Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells

Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4

The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.

Investigation of the April 2000 forest fire damage in Kang-won Province, Korea, using RADARSAT data

Kang, Sung Chul,Seo, Jin Won,Lee, Tae Hee,Park, Sang Eun,Hong, Suk Young,Moon, Wooil M. 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1

The series of forest Fires in Kangwon Province in April, 2000, were one of the mast serious ones in the Kang-won Province in recent years. The fire damaged areas are extensive and this paper investigates the utility of the satellite image data, particularly the RADARSAT SAR data. One of the main objectives of this study included evaluation of potential usefulness of the C-band RADARSAT data in the detection of forest fires in mountainous areas. Among several fire damaged sites, the area near Samchuk (city) was selected as the main study area and mufti-temporal RADARSAT(raw) data were acquired and the processed results were comparatively investigated with the IRS-1c data acquired shortly after the fire. To identify the burnt area from the undamaged background in the optical imagery, supervised classification and NDVI processing were carried out and tested with the IRS-1C data. For this experiment, several sets of raw RADARSAT standard and Fine mode (S4, F3, ascending orbit) data were processed and the final image was formed. In addition to the final image, sigma nought (σ°) was catnputed and compared for the burnt area against the undamaged areas. Because of the steep slopes in the study area and subsequent deviation from the flat surface scattering models, the fire scars in the sigma nought (σ°) image were not apparent. However, fire scars are slightly detected in the difference and ratio images obtained from the signal intensity data acquired at different dates (bath before and after fire). Texture analysis of the image data including the burnt areas were carried out using the Multiplicative Markov Random-Field (MMRF) algorithm. The detection of the fire damaged area from both standard mode and fine mode RADARSAT was not as straightforward as in optical data. However, Previous studies with ERS-1 S_AR and RADARSAT data in Indonesia and in the North American Plains indicate that C-band SAR data provide us with an effective tool for studying the forest fire damages. However, the application of C-band SAR data to the analysis of the forest fire areas requires careful processing of the data with realistic scattering models.

지역사회 연계를 고려한 진주종합경기장 활용방안 연구

강석진(Kang, Seok-Jin),안재우(Ahn, Jae-Woo),김지희(Kim, Ji-Hee),이현진(Lee, Hyun-Jin) 대한건축학회 2013 대한건축학회 학술발표대회 논문집 Vol.33 No.2

Consumer Recognition Survey for Establishing the Reasonable Expiration Dates of Health Functional Foods

( Soo Jin Youn ),( Joo Youn Park ),( Hee Su Kim ),( Eun Jin Kang ),( Kil Jin Kang1 ),( Hye Kyung Park ),( Gun Hee Kim ) 한국식생활문화학회 2009 Food Quality and Culture Vol.3 No.2

This study investigated consumers` recognition on shelf life of health functional foods to set up their rational expiration date. For this study 107 male and female adults aged 20 to 59 years were randomly selected as major consumers of health functional foods. And their data were analyzed with SPSS 17.0. The questionnaire included questions asking a consumer`s recognition on the shelf life of health functional foods and how to treat health function food passing its shelf life. In this study, the consumers were found to pay attentions considerably to the shelf life. But most of them did not know an accurate meaning of the shelf life of health functional food and mistook it for expiry date. In addition, the consumers doubted safety of health functional foods passing the shelf life. Therefore, education for consumers about an accurate meaning of the shelf life was needed. The results of this study were considered to be helpful to set up a reasonable expiration date for health functional food.

간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

성상세포종 1例에 대한 증례보고

원진희,강태희 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

35000080 Astrocytomas are tuomrs tat arise from brain cells called astromcytes. These tumors can occur anywhere in the brain and spinal cord. Cimical features and symptoms depend on the location of the tumor and the victim's age. Patients with cerebellar tumors have symptoms that include headache, vomiting ahd unsteadiness in walking. Tumors in the cerebral hemospheres commony present with seizures: occasionally there is wealness of the arms and legs. We treated a 33 year-old male patient who complained of dyarthria, TMD, nausea, dysphagia, and facial numbness etc. he had frequent underpone general weakness bofore above symptons coourred. He was diagnosed as astrocytoma and multifocal inf and responded well to treatment with chukdam-tang(). acupunture and oriental physical stimulations etc. 뇌종양의 하나인 서어상페포종으로 진단받고 두통, 현훈, 구옴장애. 개구장애, 인격변화, 연하장애를 주소증으로 본우언에 입원한 환자 1례를 경험하였기에 치료내용왁 경과를 문헌고찰과 함께 보고하는 바이다.

