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상악동에 발생한 거대한 Cholesterol 육아종 1례
김승찬,박형욱,김용기,나한조,도남용 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1
The cholesterol granuloma is not a specific clinical or pathologic entity but merely a term used to describe a tissue response to cholesterol crystal. The cholesterol granuloma in paranasal sinuses is rare disease. Recently the authors had experienced a case of huge cholesterol granuloma, which involved the right maxillary sinus. The cholesterol granuloma was removed successfully by mean of enucleation through the Caldwell-Luc approach. So, we report a case with brief review of the literature.
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OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin
Han, Jonghee,Jung, Sunmin,Jang, Jiyeon,Kam, Tae-In,Choi, Hyunwoo,Kim, Byung-Ju,Nah, Jihoon,Jo, Dong-Gyu,Nakagawa, Toshiyuki,Nishimura, Masaki,Jung, Yong-Keun Springer-Verlag 2014 Cellular and molecular life sciences Vol.71 No.13
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한국의 고령자 생체능력 조사로 안전한 운전면허 적성검사 강화 연령 추정
이준,방한나,이상조,Lee, Jun,Bang, Han-Nah,Lee, Sang-Jo 한국재난정보학회 2022 한국재난정보학회 논문집 Vol.18 No.3
Purpose: Due to the change of demography, the ratio of senior drivers has increased and the transition to a super-aged society is expected to make more seniors drive in the future. Method: In this research, we analyzed medical characteristics of the driver's age-specific decline in body function and saw that both the function of the physical as well as mental capacities deteriorates as people age. Among them, various functions are precipitously weakened after reaching 70, implying that those over the age of 70 are classified as seniors in a medical sense. In this context, we also could identify that based on such age criteria, various safety policies for senior drivers should be developed and set up in Korea. Result: We could find a steep fall in the physical function of body after reaching 70 from the chronological change of cognitive function and judgment ability. In particular, it is revealed that the driving license institution and aptitude test for drivers over 70 should be thoroughly examined, as physical functions necessary for driving such as eyesight and hearing ability is not strong enough in many drivers over 70. Conclusion: Focusing on the physical capacity to drive, we tried to find the hazardous age bracket of senior drivers which might influence driving behaviors. Going forward, we expect this work would help to understand the policies for senior drivers and drivers' physical differences.
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한-아세안 관광협력의 지속가능성 제고 방안: 교육연수 협력 프로그램을 중심으로
박효연 ( Hyo Yeun Park ),조한나 ( Han Nah Jo ),김봉석 ( Bong Seok Kim ),김대관 ( Dae Kwan Kim ) 아시아.유럽미래학회 2014 유라시아연구 Vol.11 No.2
기존의 개도국 대상 국제관광협력사업은 주로 공여국의 입장에서 진행되어 온 수혜성 사업으로 수원국의 현실을 고려하거나 효과를 간과하는 문제점이 지적되고 있다. 이에 수원국의 요청과 필요에 맞는 사업 진행을 통해 협력 효과성과 지속가능성을 확대하는 노력이 필요하다. 오늘날과 같은 지식기반사회에서는 교육과 훈련은 개도국의 인적자원의 개발과 능력향상에 가장 효율적인 방법으로 한국과 개도국이 함께 발전할 수 있는 기초를 마련하는 것으로 인식되고 있다. 특히 국제관광협력을 통한 실질적 효과를 높이고 지속가능성을 갖기 위해서는 여러 사업 분야 중에서도 개도국의 인적 역량강화를 위한 교육 및 연수프로그램에 초점을 맞춰야할 것이다. 아세안은 한국의 무역과 투자에서 가장 중요한 지역 중의 하나로 부상하였다. 아세안은 우리나라의 2대 교역 및 투자 파트너로서 다방면에 걸쳐 교류가 큰 폭으로 증가하고 있다. 그 중에서도, 2012년 한국인 해외여행자 중 아세안 지역을 방문한 여행자는 전체의 30%를 차지하였으며, 아세안 국가에서는 140만 명이 한국을 방문한 것으로 나타났다. 또한, 아세안 지역에서 한류가 크게 확산되고 있고 2015년 아세안공동체의 출범으로 인해 한-아세안간 교류는 더욱 확대될 것으로 예상되며, 관광분야에서도 한국과 아세안간 연계성 확대 및 강화가 이루어질 것으로 기대되고 있다. 본 연구는 아세안국가들을 대상으로 국제관광협력사업 중 교육연수 프로그램을 중심으로 지속가능성제고 방안을 모색하고자 수행되었다. 연구 목적 달성을 위해 먼저 관광분야 국제협력에 대해 이해하고,주요 사업 추진 현황과 전반적인 문제점 및 특징을 파악하였다. 또한 아세안국가 대상 설문조사를 실시하여 아세안국가의 관광교육 관련 수요를 파악하였으며, 다양한 채널을 통해 이루어지고 있는 관광분야 교육협력사업 현황 및 문제점, 교육분야 성공사례에 대해 전문가 심층인터뷰를 통해 알아보았다. 연구결과, 먼저 지금까지 추진된 관광관련 교육협력 프로그램은 수원국의 빈곤퇴치 등 사업 추진 배경및 목적에 있어서 당위성은 충분하나 규모가 작고 빈도도 상당히 낮은 것을 알 수 있었다. 또한 프로그램 운영에 있어서도 ODA, 한식세계화 등 정부 대외협력정책 반영, 참가국의 수요 반영 및 사업성과 관리 등 효과성 제고, 상호호혜 및 지속가능한 관점에서의 접근 등 변화하고 있는 국제협력사업 방향에는 부합하지 못하고 있음을 확인할 수 있었다. 