Glyoxal-induced exacerbation of pruritus and dermatitis is associated with <i>staphylococcus aureus</i> colonization in the skin of a rat model of atopic dermatitis

Han, Rafael Taeho,Kim, Hye Young,Ryu, Hyun,Jang, Wooyoung,Cha, Seung Ha,Kim, Hyo Young,Lee, JaeHee,Back, Seung Keun,Kim, Hee Jin,Na, Heung Sik Elsevier 2018 Journal of dermatological science Vol.90 No.3

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease associated with hyperreactivity to environmental triggers. Among those, outdoor air pollutants such as particulate matter (PM) have been reported to aggravate pre-existing AD. However, underlying mechanisms of air pollution-induced aggravation of AD have hardly been studied.</P> <P><B>Objective</B></P> <P>To investigate the molecular mechanisms by which glyoxal, a PM-forming organic compound, exacerbates the symptoms of AD induced by neonatal capsaicin treatment.</P> <P><B>Methods</B></P> <P>Naïve and AD rats had been exposed to either fresh air or vaporized glyoxal for 5 weeks (2 h/day and 5 days/week) since one week of age. Pruritus and dermatitis were measured every week. The skin and blood were collected and immunological traits such as Staphylococcus aureus skin colonization, production of antimicrobial peptides and immunoglobulin, and mRNA expression of inflammatory cytokines were analyzed.</P> <P><B>Results</B></P> <P>Exposure to glyoxal aggravated pruritus and dermatitis in AD rats, but did not induce any symptoms in naïve rats. Staphylococcus aureus skin colonization was increased in the skin of both naïve and AD rats. Expression of antimicrobial peptides such as LL-37 and β-defensin-2 was also increased by exposure to glyoxal in the skin of both naïve and AD rats. The mRNA expression of Th1-related cytokines was elevated on exposure to glyoxal. However, serum immunoglobulin production was not significantly changed by exposure to glyoxal.</P> <P><B>Conclusion</B></P> <P>In AD rats, exposure to glyoxal exacerbated pruritus and cutaneous inflammation, which was associated with increased colonization of <I>S. aureus</I> and subsequent immunological alterations in the skin.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Exposure to glyoxal aggravated the symptoms in AD rats, but did not induce AD in naïve rats. </LI> <LI> <I>S. aureus</I> skin colonization and subsequent expression of antimicrobial peptides were increased after exposure to glyoxal. </LI> <LI> Exposure to glyoxal elevated the production of Th1-related cytokines such as TNF-α and IFN-γ in the AD lesional skin. </LI> </UL> </P>

논문 : 강원도 양양지역 소나무림의 지상부 바이오매스와 수관층 연료특성에 관한 연구

김성용 ( Sung Yong Kim ),이영진 ( Young Jin Lee ),장미나 ( Mi Na Jang ),서연옥 ( Yeon Ok Seo ),구교상 ( Kyo Sang Koo ),정성철 ( Sung Cheol Jung ),김경하 ( Kyung Ha Kim ) 한국임학회 2012 한국산림과학회지 Vol.101 No.2

