급성충소돌기염의 임상 : 병리학적 고찰

양기화,조준필,하영천,한진우,정학재,손수창,이성희,황재훈,신철호 최신의학사 1989 最新醫學 Vol.32 No.4

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

인체에서 방사되는 생물광자(生物光子)에 대한 소고

이승호,김진수,박하준,양준모,소광섭,임사비나 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Objectives : The purpose of this study is to review research papers published by Korean research groups on biophoton of human beings based on experiment subject and methodology. Methods : In order to review human biophoton research executed in Korea, all the papers published in Korean and international journals by Korean research groups were selected. Several key foreign papers were also reviewed for clarification of this study. Based on experiment subjects, experiment methodology, and interpretation of experiment results were analyzed. On each experiment, its original interpretation was directly quoted. Issues on the experiment methodology and interpretation were expressed at the end of each subject. Results and Conclusions : We found that experiments on human biophoton were compelling. However it seemed that mom experiments, especially on their sample sizes, ate needed to demonstrate its clinical application. Interpretations based on Korean traditional medicine also need to be elaborated more. In order to do accomplish clinical application of biophoton, interdisciplinary works are required. Some suggestions on biophoton experiments were made.

배추 시스테인 단백질 분해 효소 억제 유전자 BCPI-1의 발현과 종자 발아 및 유묘 생장과의 연관성

홍준기,이은영,김정률,양경애,최영주,정우식,김호일,윤대진,이상열,조무제,임체오 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Phytocystatins are protein inhibitors of cysteine proteinases of the papain family that have been identified in both monocot and dicot plants. A cDNA encoding a phytocystatin, BCPI-1 (Brassica Cysteine Proteinase Inhibitor-1) has been isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds. Here, we tested whether BCPI-1 transcription is regulated by hormones, and could be involved in regulating cysteine proteinases during and after germination. BCPI-1 was sensitive to exogenous GA_(3) and ABA, which are important factors controlling seed germination, suggesting that the expression of BCPI-1 is hormonally regulated. We introduced a recombinant plasmid containing the full-length BCPI-1 cDNA under the control of cauliflower mosaic virus 35S promoter into rice embryogenic calli using the particle delivery method, and regenerated a number of transgenic rice plants. Constitutively over-expressed BCPI-1 caused changes in overall plant growth and development, including reduced germination and seedling growth. These data support the role of the BCPI-1 in the regulation of endogenous proteinases during both seed germination and subsequent seedling development. Phylocystatins은 papain계열의 cysteine 단백질 분해 효소 활성을 특이적으로 억제하는 억제자로 다양한 식물 종으로부터 분리되었다. 본고에서는, 배추 화아 cDNA library로부터 분리된 phytocystatin인 BCPI-1(Brassica Cysteine Proteinase Inhibitor-1)의 생체 내 기능에 대해 연구하였다. 먼저, BCPI-1 전사체는 발아 조절에 중요한 영향을 미치는 GA₃와 ABA에 의해 예민하게 증가, 혹은 감소되는 반응을 보임으로써, BCPI-1이 식물 호르몬의 영향을 받으며, 특히 발아나 유묘의 생장 조절에 관련이 있음을 알 수 있었다. Particle bombardment 방법을 통하여 BCPI-1을 벼의 배 형성 세포 내에 도입, 재분화 시켜 형질 전환 벼를 생성하였다. CaMV 35S promoter의 조절에 의해 지속적인 BCPI-1 발현을 보이는 형질 전환 벼의 경우, 발아와 유묘 생장이 현저히 지연되었다. 위의 결과들을 바탕으로, BCPI-1이 식물체 내에서 생성되는 cysteine 계열의 단밸질 분해 효소 활성을 조절하여 종자의 발아와 유묘의 생장에 영향을 미치는 것으로 추측한다.

