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아세트아미노펜 사용 편의성 증가 후 중독발생 위험의 지속적 관리 필요성
조승직 ( Seung Jik Jo ),강현영 ( Hyun Young Gang ),이시진 ( Si Jin Lee ),배규현 ( Gyu Hyun Bae ),이의중 ( Eui Jung Lee ),한갑수 ( Kap Su Han ),김수진 ( Su Jin Kim ),이성우 ( Sung Woo Lee ) 대한임상독성학회 2020 대한임상독성학회지 Vol.18 No.2
Purpose: Since 2012, acetaminophen can be accessed easily not only at pharmacies but also at convenience stores. The relationship between the easy access of acetaminophen and the risk of poisoning has been controversial. Several studies also reported different results regarding the risk of acetaminophen poisoning after access to acetaminophen was relaxed. This study examined the long-term effects on the risk of acetaminophen poisoning after easy access to acetaminophen was implemented. Methods: This was a retrospective analysis of an emergency department (ED)-based in-depth Injury Surveillance Cohort by the Korea Center for Disease Control and prevention from 2011 to 2018. Poisoning cases were selected from the Cohort, and the incidence of acetaminophen poisoning and the characteristics of the cases of acetaminophen poisoning were analyzed. The purchase path and the amount of ingestion in acetaminophen poisoning were sub-analyzed from data of six EDs. Results: Of 57,326 poisoning cases, 4.0% (2,272 cases) were acetaminophen poisoning. Of 2,272 cases of acetaminophen poisoning, 42.8% (974 cases) required in-patient care after ED management. Two hundred and sixty-four of these 964 cases required intensive care. The rates of cases that required in-patient treatment and the rates of cases that required intensive care increased from 29.4% in 2011 to 48.1% in 2018, and from 3.1% in 2011 to 15.2% in 2018, respectively (p<0.001, p<0.001). In the poisoning group with in-depth toxic surveillance (n=15,908), the incidence and proportion of acetaminophen (AAP) poisoning increased from 55 cases per year to 187 cases per year and 4.9% to 6.1%, respectively (p=0.009, p<0.001, respectively). The most common age group of acetaminophen poisoning was teenagers, which is different from the most common age group of other pharmaceutical agents: the middle age group of 40-49 years (p<0.001). Of 15,908 in-depth toxic surveillance patients, 693 patients had AAP poisoning, of whom 377 cases (54.2%) purchased acetaminophen from a non-pharmacy. The proportions of the purchase path from non-pharmacy were 41.4% at 2011-12 and 56.4% (2013-18) (p=0.004). The amount of acetaminophen ingestion was 13.5±14.3 g at 2011-12 and 13.9±15.1 g at 2013-18 (p=0.794). Conclusion: Although the incidence of acetaminophen poisoning did not increase remarkably in the short term after the implementation of the new regulation, the incidence of acetaminophen poisoning has increased slightly during the study period of 2017-18. In addition, the proportion of the purchase path from non-pharmacies has increased since the emergence of new regulations for the easy access of acetaminophen in 2012. The incidence of acetaminophen poisoning might have been affected after the increasing accessibility of acetaminophen in convenience stores. Continuous control of acetaminophen poisoning is required. Furthermore, the prevention of acetaminophen poisoning should be focused on teenagers with specialized school education programs.