본 연구의 목적은 강원도 양양지역에 분포하는 소나무림을 대상으로 지상부 바이오매스와 수관층 연료특성에 대하여 분석하고자 하였다. 연구대상지는 강원도 양양군 현남면 하월천리 일대 소나무림으로 선정하였으며, 총 13본의 표본목을 벌채하여 분석하였다. 본 연구 결과에 의하면, 양양지역 소나무림의 줄기밀도(g·cm-3)는 0.347~0.409, 지상부 바이오매스 확장계수는 1.251~1.419의 범위로 나타났다. 지상부 연료량은 총 161.6 Mg·ha-1로 나타났으며, 줄기 126.4 Mg·ha-1, 가지 29.3 Mg·ha-1, 잎 5.9 Mg·ha-1로 나타났다. 수관층 연료특성 인자에 관한 연구에서는 수관화 확산 시 연소될 수 있는 연소가능 연료(잎~1 cm이하 가지)의 비율은 45.2%로 나타났고, 연료량을 수관체적으로 나눈 연소가능 연료밀도(kg·m-3)는 평균 0.178로 나타났다. 본 연구의 결과는 소나무림의 바이오매스 및 탄소 흡수량 추정과 수관화 위험성을 연료적 관점에서 평가하는데 있어 유용한 기초자료가 될 것으로 사료된다. The objective of this study was to analyze the above-ground biomass and crown fuel characteristics of Pinus densiflora stands in Yangyang, Gangwon province. A total of thirteen representative trees were destructively sampled in Yangyang region. The results showed that the stem density (g·cm-3) was 0.347~0.409, whereas the above-ground biomass expansion factors ranged from 1.251~1.419. In terms of crown fuel biomass, the above-ground biomass was 161.6 Mg·ha-1 while the stem biomass, branch biomass and needle biomass were 126.4 Mg·ha-1, 29.3 Mg·ha-1 and 5.9 Mg·ha-1, respectively. Needles and twigs with less than 1 cm diameter accounted 45.2% of the total crown fuel load. The available crown bulk density, which was calculated by dividing the crown fuel load to the crown volume, was 0.178 kg·m-3. The results of this study on the biomass and carbon stocks estimation of the Pinus densiflora together with the crown fire hazard assessment based on crown fuel loads are very significant information for the forest managers.

양주별산대놀이에 내재된 신명에 관한 연구

장하나 한국무용연구회 2005 한국무용연구 Vol.23 No.-

한국의 춤 속에는 어두운 그늘이나 슬픔의 한(恨)이 서려 있다. 그러나 한국의 춤은 한이 한으로 그치는 것이 아니라 자유, 희망, 희열의 경지로까지 승화시키는 신명의 세계로 이끈다. 신명은 삶의 응어리진 한과 고통을 풀어헤쳐 삶의 활력을 주며, 공동체적 공감대를 형성하고 유지시키면서 보다 나은 삶으로 발전시키는 기능을 지니고 있다. 탈춤은 사회적 모순과 갈등을 극복하고 새로운 사회질서를 만들고자하는 지향점이 있으며, 민중들이 자기표현을 할 수 있도록 계기를 마련해 줌으로서 사회에서 느낀 개인적, 공동체적 갈등을 해소하는 신명의 장으로써 탈춤속의 신명이야말로 민중의 가장 현실적인 신명풀이라 할 수 있다. 이에 본 연구는 양주별산대놀이에 내재된 신명을 연구함으로써 탈춤 속에 신명이 어떻게 나타났으며, 탈춤에 있어서 신명의 역할을 규명하여 우리 춤이 갖고 있는 신명의 특징을 이해함과 동시에 창작춤을 지향하고 있는 오늘의 무용에 있어 신명이 중요한 정신적 바탕이 됨을 인식하는데 연구의 목적을 두고 있다. 양주별산대놀이에 내재된 신명을 사회적 신명, 삶과 죽음의 신명, 뒤풀이의 신명, 현장성의 신명으로 나누어 연구하였으며, 그 결과 양주별산대놀이에서의 신명은 사회에 내재해 있는 모순과 주요갈등을 놀이에 구체화하여 놀이꾼과 구경꾼이 춤을 통해 갈등을 해소하고 응어리진 감정을 풀어 그 정서를 현실에 되돌려 놓음으로써 그들의 내적인 유대와 결속을 강화하고 활성화 하는데 있어 중요한 역할을 하였다. 이러한 신명은 단순한 놀이나 예술이라는 차원을 넘어서 오늘의 무용이 작품의 주제의식을 표출하는데 있어 무용가와 관객이 일체감을 느끼고 공감대를 형성하는데 있어 중요한 정신적 바탕이 될 것으로 생각된다. In Korean dance, there are inclusion of dark shade or sorrow. In Korean dance, the grudges don’t stop as simple grudges, but they sublimate audience to the level of freedom, hope and joy, the cheer world. Cheerfulness is vitalizes our life by venting our grudges and easing our pains as the their lives. Also, it arouses community spirit and maintains the community, and has a potential to lead the community into a better life. Mask dance has its aim to overcome all social conflicts and problems and create a new social order, and is a space where the people disentangle private and public conflicts by that it provides opportunities for the people to express themselves. The cheerfulness inside mask dance is the most practical method to give an outlet for grudges of the people. The purpose of this study is revealing that how the cheerfulness inside of make dance appeared by studying Yangjubyeulsandaenori, and grasping the nature of Korean dance by examining the role of the cheerfulness in mask dance, and understanding the characteristics of the cheerfulness our dance has, and at the same time placing the cheerfulness as the spiritual ground of today’s dance which is aiming at creative dance. I've studied it dividing the cheerfulness into four categories, social cheerfulness and the cheerfulness of life and death as the internal characteristics seen in the content, the cheerfulness of an entertainment after a ceremony and the cheerfulness of the presence as the internal characteristics seen in the form. As the result, the cheerfulness of the Yangjubyeulsandaenori, solves the immanent conflicts and problems of the society by materializing them in the play. And by doing it, it provides an outlet for the grudges of the people, and strengthens and revitalizes their bond and solidarity. Also, I think that it would be an important spiritual basis for players and audience to feel a sense of unity and sympathize with each other in that today’s dance expresses the conscience of its main subject, which is to go beyond the domain of art.