관광분야 국제협력은 지원 규모보다는 내용과 과정이 더 중요한 소프트파워 성격의 협력형태로 정부의 대외적인 사업 방향과 연계하여 장기적인 계획아래에 실시된다면, 목표 달성 및 국가 이미지 제고에 효과적인 자산이 될 것이다. 아세안국가 중 총 6개국 38명을 대상으로 진행한 설문조사에서 아세안국가 관광 관련 종사자들은 한국과의 관광교육 협력프로그램으로 모국에서의 활용도 및 개인 역량 강화에 직접적으로 영향을 줄 수있는 현장 실무 중심의 프로그램을 선호하는 것으로 나타났다. 교육환경과 관련해서는 숙박시설과 참가국에 대한 문화적 배려를 중요하게 생각하는 것으로 조사되었다. 아세안 국제협력, 교육관련 국제협력을 담당하고 있는 전문가 8명을 대상으로 한 전문가 심층인터뷰에서는 관광분야 교육협력 프로그램의 지속성 제고를 위해 사업 브랜딩을 통한 정체성 확립, 강사 Pool 도입 및 수요자 맞춤형 교육 운영, 사후 관리 프로그램 운영, 전문성 확보 등이 필요한 것으로 파악되었다. 아세안국가와의 관광분야 국제협력 교육프로그램의 지속가능한 노력은 컨설팅, 개발 등 다른 형태의 협력 추진 및 문화교류 등 타부문의 파급효과 발생을 유도할 수 있을 것이다. 본 연구는 향후 더욱 확대될 것으로 전망되는 아세안국가 대상 관광분야 국제협력 교육프로그램에 관한 초기단계 연구로서, 본 연구결과는 향후 아세안 및 개발도상국 대상 교육연수분야 관광국제협력사업의 구성 및 정책적인 연구에 기초적인 자료를 제공하고, 한국형 관광국제협력모델에 관한 연구를 보다 폭넓게 진전시키는 데 기여할 것으로 사료된다. ASEAN is one of the most important partner in investment and trade with Korea. Especially, ASEAN is a new emerging market in tourism. Korea-ASEAN tourism exchange will be expanded and relationship will be strengthened. To expand effectiveness of international tourism cooperation between Korea and ASEAN countries, tourism education and training program should be emphasized and operated to improve capacity of human resource in ASEAN countries. The purpose this study was to determine ways for sustainable improvement of Korea-ASEAN tourism cooperation, especially focusing on the training and education programs. Detailed objectives were; 1) to understand international cooperation in tourism field; 2) to identify overall status, conditions, issues, and features relating to the tourism cooperation between Korea and ASEAN; 3) to determine demands of ASEAN countries on tourism training and education programs through inquiries; 4) to identify the status and issues of tourism cooperation which were made through various channels and best practice relating to the tourism training and education programs through in-depth interviews to the specialists in the fields of tourism, international relations, cooperations, and ASEAN. It was found that tourism related training and education cooperation programs which have been conducting were mostly sufficient to achieve their goals to alleviate recipient countries’ poverty. However, the scales of those programs were small and the frequencies were significantly lower. In the operating aspects, it was verified that those programs were not comply with the new direction of international cooperation which should reflect government’s international cooperation policies, respond to the participating countries’ demands and their needs, and administer program achievements or fruits. A survey with a total of 38 employees in tourism related businesses in six countries of ASEAN countries was conducted. They prefer field oriented and practice based training and education programs which can be applied in their home countries, and can strengthen their personal empowerment. They also emphasized that accommodation facilities and careful concerning on cultural differences are very important factors in training and education conditions. In-depth interviews were also conducted with 8 experts in the fields of international cooperation, tourism training and education, international relations, and ASEAN. They mentioned that it is very required to sustainable improve of tourism training and education programs. Those are establishing identification through program branding, managing instructors’ pool, developing and operating the programs based upon consumers’ needs, operating post-programs, maintaining expertise, and so on. This study is a kind of pilot study to deal with tourism training and education cooperation programs for ASEAN countries which expect to further expansion expecially in tourism fields. The results of this study could provide basic data and information for further researches on structuring international tourism cooperation and tourism training and education cooperation programs for ASEAN countries and other developing countries, and could contribute to develop and expand researches on international tourism cooperation models.
