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Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana
( Mi Seon Kim ),( Yun Mi Lee ),( Gi Ho Sung ),( Ji Hye Kim ),( Jae Gwang Park ),( Han Gyung Kim ),( Kwang Soo Baek ),( Jae Han Cho ),( Jae Gu Han ),( Kang Hyo Lee ),( Sung Youl Hong ),( Jong Hoon Kim 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4
Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH- 13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13- AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.
증례 : 신장 ; 거대 단순 신낭종의 경화요법 치료를 받은 환자에서 발견된 신세포암 1예
선한경 ( Han Gyung Seon ),김주환 ( Ju Hwan Kim ),구승원 ( Seung Won Koo ),유광호 ( Kwang Ho Yoo ),박경미 ( Kyeong Mi Park ),김지운 ( Ji Woon Kim ),김형종 ( Hyung Jong Kim ) 대한내과학회 2010 대한내과학회지 Vol.79 No.2
본 증례는 단순 신낭종에서 악성 신세포암이 발생하였을 것으로 생각되어 병리 검사를 시행하였으나, 신절제술 소견에서 이전 단순 신낭종 치료 부위에 근접하여 신세포암이 발견되었으며 낭성 종괴에서 종양세포는 발견되지 않았다. 아마도 단순 신낭종의 경화요법으로 치료할 당시에도 신세포암이 있었는지는 알기 어려우나, 과거 보고를 참고하였을 때 단순 신낭종으로 진단된 경우에도 드물기는 하나 악성 종양으로의 변형에 대한 가능성 및 새로운 신세포암이 발생할 수 있음을 염두에 두어 단순 신낭종의 치료 후에도 정기적인 추적관찰이 필요할 것으로 생각된다. Simple renal cysts are a common cystic disease of the kidneys, which is not symptomatic in most cases and is diagnosed by radiological examination. However, if the cyst is huge or symptomatic, it must be treated. Renal cyst aspiration and alcohol sclerotherapy is a safe and effective treatment for symptomatic simple renal cysts. Simple renal cysts have benign clinical features in the main and transformation of a simple renal cyst into renal cell carcinoma has rarely been reported. However, one case of renal cell carcinoma during renal cyst follow-up has been reported. We report a case of renal cell carcinoma that developed in a patient who was being treated with huge simple renal cyst sclerotherapy. (Korean J Med 79:201-205, 2010)
간외 담관 결석 환자에서 경피 경간 치료술의 유용성 및 안전성에 대한 연구
선한경 ( Han Gyung Seon ),권창일 ( Chang Il Kwon ),윤상필 ( Sang Pil Yoon ),유광호 ( Kwang Ho Yoo ),옥창수 ( Chang Su Ok ),김원희 ( Won Hee Kim ),고광현 ( Kang Hyun Ko ),홍성표 ( Sung Pyo Hong ),박필원 ( Pil Won Park ) 대한내과학회 2012 대한내과학회지 Vol.83 No.1
목적: ERCP를 이용한 유두 괄약근 절개술은 간외 담관결석 환자에게서 가장 널리 이용되는 치료방법이지만, ERCP가 실패하거나, 위절제술을 받은 경우, 담췌관으로의 접근이 어려운 경우, 환자의 전신상태가 불량한 경우 등에서는 시술하기가 어렵다. 본 연구의 목적은 ERCP를 시행하기 어려운간외 담관 결석을 가진 환자들에게서 PTPBD (percutaenous transhepatic papillary balloon dilatation) 및 폐쇄 풍선 카테터를 이용한 간외 담관 결석 제거술의 안전성 및 유용 유용성을 알아보고자 하였다. 방법: 2001년부터 2010년까지 10년간 간외 담도 결석으로 내원한 509명의 환자 중 PTPBD를 이용하여 간외 담도 결석 제거술을 시행한 17명의 환자를 후향적으로 자료 분석하였다. 모든 환자는 결석을 제거하기 3-4일 전에 PTBD를 시행하였다. 십이지장 유두부를 풍선 확장술로 확장시킨 후, 폐쇄 풍선 카테터(풍선 지름 11.5 mm)를 이용하여 결석을 확장된 유두부를 통해 십이지장 안으로 밀어내어 제거하였다. 크기가 15 mm를 넘는 큰 결석 일부는 부분 쇄석술을 먼저 시행한 후 시술을 시행하였다. 시술결과는 잔류 결석의 유무로 평가하였고, 합병증 및 결석의 크기와 수에 따라서 세부적으로 분석하였다. 결과: 시술을 시행한 17명의 환자들 중 이전에 위절제술을 시행한 환자는 9명, 전신상태가 불량한 환자가 4명, ERCP에 실패한 환자가 4명이었다. 결석의 크기는 직경이 평균 13.6mm (8-25 mm)이었고, 7명은 결석이 1개(41.2%), 5명은 2개 (29.4%), 그리고 남은 5명은 결석이 3개 이상(29.4%)이었다. 17명의 환자 중에 16명(94%)이 잔류 결석 없이 시술에 성공하였다. 이 중 2명의 환자(11.7%)는 시술을 2번 시행하여 성공하였다. 치료에 실패한 1명(6%)의 환자는 랑데뷰 방법을 이용하여 직시 위내시경을 통해 치료에 성공하였다. 시술과연관된 사망 및 합병증의 발생은 없었다. 췌장염의 발생은 없었고, 3명의 환자에게서 경도의 일시적인 아밀라아제 상승소견이 보였다. 