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- 저자 : ( Hajeong Lee ) (검색결과 80 건)
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Lee, Hajeong,Lee, Jae Wook,Yoo, Kyung Don,Yoo, Joo-Yeon,Lee, Jung Pyo,Kim, Dong Ki,Chin, Ho Jun,Kim, Yon Su,Yang, Seung Hee American Physiological Society 2016 American Journal of Physiology Vol.311 No.3
<P>T helper 17 (Th17) lymphocytes promote renal inflammation in antiglomerular basement membrane glomerulonephritis (anti-GBM GN), and signal transducer and activator of transcription 3 (STAT3) mediates activation of Th17 lymphocytes by IL-6 and transforming growth factor-beta (TGF-beta). Cln 3-requiring 9 (Ctr9), a subunit of RNA polymerase-associated factor complex (PAFc), regulates the transcription of IL-6/STAT3-dependent genes. Here, we investigated the role of Ctr9 in regulating Th17-driven inflammation in anti-GBM GN. In mice, STAT3 beta or IL-17 knockout ameliorated anti-GBM autoantibody-induced renal injury. This phenomenon was associated with decreases in retinoic acid receptor-related orphan receptor gamma t (ROR gamma t), IL-17, phosphorylated STAT3, and proinflammatory cytokines. Compared with wild-type mice, Ctr9 increased in both STAT3 beta(-/-) and IL-17(-/-) mice injected with anti-GBM IgG, showing a negative correlation with Th17-related transcripts. Small interfering RNA (siRNA)-mediated knockdown of Ctr9 in intrarenal lymphocytes further upregulated Th17-related transcripts, consistent with repression of Th17 differentiation by Ctr9. Interestingly, Ctr9 was also expressed in human and mouse mesangial cells and downregulated in response to anti-GBM IgG or to TGF-beta plus IL-17. Ctr9 in mesangial cells was even more repressed in the presence of both anti-GBM IgG and Th17-activating cytokines. Consistent with these findings, renal biopsies obtained from patients with anti-GBM GN showed consistent downregulation of Ctr9 and upregulation of phosphorylated STAT3 and IL-17 in the glomerulus. We conclude that Ctr9 is a negative regulator of Th17 differentiation in anti-GBM GN and repressed by anti-GBM IgG and IL-17 in mesangial cells.</P>
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A Qualitative Study on Changes in Women s Perception of Beauty Care After COVID-19
Hajeong Lee,Jaebum Lee,Hyunwoo Kim J-INSTITUTE 2021 Protection Convergence Vol.6 No.3
Purpose: This study was conducted by using a phenomenological approach among the qualitative research methods, which is an inductive narrative method, with a view to examine in greater depth as to what changes are taking place in the women s perception of beauty care after COVID-19. Method: As for the research participants, 8 women who are serving in the beauty and health related industry in Korea were selected via the purposive sampling method. As for the data analysis of the in-depth interview con-tents, the 4-step phenomenological analytical method proposed by Giorgi was used, and to secure the validity of the study, the 8 evaluation criteria of the phenomenological research proposed by Cresswell for the validity strat-egy of the qualitative study were applied mutatis mutandis. Furthermore, to secure the reliability of the study, the truth value, applicability, consistency, and neutrality proposed by Guba and Lincoln were applied. Results: Results of the study, 113 semantic units, 20 sub-components, and 6 elements were eventually derived. The contents of the components were identified to be the changes in the perception of information search, chang-es in the interest of beauty, positive perception of evaluation according to wearing a mask, negative perception of evaluation according to wearing a mask, observation of other people s appearance management and infor-mation exchange, and the changes in the interpersonal perception. Conclusion: Based on the results of this study, it was verified that the Korean women s perception of beauty care has changed, and that it is transforming into the beauty behaviors for the rational consumption according to the situation due to the social disaster of the COVID-19. It is expected that such research results will be used as the behavioral scientific data on the changes in the women s beauty care in the future era of infectious diseases.
