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고온가열처리에 의한 바다방석고둥 ( Omphalius pfeifferi capenteri ) 의 식품성분 변화
하진환(Jin Hwan Ha),송대진(Dae Jin Song),김풍호(Poong Ho Kim),허민수(Min Soo Heu),조문래(Moon Lae Cho),심효도(Hyo Do Sim),김혜숙(Hey Suk Kim),김진수(Jin Soo Kim) 한국수산과학회 2002 한국수산과학회지 Vol.35 No.2
바다방석고둥을 원료로 한 신제품 개발에 관한 일련의 기초 연구로 저장성 부여를 위하여 시도하는 고온가열처리 조건 (F_0 5분, F_0 10분, F_0 15분 및 F_0 20분)에 따른 바다방석고둥의 성분변화에 대하여 살펴보았다. 바다방석고둥 통조림은 살균을 5분 이상 처리하는 경우 저장 중 팽창관이 발생하지 않았고, 또한 생균수가 검출되지 않아 저장성이 있었다. 고온가열처리 정도가 증가할수록 바다방석고둥의 일반성분 중 수분함량은 감소하였고, 조단백질 함량은 증가하였으며, 조지방 및 조회분 함량은 거의 변화가 없었다. 또한 바다방석 통조림은 고온가열처리 정도가 증가할수록 이취에 관여하는 휘발성염기질소 함량, pH와 색조에 관여하는 갈변도는 증가하였고, 영양에 관여하는 구성아미노산, 무기질과 맛에 관여하는 유리아미노산, TMAO, total creatinine 및 수율 둥은 감소하였다. 이들을 색조, 조직감 및 맛에 대하여 관능검사한 결과 자숙 처리한 시료에 비하여 모든 항목에서 F_0 10분까지는 차이가 없었으나, 그 이상 가열처리한 경우 품질이 저하하였다고 인지되었다. 이상의 결과로 미루어 보아 바다방석고둥을 고온가열처리하여 신제품을 개발하고자 하는 경우 F_0 값이 10분 이상이면 바람직하지 않은 것으로 판단되었다. The top shell, Omphalius pfeifferi capenteri meat vacuum-packed in can (diameter× height, 74.1 ㎜ × 50.7 ㎜) were heated at 115℃ up to F_0 values of 5 min, 10 min, 15 min and 20 min, and the changes in food components were studied. After 14 days storage at 37℃ and 55℃, no growth of microorganism and panelling were recognized from the canned meats which were sterlized at 115℃ with F_0 value of 5 min and over. In the case of proximate composition of the canned meats, the moisture content decreased with the increase of F_0 value, while crude protein increased. The increase of volatile basic nitrogen content, pH and degree of browning and the decrease of mineral, total amino acid, free amino add, trimethylamine oxide, total creatinine contents and yields were observed during thermal processing. In sensory evaluation on color, texture and taste in the canned meats, no significant difference was observed among a boiled sample and the canned meats heated at F_0 value of 10 min and below. But, in the canned meats heated at F_0 value of over 15 min, its sensory scores decreased with the increase of F_0 value. From these results, the reasonable F_0 value for preparation of the heat-treated top shell meats was in the range of 5∼10 min.
심한 정신병적 증상을 나타낸 전신성 홍반성 루푸스 3례
문혜원,강민희,송정수,박원,김철응,이정섭,배재남 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3
전신성 홍반성 루푸스(systemic lupus erythematosus, 이하 SLE)는 원인을 알 수 없는 자가항체 및 면역복합체로 인하여 여러 장기의 손상을 초래하는 질환이다. SLE의 신경정신의학적 증상에 대하여는 1872년 Kaposi에 의해 처음 기술되었다. 이때에 나타나는 임상적 양상은 상당히 다양하여 정신증, 우울증, 뇌졸증과 인지기능장애등을 포함한다. 이들은 종합적인 정신과적 평가를 위해 종종 협의진료가 의뢰되고 있다. SLE의 정신병적 증상은 환자의 사망률을 높이고 좋지 않은 예후를 시사하는 지표가 될 수 있기 때문에 조기 진단 및 치료가 요구된다. 그러나 SLE의 중추신경계 침범에 대한 명확한 진단기준이 마련되어있지 않고, 증상의 다양성과 변동성은 진단을 더욱 어렵게한다. 저자들이 경험한 심한 정신병적 증상을 보인 SLE 3례의 경우, 이들은 지남력 장애, 환시, 환청, 망상, 불안정한 기분을 보였고 자주 충동적이 되거나 난폭해져 자신 또는 타인에게 위험을 초래할 수 있었다. 현재까지 SLE의 정신병적 증상에 대하여 잘 알려져 있지는 않지만, 문헌고찰을 통해 발병기전, 분류진단, 임사양상, 치료등에 대하여 알아보았다. Systemic lupus erythematosus(SLE) is a disease of unknown etiology in which multiple organs are damaged by pathogenic autoantibodies and immune complexes. Neuropsychiatric manifestations in SLE were first described by Kaposi in 1872. These are so diverse that they include psychosis, depression, stroke, seizure and cognitive dysfunction etc.These patients are frequently consulted for psychiatric evaluation. Neuropsychiatric manifestations in SEL re also among the leading causes of morbidity and mortality and associated with poor long-term outcome. So it is essential to recognize and intervene these symptoms early. But the clear diagnostic criteria for CNS involvement in SLE have not been formulated, and diversity and fluctuation of illness make it difficult to confirm it. The authors reported three cases of SLE with severe neuropsychiatric manifestation. These patients showed symptoms such as disorientation, auditory and visual hallucibation, delusion and mood instability. They became frequently impulsive and violent and had risks to injure themselves or others. Although CNS involvement in SLE is not well known, we reviewed the pathogenesis, classification, diagnosis, clinical manifestation and treatment of them.
