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사구체 신염 환자들에게 말초혈액 단핵세포의 Cytokine들의 유전자 발현에 대한 ACE Inhibitor의 영향
김홍수,김상돈,이한민,김승정,마경애,신규태,지석배,김도헌 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.1
Angiotensin II(ANG II) has been known to induce systemic and glomerular hypertension, which leads to renal tissue injury and progressive fibrosis of kidney. Some effects of ANG II may be mediated by its effect on the cytokine synthesis. In the present study, we investigated the effect of ANG II inhibition on the expression of various cytokines implicated in the pathogenesis and progression of the kidney disease. Blood samples of 11 patients with glomerulonephritis were obtained before the ACE inhibitor therapy and then while they were taking ACE inhibitors. Using peripheral blood mononuclear cells(PBMC) harvested from the samples, RT-PCR was performed to evaluate the changes in mRNA expression of TGF-β1, IL-6, TNF-α and IL-10. The ratios of target cytokines and β-actin were calculated. TGF-β1 mRNA expression was decreased in five pat ients after ANG II inhibition with ACE inhibitors, while it was increased in the remaining six patients. ACE inhibitors consistently decreased IL-6 mRNA expression in all 11 patients. IL-10 expression was decreased in 4 patients, and increased in 3 patients after ANG II inhibition. It was not expressed in 4 patients. TNF-α expression was increased in 8 patients, and decreased in only 1 patient. In two patients, it was not changed while on ACE inhibitors. Conclusion:ACE inhibitors attenuate IL-6 expression consistently in all 11 patients. This is the first-time demonstration of the in vivo inhibitory effect of ACE inhibitors on IL-6 mRNA expression in humans. The lack of significant suppression of TGF-β1 in PBMC suggests that the in vivo attenuating effect of ACE inhibitors on TGF-β1 may be derived from renal hemodynamic changes. The tendency of heightened expression of TNF-α confirms the previous investigations in which IL-6 was shown to down regulate TNF-αexpression.
다양한 고염투석액을 이용한 혈액투석시 혈액량의 변화 및 부작용 발생의 관찰
김홍수,김상돈,김도헌,김헌종,고광현,김승정,마경애,김명성,정철권,이한민,지석배,신규태 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.3
Chronic hemodialysis patients frequently experience hemodialysis(HD)-related side effects caused by excessive ultrafiltration and abrupt change of osmolality. Sodium ramping in HD is known to reduce ultrafiltration-related side effects, but it frequently induces symptoms related to sodium overload. We wanted to know the relationship between blood volume changes and the side effects related to ultrafiltration during hemodialysis and whether we can individualize various sodium ramping methods according to the effect of change in blood volume( BV) and side effects of sodium ramping. We studied 9 hypotension-prone patients during HD. The duration of the study lasted for 5 weeks, each week using different sodium ramping protocols: protocol 1; dialysate [Na+] of 140mEq/L, protocol 2; dialysate [Na?] same as the predialysis serum [Na+], protocol 3; dialysate [Na+] was 20mEq/L greater than that of the patient's serum for 1hr, 10mEq/L greater than patient's serum [Na+] for 2hr and then the same as patient's serum] for the last 1hr, protocol 4; at the beginning of dialysis, dialysate sodium was ramped to 20mEq/L above the patient's serum sodium and then on a straight linear fashion lowered to the predialysis serum [Na+] at the end of dialysis, protocol 5; sodium was constantly ramped to 10 mEq/L above serum [Na+]. We measured the BV with Crit-Line IIR(In-Line Diagnostics, Corp., Riverdale, USA), the blood pressure during each HD and interdialytic weight gain. We documented subjective symptoms which occurred during the 5 treatment protocols by patient's questionnaire after each HD. The results were as follows. 1) The mean age of the patients(M:F=3:6) was 54.1years and 6 patients were diabetics. 2) There was no significant difference in the BV among the 5 protocols in both whole study population and individual. Neither was there a statistically significant difference in the BV with respect to hypotension during HD. 3) There were no episodes of hypotension(P value $lt;0.001) with protocols 3, 4, 5 compared to protocs 1 and 2. 4) Three patients during protocols 4 and 5 experienced more thirst after HD than during protocol 1 and one patient during protocol 4, 5 had more interdialytic weight gain than the protocol 1. As a whole, patients while on protocol 4 & 5 experienced more thirst than protocol 1 but patients during protocol 3 experienced the same degree of thirst as protocol 1. In summary, sodium ramping reduced HD-related side effects but this benefit could not be explained on the basis of blood volume change measured by the Crit-Line IIR. Protocol 3 may be more appropiate sodium ramping method in 4 of the 9 patients. These data suggest that protocol 3 may be used before protocol 4, 5 when we apply sodium ramping to the patients who frequently have hypotension during HD.
