롤러스케이트 선수의 운동상해발생과 예방에 대한 조사 연구

김동희,김도수,채양석,이하얀,김선호,조성채 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

The study was intended to research the fact of roller skate players injury. For the study, kinds and parts of injuries, skills to be hurted, facility, injured time, cause, remedy, mental response and protecting were investigated through 182 roller skate players. The results were as follows : 1. The injury body part was showed that leg was the highest and followed by knee and ankle. 2. In the cause of injury was showed as follows: skills on corner work, bank track with concrete, 200m distance. 3. In the general cause of injury was showed: chronic fatigue by over training. 4. In the treatment and participation period after injury outbreak were showed: treatment period was toward the inside 1 week and participation to play during the treatment. 5. To the injury prevention players responded warm up, and cool down and mental-concentration were needed. Supervisor, coach and players responded knee protector wearing was needed in elementary school players and helmet-chin protector wearing in general players. The game rule revision was not necessary and the agree and disagree for ground unity to resemble. Almost players to be like concrete ground.

마라톤 완주가 남자선수의 성선 및 부신 축 호르몬에 미치는 영향

김동희,이하얀,김현우 한국운동과학회 2003 운동과학 Vol.12 No.1

윤진환, 이희혁, 정경훈, 김종오, 류성환, 정일규, 김영표, 오봉석, 운동이 노화된 흰쥐 췌장 랑게르한스섬의 형태학적 변화에 미치는 영향. 운동과학, 제 12권 제1호, 115-122, 2003. 본 연구는 운동이 노화 흰쥐 췌장의 랑게르한스섬의 형태학적 변화에 어떠한 영향을 미치는 가를 알아보는 것으로 22주령의 Sprague-Dawley계 흰쥐 수컷 12마리를 이용하여 통제그룹(n=6)과 운동그룹(n=6)으로 분류하여 실시하였다. 운동근은 주당 5일씩 4주 동안 운동을 실시하였다. 본 연구 결과를 요약하면, 운동전보다 운동후 체중은 감소하는 경향을 보였으나 유의한 차이는 없었다. 췌장 랑게르한스섬의 형태학적 변화를 알아보기 위해 Hematoxylineosin 염색을 실시한 결과 두 그룹간에 유의한 차이를 보이지는 않았다. 하지만 통제군에 비해 운동군의 췌장 랑게르한스섬이 더 약한 위축현상을 보였다. 췌장 ß-세포수가 더 높았음을 확인하였다. 결론적으로 본 연구결과는 운동이 노화 흰쥐의 여러 형태학적인 변호에 긍정적인 영향을 미칠 수 있음을 제시하고 있다. Yoon, J.H., Lee, H>H>, Chung, K.H., Kim, J.O., Ryu S.H., Jeong, I.G., Kim, Y.P., Oh, B.S. Effects of exercise on morphological change of pancreatic Langerhans in aging rats. Exercise Science, 12(1): 115-122, 2003. The purpose of this present study was to investigate the effect of exercise on morphological change of pancreatic islets aging rats. Twelve male Sprague-Dawley rats (22 weeks old) were used as subjects. The subjects were divided into 2 groups as control group, exercise group. Animals of the exercise group were put on running 5 days per week for 4 weeks. The conclusion of this study follows as below: Weight gain of the rats was decreased, but was not showed significantly between two groups. Hermatoxylineosin stains of pancreatic islets of exercise group was similar to those of control group, but mild atrophy of pancreatic islets was shown exercise group compared to control group. Gomori's addehyde fuchin stains of pancreatic β-cells of exercise group was shown higher than control group. In the present study, it can be suggested that exercise may modulate beneficial effects on many morphological functions in aging rats.