결론: 경피 경간 유두부 풍선 확장술 및 폐쇄 풍선 카테터를 이용한 간외 담관 결석 제거술은 ERCP에 부적절하거나 실패한 환자 군에서 안전하고 효과적인 대체 방법으로 이용될 수 있다. Background/Aims: Endoscopic retrograde cholangiopancreatography (ERCP) occasionally fails due to surgically altered anatomy, difficult cannulation, or poor general condition. This study evaluated the safety and effectiveness of percutaneous transhepatic papillary balloon dilatation (PTPBD) for managing extrahepatic bile duct stones. Methods: Between 2001 and 2010, 17 out of 509 patients with extrahepatic bile duct stones and acute cholangitis were enrolled retrospectively. After PTPBD of the sphincter, the stones were extracted using an occlusion balloon to push the stone over a guidewire into the duodenum. The procedure success was evaluated based on residual stones. In addition, the size and number of stones and complications were analyzed. Results: Of the 17 patients, nine had a previous gastrectomy, four had poor general condition, and four had unsuccessful cannulation, The stone diameter ranged from 8 to 25 mm, Seven, five, and five patients had one, two, or three or more stones, respectively. The results were successful in 16 out of 17 patients, with no residual stones. Treatment failed in one patient, who was then treated with the rendezvous technique with endoscopy. No procedure-related major complication occurred. Three patients had mild transient elevations of the serum amylase levels. Conclusions: PTPBD was safe and effective for managing extrahepatic bile duct stones in patients with unsuccessful or contraindicated ERCP.
Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana
Kim, Mi Seon,Lee, Yunmi,Sung, Gi-Ho,Kim, Ji Hye,Park, Jae Gwang,Kim, Han Gyung,Baek, Kwang Soo,Cho, Jae Han,Han, Jaegu,Lee, Kang-Hyo,Hong, Sungyoul,Kim, Jong-Hoon,Cho, Jae Youl The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4
Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH-13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13-AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.
Simultaneous Expression of the Protease Inhibitors in a Rice Blast-Resistant Mutant
Han, Chong U.,Lee, Chan-Hui,Choi, Gyung-Ja,Kim, Jin-Cheol,Ahn, Sang-Nag,Choi, Jae-Eul,Cha, Jae-Soon,Cho, Kwang-Yun,Lee, Seon-Woo The Korean Society of Plant Pathology 2005 Plant Pathology Journal Vol.21 No.4
We have previously identified genes for four different protease inhibitors (PIs) that were induced upon rice blast infection in a rice blast resistant mutant SHM-11. Our expression analysis of the PIs indicated that induction of the PIs was the highest 24 hr after rice blast inoculation in the rice mutant SHM-11. Three PIs in the group of serine PIs were highly expressed while a cystein PI was weakly expressed upon rice blast inoculation. Four PIs were weakly induced 48 hr after pathogen inoculation in rice blast susceptible wild type rice plant. The simultaneous expression of three serine PIs was apparent from SHM-11 and two of them were induced in rice blast resistant Taebaegbyeo. One of them was induced in rice blast resistant Hwayeongbyeo while none of them were expressed in rice blast susceptible Nagdongbyeo and rice blast resistant Dongjinbyeo. Our results suggest that the expression of PI gene is rice cultivar specific and may be linked with the rice blast resistance in a specific rice mutant by the simultaneous expression of the PI genes.