김영수,김홍수,김상돈,정도영,이한민,김도헌,김승정,마경애,신규태,지석배,안현수 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.1
Hematuria is a common presentation of bladder cancer. As medical examinations for health screening are becoming more popular, increasing number of patients are found to have hematuria. When to refer these patients to urologists for cystoscopy is a common problem to nephrologists and a matter of debate as well. In fact, many authors differ in their opinions on this issue, especially in cases of microscopic hematuria. Given the fact that the incidence of bladder cancer varies between countries, it will be reasonable that the investigation strategy for Koreans should be determined according to the studies on Korean people. In the present study, we retrospectively analyzed 349 patients who underwent cystoscopic examinations in our institution to investigate causes of microscopic or gross hematuria. Bladder cancer was detected on cystoscopy in 35(15.9%) of 220 patients with gross hematuria, in contrast to patients with microscopic hematuria in whom 2(1.6%) of 129 patients were found to have bladder cancer. Eighty nine percents of cancer patients were male. Bladder cancer was detected even in relatively young patients with gross hematuria, while no bladder cancer was found in patients with microscopic hematuria below 60 years of age. Urine cytology was revealing in 59.5% of cancer patients. Bladder cancer was detected in 71.4% and 76.2% of cancer cases by sonography and IVP, respectively. Urine protein by dipstick was unreliable in predicting the presence of cancer. In conclusion, decision on cystoscopy in patients with asymptomatic microscopic hematuria younger than 50-60 years of age should be made conservatively, while more aggressive diagnostic work up is necessary in patients with gross hematuria regardless of their age.
박은경,김석호,강흥선,조정휘,김권삼,김명식,송정상,배종화 대한내과학회 1993 대한내과학회지 Vol.44 No.1
저자들은 분만후 울혈성 심부전으로 인한 심한 호흡곤란을 주소로 내원했던 환자에서 경흉부 심초음파도, 경식도 심초음파도 그리고 심도자술 및 심장조영술로 삼방심을 진단하여 치료하였던 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Cor triatriatum is well konwn rare cardiac malformation consisting of accessory chamber that lie within the left atrium and receives the pulmonary vein. Recently, we have experienced one case of isolated cor triatriatum presenting as congestive heart failure. A 24 years old women was admitted to the hospital because of severe dyspnea. We diagnosed isolated cor triatriatum by the transthoracic and transesophageal echocardiography and cardiac catheterization.
Uhm, Ji Eun,Park, Byeong-Bae,Ahn, Myung-Ju,Lee, Jeeyun,Ahn, Jin Seok,Kim, Sang We,Kim, Heung-Tae,Lee, Jong Seog,Kang, Jin Hyung,Cho, Jae Yong,Song, Hong Suk,Park, Se Hoon,Sohn, Chang Hak,Shin, Sang Wo Elsevier 2009 Journal of thoracic oncology Vol.4 No.9
<P>Erlotinib (Tarceva, OSI Pharmaceuticals, Melville, NY) is an oral, epidermal growth factor receptor tyrosine kinase inhibitor that has antitumor activity and good tolerability in non-small cell lung cancer (NSCLC). In particular, higher response rates have been reported in Asian patients than in Western patients. The aim of this study conducted by the Korean Cancer Study Group was to evaluate the efficacy and tolerability of erlotinib monotherapy as a palliative treatment for advanced NSCLC patients in Korea.</P>
100-GHZ BAND TEST OBSERVATIONS OF THE KVN 21-M RADIO TELESCOPES
Kim, Kee-Tae,Byun, Do-Young,Je, Do-Heung,Wi, Seog-Oh,Bae, Jae-Han,Jung, Tae-Hyun,Lee, Chang-Hoon,Han, Seog-Tae,Song, Min-Gyu,Jung, Jae-Hoon,Chung, Hyun-Soo,Kim, Hyo-Ryung,Kim, Bong-Gyu The Korean Astronomical Society 2011 Journal of The Korean Astronomical Society Vol.44 No.3
We carry out 100-GHz band test observations with the newly-constructed KVN 21-m radio telescopes in order to evaluate their performance. The three telescopes have similar performance parameters. The pointing accuracies are about 4" rms for the entire sky. The main beam sizes are about 30" (FWHMs), which is nearly the diffraction limit of the telescopes at the observing frequency (97 GHz). The measured aperture and main-beam efficiencies are about 52% and 46%, respectively, for all three telescopes. The estimated moon efficiency is ~84% for the KVN Tamna telescope. The first sidelobes appear 50" (~1.6${\times}$FWHM) from the main beam centers and the levels are on average -14 dB.
