http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Tae Hyeon,Kim, Jeong Jae,Kim, Seung Hyoung,Kim, Bong Soo,Song, Hyun Joo,Na, Soo Young,Boo, Sun Jin,Kim, Heung Up,Maeng, Young Hee,Hyun, Chang Lim,Kim, Kwang Sig,Jeong, In Ho The Korean Gastric Cancer Association 2012 Journal of gastric cancer Vol.12 No.4
Purpose: Clinical staging of gastric cancer appears to be important more and more for tailored therapy. This study aimed to verify the accuracy of clinical T staging in a low-volume institute. Materials and Methods: We retrospectively reviewed prospectively collected data of gastric cancer patients who underwent resection. A total of 268 patients of gastric cancer were enrolled from March 2004 to June 2012. These demographics, tumor characteristics, and clinical stages were analyzed for identification of diagnostic value of clinical T staging. Results: The predictive values for pT1 of endoscopy and computed tomography were 90.0% and 89.4%, respectively. In detail, the predictive values of endoscopy for pT1a, pT1b, and pT2 or more were 87%, 58.5%, and 90.6%, respectively. The predictive values of computed tomography for pT1a, pT1b, and pT2 or more were 68.8%, 73.9%, and 84.4%, respectively. The factors leading to underestimation of pT2 or more lesions by gastroscopy were the middle third location, the size greater than 2 cm, and younger age. Those for overestimation of pT1 lesion by computed tomography were male, age more than 70 years, elevated type, and size greater than 3 cm. Conclusions: Diagnostic accuracy of early gastric cancer was 90%, which is comparable to those of high volume center. In patients with early gastric cancer, limited gastrectomy or minimal invasive surgery can be safely introduced at a low volume center also. However, the surgeon of low-volume institute should consider the accuracy of clinical staging before extending the indication of limited treatment.
알코올성 간경화증에 동반된 상행 결장의 정맥류 출혈 1예
김흥업 ( Heung Up Kim ),허규희 ( Kyu Hee Her ),김승형 ( Seung Hyoung Kim ),김봉수 ( Bong Soo Kim ),강영준 ( Young Joon Kang ),이재천 ( Jae Chun Lee ),김광식 ( Kwang Sik Kim ) 대한내과학회 2008 대한내과학회지 Vol.75 No.2
간경변증이나 문맥 고혈압에 의한 정맥류 출혈은 주로 식도와 위에 발생하나 일부에서는 소장과 대장 등에서도 발생할 수 있다. 대장의 정맥류 출혈은 주로 직장과 맹장에 발생하며 국내에서는 좌측 대장에 발생된 소수의 예만 보고되었고, 아직 상행 결장의 정맥류 출혈은 보고된 바 없다. 알코올성 간경변증으로 의심되는 43세 남자 환자가 대량의 혈변으로 내원하였고, 복부 전산화단층촬영 및 혈관조영술로 상행 결장의 정맥류를 확인하고 우 결장반절제술을 시행하였고, 수술 후 지혈되었으며 수술 검체에서 정맥류에 의한 출혈이 확인되었다. 저자는 43세 남자 환자에서 발생한 알코올성 간경화증에 의한 상행 결장의 정맥류 출혈을 문헌고찰과 함께 보고하는 바이다. We report a very rare case of colonic varix with massive bleeding. A 43-year-old male patient was transferred to our hospital for hematochezia. The patient had a history of chronic liver disease associated with alcohol use. The initial blood pressure was 93/73 mmHg, and the hemoglobin level was 8.4 g/dL. Severe hepatomegaly and periportal fatty infiltration were seen on abdominal computed tomography. Markedly ectatic veins protruded from the luminal side of the proximal ascending colon and drained to the dilated ileocecal and retroperitoneal veins. Emergent colonoscopy failed because of continuous hematochezia and hypovolemic shock, despite massive transfusion. Markedly dilated colonic varices were noticed around the ileocecal and ascending colon on superior mesenteric arteriography. An emergent right hemicolectomy was performed. The presumed bleeding focus was a protruding varix with a red clot on the top of a denuded vein on the anteromedial wall of the proximal ascending colon. (Korean J Med 75:215-220, 2008)
김상훈,김상헌,김유영,김윤근,박흥우,민경업,조상헌,장윤석,정재원 대한알레르기학회 2000 천식 및 알레르기 Vol.20 No.5
Hypersensitivity pneumonitis is an imrnunologically mediated disease resulted from repeated exposure to sensitizing agents such as organic dusts or chemicals. We report two cases of familial hypersensitivity pneumonitis diagnosed by typical symptoms, physical findings, chest x-ray abnormalities, and histologic findings with a brief review of the literature. A 60-year-old woman and her 62-year-old husband successively presented with dry cough and exertional dyspnea. These symptoms developed about 20 days after the womon had started feeding cows with stored hay. The same symptoms also developed in her husband when he had handled the stored hay instead of her because of her illness. We confirmed hypersensitivity pneumonitis with bronchoalveolar lavage fluid analysis and open and transbronchial lung biopsies.
Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma
Kim, Sang-Heon,Kim, Yoon-Keun,Park, Heung-Woo,Kim, Sang-Hoon,Kim, Seung-Hyun,Ye, Young-Min,Min, Kyung-Up,Park, Hae-Sim Elsevier 2009 Respiratory medicine Vol.103 No.3
<P><B>Summary</B></P><P>In asthmatic airways, adenosine is a potent bronchoconstrictor with either pro- or anti-inflammatory effects depending on receptor interactions. While aspirin has been suggested to mediate adenosine action, the roles of adenosine and its receptors in aspirin-intolerant asthma (AIA) are not well-defined. Therefore, we evaluated associations between genetic polymorphisms of adenosine deaminase and the four adenosine receptors (A<SUB>1</SUB>, A<SUB>2A</SUB>, A<SUB>2B</SUB>, and A<SUB>3</SUB>) with the AIA phenotype. The genes for adenosine deaminase (<I>ADA</I>) and the four adenosine receptors (<I>ADORA1</I>, <I>ADORA2A</I>, <I>ADORA2B</I>, and <I>ADORA3</I>) were screened by direct sequencing, and 13 single nucleotide polymorphisms (SNPs) were selected among 23 polymorphisms. Using multivariate logistic regression analysis, we compared the frequencies of SNP genotypes and haplotypes among 136 patients with AIA, 181 patients with aspirin-tolerant asthma (ATA), and 183 normal individuals. We found significant differences between normal and patients with AIA in the <I>ADORA1</I> SNP genotype frequencies for 1405C>T (<I>P</I>=0.001) and A102A (<I>P</I>=0.013). No other significant associations were detected for the other SNPs. In the haplotype analysis, ht[C–T–G] (<I>P</I>=0.003) and ht[A–C–G] (<I>P</I>=0.032) in <I>ADORA1</I> and ht[A–T] in <I>ADORA2</I> (<I>P</I>=0.013) were significantly associated with AIA. Genetic polymorphisms of adenosine receptors A<SUB>1</SUB> and A<SUB>2A</SUB> were associated with AIA, suggesting that adenosine might play a crucial role in the development of AIA through interactions with the A<SUB>1</SUB> and A<SUB>2A</SUB> receptors.</P>
Oroesophageal Fish Bone Foreign Body
Heung Up Kim 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.4
Fish bone foreign body (FFB) is the most frequent food-associated foreign body (FB) in adults, especially in Asia, versus meat in Western countries. The esophageal sphincter is the most common lodging site. Esophageal FB disease tends to occur more frequently in men than in women. The first diagnostic method is laryngoscopic examination. Because simple radiography of the neck has low sensitivity, if perforation or severe complications requiring surgery are expected, computed tomography should be used. The risk factors associated with poor prognosis are long time lapse after FB involvement, bone type, and longer FB (>3 cm). Bleeding and perforation are more common in FFB disease than in other FB diseases. Esophageal FB disease requires urgent treatment within 24 hours. However, FFB disease needs emergent treatment, preferably within 2 hours, and definitely within 6 hours. Esophageal FFB disease usually occurs at the physiological stricture of the esophagus. The aortic arch eminence is the second physiological stricture. If the FB penetrates the esophageal wall, a life-threatening aortoesophageal fistula can develop. Therefore, it is better to consult a thoracic surgeon prior to endoscopic removal.
Heung Up Kim 대한상부위장관ㆍ헬리코박터학회 2020 Korean Journal of Helicobacter Upper Gastrointesti Vol.20 No.3
It is well known that Helicobacter pylori (H. pylori) can cause peptic ulcer, mucosa-associated lymphoid tissue lymphoma, atrophic gastritis, intestinal metaplasia, and ultimately, gastric cancer. Various studies have proven that H. pylori, which attaches to the gastric mucosa, is the cause of gastric cancer and can be eradicated using appropriate antibiotics. Since 2013, Japan has been carrying out national-led eradication treatment of H. pylori for the whole population. However, as drug exposure increases, the resistance rate to some antibiotics increases, and the pattern of antibiotic resistance varies from region to region. Therefore, the development of individualized antimicrobial therapies has become important since antibiotic resistance to H. pylori eradication is a problem worldwide. To help overcome this, remedies such as selection of antibiotics through susceptibility testing, selection of empirical treatment combinations appropriate for the region, dual therapy with high doses of amoxicillin, and the use of rifabutin or sitafloxacin with low antibiotic resistance have been studied. Potassium-competitive acid blocker has been reported to be more potent in inhibiting acid secretion than proton pump inhibitor, and its role in H. pylori eradication is expected. Drug formulations and regimens that are easy to take are being developed to increase compliance. New treatments such as spraying antibiotics directly to the gastric mucosa are being developed and studied.