Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

육지한우의 제주지역 적응성 연구 : 1. 육지한우 제주도입시 Theileria sergenti 저항성에 관한 연구

김동철,오운용,김희석,현관종,강영배 濟州大學校 農科大學 動物科學硏究所 1993 動物科學論叢 Vol.8 No.1

This study was conducted to fine the adaptatbility of Korean Native Cattle lacking in the resistance ability to Theileriosis being occured by ticks born parasites in Cheju Island. Data used in this study were collected from none-treated and treated Thpileria sergenti blood vaccine to Korean Native Cattle, Cheju Native Cattle and Cheju Native CattlexBrahman crossbreds during the grazing season in 1988. The parasitemia level of Theileria sergenti in artificial immunized Korean Native Cattle were fewer than none-treated Korean Cattle's, due to immunizing effects. the RBC and PCV reduction were prevented, and average daily gain's 0.25kg in artificial immunized Korean Native Cattle was higher than those of 0.20kg in none-treated. The mortality numbers were one in artificial immunized Korean Native Cattle and four in none-treated Korean Native Cattle. The resistance ability of Theileriosis of Korean Native Cattle was the weakest and Cheju Native Cattle×Brah-man crossbred was the strongest among the breeds.

「心因性皮膚疾患크리닉」환자들에 關한 豫備調査

金哲應,趙斗英,姜民熙 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

1983年 3月부터 1984年 2月까지 서울大學校病院 皮膚科 외래진료소내의 「心因性皮膚疾患크리닉」에 諮問依賴된 患者 51명 (남:32명, 여:19명) 을 對象으로 社會人口學的持性을 調査分析하고 呼訴하는 症狀, 身體部位, 依賴前 皮膚科診斷, 依賴後 精神科的 診斷 및 治療등에 대해 분석하고 이를 外國의 경우와 比較ㆍ考察하였다. 1. 男ㆍ女 비율은 男子에서 높았고 (1.68:1), 年齡別 有意한 差異는 없었다. 2. 職業은 非生産的인 狀態가 많았고 (68.18%) 經濟狀態는 中下位가 많았다. 3. 依賴된 患者는 대부분 (8401%) 이 皮膚疾患과는 관계없이 精神疾患者이었다. 4. 呼訴하는 증상은 瘙痒感이 가장 많았다(29.55%) 5. 呼訴하는 身體部位는 男子의 경우 肛門生殖器部位(45.45%), 女子는 顔面部位 (54.55%)가 많았다. 6. 객관적인 皮膚病變은 男子, 78.57%, 女子의 82.25%에서 없었다. 7. 依賴前 皮膚科診斷은 「診斷保留」가 많았고 (38.69%), 精神科的診斷은「單症性健康念慮精神病 」이 많았다 (25.0%). 8. 精神科治療를 권유 했을때 거부하는 例가 많았으나 (46.15%) 6개월이상의 장기 추적치료는 精神科外來에서 하는게 더 효과적이다. 이상의 結果에서 시사되는 바와 같이 본 크리닉에서의 정신과 諮問醫의 연결활동은 여러면에서 의의가 있었다. 그러나 본 연구조사는 소수의 대상환자들에게서 관찰된 것인 바 앞으로 본 크리닉에 의뢰되는 더 많은 환자들을 對象으로 한 각각의 문제점에 대한 철저한 硏究는 물론 개개의 환자들에 대한 보다 더 깊이있는 정신의학적 접근이 필요하다고 생각된다. In 1983 the psychodermatoloy outpatient clinic was established at the Seoul National University Hospital, open one afternoon a week, where one liaison-psychiatrist and one dermatologist conjointly treat the patients referred from the dermatology outpatient clinic. This study purported to investigate the demographic characteristics and clinical aspects of the total 51 patients treated at the clinic during the period from March 1, 1983 to Feb. 28, 1984, and the results were summarized as follows; (1) Males predominated over females (62.7% vs 36.6%) and there were no age-specific findings. Majority of the patients came from middle-and-lower socioeconomic classes (90.0%) and majority of the patients suffered from psychiatric problems rather than actual dermatologic disorders (81.0%). (2) Pruritus was the most frequent complaint among them, with males on the anogenital regions (45.5%) and females on the facial region (54.6%), and the most frequent psychiatric diagnosis was monosymptomatic hypochondriacal psychosis (25.0%). (3) While two-fifth (42.1%) of the patients dropped-out after 1-2 visits, the fact that another two-fifth (39.5%) continued to visit the clinic more than 5 times showed our liaison activities gave some positive impacts in the care of psychodermatologic problems. It also seemed that with a better psychological preparations for those patients upon the referral by the dermatologists the early drop-out rate could be markedly reduced.