사범대학 영어 강의에 대한 학생들의 인식 및 만족도 조사

강순희,서혁,신상근,이종원,이현주,최진영 이화여자대학교 교과교육연구소 2007 교과교육학연구 Vol.11 No.2

이 연구는 교사교육의 국제화를 지향하는 사범대학 특성화 프로그램 개발을 위한 기초 조사 차원에서 2007학년도 1학기에 146명의 사범대학 학생들을 대상으로 전공 영어 강의에 대한 인식과 만족도 등에 대해 설문조사의 방법으로 이루어졌다. 학생들의 영어 능력에 대한 자기 평가 결과, 대부분의 학생들이 자신의 영어 능력이 영어 강의 수강에 부족하고, 영어 강의에 대한 심리적 부담이 크다는 반응을 나타냈다. 또 영어 강의가 한국어 강의에 비해 전공 지식을 쌓는 데 도움이 되었다는 반응은 이공계를 중심으로 한 기존의 연구 결과보다 상대적으로 낮게 나타나는데, 이는 사범대학 영어 강의의 운영과 관련하여 좀 더 다양하고도 효과적인 방안이 고려되어야 함을 시사한다. 영어 강의 수강 시 어려움을 묻는 질문에서 과제 발표하기, 질문하기, 보고서 작성하기의 순으로 어려움을 호소하고 있는데, 이 역시 영어 강의를 위해서는 전반적인 영어 표현 및 이해 능력 향상 이 전제되어야 하며 무엇보다도 말하기, 듣기의 구어 능력 신장이 우선되어야 함을 재확인해 준다. 영어 강의 개선안에 대한 의견으로는 평가 방법의 다양성 및 융통성 확대, 영어 강의 수강을 돕는 전공 교재의 개발, 영어 강의 내에서의 교수-학생 상호 작용 증대, 국제교류의 기회 확대 등의 순으로 높은 반응을 보였다. 이는 향후 사범대학 영어 강의와 관련한 프로그램 개발에 시사하는 바가 크다. 즉, 영어 강의 평가를 결과 중심의 평가뿐만 아니라 과정평가와 수행평가에 초점을 두고, 영어 표현이 어려운 복잡한 사고 과정이 요구되는 경우 제한적으로 국문 반응을 허용하는 방안도 고려할 만하다. 또한 학습자들에게 좀 더 상세화된 강의 교재를 제공하고, 온·오프라인을 모두 활용하여 교수와 학생의 상호작용을 활성화할 수 있는 방안을 적극적으로 탐색할 필요가 있다. 아울러 학생들이 실질적인 국제교류가 가능하도록 다양한 교류 방안 함께 구체적인 강좌 개설도 요구된다.

點鳳山一帶 天然闊葉樹林의 地形的 位置에 따른 群集 構造的 屬性 分析(Ⅰ) : 樹種構性, 種多樣性, 生活型을 中心으로

姜聲基,金知洪,金光澤,梁熙文 강원대학교 삼림과학연구소 2000 Journal of Forest Science Vol.16 No.-

이 연구는 점봉산 일대 천연활엽수림을 대상으로 산림의 지형적 위치에 따라 군집의 구조적 속성이 달라진다는 가정하에 대상산림을 계곡, 산복, 능선으로 구분하고 각 군집별 수종구성, 종다양성, 생활형 분석을 통해 산림 생태계의 군집 속성을 파악하여 산림경영의 생태적 접근 방안을 위한 기초자료를 제공하고자 실시 되었다. 연구 결과, 계곡지역 상층의 수종구성은 신갈나무, 전나무, 들메나무 순으로 우점하고 있는 것으로 나타났고, 산복지역에서는 피나무, 신갈나무, 가래나무 순으로 나타났으며, 능선지역에서는 신갈나무, 피나무, 물푸레나무 순으로 나타났다. 그러나 중층과 하층에서 높은 우점률을 보이는 까치박달과 당단풍은 생육특성상 상층목으로의 도약을 기대하기 어려울 것으로 추정되었다. 종다양성은 계곡, 산복, 능선등 모든 지역의 중층과 하층에서는 유사한 것으로 파악되었으나, 상층에서는 능선지역이 계곡과 산복지역에 비해 매우 낮게 나타났다. 그리고 수분조건이 좋은 계곡보다 산복지역이 종다양성이 높은 것으로 파악되었다. 조사된 146종의 관속식물을 대상으로 생활형을 휴면형을 기준으로 구분한 결과, 지중식물, 교목, 반지중식물, 아교목, 관목, 1년생식물, 지표식물, 수생식물 순으로 나타났다. 특히 희귀 및 멸종식물로 지정된 금강초롱꽃은 본 연구 대상지 전역에서 쉽게 관찰되었다. Taking account of the structural variation on species composition according to the different topographic positions, i.e. valley, mid-slope, and ridge, the species composition, species diversity, life tool·m were comparatively analyzed fort· the three topographic positions in the natural deciduous forest of Mt. Chumbong area. The results are as follows. 1.Specise Composition : Dominant species in the overstory were Quercus mongolica. Abies holophylla, and Fraxinus mandshurica in valley ; Tilia amuresis, Quercus mongolica, and Juglans mandshurica in mid-slope ; and Quercus mongolica, Tilia amurensis, and Fraxinus rhynchophylla in ridge. Acer p. and Carpinus c. which have maintained high composition ratio in mid-story were not considered to be dominant overstory species due to inherent growth form. 2.Species Diversity : The species diversity indices of mid- and understory showed not much different value in three topographic positions. However, the index of overstory in ridge had smaller value than those of valley and mid-slope. The stand in ridge had greater species diversity index than in valley where moisture condition could be more favorable. 3.Life Form : The total of 146 vascular were observed in Mt. Chumbong in this study Especially, Hanabusaya asiatica Nakai, were supposed to be the rare and endangered species, was easily found in many places. The proportion of life form spectra in the study forest was G-MM-H-N-Th-Ch-HH. Key words : natural deciduous forest, species composition, species diversity, life form.

임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.