李相正,權寧敏,金惠蘭 慶尙大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.14 No.-
The purpose of this study is to establish the handicapped provision on service centers. Because of the architectural barriers on existing welfare facilities, the disabled elderly people have to be restricted or inconvenienced in their of such buildings. For the establishment of physical environmental criteria for the handicapped, focus to present the architectural standards and recommendations considering to the handicapped. Eventually aim to equip the architectural environment and provided guide for designing of welfare facilities.
FGF-2 inhibits TNF-α mediated apoptosis through up-regulation of Bcl2-A1 and Bcl-xL in ATDC5 cells
( Hey Ryun Kim ),( Youn Moo Heo ),( Kyoung Il Jeong ),( Yong Min Kim ),( Hae Lan Jang ),( Kwang Yeol Lee ),( Chang Yeol Yeo ),( Sung Hoon Kim ),( Hak Kyo Lee ),( Seung Ryul Kim ),( Eung Gook Kim ),( J 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.5
FGF-2 is involved in cell survival, proliferation, apoptosis, and angiogenesis in a wide variety of cells. FRGRs, PI3K and MAP kinases are well known mediators of FGF signaling. Despite its known roles during many developmental processes, including osteogenesis, there are few known targets of FGF-2. In the present study, we identified Bcl2-A1 and Bcl-xL as two prominent targets involved in promoting cell survival. Pretreatment of ATDC5 cells with FGF-2 increased cell survival, while siRNAs specific for Bcl2-A1 and Bcl-xL compromised the anti- apoptotic effect of FGF-2, sensitized the cells to apoptosis triggered by TNF-α. Chemical inhibition of FGFR, NFkB, and PI3K activity by PD173074, pyrrolidine dithiocarbamate, and LY294002 respectively abrogated the FGF-2-mediated induction of Bcl2-A1 and Bcl-xL expression. Taken together, our data demonstrate that a subset of Bcl2 family proteins are the targets of FGF-2 signaling that promotes the survival of ATDC5 cells. [BMB reports 2012; 45(5): 287-292]
Actual situation and prescribing patterns of opioids by pain physicians in South Korea
Min Jung Kim,Ji Yeon Kim,Yun Hee Lim,Sung Jun Hong,Jae Hun Jeong,Hey Ran Choi,Sun Kyung Park,김정은,Min Ki Lee,Jae Hun Kim 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.4
Background: Use of opioids for chronic intractable pain is increasing globally, and their proper use can improve patients’ quality of life. In contrast, opioid use disorders, such as abuse or addiction, caused by prescribing opioids, are a worldwide issue. This study aimed to understand current opioid prescribing patterns and pain physicians’ experiences with opioid use in South Korea. Methods: Pain physicians in 42 university hospitals in South Korea were asked to complete anonymous questionnaires regarding opioid prescriptions. Results: A total of 69 surveys were completed. Most pain physicians started prescribing opioids at a pain score of 7/10 and aimed to reduce pain by 50%. Most physicians (73.1%) actively explained the prescribed medications and possible side effects, and 61.2% of physicians preferred the prescription interval of 4 weeks. Immediate-release opioids were the most popular treatment for breakthrough pain (92.6%). The most common side effect encountered by physicians was constipation (43.3%), followed by nausea/vomiting (34.3%). Of the physicians, 56.5% replied that addiction and misuse prevalences were less than 5%. However, the most concerning side effect was addiction (33.0%). Conclusions: The survey results showed that the prescribing patterns of pain physicians generally followed Korean guidelines. Physicians were most interested in the safety and effectiveness of opioid prescriptions. They were most concerned about respiratory depression and abuse or addiction. A significant number of physicians agreed that the NHIS regulations needed improvement for patient convenience and safe and effective treatment, though there were pros and cons of the NHIS restrictions on prescription conditions.
