정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

논문 : 강원도 양양지역 소나무림의 지상부 바이오매스와 수관층 연료특성에 관한 연구

김성용 ( Sung Yong Kim ),이영진 ( Young Jin Lee ),장미나 ( Mi Na Jang ),서연옥 ( Yeon Ok Seo ),구교상 ( Kyo Sang Koo ),정성철 ( Sung Cheol Jung ),김경하 ( Kyung Ha Kim ) 한국임학회 2012 한국산림과학회지 Vol.101 No.2

본 연구의 목적은 강원도 양양지역에 분포하는 소나무림을 대상으로 지상부 바이오매스와 수관층 연료특성에 대하여 분석하고자 하였다. 연구대상지는 강원도 양양군 현남면 하월천리 일대 소나무림으로 선정하였으며, 총 13본의 표본목을 벌채하여 분석하였다. 본 연구 결과에 의하면, 양양지역 소나무림의 줄기밀도(g·cm-3)는 0.347~0.409, 지상부 바이오매스 확장계수는 1.251~1.419의 범위로 나타났다. 지상부 연료량은 총 161.6 Mg·ha-1로 나타났으며, 줄기 126.4 Mg·ha-1, 가지 29.3 Mg·ha-1, 잎 5.9 Mg·ha-1로 나타났다. 수관층 연료특성 인자에 관한 연구에서는 수관화 확산 시 연소될 수 있는 연소가능 연료(잎~1 cm이하 가지)의 비율은 45.2%로 나타났고, 연료량을 수관체적으로 나눈 연소가능 연료밀도(kg·m-3)는 평균 0.178로 나타났다. 본 연구의 결과는 소나무림의 바이오매스 및 탄소 흡수량 추정과 수관화 위험성을 연료적 관점에서 평가하는데 있어 유용한 기초자료가 될 것으로 사료된다. The objective of this study was to analyze the above-ground biomass and crown fuel characteristics of Pinus densiflora stands in Yangyang, Gangwon province. A total of thirteen representative trees were destructively sampled in Yangyang region. The results showed that the stem density (g·cm-3) was 0.347~0.409, whereas the above-ground biomass expansion factors ranged from 1.251~1.419. In terms of crown fuel biomass, the above-ground biomass was 161.6 Mg·ha-1 while the stem biomass, branch biomass and needle biomass were 126.4 Mg·ha-1, 29.3 Mg·ha-1 and 5.9 Mg·ha-1, respectively. Needles and twigs with less than 1 cm diameter accounted 45.2% of the total crown fuel load. The available crown bulk density, which was calculated by dividing the crown fuel load to the crown volume, was 0.178 kg·m-3. The results of this study on the biomass and carbon stocks estimation of the Pinus densiflora together with the crown fire hazard assessment based on crown fuel loads are very significant information for the forest managers.

Glyoxal-induced exacerbation of pruritus and dermatitis is associated with <i>staphylococcus aureus</i> colonization in the skin of a rat model of atopic dermatitis

Han, Rafael Taeho,Kim, Hye Young,Ryu, Hyun,Jang, Wooyoung,Cha, Seung Ha,Kim, Hyo Young,Lee, JaeHee,Back, Seung Keun,Kim, Hee Jin,Na, Heung Sik Elsevier 2018 Journal of dermatological science Vol.90 No.3

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease associated with hyperreactivity to environmental triggers. Among those, outdoor air pollutants such as particulate matter (PM) have been reported to aggravate pre-existing AD. However, underlying mechanisms of air pollution-induced aggravation of AD have hardly been studied.</P> <P><B>Objective</B></P> <P>To investigate the molecular mechanisms by which glyoxal, a PM-forming organic compound, exacerbates the symptoms of AD induced by neonatal capsaicin treatment.</P> <P><B>Methods</B></P> <P>Naïve and AD rats had been exposed to either fresh air or vaporized glyoxal for 5 weeks (2 h/day and 5 days/week) since one week of age. Pruritus and dermatitis were measured every week. The skin and blood were collected and immunological traits such as Staphylococcus aureus skin colonization, production of antimicrobial peptides and immunoglobulin, and mRNA expression of inflammatory cytokines were analyzed.</P> <P><B>Results</B></P> <P>Exposure to glyoxal aggravated pruritus and dermatitis in AD rats, but did not induce any symptoms in naïve rats. Staphylococcus aureus skin colonization was increased in the skin of both naïve and AD rats. Expression of antimicrobial peptides such as LL-37 and β-defensin-2 was also increased by exposure to glyoxal in the skin of both naïve and AD rats. The mRNA expression of Th1-related cytokines was elevated on exposure to glyoxal. However, serum immunoglobulin production was not significantly changed by exposure to glyoxal.</P> <P><B>Conclusion</B></P> <P>In AD rats, exposure to glyoxal exacerbated pruritus and cutaneous inflammation, which was associated with increased colonization of <I>S. aureus</I> and subsequent immunological alterations in the skin.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Exposure to glyoxal aggravated the symptoms in AD rats, but did not induce AD in naïve rats. </LI> <LI> <I>S. aureus</I> skin colonization and subsequent expression of antimicrobial peptides were increased after exposure to glyoxal. </LI> <LI> Exposure to glyoxal elevated the production of Th1-related cytokines such as TNF-α and IFN-γ in the AD lesional skin. </LI> </UL> </P>

