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Yoshida, Hiroyuki,Tamai, Hidesada,Ohnuki, Akira,Takase, Kazuyuki,Akimoto, Hajime Korean Nuclear Society 2006 Nuclear Engineering and Technology Vol.38 No.2
We start to develop a predictable technology for thermal-hydraulic performance of the RMWR core using an advanced numerical simulation technology. As a part of this technology development, we are developing the advanced interface tracking method to improve the conservation of volume of fluid. The present paper describes a part of the development of the twophase flow simulation code TPFIT with the advanced interface tracking method. The numerical results applied to large-scale water-vapor two-phase flow in tight lattice rod bundles are shown and compared with experimental results. In the results of numerical simulation, a tendency of the predicted void fraction distribution in horizontal plane agreed with the measured values obtained by the advanced neutron radiography technique including the bridge formation of the liquid at the position of adjacent fuel rods where an interval is the narrowest.
Production of Organic Acids and Amino Acids from Fish Meat by Sub-Critical Water Hydrolysis
Yoshida, Hiroyuki,Terashima, Masaaki,Takahashi, Yohei 嶺南大學校 環境問題硏究所 1999 環境硏究 Vol.19 No.1
Fish meat was easily liquefied by hydrolysis under aubcritical conditions without oxidants, and aqueous phase and water-insoluble phase containing oil and fat-like solid were farmed. Lactic acid found in the raw fish meat (about 0.03 g/g-dry meat) was stable up to the reaction temperature 513 K (3.35 MPa). Pyroglutamic acid was produced with a field of 0.095 kg/kg of dry meat by 30 min reaction at 553 K (6.42 MPa). Amino acids such as cystine, alanine, glycine, and leucine were produced in the temperature range 513-623 K with a maximum peak at 543 K. Amounts of crystine, alanine, glycine, and leucine produced in 5 min at 543 K(5.51 MPa) were 0.024, 0.013, 0.009, and 0.004 kg/kg of dry meat, respectively. The oil extracted with hexane contained useful fatty acids such as eicosapentanoic acid (EPA) and docosahexianoic acid (DHA). Thus, subcritical water hydrolysis would be an efficient process for recovering useful substances from organic waste such as fish waste discarded from fish market.
PC-766B' and PC-766B, 16-Membered Macrolide Angiogenesis Inhibitors Produced by Nocardia sp. RK97-56
KO, HACK-RYONG,KAKEYA, HIDEAKI,YOSHIDA, ARIKA,ONOSE, RIE,UEKI, MASASHI,MUROI, MAKOTO,TAKATSUKI, AKIRA,MATSUZAKI, HIROSHI,OSADA, HIROYUKI 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.5
Angiogenesis is an essential event in a variety of physiological and pathological processes. Therefore, effective inhibition of event is a promising strategy for treating angiogenesis-related diseases, including cancer. The current study investigated two unique bafilomycin-type macrolide inhibitors of angiogenesis, PC-766B' (1) and PC-766B (2). The strain RK97-56 which produced the inhibitors was identified as Nocardia sp. by chemotaxonomic analyses, and the purification of the inhibitors was guided by their anti-angiogenic actives. PC-766B' (1) and PC-766B (2) exhibited potent inhibitory activities towards endothelial cell migration stimulated by the vascular endothelial growth factor(VEGF).
Resolution of Time and Worker Conflicts for a Single Project in a Max-Plus Linear Representation
Yoshida, Shotaro,Takahashi, Hirotaka,Goto, Hiroyuki Korean Institute of Industrial Engineers 2011 Industrial Engineeering & Management Systems Vol.10 No.4
This research develops a framework for resolving time and worker conflicts in the Critical Chain Project Management (CCPM) method, expressed in the form of a Max-Plus Linear (MPL) system. Our previous work proposed a method for resolving time conflicts. However, in practical cases, both time and worker conflicts may occur. Hence, we propose a method for resolving both time and worker conflicts for a single project. We first consider how to detect a resource conflict. Then, we define an adjacency matrix to resolve the detected conflicts. Using the proposed method, we confirm that the resource conflict can be resolved through a numerical example.
Resolution of Time and Worker Conflicts for a Single Project in a Max-Plus Linear Representation
Shotaro Yoshida,Hirotaka Takahashi,Hiroyuki Goto 대한산업공학회 2011 Industrial Engineeering & Management Systems Vol.10 No.4
This research develops a framework for resolving time and worker conflicts in the Critical Chain Project Management (CCPM) method, expressed in the form of a Max-Plus Linear (MPL) system. Our previous work proposed a method for resolving time conflicts. However, in practical cases, both time and worker conflicts may occur. Hence, we propose a method for resolving both time and worker conflicts for a single project. We first consider how to detect a resource conflict. Then, we define an adjacency matrix to resolve the detected conflicts. Using the proposed method, we confirm that the resource conflict can be resolved through a numerical example.
( Naminatsu Takahara ),( Hiroyuki Isayama ),( Yousuke Nakai ),( Shuntaro Yoshida ),( Tomotaka Saito ),( Suguru Mizuno ),( Hiroshi Yagioka ),( Hirofumi Kogure ),( Osamu Togawa ),( Saburo Matsubara ),( 대한간학회 2017 Gut and Liver Vol.11 No.4
Background/Aims: Endoscopic placement of self-expandable metal stents (SEMSs) has emerged as a palliative treatment for malignant gastric outlet obstruction (GOO). Although covered SEMSs can prevent tumor ingrowth, frequent migration of covered SEMSs may offset their advantages in preventing tumor ingrowth. Methods: We conducted this multicenter, single-arm, retrospective study at six tertiary referral centers to evaluate the safety and efficacy of a partially covered SEMS with an uncovered large-bore flare at the proximal end as an antimigration system in 41 patients with symptomatic malignant GOO. The primary outcome was clinical success, and the secondary outcomes were technical success, stent dysfunction, adverse events, and survival after stent placement. Results: The technical and clinical success rates were 100% and 95%, respectively. Stent dysfunctions occurred in 17 patients (41%), including stent migration in nine (23%), tumor ingrowth in one (2%), and tumor overgrowth in four (10%). Two patients (5%) developed adverse events: one pancreatitis and one perforation. No procedurerelated death was observed. Conclusions: A novel partially covered SEMS with a large-bore flare proximal end was safe and effective for malignant GOO but failed to prevent stent migration. Further research is warranted to develop a covered SEMS with an optimal antimigration system. (Gut Liver 2017;11:481-488)