( Md. Asaduzzaman Sikder ),( Hyun Jae Lee ),( Su Yel Lee ),( Heung Seog Bae ),( Jang Hyun Kim ),( Gyu Tae Chang ),( Choong Jae Lee ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.3
We conducted this study to investigate whether berberine significantly affects MUC5AC mucin gene expression and mucin production induced by epidermal growth factor (EGF), phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-α (TNF-α) from human airway epithelial cells. Confluent NCI-H292 cells were pretreated with varying concentrations of berberine for 30 min and then stimulated with EGF, PMA or TNF-α for 24 h. MUC5AC mucin gene expression and mucin production were measured by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. Berberine was found to inhibit the expression of MUC5AC mucin gene induced by EGF, PMA or TNF-α. Berberine also inhibited the production of MUC5AC mucin protein stimulated by the same inducers. This result suggests that berberine can regulate the expression of mucin gene and production of mucin protein, by directly acting on human airway epithelial cells.
( Jae Woo Lee ),( Hyun Jae Lee ),( Choong Jae Lee ),( Su Yel Lee ),( Byeong Kyou Jeon ),( Heung Seog Bae ),( Kyoung Rai Cho ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.1
In this study, we investigated whether ambroxol significantly affects secretion, production and gene expression of mucin from cultured airway epithelial cells. Confluent primary rat tracheal surface epithelial (RTSE) cells were pretreated with adenosine triphosphate (ATP) for 5 min and then treated for 30 min with ambroxol to assess the effect on mucin secretion using ELISA. Additionally, confluent NCI-H292 cells were pretreated with ambroxol for 30 min and then stimulated with EGF or PMA for 24 h. The MUC5AC mucin gene expression and mucin protein production were measured by RT-PCR and ELISA. The results were as follows: (1) ambroxol did not significantly affect ATP-induced mucin secretion from cultured RTSE cells; (2) ambroxol inhibited the production of MUC5AC mucin protein induced by EGF and PMA in NCI-H292 cells; (3) ambroxol also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA in NCI-H292 cells. This result suggests that ambroxol can inhibit the production and gene expression of MUC5AC mucin, by directly acting on human airway epithelial cells.
( Young Sik Kim ),( Jae Woo Lee ),( Hyun Jae Lee ),( Choong Jae Lee ),( Su Yel Lee ),( Byeong Kyou Jeon ),( Heung Seog Bae ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.4
We conducted this study to investigate whether baicalin, baicalein or schizandrin significantly affect MUC5AC mucin production induced by epidermal growth factor (EGF) or phorbol ester (PMA) in human airway epithelial cells. Confluent NCI-H292 cells were pretreated with varying concentrations of baicalin, baicalein or schizandrin for 30 min and then stimulated with EGF or PMA for 24 h, respectively. MUC5AC mucin protein production was measured by ELISA. The results were as follows: (1) Baicalin was found to inhibit the production of MUC5AC mucin protein induced by both EGF and PMA. (2) Baicalein, the aglycone of baicalin, also inhibited MUC5AC mucin production. (3) Schizandrin, derived from Schizandrae Fructus, inhibited MUC5AC mucin production by the same inducers. These results suggest that baicalin, baicalein and schizandrin can regulate the production of mucin protein by directly acting on human airway epithelial cells.