요관석의 요관경하배석술 후 요관부목의 선별적 유치

이상훈,윤하나,심봉석,이시내 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Purpose : Ureteral stent is commonly used after ureterscopic stone removal(URS). However, there is no definitive clinical criteria in inserting the ureteral stent after URS. Patients often complain of bladder irritative symptoms, hematuria. flank pain and additive endoscopic prodedure is neces-sary to remove the ureteral stent. Therefore, we studied the clinical epicacy of selective ureteral stenting only when it is required. Materials and Methods : Of the patients who was taken URS, the following patients were exclu-ded from stent insertion ; 1) Patients who have mild hydronephrosis or symptoms less than 1week. 2) Patients who were able to insert the ureteroscope through the ureteral orifice without difficulty. 3) Patients who hardly have ureteral mucosal damage seen through the ureteroscopic field after the removal of ureteral stone. 4) Patients who did not need the additional lithoclast during the remo-val of ureteral stone. Other than the above patients and those with stones above the mid-ureter, a 6Fr. ureteral stent was inserted and kept for 3weeks. There were 29 unstented patients and 38 stented patients. Results : The average age of the non-stenting and stenting group were 37.5years old and 39.7years old and the average stone size were 0.68cm and 0.80cm. The average operation time was 3 minutes in the non-stenting and 8minutes(including ureteral stent insertion time) in the stenting group. Hos-pital stay was 3days in both groups. Intermittent gross hematuria and irritative symptoms of the bladder was shown for 3weeks after operation in most of the patients(32cases, 84.2%) of the sten-ting group while those in the unstenting group, the symptoms were relieved after2days after operation. Although mild flank pain was shown in few patients(4cases, 13.8%) of the non-stenting group, severe pain requiring intravenous analgesics was not seen in both groups. There were no specific findings in the intravenous urography which was done at 6weeks after operation, and no hematuria and pyuria was found in both groups. Conclusion : The selective placement of ureteral stent following the ureteroscopic removal of stone did not bring specfic complications. We believe that ureteral stent insertion will minimize the inconvenience especially in patients who need to return to their everyday living immediately after operation. Thus ureteral stent insertion should be used in limited situations. 요관경하배석술 후 많은 경우에 있어서 요관부목을 유치하고 잇지만 선별적으로 판단하여 설치할 경우 특별한 문제점이 없었으며, 수술 수 바로 일상생활에 복귀하여야 하는 환자들의 불편함을 최소화할 수 잇을 것으로 생각되며, 요관부목 설치는 제한적인 상황하에서 시행되어야 할 것으로 사료된다.

펌제와 염모제가 곱슬모에 미치는 영향에 관한 연구

이하나,강상모 한국패션뷰티학회 2008 한국패션뷰티학회지 Vol.6 No.2

To study of the rate of damage and morphological change when apply perm and dye according to kinds of curly hair, measured the thickness of hair and divided the samples into groups. Measured the chromaticity and thickness according to kinds of curly hair and chemical treatment with Spectrum colormeter and Micrometer. Measured the tensile strength of hair then calculated the damage rate. After tensile test, took photographs of the section and surface with the electron microscope.

