정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

SHOTCRETE 配合設計에 關한 實驗的 硏究

白榮植,金一憲,張喜相 慶熙大學校 1984 論文集 Vol.13 No.-

A series of laboratory test is performed to determine the optimum shotcrete mix design. Engineering properties of various cements and aggregates are tested. Using the results obtained in the tests, the standard concrete mix design can be obtained. Compatibility of cements and accelerators is also investigated by comparing the compress strength of shotcrete specimens with various types and contents of accelerators. Finally, a recommended shotcrete mix design is suggested for practical use in field.

기능성 소화불량증에서 증상에 따른 고형식의 반위배출시간의 차이

김영호,이풍렬,성인경,손희정,김재준,고광철,백승운,이종철,최규완 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

일산화탄소 및 고압산소의 폭로가 흰쥐의 제2형 폐포세포와 사구체에 미치는 영향에 관한 연구

백두진,정호삼,이계훈,황세진,전영호,전영희 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

The present study was performed to investigate the ultrastructural changes of the type Ⅱ pneumocyte in the lung and that of the glomerulus in the kidney after carbon monoxide(CO) or hyperbaric oxygen (HBO) exposure. The male Sprague-Dawley rats, weighing about 200gm, were used as experimental animals. The animals were divided into CO exposure group, air exposure after CO exposure group, HBO exposure group and HBO exposure after CO exposure group. After single CO and HBO exposure (3790ppm), the specimen of lung and kidney were obtained. According to routine method, EM preparations were made and observed with electron microscope. The results obtained were as follows ; 1. Slight disruption of the mitochondrial membrane was observed in alveolar type Ⅱ pneumocyte, after single CO exposure. 2. In all experimental groups except CO exposure group, decrease in number and atropy of rough endoplasmic reticulum, disruption of double membrane and crista of mitochondria and vacuolar degeneration of lamellar bodies in alveolar type Ⅱ pneumocytes were observed. 3. In all experimental groups, fusion of the pedicles of podocytes, and obliterations of the endothelial fenestrations were observed. These results suggested that CO and HBO exposure may induced the ultrastructural damages in the alveolar type Ⅱ pneumocyte and the glomerulus.

스포츠생리학 : Creatine 투여가 쇼트트랙 스피드 스케이팅 선수의 운동 수행력과 혈중 피로 요인에 미치는 영향

백일영(Paik11-Young),우진희(WooJin-Hee),채지훈(ChaefJi-Hoon) 한국체육학회 2000 한국체육학회지 Vol.39 No.2

본 연구의 목적은 주니어 국가대표급 쇼트트랙 스피드 스케이팅 선수 5명을 대상으로 Creatine(Cr)을 구강 투여하여, 투여된 Cr이 최대 운동 부하 수행력에 미치는 영향과 혈중 젖산, 무기인산, 암모니아, pH등과 같은 생리학적 피로 요소의 변화를 고찰하여, Cr 투여가 운동수행에 미치는 영향뿐만 아니라, 피로 요소들의 변화에 미치는 영향을 연구하는데 있으며, 특히, 중추신경계의 피로물질로 알려진 serotonin(5-HT)의 변화를 고찰함으로써 Cr의 피로 유발 지연 효과를 규명하는데 그 목적이 있다. 운동 부하 테스트는 정규 국제규격인 쇼트트랙 전용 경기장에서 Cr을 투여하기 전 500m와 3,000m를 충분한 휴식을 두고 자신의 최대역량으로 주파하게 하는 형태를 취하였으며, Cr의 투여는 하루에 20g씩 5일간 투여하였고,6일째 되는 날 같은 조건으로 재측정 하였다. 운동 수행력의 변화는 각각의 실험 조건에서 Cr을 투여한 실험 조건과 투여하지 않은 실험 조건을 비교해서 유의한 향상이 나타나지 않았으나(p>.05), 쇼트트랙 경기의 특성을 고려할 때, Cr의 투여로 순위를 결정지을 수 있는 기록이 단축 되는 것으로 나타났다. 혈중 젖산의 변화는 운동 종료시 Cr을 투여한 실험조건에서 투여하지 않은 실험조건에서 보다 더 낮은 혈중 젖산 농도를 보였으며, 통계적으로도 유의한 차이가 나타났다(p<.05). 혈중 암모니아와 무기인산의 변화 역시, 혈중 젖산 농도 변화와 마찬가지로 운동시 모든 경우에 증가하는 현상을 보였으며, 운동 종료시 Cr을 투여한 실험조건에서 투여하지 않은 실험조건에서 보다 낮은 혈중 젖산 농도를 보였고 통계적으로 유의한 차이가 나타났다(p<.05). 혈중 pH의 변화는 운동 종료시 Cr을 투여한 실험조건에서 투여하지 않은 실험조건에서 보다 높은 혈중 pH를 보였으나, 통계적으로 유의한 차이가 나타나지 않았다(p>.05). 혈중 5-HT의 농도 변화는 두 그룹 모두에서 Cr을 투여한 실험 조건에서 더 높은 5-HT의 농도를 보였고, 통계적으로도 유의한 차이가 나타났다(p<.05). 전체적으로 운동이 반복되면서 5-HT의 농도는 일정한 형태로 증가하다가 회복시에 감소하는 양상을 보였지만, 피로유발 요인이라고 단정하기엔 무리가 있다고 본다. 따라서, 쇼트트랙과 같은 단시간의 고강도 운동 형태의 경기 종목 선수에게 있어서, Cr의 효율적인 공급은 운동 수행시 에너지 보충제로서의 역할을 충분히 수행할 수 있는 잠재적 역량을 가지고 있을 뿐만 아니라, 피로 유발 물질의 감소와 그로 인한 운동 수행력의 향상에 많은 도움을 줄 수 있을 것으로 본다. 또한, 대사적 생성기전과 피로인식 기전의 개념으로 5-HT에 대한 연구가 추가적으로 수행되어, 피로유발 요인으로서 5-HT에 대한 과학적인 증거의 제시가 이루어져야 할 것으로 본다. The purpose of this study was to examine the effect of oral creatine supplementation on exercise performance, and to follow the changes of blood fatigue elements, such as lactate, ammonia, inorganic phosphate, pH & 5-HT. All of the tests were performed on a international standard arena ice rink. The subject of present study was divided into two groups; 500m skaters(500-AT), and 3,000m skaters (3,000-AT). Each skaters participated in their own skating distances(500 and 3,000m). After the preliminary test, all subjects were given a 5-day supplementation of Creatine monohydrate at a rate of 20g·d^-1.When the study was performed, we could not find a significant difference in developing a record by Cr supplementation(p>.05). However, as the rank of skating is determined by hundreds of second, we could find a result, which can change the rank of the skating competition by the Cr supplementation. There were significant differences in mean blood lactate between Cr supplementation and Cr non-supplementation for the 500-AT and the 3,000-AT groups(p< .05). Also, there were big significant differences in mean blood inorganic phosphate and ammonia concentrations between Cr supplementation and Cr non-supplementation for the 500-AT and the 3,000-AT groups(p < .05). The mean blood pH in Cr supplementation experimental condition was higher than Cr non-supplementation experimental condition, but we could not find a significant differences in mean blood pH between Cr supplementation and Cr non-supplementation for the 500-AT and the 3,000-AT groups(p >.05).Blood 5-HT concentrations in Cr supplementation experimental condition was higher than non supplementation experimental condition, and there were significant differences between Cr supplementation and Cr non-supplementation for the 500-AT and the 3,000-AT groups.(p<.05). However, it was difficult to explain that 5-HT occurs fatigue unless the physiological mechanism of 5-HT was provided.Therefore, this study concluded that Cr supplementation had a ergogenic effect on energy metabolism. Especially, in a high intensive exercise as short-track skating, Cr supplementation will help for fatigue elements reduction and exercise performance improvement. Also, we believe the additional research of 5-HT must be accomplished so that we can provide the scientific evidence of fatigue, which was cause by 5-HT.