사회적 음주자에서 매운 맛 선호도가 급성 음주 반응에 대한 Naltrexone 효과에 미치는 영향

정희정,김성곤,김종현,박숙현,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Capsaicin과 알코올이 각각 중추신경 아편계 활성도를 증가시킨다는 선행 연구들이 있다. 이에 본 연구는 매운맛 선호도에 따라 급성 음주 반응에 차이가 있는지와 급성 음주 반응에 naltrexone이 미치는 영향에 차이가 있는지를 조사하고자 하였다. 12명의 의과대학 남학생을 대상으로 두 군으로 나눈 후 cross-over design을 사용하여, 한 군(6명)은 naltrexone 25 mg을 실험 1일째에, 50 mg을 실험 2일러에 주었고, 다른 군(6명)은 naltrexone 25 mg을 실험 8일째에, 50mg을 실험 9일째에 주었다. 실험 2일째와 9일째에 각대상자의 Biphasic Alcohol Effects Scale (BAES)로 측정한 급성 음주 반응과 음주갈망, 혈중알코을 농도 등을 음주 전, 음주(0.6 ml/kg) 후 15분, 30분, 60분에 측정하였다. 통계 분석 시 Food Preference Scale 점수에 따라 모든 대상자를 매운 맛을 선호하는 군(strong preference for hot food, SP)과 매운 맛을 덜 선호하는 군(lesser preference for hot food, LP)의 두 군으로 다시 나누어 분석하였다. 결과는 다음과 같다. 1) Naltrexone을 투여 여부에 관계없이 알코올의 급성 흥분 효과는 매운 맛 선호도에 따른 차이가 없었다. 그리고 LP에서도 naltrexone의 투여 여부에 따른 알코올의 급성 흥분 효과의 차이가 없었다. 그러나 SP에서는 알코올의 급성 흥분 효과가 naltrexone 투여 시 유의하게 억제되었다. 2) 알코올의 급성 진정 효과, 음주 갈망 및 혈중 알코올 농도는 매운 맛 선호도 혹은 naltrexone 투여 여부에 따른 차이가 없었다. 본 연구에서 매운맛을 선호하는 경우 알코올의 급성 흥분효과가 naltrexone에 의해 억제되었다. 이것으로 naltrexone이 매운맛을 선호하는 군에서 알코을 의존 재발 예방 효과가 더 클 가능성을 제시한다. Objectives : Both capsaicin, a pungent substance of hot food, and alcohol, are known to affect central opioid activity. The purpose ofthis study was to investigate the difference in the subjective acute responses to alcohol and the effect of naltrexone on them among those who prefer hot food to varying degrees. Methods : Twelve male medical students were divided into two groups using a cross-over design. One group was given naltrexone on only the first (25 mg) and the second day (50 mg), and the other group was given naltrexone on only the eighth (25 mg) and the ninth day (50 mg). On the second and the ninth day, the acute effect of alcohol was assessed in all subjects, using the Biphasic Alcohol Effects Scale (BAES) just before drinking and at 15 minutes, 30 minutes and 60 minutes after drinking (0.6 ml/kg). Alcohol craving was also measured, using Visual Analogue Scale for craving (VAS-C) and blood alcohol concentration (BAC), at the same interval. For statistical analysis, subjects of both group were re-divided into two group, those with a strong preference and those with a less preference (LP) for hot (spicy) food (SP), using the Food Preference Scale. Results : 1) Repeated measures of ANOVA (2 preference groupsX4 time blocks) on the stimulative subscale of BAES yielded no significant group by block interaction of naltrexone administration. Repeated measures of ANOVA (2 drug groupsX4 time blocks) on the stimulative subscale of BAES revealed a significant group by block interaction in SP (p=0.028), but not in LP. The paired t-test revealed that significant suppression of the stimulative subscale of BAES was observed at 15 minutes and 30 minutes after drinking when naltrexone condition was compared with no-medication condition in SP(p=0.014 ; p=0.007). 2) For the sedative subscale ofBAES, VAS-C and BAC, repeated measures of ANOVA yielded nosignificant group by block interaction by either hot food preference or naltrexone administration. Conclusion : For those who prefer hot food, the effect of stimulative acute alcohol was suppressed by naltrexone. This result strongly suggests that naltrexone could prevent relapse more effectively in those who prefer hot food.

