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이행남,박길문,이덕구,정한별,김건일,설재림 朝鮮大學校 機械技術硏究所 2005 機械技術硏究 Vol.8 No.1
The sirocco fan is used to get low noise, and it has been applied to a lot of industry field like the heat engine, the fluid instrument power plant, the food industry, environment industry etc... because there are not problems even it is mixed with a any kind of liquid, gas, and solid. The flow characteristics in sirocco fan are investigated by PIV. The experiment using PIV measurement for Test section's flow characteristics acquired velocity distribution, Condition : when sirocco fan in automobile air controller maximum 1450RPM, and a revolution is a variation (l)950RPM, (2)l100RPM, (3) 1250RPM. The agreement a experiment shows the validity of this study and the results of this study would be useful to the engineers who design for the flow systems
김한별 ( Kim Han-byul ) 서강대학교 언어정보연구소 2019 언어와 정보 사회 Vol.36 No.-
This article conducts a bibliographic and linguistic study on Hakpong kim sonsaeng haengjang (‘An Annotation of the Behaviors of Great Scholar Kim Hakpong’ 鶴峯金先生行狀), which is not a well-known source in Korean historical linguistics. The annotation book is a one-volume manuscript translated from Classical Chinese into Korean vernacular in 1770 by Kim Chuguk, the 7th eldest son of the eldest son’s family of Kim Hakpong. Evidence from the number of handwritings, types of misspelling and the use of a certain punctuation mark, however, indicates that the book is not the original version, but a copied one. According to some intra- and extra-linguistic evidence, the transcribers must be Kim Chuguk’s family members. Based on the bibliographic characteristics of the annotation, in order to reveal its linguistic value I have researched the following topics: its dialectal background; its orthographical, phonological, grammatical and lexical characteristics; and its translational aspect.
김한별(Kim, Han-byul) 우리말글학회 2017 우리말 글 Vol.73 No.-
본고는 지금까지 국어학계에 공개되지 않은 문헌인 『녀자초학』을 소개하고 그것을 국어사적 측면에서 조명해 보기 위해 작성된 것이다. 이 책은 한글로 필사된 학봉 종가의 계녀서로, 두 이본이 존재한다. 하나는 학봉의 9대 종손인 김종수가 작성한 ‘고본(稿本)’이고, 다른 하나는 그의 증손자인 김응식이 그것을 베껴 쓴 ‘전사본(轉寫本)’이다. 본고는 전사본과의 대비 작업을 중심으로 하여 고본의 언어적 특징을 ‘표기ㆍ음운ㆍ문법ㆍ어휘’로 나누어 살펴보는 데 주력하였다. 고본의 저자 김종수는 표기법을 중시하고, 서울말이나 중부 방언뿐만 아니라 자신의 경북 양반 계층 방언도 중시하는 인물이다. 이에 따라, 그는 많은 음운 변화에서 보수적인면을 보였으나, 현실 언어를 수용하는 데에서 완전히 자유롭지 못한 모습을 보이기도 하였고, 일부 변화에서는 개신적인 태도를 드러내기도 하였다. 문법적인 측면에서는 사동사 ‘보이-[使試]’와, 척도 파생 접미사 ‘-(-애)/의’의 대당 표현으로 쓰이는 명사형 어미 ‘-기’, 목적격 조사 ‘-으로’의 존재, 접속 조사로 연결되는 명사구 나열 구성에서의 맨 마지막 격조사 생략 문제, 비교 구문에서의 조사 생략 문제 등을 다루었다. 어휘적인 측면에서는 동남 방언형과 의미 변화를 상정할 수 있는 어휘, 그리고 희귀어를 소개하였다. This article introduces a new historical literature Nyŏjach"ohak (女子初學), which has never been studied in Korean linguistics, and examines its linguistic characteristics. This book is a Hangŭl manuscript written by a father who wanted to teach one of his daughters the proper virtues and manners for a noble woman at the period. There are two different versions of the text: the one is the original text written by Kim Chongsu, the 9th descendent of Hakpong, and the other is the one copied by Kim Ŭngsu, a great-grandson of Kim Chongsu. In this article, I examined the orthographical, phonological, grammatical and lexical characteristics of the original version based on the result from contrasting between the two versions. Kim Chongsu, the author of the original version, regarded the orthographic tradition as important and seemed to pursue not only Seoul or Central Dialect, but also his own upper class dialect in Kyŏngsangbukdo area. Consequently, phonological changes in the text show both conservative and innovational forms depending on individual change. As for grammatical characteristics, I dealt with causative verb pwoi-; nominalizer –ki used as nominal suffix –oy/uy; accusative particle –urow; omitting of case particles after the last comitative particle in a construction of coordinated noun phrases; and omitting of particles in a comparison construction. Finally, I indicated the lexical characteristics of the book in terms of the following three categories: Southeastern dialect, semantic change and rare words.