식도암 병기 결정에 있어서 초음파내시경의 유용성

이화영,김재준,김영호,성인경,손희정,이풍렬,고광철,백승운,이종철 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.2

건조 재료를 사용한 콘크리트의 포장화에 관한 실험적 연구

한다희,박희곤,백민수,김성식,이영도,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

Most concrete is recently made of an aggregate which is properly absorbed, and earned in it in order to do capability at every fields. We have been close to demand new capability of high flowing and enduring for specific concretes. That is difficult to cope with claiming the efficiency on deterioration from lack of a high quality aggregate. Therefore, For solving the problems we apply to a packing method for using dried materials. That is to say it is a kind of making into an instant. In this study, There is a purpose to present fundamental data, comparing and analyzing a phenomenon about aggregate's absorption following the rate of adding water, for using existing materials.

심리적 계약이 구성원의 태도에 미치는 영향

이동영,고명희,백정숙,김희선 서울여자대학교 대학원 1999 論文集 Vol.- No.7

일산화탄소 폭로후 고압산소 재폭로시 흰쥐 신장 및 심장의 SOD 활성 변동에 관한 연구

전영희,백두진,황세진,박준숙,정호삼 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1

Carbon monoxide is generated from the incomplete combustion of carbon-containing materials. Carbon monoxide cause muscle necrosis leading to myoglobinuria and acute renal failure. The hyperbaric oxygen exposure is increased production of active free radicals. Free radicals which promoted peroxidation of unsaturated fatty acids may destroy essential cellular components and itself cytotoxic materials. Superoxide dismutase, one of the protective mechanisms against tissue damage, catalyzed the dismutation of superoxide anion to less toxic product. The author performs the present study to investigate on Mn-SOD and Cu, Zn-SOD immunoreactivities in kidney and heart carbon monoxide (CO) and hyperbaric oxygen (HBO) exposure. The animals were divided CO exposure group, air release after CO exposure group, HBO exposure group and, CO and HBO exposure group. The specimen were sectioned in 16㎛ with cryostate. The Mn-SOD and CuZn-SOD immunohistochemistry was performed in renal corpuscle, proximal and distal convoluted tubules of kidney and, in sarcoplasm and sarcolemma of heart muscle. The results obtained were as follows: 1. The immunoreactivity of Mn-SOD were increased in renal corpuscles and distal convoluted tubules, were similar to control group in proximal convoluted tubules. 2. The immunoreactivity of Cu, Zn-SOD were increased than that of control group in renal corpuscles and distal convoluted tubules, were same that of the control group in proximal convouted tubules. 3. The immunoreactivity of Mn-SOD were increased at all experimental group of sarcoplasms of heart muscle. 4. The immunoreactivity of Cu,Zn-SOD were increased than that of control group in sarcolemma of heart muscle. These results suggest that the immunoreactivity of SOD after CO or HBO exposure is greatly increased in kidney and heart.