A)-R_(G))/R_(A)}><100, which R_(A) and R_(G) are resistance in air and that in the gas ambient, respectively.

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