경상분지 남서부 진교-사천 지역 전기백악기 퇴적암에 대한 고자기 연구

김인수,강희철,이현구 부산대학교 기초과학연구소 1994 부산대학교 기초과학연구소 연구논문집 Vol.14 No.-

A total of 264 independently oriented core samples were collected from 26 sites in the southwestern part(the Naktong Trough) of the Cretaceous Kyongsang Basin in south Korea. The sampled formations comprise the sedimentary Shindong and the Hayang Groups of the Lower Cretaceous age. alternating field and thermal demagnetizations were conducted. Chrarcteristic remanent magnetization(ChRM) was relatively easily isolated in each formation except in the Chinju foramation, from which only remagnetization circles were observed. Even though an extensive use of the fold test was not possible due to the nearly homoclinal nature of the strata in the area, we believe that the ChRM of each formation is of primary origin based on the following grounds : The in-situ ChRM direction of each formation is different from the present geomagnetic field direction. Fisherian precision parameter becomes enhanced through the tilt correction in all formations, closely to the values, requird for a positive fold test. Three out of the five studied formations pass the reversal test. The mean palaeomgnetic pole position from the studied area is found to be statistically different from the contemporary pole from the Chinese block exclusive of the Shandong area. The difference in magnetic declination suggests a 14.5°(±10.5°) clockwise rotation from the studied area relative to the Chinese block comprising the west of the Tan-Lu fault. On the other hand, any significant difference in magnetic inclination and concurrent palaeolatitude is not obaseved between the studied area and China as well as the other area (Taegu-Andong area) in the Kyongsang Basin. The dual nature of the magnetic polarity confirmed in all formations suggests an older than 124Ma(Neocomian or older) age of the studied sedimentary strata.

SPORTS 外傷에 關한 調査硏究 : Centering around 88 Olympic with representative player '88서울올림픽男子代表選手를 中心으로

盧日煥,姜忠植,金達永,金興植,朴贊弘,元忠熙,姜信一,金正洙,朴晶來,李哲遠,林鎬根 公州大學校스포츠科學硏究所 1988 스포츠科學硏究所論文集 Vol.- No.2

According to the investigation made by analyzing cause of the detail about sports injury. We make this things an object of all the male representative players 254 out of 286 (88.81%) that took part in the whole event from April 15, 1988 to September 16, 1988 in Seoul Olympic Games. The results are as follows. 1. The representative players in Korea started in the athlete life at age 13.1 on the average. Gymnast early started at age 8.4 and yachtist was later at age 18 in the athlete life. 2. There are about 5.7 cases on the outbreak of the sports trauma per person of player a year. This came into existence near the ankle at the high rate of damage formed 11.90%. 3. A sort of sports injury in analysis muscular bruise broke out at the highest rate of occurrence formed 15.70%. 4. The greater part of representative players themselves the injury of trauma by massage (12.53%). Some of them undergo medical treatment to the specialist hospital once a year on the average. Most of hockey players have had experience in this kind of injury treatment three times one year to per person of players. A few of them showed 0.15 times per person a year. 5. Most of representative players have been periodically to the orthopedist formed 27.59 (732) out of all 2653 cases at the high rate of fact. Especially a sort of injury in analysis, the injury of ankle region showed the percentage 11.86 (704) out of all 5,937 cases at the highest rate. 6. The period of medical treatment of the representative players in Korea came out about 14.7 days. Besides period of the other player's treatment came out mostly from one to five days formed 44.82%(935 cases) 7. Manyof them have been roughly treated with muscular bruise in analysis of sports injury. They were taking pains with muscular bruise formed 15.65% (1003) out of all 6408 case. 8. In major cause of sports injury came into existence during the training with waste of physical stamina formed 35.89% and were beyond their power with practicing the game formed 48.09%. Also, a sort of those were brought about the cause of sports injury with desire of outcome too much during in the game formed 44.20%

노인 환자에서 경피적 관동맥 중재술 후 조영제 유발 신부전의 발생률, 위험인자와 임상적 의의

김광일,배장환,강현재,채인호,김효수,손대원,김철호,오병희,이명묵,박영배,최윤식 대한노인병학회 2004 대한노인병학회지 Vol.8 No.1

관동맥연축의 진단을 위한 Ergonovine Echocardiography의 안전성 및 임상적 유용성

송재관,박성욱,강덕현,조구영,나득영,이내희,이철환,홍명기,김재중,박승정 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