난소의 호산성 투명세포암종 - 1예의 보고 -

하창원,고재수,명나혜,조경자,박상윤,김미경,장자준 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.5

여성의 유방자가검진의 지식 정도

구한나,박인경,박하영,성초아,장다엘,홍은민 이화여자대학교 간호과학대학 2012 이화간호학회지 Vol.- No.46

Purpose: This study was to grasp women’s knowledge about Breast Self-examination. Methods: We collected data from 317 women who lives in certain city, Korea using structured questionnaire from 5th, August to 20th, September. The collected data was analyzed by SPSS 19.0. Results: The average score of women’ Breast Self-examination knowledge was 6.79±3.68 (of 17). There are three categories in knowledge about Breast Self-examination. Average score of category is 2.31 ± 0.71(of 4) for knowledge of breast cancer, 2.11 ± 0.57(of 5) for knowledge of breast cancer symptom, 2.37 ± 0.45(of 8) for knowledge of Breast Self-examination. Knowledge about Breast Self-examination according to general characteristics varied significantly for different age, marital status, education, and history of breast disease. Knowledge about Breast Self-examination according to characteristics related Breast examination was higher for women who received Breast Self-examination education, received Breast Self-examination education by lecture, performed Breast Self-examination, and who received Clinical Breast Examination Conclusion: People who are teenager and over sixties, their knowledge of Breast Self-examination was low. Therefore, effective Breast Self-examination education program should be provided for women who are teenager and over sixties to promote their Breast Self-examination practice regularly.

中學 科學敎育의 探究學習에 대한 評價問項 開發 (Ⅱ)

閔庚德,楊洪準,李善行,鄭遠佑,이병교,金裕漢,羅長薰 경북대학교 과학교육연구소 1985 科學敎育硏究誌 Vol.9 No.-

This study was accomplished to develope the evaluation items for inquiry learning in the 2nd grade Middle School Science for the consecutive study of the evaluation items for inquiry learning in the 1st grade Middle School Science(U-Hang Ki et al, 1984). In this study, paper and pencil test items and performance test items are made by analyzing the abilities of inquiry according to the contents and four basic experiments from each unit in the 2nd grade Middle school science. These evaluation items were applied to tke five classes of the 2nd grade of middle school to test their validity. It is desirable that performance test schuld be used for the evaluation for the abilities of inquiry which can not be evaluated by paper and pencil test. In the evaluation methods of performance test, tester evaluation, peer evaluation and self-evaluation can be applied to the science class in a multi-student class. In higher grade, however tester evaluation is more desirable than peer and self evaluation. It is found that peer evaluation and self-evaluation make possible the perfect study by feedback.