S-267 Impact of Ezetimibe/Simvastatin on neointimal response to Biolimus-eluting stent Implantation
( Han Chul Lim ),( Young Joon Hong ),( Sang Wook Kim ),( Young Mi Cho ),( Ji Won Kim ),( Jung A Choi ),( Han Byul Kim ),( Min Chul Kim ),( Doo Sun Sim ),( Ju Han Kim ),( Youngkeun Ahn ),( Myung Ho Jeo 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Impact of Ezetimibe/Simvastatin on neointimal response to Biolimus-eluting stent Implantation
Kim, Dong Eon,Jang, Mi-Jin,Kim, Young Ran,Lee, Joo-Young,Cho, Eun Byul,Kim, Eunha,Kim, Yeji,Kim, Mi Young,Jeong, Won-il,Kim, Seyun,Han, Yong-Mahn,Lee, Seung-Hyo Elsevier 2017 Toxicology Vol.387 No.-
<P><B>Abstract</B></P> <P>Drug-induced liver injury (DILI) is a leading cause of liver disease and a key safety factor during drug development. In addition to the initiation events of drug-specific hepatotoxicity, dysregulated immune responses have been proposed as major pathological events of DILI. Thus, there is a need for a reliable cell culture model with which to assess drug-induced immune reactions to predict hepatotoxicity for drug development. To this end, stem cell-derived hepatocytes have shown great potentials. Here we report that hepatocyte-like cells derived from human embryonic stem cells (hES-HLCs) can be used to evaluate drug-induced hepatotoxic immunological events. Treatment with acetaminophen significantly elevated the levels of inflammatory cytokines by hES-HLCs. Moreover, three human immune cell lines, Jurkat, THP-1, and NK92MI, were activated when cultured in conditioned medium obtained from acetaminophen-treated hES-HLCs. To further validate, we tested thiazolidinedione (TZD) class, antidiabetic drugs, including troglitazone withdrawn from the market because of severe idiosyncratic drug hepatotoxicity. We found that TZD drug treatment to hES-HLCs resulted in the production of pro-inflammatory cytokines and eventually associated immune cell activation. In summary, our study demonstrates for the first time the potential of hES-HLCs as an <I>in vitro</I> model system for assessment of drug-induced as well as immune-mediated hepatotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Generation and characterization of hES-HLCs for evaluation of drug-induced immune cell-mediated hepatotoxicity. </LI> <LI> The secretion of inflammatory cytokines is highly enhanced from APAP-treated hES-HLCs. </LI> <LI> Immune cells are activated and produce pro-inflammatory cytokines by conditioned medium from hES-HLCs cultured with APAP. </LI> <LI> Hepatotoxic results in hES-HLCs are consistent with those of primary human hepatocytes. </LI> <LI> Hepatotoxic drugs such as TZD, and non-hepatotoxic drugs such as aspirin and metformin, are also validated with our drug screening system. </LI> </UL> </P>
Cushing syndrome in pregnancy, diagnosed after delivery
( Han Byul Kim ),( Mi Kyung Kim ),( El Kim ),( Keun Soo Ahn ),( Hye Soon Kim ),( Nam Kyung Kim ) 영남대학교 의과대학 2021 Yeungnam University Journal of Medicine Vol.38 No.1
Cushing syndrome (CS) is rare in pregnancy, and few cases have been reported to date. Women with untreated CS rarely become pregnant because of the ovulatory dysfunction induced by hypercortisolism. It is difficult to diagnose CS in pregnancy because of its very low incidence, the overlap between the clinical signs of hypercortisolism and the physiological changes that occur during pregnancy and the changes in hypothalamus-pituitary-adrenal axis activity that occur during pregnancy and limit the value of standard diagnostic testing. However, CS in pregnancy is associated with poor maternal and fetal outcomes; therefore, its early diagnosis and treatment are important. Here, we report two patients with CS that was not diagnosed during pregnancy, in whom maternal and fetal morbidity developed because of hypercortisolism.