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Choi, Sun-Hye,Shin, Tae-Joon,Hwang, Sung-Hee,Lee, Byung-Hwan,Kang, Jiyeon,Kim, Hyeon-Joong,Jo, Su-Hyun,Choe, Han,Nah, Seung-Yeol Elsevier 2011 european journal of pharmacology Vol.663 No.1
<P><B>Abstract</B></P><P>The human <I>ether-a-go-go</I>-related gene (hERG) cardiac K<SUP>+</SUP> channels are one of the representative pharmacological targets for development of drugs against cardiovascular diseases such as arrhythmia. <I>Panax</I> ginseng has been known to have cardio-protective effects. However, little is known about the molecular mechanisms of how ginsenosides, the active ingredients in <I>Panax</I> ginseng, interact with hERG K<SUP>+</SUP> channel proteins. In the present study, we first examined the effects of various ginsenosides on hERG K<SUP>+</SUP> channel activity by expressing human α subunits in <I>Xenopus</I> oocytes. Among them ginsenoside Rg<SUB>3</SUB> (Rg<SUB>3</SUB>) most potently enhanced outward <I>I</I><SUB><I>hERG</I></SUB> and peak <I>I</I><SUB><I>tail</I></SUB>. Rg<SUB>3</SUB> induced a large persistent deactivating-tail current (<I>I</I><SUB><I>deactivating-tail</I></SUB>) and profoundly decelerated deactivating current decay in both concentration- and voltage-dependent manners. The EC<SUB>50</SUB> for steady-state <I>I</I><SUB><I>hERG</I></SUB>, peak <I>I</I><SUB><I>tail</I></SUB>, and persistent <I>I</I><SUB><I>deactivating-tail</I></SUB> was 0.41±0.05, 0.61±0.11, and 0.36±0.04μM, respectively. Rg<SUB>3</SUB> actions were blocked by bepridil, a hERG K<SUP>+</SUP> channel antagonist. Site-directed mutation of S631, which is located at the channel pore entryway, to S631C in hERG K<SUP>+</SUP> channel abolished Rg<SUB>3</SUB> actions on hERG K<SUP>+</SUP> channels. These results indicate that S631 residue of hERG K<SUP>+</SUP> channel plays an important role in Rg<SUB>3</SUB>-mediated induction of a persistent <I>I</I><SUB><I>deactivating-tail</I></SUB> and in a deceleration of hERG K<SUP>+</SUP> channel deactivation.</P>
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( Ji Hun Na ),( Hong Jun Park ),( Hyun Soo Kim ),( Hee Man Kim ),( Jae Woo Kim ),( Kyong Joo Lee ),( Jae Hyun Kim ),( Hyun Sik Kim ),( Ji Su Lee ),( Han Nah Jo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The aim of this study was to evaluate the characteristics of advanced colorectal neoplasias in asymptomatic subjects with positive fecal immunochemical test(fiT) Methods: A total of 378 subjects who have undergone colonoscopy were enrolled as fiT positive group. In addition, a total of 378, age-sex matched subjects with negative fiT who have undergone colonoscopy were recruited as well as a control group. Results: Among a total of 756 subjects, 350 subjects had one or more adenomas. On per polyp analysis, a total of 783 colorectal neoplasias were found in both group (448 in fiT (-) vs. 335 in fiT (+), p=0.022). Cancers, HAA and large adenomas more than 10 mm in size were more frequently found in fiT positive group (figure 1). Interestingly, among adenomas more than 10 mm in size, adenomas with advanced histology including HGD or cancer were equally found in both groups (41.4% in fiT (-) vs. 48.9% in fiT (+), p=0.527). However, adenomas less than 9 mm in size with advanced histology including HGD or cancer were signifi cantly more frequent in fiT positive group than those in fiT negative group (7.6% vs. 0.7%, p<0.001, respectively). The site specifi c performance of fiT (right vs. left) for detecting AAs was not different between both groups (p=0.079). Conclusions: Compared to those with fiT negative, asymptomatic subjects with fiT positive on colorectal cancer screening showed similar non-advanced adenomas but higher advanced histologies even a small sized lesion. These results suggest the necessity of more rapid and complete resection for lesion found in asymptomatic subjects with fiT positive lesion. This study was supported by a grant from the National R&D Program for Cancer
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