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Predictors of Relapse in Adult-Onset Nephrotic Minimal Change Disease
Lee, Hajeong,Yoo, Kyung Don,Oh, Yun Kyu,Kim, Dong Ki,Oh, Kook-Hwan,Joo, Kwon Wook,Kim, Yon Su,Ahn, Curie,Han, Jin Suk,Lim, Chun Soo Wolters Kluwer Health 2016 Medicine Vol.95 No.12
<P><B>Abstract</B></P><P>Minimal change disease (MCD) is a well-known benign primary glomerulonephritis because of its distinct rare tendency to progress to end-stage renal disease. However, factors associated with relapse in adults are not well known. We aimed to identify predictors of relapse in adult-onset MCD patients.</P><P>A retrospective cohort of 195 patients with adult-onset primary MCD with nephritic syndrome and disease onset between 1979 and 2013 was followed up for >12 months. The number of relapses was counted and predictors of relapse were analyzed.</P><P>A total of 195 patients were included. Median age at diagnosis was 38 years (IQR, 23–53 years) and 113 (57.9%) were men. During 81 months (IQR, 44–153 months) of follow-up, 92% of patients achieved remission after initial treatment. However, only 60 (32.8%) did not experience a relapse and 11 patients failed to remit. Among the remaining 124 patients, 65 experienced a relapse once or twice and 59 experienced a relapse more than twice. Younger onset age, increased severity of nephrotic features such as lower serum albumin levels and higher cholesterol level were associated with relapse. Interestingly, the grade of mesangial proliferation was lower in patients who experienced a relapse. Initial combined treatment with corticosteroids (CS) and cyclophosphamide reduced the number of relapses. In addition, patients with shorter treatment duration tended to experience relapse more often. Multivariate analysis showed that younger onset age, combined mesangial proliferation, initial treatment regimen, and treatment duration were independent risk factors for relapse. Progression to end-stage renal disease was developed in only a patient.</P><P>In conclusion, more than two-thirds of adult-onset nephrotic MCD patients experienced relapse, although their renal progression was rare. Younger onset age, CS without cyclophosphamide treatment, and shorter treatment duration were independent risk factors for relapse in adult-onset MCD patients.</P>
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( Hajeong Kim ),( Chang-min Choi ),( Jae Seung Lee ),( Sei Won Lee ),( Kyung-wook Jo ),( Younsuck Koh ),( Woo Sung Kim ),( Sang-do Lee ),( Chae-man Lim ),( Yeon-mok Oh ),( Sang-bum Hong ),( Jin Won Hu 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Introduction Although tracheobronchial foreign body (FB) aspiration is life-threatening condition, there are a few studies on the effectiveness of bronchoscopic treatment in adults. This study aimed to evaluate the clinical characteristics, outcomes of bronchoscopic FB removal in adults. Method In this retrospective study, we reviewed the medical records of 68 patients who underwent bronchoscopic removal of FB at Asan Medical Center, South Korea, from January 2003 to December 2020. Result The median age of the patients was 65 years, 85% was males. Among the 68 patients, 66 patients (97.1%) received flexible bronchoscopy and FB was removed successfully in 94% of patients (62/66). All 4 patients, failed FB removal by flexible bronchoscopy, were rescued by rigid bronchoscopy. Neurologic disease with dysphagia was the most common underlying comorbidities (26.5%); artificial teeth and dental device were the most common aspirated FB (38.2%). It showed a tendency to aspirate better into the right (43/68, 63.2%) than the left bronchus (23/68, 33.8%, p=0.056). The success rate of FB removal within 4 weeks was higher than those after 4 weeks (P=0.005). Conclusion Flexible bronchoscopy is useful procedure to remove tracheobronchial FB and bronchoscopic removal delayed more than 4 weeks after aspiration had a high possibility of technical failure. Furthermore, aspiration of FB in tracheobronchial tree appeared to be prevalent in the patients who had neurologic disease or underwent dental procedure.
