서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

경막내 척수외 종양의 수술적 치료

신병준,이재철,윤태경,정호원,한성우,김동원,김경제,김연일 대한척추외과학회 2002 대한척추외과학회지 Vol.9 No.3

파킨슨씨병에서 Selegiline HCI (MAO-B^(�))의 효과 및 안전성

조기현,김명규,김태선,김병채,이승한,황인용,김준태,김종기 全南大醫大 2000 전남의대학술지 Vol.36 No.2

고콜레스테롤혈증 환자에서 Atorvastation의 유용성 및 안전성에 관한 연구

고종훈,신준한,김한수,탁승제,최병일,김동수,권혁문,김현승 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

Distribution of Aquaporins (Water Channels) in the Rat Salivary Glands

정지연(Ji-Yeon Jung),한창룡(Chang-Ryoung Han),정연진(Yeon-Jin Jeong),오원만(Won-Mann Oh),김미원(Mi-Won Kim1),김선헌(Sun-Hun Kim),김옥준(Ok-Joon Kim),김현진(Huyn-Jin Kim),고정태(Jeong-Tae Koh),최홍란(Hong-Ran Choi),김원재(Won-Jae Kim) 대한해부학회 2002 Anatomy & Cell Biology Vol.35 No.3

침샘은 하루 1.5 l의 침을 분비하며, 일반적으로 침샘에서 수분이동은 능동적 염분 이동에 따른 삼투현상에 의해 일어난다. 따라서 침샘에서 높은 수분투과성으로 인해 수분통로 단백인 aquaporin (AQP)들이 풍부하게 존재할 수 있다. 지금까지침샘에 4가지 형태의 AQP이 존재한다고 알려져 있지만 침샘에서 정확한 위치와 수분 이동에 대한 각 AQP들의 역할은 아직 확실치 않다. 본 연구는 300 g 정도의 흰쥐를 pentobarbital sodium (50 mg/kg, IP) 마취하에서 carbarchol (10 μg/kg)을 복강 내 투여한 후 AQP들의 역할과 분포를 면역조직화학방법으로 조사하였다. AQP1은 침샘의 미세혈관의 내피세포와 샘세포와 샘관 주위에 존재하는 근육상피세포에 존재하였다. AQP4는 침샘관의 마지막 부위인 배출관에 존재하였다. AQP5는 주로 장액세포의 바닥가쪽과 세포사이 분비소관을 포함한 세포꼭대기쪽막 에 존재하였으며 콜린성 분비 자극으로 세포꼭대기쪽막으로 이동되어 밀집되었다. AQP5는 모든 침샘의 사이관과 줄무늬 관에도 존재하였으며 점액세포는 약하게 존재하였다. AQP8은 AQP5처럼 장액세포의 바닥쪽막과 세포사이 분비소관을 포함한 세포꼭대기쪽막에 존재하였으며 콜린성 침분비 자극으로 세포꼭대기쪽막쪽으로 이동되어 밀집되었다. 이상의 실험결과는 AQP5와 AQP8이 장액세포에서 일차 침 형성시 일어나는 수분이동의 주된 통로임을 시사하였다. The salivary glands produce 1.5 l of fluid per day. As in other organs, the general paradigm in the salivary glands is that water movement occurs secondary to osmotic driving forces created by active salt transport. Therefore, high water permeability in salivary glands is expected to need a variety of aquaporin (AQP), a water channel. Although four AQPs have been known to reside in salivary glands, the precise location and roles of AQPs have been not well examined. This study is aimed to investigate the distribution of AQPs in 3 major salivary glands and their changes after cholinergic stimulation using immunohistochemical study in Sprague Dawley rats weighing 300 g under pentobarbital sodium anesthesia. AQP1 was localized in the endothelial cells of all salivary capillary vessels and the myoepithelial cells. AQP4 was demonstrated in the epithelium of the excretory ductal cells of all salivary glands. AQP5 and 8 were abundantly present in the basolateral membrane and apical membranes of the serous acini including intercellular secretory canaliculi, whereas AQP5 was weakly present in mucous acini. In addition, AQP5 was found in the epithelium of the intercalated and striated ducts. Upon stimulation of carbachol (10 μg/kg, I.P). AQP5 and 8 tended to translocate from basolateral membrane to the apical membrane, appearing as clusters of dots. These results suggest that AQP5 and 8 are the candidate molecules responsible for the water movement in salivary acinar cells.

다중 평행판 축전기형 전송회로를 사용한 질소레이저의 제작과 출력 특성의 기체 온도 의존성

김원호,양준목,추한태 충남대학교 기초과학연구소 1994 忠南科學硏究誌 Vol.21 No.1

We have studied the operational characteristics of a nitrogen laser system which consists of a laser tube of 200 ㎜ in length, multiple parallel plate capacitor type transmission circuitry, pulse type high voltage power source and temperature control system for the nitrogen gas. The optimum operational condition is measured to be 30 ℃ in gas temperature, 70 torr in gas pressure, and E/P of 411 (V/㎝.torr) at 4 ㎜ in spark gap spacing and 20 ㎐ in repetation rate. With increasing the nitrogen gas temperature, the optimum nitrogen gas pressure is found to be increased but the optimum value of E/P is decreased. These results are in accordance with the theory of other studies so far.