<i>GSTT1</i> as a Prognosticator for Recurrence and Progression in Patients with Non-Muscle-Invasive Bladder Cancer

Ha, Yun-Sok,Yan, Chunri,Lym, Min Su,Jeong, Pildu,Kim, Won Tae,Kim, Yong-June,Yun, Seok-Joong,Lee, Sang-Cheol,Moon, Sung-Kwon,Choi, Yung Hyun,Kim, Wun-Jae IOS Press 2010 Disease markers Vol.29 No.2

<P>Although polymorphisms in glutathione S-transferase (GST) have been associated with the risk of bladder cancer (BC), few reports provide information about the development of BC. The aim of the present study was to investigate the effect of homozygous glutathione S-transferase-μ (GSTM1) and glutathione S-transferase-&phis; (GSTT1) deletions as prognostic markers in non-muscle-invasive bladder cancer (NMIBC). A total of 241 patients with primary NMIBC were enrolled in this study. GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction (PCR) using blood genomic DNA. The results were compared with clinicopathological parameters. The prognostic significance of the GSTs was evaluated by Kaplan-Meier and multivariate Cox regression model. A statistically significant association between genotype and histopathological parameter was not observed. The patients with the GSTT1-positive genotype had significantly reduced recurrence- and progression-free survival than those with the GSTT1-null genotype (log-rank test, <I>p</I> < 0.05, respectively). Recurrenceand progressionfree survival were not related to the GSTM1 genotypes. In multivariate regression analysis, the GSTT1positive genotype was the independent predictor for recurrence [hazard ratio (HR), 1.631; <I>p</I> = 0.043] and progression (HR, 3.418; <I>p</I> = 0.006). These results suggested that the GSTT1 genotype could be a useful prognostic marker for recurrence and progression in NMIBC. </P>

Pretreated fucoidan confers neuroprotection against transient global cerebral ischemic injury in the gerbil hippocampal CA1 area via reducing of glial cell activation and oxidative stress

Kim, Hyunjung,Ahn, Ji Hyeon,Song, Minah,Kim, Dae Won,Lee, Tae-Kyeong,Lee, Jae-Chul,Kim, Young-Myeong,Kim, Jong-Dai,Cho, Jun Hwi,Hwang, In Koo,Yan, Bing Chun,Won, Moo-Ho,Park, Joon Ha Elsevier 2019 BIOMEDICINE AND PHARMACOTHERAPY Vol.109 No.-

<P><B>Abstract</B></P> <P>Fucoidan is a sulfated polysaccharide derived from brown algae and possesses various beneficial activities, including antioxidant property. Previous studies have shown that fucoidan displays protective effect against ischemia-reperfusion injury in some organs. However, few studies have been reported regarding the protective effect of fucoidan against transient cerebral ischemic insults and its related mechanisms. Therefore, in this study, we examined the neuroprotective effect of fucoidan against transient global cerebral ischemia (tGCI), as well as underlying its mechanism using a gerbil model of tGCI which shows a loss of pyramidal neurons in the hippocampal cornu ammonis 1 (CA1) area after 5 min of tGCI. Fucoidan (25 and 50 mg/kg) was intraperitoneally administered once daily for 5 days before tGCI. Pretreatment with 50 mg/kg of fucoidan, not 25 mg/kg of fucoidan, attenuated tGCI-induced hyperactivity and protected CA1 pyramidal neurons from tGCI. In addition, pretreatment with 50 mg/kg of fucoidan inhibited activations of astrocytes and microglia in the ischemic CA1 area. Furthermore, pretreatment with 50 mg/kg of fucoidan significantly reduced the increased 4-hydroxy-2-noneal and superoxide anion radical production in the ischemic CA1 area and significantly increased expressions of SOD1 and SOD2 in the CA1 pyramidal neurons before and after tGCI. Additionally, treatment with diethyldithiocarbamate (an inhibitor of SODs) to the fucoidan-treated gerbils notably abolished the fucoidan-mediated neuroprotection. In brief, our present results indicate that fucoidan can effectively protect neurons from tGCI through attenuation of activated glial cells and reduction of oxidative stress via increase of SODs. Thus, we strongly suggest that fucoidan can be used as a useful preventive agent in cerebral ischemia.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pretreatment with fucoidan protects CA1 pyramidal neurons from ischemic damage. </LI> <LI> Pretreated fucoidan inhibits activation of glial cells in ischemic CA1 area. </LI> <LI> Pretreated fucoidan attenuates oxidative stress in CA1 area after ischemic insult. </LI> <LI> Pretreated fucoidan increases SODs expressions in ischemic CA1 pyramidal neurons. </LI> <LI> Fucoidan-mediated neuroprotection is abolished by DDC (SODs inhibitor) treatment. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