다중 평행판 축전기형 전송회로를 사용한 질소레이저의 제작과 출력 특성의 기체 온도 의존성

김원호,양준목,추한태 충남대학교 기초과학연구소 1994 忠南科學硏究誌 Vol.21 No.1

We have studied the operational characteristics of a nitrogen laser system which consists of a laser tube of 200 ㎜ in length, multiple parallel plate capacitor type transmission circuitry, pulse type high voltage power source and temperature control system for the nitrogen gas. The optimum operational condition is measured to be 30 ℃ in gas temperature, 70 torr in gas pressure, and E/P of 411 (V/㎝.torr) at 4 ㎜ in spark gap spacing and 20 ㎐ in repetation rate. With increasing the nitrogen gas temperature, the optimum nitrogen gas pressure is found to be increased but the optimum value of E/P is decreased. These results are in accordance with the theory of other studies so far.

영광원자력발전소 주변의 식생과 식물현존량 추정

이호준,양효식,전영문,정흥락,강재구,방제용 建國大學校基礎科學硏究所 1996 理學論集 Vol.21 No.-

영광원자력발전소 주변의 식생에 대한 식물사회학적 조사를 실시하였으며, 순 1차 생산량과 식물현존량을 추정하였다. 또한 상관에 의해 현존식생도 및 녹지자연도를 작성하였다(1:50,000). Z-M 방식에 의한 삼림식생은 소나무군락과 곰솔군락으로 구분되었다. 전체적으로 교목층에 소나무와 곰솔, 아교목층에 졸참나무와 곰솔, 관목층에 털진달래와 신갈나무, 초본층에 털대사초와 그늘사초 등의 피복지수가 우세하게 나타났다. 토양의 pH는 4.65∼4.67, 유기물 함량은 7.28∼7.53%의 범위였다. 현존식생도에 의한 분포비율은 경작지(67%), 소나무(21.9%) 및 곰솔군락(9.1%)의 순으로 나타났으며, 녹지자연도는 등급 2가 67%(경작지), 7등급(이차림(A))과 6등급(조림지)이 각각 29.2%와 1.8%로 나타났다. Montreal model에의한 소나무림과 곰솔림의 식물현존량은 657,817.2와 177,367.0ton으로 각각 산정되었다. The forest vegetation and estimation of phytomass and net primary production in the vicinity of Yonggwang Atomic Power Plant were analyzed on the basis of the phytosociological data. Depending on physiognomy, the actual vegetation map and the degree of green naturality(DGN) were also drawn in the scale of 1:50,000. According to Z-M method, the forest vegetation was classified into two communities; Pinus densiflora and Pinus thunbergii communities. It was generally shown that Pinus densiflora and Pirus thunbergii in tree-1 layer, Quercus serrata and Pinus thunbergii in tree-2 layer, Rhododendron mucronulatum var. ciliatum and Quercus serrata in shrub layer, and Carex ciliato-marginata and Carex lanceolata in herb layer had high coverage index. The pHs and contents of organic matter of the forest soils collected in each sites were in the 4.64 to 4.67 and 7.28% to 7.53% in average, respectively. The distribution area of each vegetationindex. The pHs and contents of organic matter of the forest soils collected in each sites were in the 4.64 to 4.67 and 7.28% to 7.53% in average, respectively. The distribution area of each vegetation type in the actual vegetation map was 67% cultivated land, 21.9% in Pinus densiflora community and 9.1% in pinus thunbergii community. The distribution of the degree of green naturality(DGN) was 67% in the second-grade (cultivated land), 29.2% in 7th grade (second forest(A)) and 1.8% in 6th grade (plantation). It was estimated that phytomass of Pinus densiflora and Pinus thunbergii in the study sites, which was calculated by Montreal model, was 657,817.2 and 177,367.0 ton, respectively.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