젓갈로부터 유용 박테리오신 생산균주의 탐색

이나경,전송애,하정욱,백현동 경남대학교 환경문제연구소 1998 환경연구 Vol.21 No.-

Bacteriocins are proteins produced by heterogeneous group of bacteria that have a bactericidal effect on closely related organisms. Recently, bacteriocins from lactic acid bacteria(LAB) and other food-related organisms have been the subject of much research of their potential as food biopreservatives. The goal of this study were to isolate LAB from commercial fermented fish products and identify their bacteriocin activity. All bacteriocin-producing isolates were identified as LAB. The NK24, NK34, and SA72 isolates were as identified as Lactococus lactis subsp. Lactis where as SA131 isolate was Lactobacillus brevis according to database of API50 CHL kit. All antimicrobial substance(s) produced from 4 LAB isolates were lost their antibacterial activity completely by treatment of some proteases, which indicate its proteinaceous nature. The bacteriocins produced from NK24, NK34, and SA72 isolate showed broad spectrum of activity when compared to SA131 bacteriocin.

Effect of Poly-L-Lysine as Cryoprotectant Agent on the Post-That Developmental Competence of In Vitro-Matured Bovine Oocytes

A-Na Ha1,Seok-Hwan Song,Imran Khan,Kyeong-Lim Lee,Chowdhury MMR,Mesalam Ayman,Pu-Rum Park,Xu Lian Guang,Myeong-Don Joo,Il-Keun Kong 한국동물생명공학회(구 한국동물번식학회) 2015 발생공학 국제심포지엄 및 학술대회 Vol.2015 No.10

인간의 행위를 고려한 공동주택 단위공간의 디자인평가를 위한 공간데이터모델 개발에 관한 연구

김하나,강미선,이상현 대한건축학회 2004 대한건축학회논문집 Vol.20 No.10

This research intends to implement an evaluator as well as a building unit data model Through this system, It will be possible to represent a building unit in such a semantically rich manner and also to evaluate a building unit design against the given design criteria To do this, 1) a design checklist was created, 2) it was structured according to its original intentions, 3) the set of structured checklist was transformed into the computable format, 4) the classes representing the elements inn a building unit were developed, 5) finally the building unit data model was developed, 6) in addition, an evaluator module which works on the building unit data model was implemented

IT 융복합형 공공자전거 대중교통 연계운영관리 지불 시스템 개발

박하나,이기한 서울여자대학교 2010 정보기술논문지 Vol.8 No.-

To solve the problems have been occurreo such as air pollution, global warning, greenhouse effect, climatic change, exhaustion of energy resource, using of bike is encouraged in all over the world. The bike doesn't need energy resource to provide power for the wheels and doesn't release gas. And the bike is of help personal's health promotion and traffic congestion reduction because of character of sports. In our country also, a public bike system was introduced to encourage using of bike but it wasn't a striking effect. In this paper, to encourage using of a public bike, we propose to operate and manage by combining a public bike system with nation wide interoperable transportation card system. In character of Nation-wide interoperable transportation card system, users can use always a transportation card wherever they go and users are provided a service such as transfer discounts, so user's convenience is increased. Also the government can establish rule related transportation and provide service better, because this systems can collect and count to use-date of card. Therefore through it, we can expect to lead invigoration of a public bike, so protect earth and expect to green growth together. Thus we constructed a kiosk that is made up combining public bike system with nation wide interoperable transportation card system, and tested it by using Nation-wide interoperable transportation card. Then through application, we proved that this system works normally and it is operated and managed effective.

상황버섯(Phellinus linteus)으로부터 Ergosterol의 분리

류하나,유종수,송명종,이대영,김동현,노영덕,김인호,백남인 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

상황버섯을 80% MeOH 용액으로 추출하고, 추출물을 EtOAc, n-BuOH 및 물로 분배, 추출하였다. 이 중 EtOAc 분획을 silica gel 및 octadecylsilica gel(ODS) column chromatography로 정제하여 1종의 sterol 화합물을 분리하였다. 화합물의 화학구조는 NMR, MS 및 IR 등의 스펙트럼 데이터를 해석하여, ergosta-7,22E-diene-3β,5α,6β-triol(cerevisterol, 1)로 동정하였다. 이 화합물은 상황버섯에서 처음 분리 보고 되었다. Phellinus linteus was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H_(2)O. The repeated silica gel and ODS column chromatographies of the EtOAc fraction led to the isolation of one sterol. From the result of spectral data including NMR, MS and IR, the chemical structure of the sterol was determined as ergosta-7,22E-diene-3β,5α,6β-triol (cerevisterol, 1). Compound 1 was isolated from the Phellinus linteus for the first time in this study.