LC : Clinicopathologic performance for histologic activity of chronic viral hepatitis and Liver fibrosis (초)

( Ha Yan Kang ),( Won Ae Lee ),( Hoon Choi ),( Soung Min Jeon ),( Sung Hoon Moon ),( Hyun Duk Shin ),( Suk Bae Kim ),( Jeong Eun Shin ),( Hong Ja Kim ),( Il Han Song ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)

Ideal Blood Pressure in Patients With Atrial Fibrillation

Kim, Daehoon,Yang, Pil-Sung,Kim, Tae-Hoon,Jang, Eunsun,Shin, Hyejung,Kim, Ha Yan,Yu, Hee Tae,Uhm, Jae-Sun,Kim, Jong-Youn,Pak, Hui-Nam,Lee, Moon-Hyoung,Joung, Boyoung,Lip, Gregory Y.H. Elsevier 2018 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - Vol.72 No.11

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>The 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline for High Blood Pressure in Adults redefined hypertension as systolic blood pressure (BP) ≥130 mm Hg or diastolic BP ≥80 mm Hg. The optimal BP for patients with atrial fibrillation (AF) is uncertain.</P> <P><B>Objectives</B></P> <P>The goal of this study was to investigate the impacts of the 2017 ACC/AHA guideline and to determine the ideal BP threshold for the management of high BP in patients with AF.</P> <P><B>Methods</B></P> <P>This study analyzed data for 298,374 Korean adults with oral anticoagulant–naive, nonvalvular AF obtained from the National Health Insurance Service database from 2005 to 2015.</P> <P><B>Results</B></P> <P>According to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure guideline, 62.2% of the individuals in our sample had hypertension. After applying the 2017 ACC/AHA guideline, 79.4% had hypertension, including 17.2% with newly redefined hypertension (130 to 139/80 to 89 mm Hg). Those with newly redefined hypertension had greater risks of major cardiovascular events (hazard ratio: 1.07; 95% confidence interval: 1.04 to 1.10; p < 0.001), ischemic stroke, intracranial hemorrhage, and heart failure admission, compared with nonhypertensive patients (<130/80 mm Hg). Among patients with AF undergoing hypertension treatment, patients with BP ≥130/80 mm Hg or <120/80 mm Hg were at significantly higher risks of major cardiovascular events than patients with BP of 120 to 129/<80 mm Hg.</P> <P><B>Conclusions</B></P> <P>Patients with AF and newly redefined hypertension according to the 2017 ACC/AHA guideline were at higher risk of major cardiovascular events, suggesting that the new BP threshold is beneficial for timely diagnosis and intervention. BP of 120 to 129/<80 mm Hg was the optimal BP treatment target for patients with AF undergoing hypertension treatment.</P> <P><B>Central Illustration</B></P> <P>[DISPLAY OMISSION]</P>

Hydroquinone Strongly Alleviates Focal Ischemic Brain Injury via Blockage of Blood–Brain Barrier Disruption in Rats

Ha Park, Joon,Yoo, Ki-Yeon,Hye Kim, In,Cho, Jeong-Hwi,Lee, Jae-Chul,Hyeon Ahn, Ji,Jin Tae, Hyun,Chun Yan, Bing,Won Kim, Dae,Kyu Park, Ok,Kwon, Seung-Hae,Her, Song,Su Kim, Jin,Hoon Choi, Jung,Hyun Lee, Oxford University Press 2016 TOXICOLOGICAL SCIENCES Vol.154 No.2