갈륨합금과 아말감의 전기화학적 부식거동 비교

고영무,최한철,강성남,강희영,이승윤 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.3

A gallium based alloy(GA) that was developed as a substitute for dental amalgam was investigated for electrochemical corrosion behavior in 4 kinds of electrolytes(1% lactic acid, 0.05% HCI, Modified Fusayama's artificial saliva, and 0.9% NaCl). The related corroded microstructure were examined and microanalyses were conducted using ICPES. Polarization tests were conducted by scanning from -1,500㎷ to 1,000㎷(vs.SCE) at 75㎷/min. The obtained results were as follows: 1. GA showed wide passivation area next to SYB in artificial saliva, suggesting good stability. 2. The amounts of Sn, Cu released from GA were similiar to those of CAV, and decreased in the order of KAT, SYB. 3. All of specimens were observed pits at the area of pores in electrolytes containing chloride ions, and forming much corrosion products in 1% lactic acid and artificial saliva after corrosion test. 4. From the surface analyses of XRD, GA showed much corosion products containing gallium at the surface after corrosion test. In conclusion, the corrosion resistance of GA was lower than that of SYB and similiar to that of CAV and KAT.

간경변증 환자에서 Escherichia coli 균혈증 합병 시 간기능 장애에 따른 C-reactive protein 생성 능력에의 영향

박완범,강철인,김동민,이기덕,장희창,김홍빈,오명돈,이효석,최강원 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

목적 : C-reactive protein(CRP)은 간에서 생성되는 급성 반응물질이다. 하지만 간부전증 환자에서 CRP의 반응이 간기능에 따라 어느 정도 영향을 받는지는 별로 알려진 바가 없다. 본 연구에서는 간기능에 따른 CRP 생성 능력을 평가하고자 하였다. 방법 : E. coli 균혈증이 있는 간경변증 환자 30명을 대상으로 하였고 간기능은 균혈증이 발생하기 전 2개월 이내에 측정된 혈청 빌리루빈, 혈청 알부민, 프로트롬빈시간, Child-Pugh 점수로 평가하였다. 대조군 A는 간질환이 없으면서 E. coli 균혈증이 발생한 환자 30명으로 하였고 대조군 B는 간경변증이 있으면서 급성 감염의 증거가 없는 환자 30명으로 하였다. 환자군과 대조군 간에 CRP의 최대값을 비교하였다. 결과 : CRP의 최대값은 환자군에서 7.3±5.0㎎/dL, 대조군 A에서 17.9±8.3㎎/dL로 환자군에서 유의하게 낮았다.(P<0.001). 간경변증 환자에서 CRP의 생성은 Child-Pugh 점수에 비례하여 감소하였으나(P=0.004) Child=Pugh class C의 간기능을 가진 환자군에서도 대조군 B와 비교하여 의미있는 CRP의 생성을 보였다(5.3±3.2 vs. 0.5±0.4㎎/dL, P<0.001). 결론 : 간기능부전 환자에서 CRP 반응은 간기능 저하 정도에 따라 둔화되지만 심한 간기능 장애를 가진 환자에서도 CRP의 생성은 유지된다. Background : C-reactive protein (CRP) is an acute phase reactant produced in the liver. To assess the influence of liver dysfunction on the production of CRP, we evaluated CRP response to E. coli bacteremia in patients with or without liver cirrhosis (LC). Methods : 30 LC patients who developed spontaneous peritonitis with E. coli bacteremia were enrolled in the study. Baseline values of total bilirubin, serum albumin, and prothrombin time were obtained within 2 months prior to infection. Liver dysfunction was categorized according to the Child-Pugh score. 30 patients with E. coli bacteremia who had no underlying liver dysfunction were included as a control group. Matched-control of 30 LC patients without evidence of acute infection was also included. The peak CRP values were compared among the groups. Results : In the patients with E. coli bacteremia, the mean value of peak CRP was 7.3 (+/- 5.0) ㎎/dL in LC patients, 17.9 (+/- 8.3) mg/dL in patients without liver dysfunction (p<0.001). In the advanced LC patients with Child-Pugh class C, the level of CRP was 5.2 (+/- 3.3) ㎎/dL in patients with E. coli bacteremia, 0.5 (+/- 0.4) ㎎/dL in patients without acute infection (P<0.001). Child-Pugh score had correlation with decrease of CRP (linear regression test, P=0.004). Conclusion : CRP response during E. coli bacteremia was attenuated but maintained even in patients with advanced liver dysfunction.