Jung, Jang Han,Lee, Hyun Jik,Lee, Hee Seung,Jo, Jung Hyun,Cho, In Rae,Chung, Moon Jae,Park, Jeong Youp,Park, Seung Woo,Song, Si Young,Bang, Seungmin Baishideng Publishing Group Inc 2017 WORLD JOURNAL OF GASTROENTEROLOGY Vol.23 No.18
<P><B>AIM</B></P><P>To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA).</P><P><B>METHODS</B></P><P>We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows: (1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or (2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging.</P><P><B>RESULTS</B></P><P>The median disease-free survival (DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 26.0 and 15.1 mo, respectively (<I>P</I> = 0.91). The median overall survival (OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively (<I>P</I> = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis (<I>P</I> = 0.01).</P><P><B>CONCLUSION</B></P><P>NACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability.</P>
열해석을 이용한 Butterfly Valve의 초저온환경에서의 구조안전성 평가
조영직(Young-Jik Jo),박한석(Han-Seok Park),김세훈(Se-Hun Kim),강정호(Jung-Ho Kang),박영철(Young-Chul Park) 한국기계가공학회 2008 한국기계가공학회 춘추계학술대회 논문집 Vol.2008 No.-
A cryogenic butterfly valve is used to transfer the liquefied natural gas (LNG) which temperature is -162 ℃. This valve is core part in the piping system using LNG. This paper performed coupling analysis using FEM to evaluate safety of cryogenic butterfly valve. Flow analysis is calculated numerically the CAE and CFD methods are useful to predict the thermal matter and the inner flow field of the valve. Thermal analysis and structural analysis used ANSYS Workbench.
Kim, Bong Jik,Cho, Sung Woo,Jeon, Yung Jin,An, Sujin,Jo, Ara,Lim, Jae Hyun,Kim, Dong-Young,Won, Tae-Bin,Han, Doo Hee,Rhee, Chae-Seo,Kim, Hyun Jik Springer-Verlag 2018 Applied microbiology and biotechnology Vol.102 No.1
<P>We studied the contribution of Duox2 in mucosal host defense against influenza A virus (IAV) infection in in vivo lung. We found that Duox2 was required for the induction of type I and III interferon (IFN)s and transient Duox2 overexpression using cationic polymer polyethyleneimine (PEI) leads to suppression of IAV infection in in vivo lung. Twenty mice (C57BL/6J) were anesthetized and challenged by intranasal administration of 213 pfu/30 mu l of IAV (WS/33/H1N1), and IAV-infected mice were euthanized at 1, 3, 5, 7, 10, 14 days post infection (dpi). Duox2 small hairpin RNA (shRNA) and pCMV-Duox2 formulated with PEI were inoculated to mice to assess the regulatory mechanism between Duox2 and IFN secretion. Following intranasal IAV inoculation, viral infection was significantly aggravated from 3 dpi in in vivo lung and viral titer was highest at 7 dpi. Consistent with this, Duox2 messenger RNA (mRNA) and protein expressions were significantly induced from 3 dpi in the lung tissue of IAV-infected mice. Viral titer was much higher in IAV-infected mice that were inoculated with Duox2 shRNA accompanied with lower survival rate and extensive lung pathologies. Interestingly, severe lung pathologies in IAV-infected mice were not observed and viral titer was significantly reduced in mice with pulmonary administration of pCMV-Duox2 formulated with PEI before IAV inoculation. Both mRNA and secreted protein levels of IFN-beta and IFN-lambda(2/3) were highly elevated in IAV-infected mice with pCMV-Duox2 formulated with PEI. Duox2 is necessary for the regulation of IFN secretion in in vivo lung, and pulmonary administration of Duox2 DNA using cationic polymer triggers the induction of type I and III IFNs resulting in more complete suppression of IAV infection.</P>
Sung-Yoon Jung,Jik-Han Jung,Byung-Gu Lee,Dong-Jo Park 한국과학기술원 인간친화 복지 로봇 시스템 연구센터 2004 International Journal of Assistive Robotics and Me Vol.5 No.2
In this paper, we present a robot system to assist the handicapped and the elderly at work places. The proposed system is based on the results of the mobile platform, robot arm, control and wireless communication systems previously developed for the fire-fighting robot. For this purpose, we carried out a survey to select the type and class of the handicapped to be assisted and decided the task for each class. In following, we perform the conceptual design of the robot system and manufacture the prototype robot system. Relying on field tests and modifications, we designed the first version of the robot system conceptually and planned to build the robot system.