<P>Hydroquinone (HQ), a major benzene metabolite, occurs naturally in various plants and is manufactured for commercial use. Although HQ displays various biological effects, its neuroprotective effects following ischemic insults have not been investigated. In this study, we first examined neuroprotective effects of HQ in a rat model of transient focal cerebral ischemia. Animals were subjected to transient middle cerebral artery occlusion for 120 min. HQ (50 or 100 mg/kg) or vehicle was intraperitoneally administered once at 30 min after ischemia-reperfusion. Neuroprotection by treatment with 100 mg/kg of HQ was shown using evaluation of neurological deficits, positron-emission tomography (PET) and 2,3,5triphenyltetrazoliumchloride (TTC) staining. In addition, HQ treatment significantly attenuated ischemia-induced Evans blue dye extravasation from blood vessels and significantly increased immunoreactivities of SMI-71 (an endothelial BBB marker) and glucose transporter-1 (GLUT-1, an endothelial cell marker) in ischemic cortex compared to the vehicle-treated ischemia-operated group. Confocal microscopy and western blot analysis also showed that HQ treatment maintained expressions of tight junction proteins (zonula occludens-1 and occludin) in the ischemic cortex. Post-treatment with HQ protected neurons from transient focal cerebral ischemic injury and the neuroprotective effect of HQ might be closely associated with prevention of BBB disruption via maintaining SMI-71 and GLUT-1 expressions as well as prevention of the degradation of zonula occludens-1 and occludin proteins.</P>

Case Report : Ruptured duodenal varices arising from the main portal vein successfully treated with endoscopic injection sclerotherapy: a case report

( Ha Yan Kang ),( Won Kyung Lee ),( Yong Hyun Kim ),( Byung Woon Kwon ),( Myung Soo Kang ),( Suk Bae Kim ),( Ii Han Song ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.2

Duodenal varices result from retroperitoneal portosystemic shunts that usually come from the pancreaticoduodenal vein and drain into the inferior vena cava. Because they are a rare but fatal cause of gastrointestinal bleeding, a prompt hemostatic intervention is mandatory. A 62-year-old man who had a history of excessive alcohol consumption presented with massive hematemesis and melena. Emergent endoscopy revealed ruptured varices with an adhering whitish fibrin clot on the postbulbar portion of the duodenum. Abdominal computed tomography demonstrated a cirrhotic liver with venous collaterals around the duodenum and extravasated contrast in the second and third portions. The collaterals originated from the main portal vein and drained via the right renal vein into the inferior vena cava. Endoscopic injection sclerotherapy with cyanoacrylate was successful in achieving hemostasis, and resulted in the near eradication of duodenal varices at a 6-month follow-up.

<i>GSTM1</i> Tissue Genotype as a Recurrence Predictor in Non-muscle Invasive Bladder Cancer

Ha, Yun-Sok,Yan, Chunri,Jeong, Pildu,Kim, Won Tae,Yun, Seok-Joong,Kim, Isaac Yi,Moon, Sung-Kwon,Kim, Wun-Jae The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.2

<P>Tissue genotyping is more useful approach than using blood genomic DNA, which can reflect the effects of the somatic mutations in cancer. Although polymorphisms in glutathione S-transferase (<I>GST</I>) have been associated with the risk of bladder cancer (BC) development, few reports provide information about the prognosis of BC. We investigated glutathione S-transferase mu (<I>GSTM1</I>) and glutathione S-transferase theta (<I>GSTT1</I>) genotypes using genomic DNA from primary 165 BC tissue samples to assess the association with disease prognosis. DNA samples from tumor were analyzed by multiplex polymerase chain reaction (PCR). The results were compared with clinicopathological parameters. The prognostic significance of the <I>GST</I>s was evaluated by Kaplan-Meier and multivariate Cox regression model. Kaplan-Meier estimates revealed significant differences in time to tumor recurrence according to the <I>GSTM1</I> tissue genotype (<I>P</I> = 0.038) in non-muscle invasive bladder cancer (NMIBC). Multivariate Cox regression analysis also revealed that the tissue <I>GSTM1</I> genotype (hazards ratio [HR]: 0.377, <I>P</I> = 0.031) was an independent predictor of bladder tumor recurrence in NMIBC. This identification of <I>GSTM1</I> tissue genotype as a prognosticator for determining recurrence in NMIBC should prove highly useful in a clinical setting.</P>

Changes of Physicochemical components and antioxidant activity of Gastrodina eleta Blume during its processing

Ha-Yan Kim,Yuri Lee,Eun-Jeong Jeong,Hyun A Kim,Yong-Seob Jeong 한국식품영양과학회 2013 한국식품영양과학회 학술대회발표집 Vol.2013 No.11