충주시 농촌지역 주민들에 대한 보건교육 평가

권복규,양준호,송진범,이건세,이원진,장성훈 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

The aim of this study was to evaluate the effect of health education program in Choongju rural area which had conducted by Public Health Doctor during winter in 1994 and 1995. We used two step sampling method for a household survey. First, six were selected from 12 Myuns, which were stratified by the level of health education activity. Second, we applied convenient sample method. Of the 307 respondents, most of them knew Health-subcenter's existence in their region. However, only 149 persons(45%) visited it during last year. They visited Health-subcenter because it was easy to travel and convenient. Some of them thought that Health-subcenter had very poorly equipped and supplied. About 32∼34% of respondents participated the health education program for hypertension and diabetes mellitus which was done last winter, and 59∼70% of participants of the program answered that it was very, moderately helpful. 82∼83% of participants recognized complications of hypertension and diabetes mellitus, and 18∼20% of them did not know that medications of hypertension and diabetes mellitus should be continued one's whole life. The respondents want to receive health educations for cancer, arthritis, viral hepatitis and AIDS in orders. Many of rural residents utilize Health-subcenters because health clinics in Choongju rural area are very few.

티타늄의 산화 조건에 따른 산화막의 특성 및 인산칼슘 생성에 미치는 영향

김인,양홍서,박연준,송호준,이용렬 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.3

The objective of this study was to evaluate the changes of micro morphology, roughness and crystalline structure of titanium surface after various oxidation treatments. Moreover, the effect of titanium surface oxide characteristics on the formation of calcium phosphate in Eagle's MEM. Commercially pure Ti disks were treated at various thermal conditions of 530℃ (Ti-530), 600℃(Ti-600), 700℃(Ti-700), 800℃(Ti-800), 900℃(Ti-900), and 1000℃(Ti-1000), respectively, and as received cp Ti (AS-R) and passivated cp Ti (PAS) were used as comparison groups. Surface characteristics were investigated using FE-SEM, profilometer and XRD. After immersing each sample in MEM for 7days, calcium phosphate (Ca-P) formation was evaluated using FE-SEM and EDS. Crystallites of 10~30nm-size were observed on the surface of Ti-530 and Ti-600 samples. Needle-like crystals were formed on Ti-700 samples, and the crystal grain size was increased dramatically as the temperature increased higher than 800℃. The roughness of Ti-530 was higher comparing to AS-R and PAS, and the roughness decreased in the treatment range of 530-700 with dense crystalline oxide formation. However, at treatment temperatures higher than 800℃, the roughness increased and its degree was depended to the size of the crystals. The anatase structures were observed in Ti-530 and Ti-600, and anatase and rutile structures were co-existed in Ti-700 specimen. Only rutile TiO_(2) were observed in Ti-800, Ti-900 and Ti-1000 specimens. The Ca-P formation on AS-R and PAS specimens was low in MEM solution. However, the Ca-P formation was well observed on heat-treatedgroups, and its degree of formation and micro-morphology was different by the specimen groups. The crystalline and chemical structure, micro-morphology, and surface roughness of titanium were various by the conditions of heat treatments, and the grain size and crystal structure of titanium oxide affected on the degree of Ca-P formation on Ti samples in MEM solution

기계적 합금화에 의해 제조된 고규소 Al-Si 합금 나노 결정의 특성

이정일,김일호,홍태환,어순철,양계준,석현광,한만갑,최국선,김준수 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.7

High silicon Al-Si alloys with nanocrystalline structures have been produced by mechanical alloying process. Microstructural changes of the Al-Si alloys were investigated by scanning electron microscopy and the transmission electron microscopy. X-ray diffraction analysis was also made to characterize the lattice constant, crystallite size and misfit strain. It was found that the effective milling time by attrition milling was about 12hours for Al-70 wt%Si alloy system. The Al and Si crystallites were reduced to about 30 nm and 70 nm, respectively, by the mechanical alloying for more than 12hours. The misfit strains increased with milling time UD to 240 hours, and saturated to 5.73×10^(-3) for Al and Si crystallites, respectively.