Material Corrosion Troubles on Boiler Tube in Waste to Energy Facility

( Ha-na Jang ),( Hyun-tae Jeong ) 한국폐기물자원순환학회(구 한국폐기물학회) 2020 한국폐기물자원순환학회 추계학술발표논문집 Vol.2020 No.-

Typically, municipal solid waste contains large portion of combustible matter to recover heat energy by thermal treatment. Conventional combustion is promising and well-known technology to treat municipal solid waste safely. However, municipal solid waste in Korea consists of miscellaneous materials with incombustible materials and large amounts of moisture, which prevent heat recovery from combusting. Due to fossil fuel limitation, technological development of renewable and sustainable energy such as waste to energy (WtE) is necessary. Solid refused fuel (SRF) mainly consists of combustible matter which is derived from municipal solid waste by separation process, and heat content was maximized by intensive drying process. Combustible matter in SRF contains plastics fraction to increase calorific value. In this study, commercial SRF boiler with 100MW capacity was selected to investigate corrosion issue in boiler tube and convection pass. Usually, chlorine content of fuel occur boiler tube corrosion, and alkali metals such as K, Na, Ca occur slagging and fouling. Based on the fuel analysis, the average chlorine content of SRF was 1.32%. In XRF analysis, the chlorine content in boiler tube ash and bottom ash was 6.1% and 4.3%, respectively. In SEM-EDX analysis, the chlorine content in corrosion part on boiler tube was ranged from 11.95% to 30.52%. Figure 1 shows the corrosion part of boiler tube and facility location which was occurred alkali-chlorine corrosion.

Enterotypes of the Healthy Adults Gut Microbiome and Relationship Between Dietary Intake

Ha Na Jang,Mi Jang,Ui Jin Bae,Gi Chang Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

We investigated diversity of the human gut microbiota and associations of dietary intake with the microbial community in 222 Koreans. Gut microbiota data were obtained by 16SrRNA gene sequencing on DNA extracted from fecal samples. The dietary information was collected using a validated food frequency questionnaire (FFQ). We found that subjects could be grouped into two groups simply by their relative abundance of Prevotella divided by Bacteroides (P/B ratio) at the phylum Level. The microbial diversity (shannon index) of Prevotella enterotype was significantly higher than that of Bacteroides enterotype. In addition, we found that Bacteroides enterotype intake of protein from plant was significantly higher than Prevotella enterotype using two sample t-test. Further studies research is needed to validate our findings and look into the potential health implications of the diet-gut microbiota relationships.

Material corrosion troubles on heat recovery section in waste to energy facility

( Ha-na Jang ),( Hyun-tae Joung ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-

Typically, municipal solid waste contains large portion of combustible matter to recover heat energy by thermal treatment. Conventional combustion is promising and well-known technology to treat municipal solid waste safely. However, municipal solid waste in Korea consists of miscellaneous materials with incombustible materials and large amounts of moisture, which prevent heat recovery from combusting. Due to fossil fuel limitation, technological development of renewable and sustainable energy such as waste to energy (WtE) is necessary. Solid refused fuel (SRF) mainly consists of combustible matter which is derived from municipal solid waste by separation process, and heat content was maximized by intensive drying process. Combustible matter in SRF contains plastics fraction to increase calorific value. In this study, commercial SRF boiler with 100MW capacity was selected to investigate corrosion issue in boiler tube and convection pass. Usually, chlorine content of fuel occur boiler tube corrosion, and alkali metals such as K, Na, Ca occur slagging and fouling. Based on the fuel analysis, the average chlorine content of SRF was 1.32%. In XRF analysis, the chlorine content in boiler tube ash and bottom ash was 6.1% and 4.3%, respectively. In SEM-EDX analysis, the chlorine content in corrosion part on boiler tube was ranged from 11.95% to 30.52%. Figure 1 shows the corrosion part of boiler tube and facility location which was occurred alkali-chlorine corrosion.

OXY-FUEL CO-COMBUSTION OF WASTE SLUDGE AND BIOMASS USING A CIRCULATING FLUIDIZED BED

Ha-Na Jang(장하나),Jin-Ho Sung(성진호),Seung-Ki Back(백성기),Jeong-Hun Kim(김정훈),Yong-Chil Seo(서용칠) 한국환경에너지공학회 2020 열환경공학 Vol.15 No.2