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이하정 ( Hajeong Lee ) 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.6
본 연구의 목적은 창의 인성교육의 관점에서 일본의 유치원교육요령을 분석하고 그 의미를 탐색하여 우리나라 유아교육에 주는 시사점을 찾는 것이다. 이를 위해 일본 유치원교육요령과 해설서, 관련문헌을 수집하여 분석하였고, 그 연구결과는 다음과 같다. 첫째, 일본 유치원교육요령은 유아기에 살아가는 힘의 기초를 육성하는 것을 교육의 목표로 하고 있으며, 이는 창의 인성교육의 방향성과 부합되고 있다. 둘째, 일본 유치원교육요령은 유치원을 다양한 연령의 또래를 만날 수 있는 만남의 장으로 설정하고 있으며 이는 창의 인성교육이 이루어지는 장의 마련과 일치한다. 셋째, ‘환경을 통한 교육’을 강조하는 것에서 창의 인성교육을 발현할 수 있는 교육의 기초 마련과 충분히 연관이 있다. 본연구 결과를 토대로 창의 인성교육의 관점에서 우리나라 유아교육에 주는 시사는 다음과 같다. 앞으로의 유아교육은 유아가 어떠한 상황에서도 유연하게 대처할 수 있는 역량에 중점을 두고, 또래집단을 강조한 교육과정을 실행할 필요성이 있으며, 유아들이 일상에서 마주하는 환경의 확장이 필요하다. 앞으로 창의 인성교육의 바탕 마련과 함께 실제로 어떠한 교육운영이 이루어질 것인지를 비교 검토하여 시사점을 도출하는 연구가 지속되기를 기대한다. The purpose of this study is to find implications for early childhood education in Korea by analyzing Japanese national kindergarten curriculum from the perspective of creativity and character education. To this end, Japanese national kindergarten curriculum, explanations, and related documents were collected and analyzed, and the results of the study are as follows. First, the Japanese national kindergarten curriculum aim to cultivate the basics of the power to live, which is consistent with the direction of creativity and character education. Second, Japanese national kindergarten curriculum set kindergarten as a meeting place to meet peers of various ages, which is consistent with the provision of a place for creative and character education. Third, the emphasis on “education through the environment” is sufficiently related to the preparation of the foundation for education that can express creativity and character education. In the future, it is hoped that research will continue to draw implications by comparing and reviewing what kind of educational operation will actually be carried out along with laying the groundwork for creativity and character education.
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이하정 ( Hajeong Lee ) 인문사회 21 2023 인문사회 21 Vol.14 No.1
연구 목적: 이 연구는 예비교사들이 교육봉사 활동에서 어떠한 경험을 하는지를 교육현장에서 맺는 관계에 초점을 두고 탐색하고자 하였다. 연구 방법: 교육봉사활동을 마친 유아교육과 예비유아교사 6명을 대상으로 면담을 실시하고 문서자료를 수집하였다. 수집한 면담자료와 문서자료는 Spradley(1980)의 질적 연구 방법으로 분석하였다. 연구 내용: 첫째, 본 연구에 참여한 예비유아교사는 교육봉사활동에서 유아를 처음 만나고 관계를 맺으며, 유아의 특성을 면밀히 관찰하며, 유아와의 관계 속에서 교사가 되어가는 나를 인식하였다. 둘째, 본 연구에 참여한 예비유아교사는 교육봉사활동에서 교사를 지켜보고 교사로서의 역할을 배우는 경험을 하였다. 결론 및 제언: 후속연구로는 교육봉사활동의 교육적 효과를 뒷받침해줄 수 있는 양적연구와 교육봉사활동의 학생과 기관의 양측 입장을 모두 고려한 연구가 이루어질 필요가 있다. This study aimed to explore what kind of experiences preservice teachers have in educational volunteer activities, focusing on the relationship they have in the educational field. Interviews were conducted with 6 prospective early childhood teachers of the Department of Early Childhood Education who completed educational volunteer activities, and document data were collected. The collected interview data and document data were analyzed using the qualitative research method of Spradley (1980), focusing on the experience and perception of relationships made in educational volunteer activities. First, the pre-service early childhood teachers who participated in this study met and formed relationships with young children for the first time in educational volunteer activities, closely observed the characteristics of young children, and recognized themselves as teachers in the relationship with young children. Second, the pre-service early childhood teachers who participated in this study watched teachers in educational volunteer activities and had the experience of learning their role as teachers. As a follow-up study, it is necessary to conduct quantitative research that can support the educational effects of educational volunteer activities and studies that consider both the positions of students and institutions in educational volunteer activities.
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