예측적 공간정보 모형을 이용한 Web 기반의 환경관리시스템의 개발 및 적용

김준현,한영한 江原大學校 附設 環境硏究所 2000 環境硏究 Vol.17 No.-

본 연구는 G7 과제의 일환으로서, Internet상에서 운영될 수 있는 광역적 환경 관리 시스템의 개발에 목표를 두었다. 이러한 목적을 달성하기 위해서는 아직 더 많은 연구가 수행되어야 하지만, 예비적인 개발 성과를 다음과 같이 요약할 수 있다 : 1) 통합적 환경 정보 관리 시스템, 2) web 기반의 제어 엔진, 3) 지표수환경 관리 시스템, 4) 지하수환경 관리 시스템, 5) 하수도 및 시설 관리 시스템. 본 엔진의 핵심 방법론은 다양한 편미분 방정식의 해석에 있어서 각 미분항을 서술하는 범용적 다차원 유한요소 행렬이다. GUI 지향적인 web 기반의 시스템을 구축하기 위해 공간 정보 관리 시스템(ArcView) 및 Visual Basic이 폭넓게 사용되었다. 개발된 시스템들은 환경 문제의 복합적인 관리의 필요성으로 인해 매우 집약적인 프로그램으로 구성되었다. web 기반의 엔진은 환경관련 사업의 통합적인 관리를 위한 정책 결정 도구로 제공될 수 있을 것이다. This study is aimed at the development of comprehensive environmental management system, which can be operated on the basis of world wide web, as a topic of G7 project. Even though there should be lots of works remaining to achieve this goal, preliminary products can be summarized as follows : 1) integrated environmental information management system, 2) web based control engine, 3) surface water environment management system, 4) subsurface water environment management system, 5) sewer and waterworks management system. The core methodology of the engine is the generalized multidimensional finite element matrices to depict the terms in the analysis of various partial differential equations. Spatial information management system (ArcView) and Visual Basic were extensively employed to construct GUI oriented web based engine. The developed systems were composed of very intense computer codes due to the necessity of combinatory management of environmental problems. The web based engine could be served as a decision tool for the integrated management of environmental projects in Korea.

DC Parameter Test System 개발

金俊植,愼漢重 호서대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.19 No.-

in this Paper, we developed the DC parameter system which inspects the property of DC parameter for semiconductor products. The conventional system has complex hardware. Also the interfacing with IBM-PC is hard because that was almost materialized by analogy circuits. The proposed system is interfaced by IBM-PC. It is consisted of CPLD (Complex Programmable Logic Device) part, ADC (Analogue to Digital Converter), DAC (Digital to Analogue Converter), voltage/current source, variable resistor and measurement part. In the proposed system, we have designed the constant voltage source and the constant current source in a part. The CPLD part is designed by VHDL (VHSIC Hardware Description Language), which it generates the control and converts the serial data to parallel data. Voltage source part generates analogue test voltage and maintains that one. Current source part generates the analogue test current and maintains the current. ADC part converts analogue data to 16 bits digital data. DAC part converts the 12 bits digital test voltage to analogue voltage. Variable resistor is the part far the controlling the range of current. The proposed DC parameter test system has two test channels and it operates VFCS (Voltage Force Current Sensing) mode and CFVS (Current Force Voltage Sensing) mode. The normal resistor with error range ±5% and diode is tested. When the normal resistor testing about 10% error is measured. When the diode testing about 7% error is measured.

춘천시의 지하 저장 탱크의 예비적 위해성 평가를 위한 설치 현황 분석 및 지리정보시스템의 적용

김준현,한영한,이종춘,권영성,이광연 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A

In this study, the preliminary risk assessment for the underground storage tanks(UST) in Chunchon city was implemented using the geographical information system(GIS). The estimation variables, such as the installation year, storage capacity, the distances from streams, and from groundwater pumping wells, were selected to estimate the relative risk levels. The weighting factors were given to all the estimation variables. Cumulative scores were induced by the combination of al1 the scores of the corresponding variables using the buffering technique and the overlay analysis in ArcView. Using the these process, the relative risk level of each UST was estimated. Some sites in this study are simplified and reduced because the number of useable data are limited or too enormous. Thus the selection of the comprehensive estimation variables and the proper weighting values are required for the future study. The methodology in this study could be served not only for the preliminary risk assessment of UST but also for the selection of the proper location of new and old UST. And, it can be used for the effective management system of UST.

자매에서 발생한 중증 마이코플라즈마 폐렴에서 스테로이드 치료

김도희,이경일,김명숙,윤유숙,황자영,임정우,강진한,이준성 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Numerous evidences support the pathogenesis that M. pneumonias pneumonia is associated with cell-mediat-ed immune reaction. We report 2 cases of severe M. pneumoniae pneumonia in previously healthy sisters, who were both admitted during an epidemic of M. pneumoniae pneumonia. The elder sister, who was 16 years old, was admitted with M. pneumoniae pneumonia. She showed no response to treatment with clarithroycin and levo-floxacin, and eventually progressed to severe ARDS, requiring mechanical ventilation. After treatment with hydrocortisone (200 mg/day), there were rapid improvements in clinical manifestations and chest radiographic findings. The younger sister, who was 14 years old, was admitted 10 days later, Presenting with fever but no pneumonic lesions on chest radiograph. Just like her sister, the infection showed no response to clarithromycin. Fever persisted and pneumonic consolidation with mild pleural effusion was noticed in the left lower lobe on the 5th hospital-day. After treatment with oral prednisolone (1 mg/kg), she showed rapid defervescence and on the 8th hospital day, no pneumonic lesions were detectable on chest radiograph. Given the fact that the pathogenesis of pneumonia and extrapulmonary manifestations in M. pneumoniae infection is immune-mediated, an immuno-suppressive therapy would be validated for selected patients with M. pneumoniae infections.