Lee, Min‐,Jae,Jung, Jieun,Na, Kyu‐,Hwan,Moon, Ji Suk,Lee, Hey‐,Jin,Kim, Jae‐,Hwan,Kim, Gwang Il,Kwon, Sung‐,Won,Hwang, Seong‐,Gyu,Kim, Gi Jin Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of cellular biochemistry Vol.111 No.6
<P><B>Abstract</B></P><P>Translational studies have explored the therapeutic effects of stem cells, raising hopes for the treatment of numerous diseases. Here, we evaluated the therapeutic effect of chorionic plate‐derived mesenchymal stem cells (CP‐MSCs) isolated from human placenta and transplanted into rats with carbon tetrachloride (CCl<SUB>4</SUB>)‐injured livers. CP‐MSCs were analyzed for hepatocyte‐specific gene expression, indocyanine green (ICG) uptake, glycogen storage, and urea production following hepatogenic differentiation. PKH26‐labeled CP‐MSCs were directly transplanted into the livers of rats that had been exposed to CCl<SUB>4</SUB> (1.6 g/kg, twice per week for 9 weeks). Blood and liver tissue were analyzed at 1, 2, and 3 weeks post‐transplantation. The expression of type I collagen (Col I) and matrix metalloproteinases (MMPs) was analyzed in rat T‐HSC/Cl‐6 hepatic stellate cells co‐cultured with CP‐MSCs following exposure to TGF‐β. The expression levels of α‐smooth muscle actin (α‐SMA) and Col I were lower in transplanted (TP) rats than in non‐transplanted (Non‐TP) animals (<I>P</I> < 0.05), whereas the expression levels of albumin and MMP‐9 were increased. TP rats exhibited significantly higher uptake/excretion of ICG than non‐TP rats (<I>P</I> < 0.005). In addition, collagen synthesis in T‐HSC/Cl‐6 cells exposed to TGF‐β was decreased by co‐culture with CP‐MSCs, which triggered the activation of MMP‐2 and MMP‐9. These results contribute to our understanding of the potential pathophysiological roles of CP‐MSCs, including anti‐fibrotic effects in liver disease, and provide a foundation for the development of new cell therapy‐based strategies for the treatment of difficult‐to‐treat liver diseases. J. Cell. Biochem. 111: 1453–1463, 2010. © 2010 Wiley‐Liss, Inc.</P>
症例(증례) : 관상동맥 스텐트로 치료한 베체트병에 동반된 급성 심근경색증 1예
정혜진 ( Hey Jin Jeong ),김세인 ( Se In Kim ),김소리 ( So Ri Kim ),이규선 ( Kyu Sun Lee ),고은영 ( Eun Young Ko ),김성훈 ( Seong Hun Kim ),김성식 ( Sung Sik Kim ),임호영 ( Ho Young Yhim ),민경훈 ( Kyung Hoon Min ),이상일 ( Sang Il 전북대학교 의과학연구소 2004 全北醫大論文集 Vol.28 No.1
베체트병은 반복되는 아프타성 구강궤양과 성기궤양 및 포도막염과 같은 눈의 반복적인 염증성 병변을 특징으로 하는 전신 질환이다. 베체트병에 동반된 심근경색은 매우 드물어서 소수의 증례만이 보고 되고 있다. 저자들은 베체트병 환자에서 발생한 심근 경색증 1예를 경험하였기에 보고하는 바이다. Behcet`s disease is a systemic disease of unknown cause, belonging to vasculitis pathologically. It rarely involves the coronary arteries. Coronary arteritis may lead to myocardial infarction and death, and the management of coronary lesions due to Behcet`s disease has been described only in a small number of patients. We experienced a -36-year-old man with Behcet`s disease who presented with acute coronary syndrome, and underwent balloon angioplasty and coronary stent implantation. The reduction of the coronary stenosis by balloon angioplasty induced immediate relief of chest pain. He has been still in reltively good health without chest pain during the 24 months of follow-up.