Sliding Wear Behavior of Steam Generator Tube Materials in Nuclear Power Plants
Kim, Gyung Guk,Kim, Ji Hui,Lee, Kwon Yeong,Kim, Seon Jin,Lee, Deok Hyun,Hur, Do Haeng,Choi, Myung Sik,Han, Jung Ho Trans Tech Publications, Ltd. 2005 Materials science forum Vol.486 No.-
<P>Wear damage of steam generator tubes of nuclear power plants can cause leakage of radioactive substances. So the evaluation of tubes’ integrity is very important from the viewpoint of nuclear ecocide. In the present study, sliding wear behaviors of Inconel 600 and 690 steam generator tube materials mated with 409 stainless steel commonly used as the support plate were investigated at room temperature in an air environment. For more precise prediction of wear behaviors of steam generator tubes, Archard equation was modified, and the modified wear coefficients were estimated as a function of sliding distance. When using the modified Archard equation, the reliabilities for prediction of wear behavior of Inconel 600 and 690 mated with 409 stainless steel increased from 71.8% to 83.8% and from 60.2% to 85.2%, respectively.</P>
김경임 ( Gyung-im Kim ),한창민 ( Chang-min Han ),양수영 ( Su-yeoung Yang ),박정선 ( Jeong-seon Park ),정희택 ( Hee-taek Ceong ) 한국정보처리학회 2012 한국정보처리학회 학술대회논문집 Vol.19 No.1
일반적인 환경모니터링시스템은 다양한 환경 상태 데이터를 수집하여 사용자들에게 다양한 정보를 제공한다. 측정된 정보를 원격 CDMA의 단말기를 이용하여 사용자가 쉽게 관찰할 수 있도록 구성되어 있으나 이동성의 제한 및 SMS 요금이 발생하는 단점을 지닌다. 본 연구에서는 스마트폰을 기반으로 모바일 애플리케이션의 장점을 활용할 수 있는 안드로이드 기반의 환경정보 모니터링 시스템을 제안한다. 제안된 시스템에서는 푸시기반 알림 기능을 제공함으로써 사용자는 이동성을 확보함과 동시에 기존의 SMS 방식에서 발생한 비용의 문제를 해결할 수 있는 장점이 있다.
Park, Gyung-Min,Kim, Seon Ha,Jo, Min-Woo,Her, Sung Ho,Han, Seungbong,Ahn, Jung-Min,Park, Duk-Woo,Kang, Soo-Jin,Lee, Seung-Whan,Kim, Young-Hak,Lee, Cheol Whan,Kim, Beom-Jun,Koh, Jung-Min,Kim, Hong-Kyu Williams & Wilkins Co 2015 Medicine Vol.94 No.21
<P><B>Abstract</B></P><P>It is not clear whether screening by coronary computed tomographic angiography (CCTA) and/or exercise electrocardiogram (ECG) can improve clinical outcomes and reduce costs in individuals without known cardiovascular disease (CVD).</P><P>In total, 71,811 consecutive individuals without known CVD who underwent general health examinations were enrolled. Using propensity-score matching according to screening tests, 1-year clinical outcomes and 6-month total and coronary artery disease–related medical costs were analyzed in separate groups: group 1 (CCTA [n = 2578] vs no screening [n = 5146]), group 2 (exercise ECG [n = 2898] vs no screening [n = 5796]), and group 3 (CCTA and exercise ECG [n = 2003] vs no screening [n = 4006]).</P><P>There were no significant differences in the composite outcome of death, myocardial infarction, and stroke in each matched group: group 1 (0.35% vs 0.45%, <I>P</I> = 0.501), group 2 (0.14% vs 0.28%, <I>P</I> = 0.157), and group 3 (0.25% vs 0.27%, <I>P</I> = 0.858). However, revascularization was more frequent in the CCTA screening groups: group 1 (2.02% vs 0.45%, <I>P</I> < 0.001) and group 3 (1.40% vs 0.45%, <I>P</I> < 0.001). Matched screening groups had higher 6-month total and coronary artery disease–related medical costs: group 1 ($777 vs $603, <I>P</I> < 0.001 and $177 vs $39, <I>P</I> < 0.001), group 2 ($544 vs $492, <I>P</I> = 0.045 and $12 vs $15, <I>P</I> = 0.611), and group 3 ($705 vs $627, <I>P</I> = 0.090 and $135 vs $35, <I>P</I> < 0.001).</P><P>In individuals without known CVD, CCTA screening with or without exercise ECG led to more frequent revascularization at the expense of higher medical costs, but did not decrease the 1-year risk of death, myocardial infarction, and stroke.</P>