열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

국내산 식물의 항균활성 검색

최원균,김용성,조규성,성창근 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.4

한국에서 자생하는 125종의 식물에서 추출한 141가지 메탄올 추출물들에서 식품부패미생물인 Bacillus subtillis, Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes 그리고 Pseudomonas aeruginosa에 대한 항균 활성도를 조사하였다. Bacillus subtillis에 대해 가장 강한 항균력을 보인 것은 오미자였으며 staphylococcus aureus 에 대해서 대황이, Pseudomonas aeruginosa에 대해서는 산사가 가장 강한 항균력을 나타냈다. 금은화는 Bacillus subtilis를, 산사는 Stophylococcus aureus를, 모과와 황금은 Pseudomonas aeruginosa를, 모감주나무꽃, 밤나무꽃, 장미꽃과 파꽃은 Enterobacter aerogenes를, 오미자는 Escherichia coli를 제외한 나머지 4가지 균주에 모두 항균력이 있었다 141 methanol extracts from 125 plant species which populate in Korea were screened for antimicrobial activity against various food-borne pathogens and food spoilage microorganisms. Those plants were selected from 3 different plant groups : traditional herbs, edible plants and flowers. The methanol extracts were tested by using the disk diffusion assay against five bacteria : Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli. From the evaluation of the inhibition zone diameter of microbial growth, the most significant antimicrobial activity against bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli was observed from the extract of Schizandra chinensis (Turcz) Baill., Rheum officinale Baill., Schizandra chinesis (Turcz) Baill., Koelreuteria paniculata Lax and Crataegus pinnatifida Bunge, respectively. The extract from many plants - Koelreuteria paniculata Lax, Chaenomeles sinensis Koehne, Scutellaria bacicalensis Georgi, Castanea crenata Sieb. et Zucc., Rosa centifolia L;, Allium fistulosum L. var. giganteum Makino, Crataegus pinnatifida Bunge, Schizandra chinensis (Turcz) Baill., Lonicera japonica - showed antimicrobial activity all four tested bacteria.

고출력 다이오드 레이저를 이용한 SKD11 표면 열처리 특성

최성대,정선환,양승철,김잠규 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

An experimental investigation with high power diode laser system was carried out to study the effect of surface heat treatment on the SKD11. The surface heat treatment characteristics of the laser beam were evaluated using hardness tests, optical microscopy, X-ray diffraction and energy dispersive X-ray spectroscopy(EDS). Results indicated that the Hardness were changed by beam size, focal length, feed rates. The micro grain structure was observed retained austenite grain at hardened zone and globular cementite grain at fine grain zone and base metal zone by optical microscopy. The intensive X-ray diffraction patterns of (110)-(200)-(211) was detected on the surface and the hardened surface intensity level was bigger than the unhardened surface. The intensive X-ray diffraction patterns of (110)-(200)-(211) was detected hardened surface and the hardened surface distributed plenty of carbon density than metal zone.

폐모세포종 : 1례보고 A Case Report

최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.

이란산 흑석류 농축액과 그 제품의 성분 및 함유된 Phyto 에스트로겐류에 관한 연구

최원균,정교순,조규성,황명오,유영숙 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.2

천연 호르몬 보충 제제의 개발을 위한 기초 연구로 이란산 흑석류 과즙 농축액과 이를 이용한 제품의 화학성분들을 분석하였다. 석류 농축액의 일반성분은 수분 39.3%, 조지방 0.4%, 조단백질 0.9%, 조회분 1.4%, 그리고 탄수화물은 42.0%이었다. 아미노산 함량은 글루탐산이 1310.Oppm, 아스파르트산이 896.2ppm, 아르기닌이 877.7ppm, 페닐알라닌이 57.5ppm순으필 무기 성분들은 철분 6640.Oppm, 염소 3464.Oppm, 칼륨 2550.8ppm, 인 150.Oppm, 칼슘 80.Oppm 순으로 많이 함유되 어 있었다 비타민은 5가지의 수용성 비타민이 함유되어 있었으며 그 중 비타민 C(20mg/100g)를 제외한 나머지 비타민들이 아주 적은 양이 있었다. 주요 지방산은 palmitic acid(8.3%)와 stearic acid(69.4%)로 전체 지방산의 약 60~80%를 차지하고 있었다. 또한 6종의 phyto및 에스트로겐류가 들어 있었으며 각각daidzein 23.72ppm, quercetin 9,75ppm, catechin 1.48ppm, genistein 0.29ppm, 2,3-di-MeO-estradiol이 0.04ppm, 그리고 17β-에스츠라디올이 0.15ppm이 함유되어 있었다. 이상의 결과들을 석류 농축액으로 제조한 제품 포에버 120과 칡과 대두 isoflavon 농축분말과 비교하다. Phytoestrogens are non-steroidal compounds found in a variety of plants, which exert estrogenic effects in animals. In this study, the physico-chemical properties of Iranian black pomegranate extract and its products as preliminarily research for the developing of natural estrogen supplement were evaluated. The chemical components of Iranian black pomegranate extracts and its product (Forever 120) were analyzed. Proximate compositions of pomegranate extracts were as follows; crude lipid 0.4%, crude protein 0.9%, crude ash 1.4% and carbohydrate 42.0%. Major amino acids of pomegranate extracts are glutamic acid (1310.Oppm), aspartic acid (896.2ppm), arginine (877.7ppm) and phenylalanine (57.5ppm). Fatty acid compositions of pomegranate extract lipid extracted by chloroform-methanol (2:1) were myristic (13.1%), stearic (69.4), oleic acid (6.8%) and palmitic acid (8.3%). Mineral elements were ferrous (6640.Oppm) and potassium (2550.8ppm). Vitamins were composed of ascorbic acid(20.Omg/100g), Vit. B_1 (0.12mg/100g) and niacin (0.80mg/100g), 20 phytoestrogens and 20 estrogens of pomegranate extracts were detected Daidzein (0.29ppm), quercetin (9.75ppm) genistein (0.29ppm) and 17 β-estradiol(0.15ppm). Above the chemical components of pomegranate extracts were compared with that of pome granate its product or other isoflavon concentrates.

한의 진단의 추론 형식과 실재성

박경모,최승훈,안규석 현곡학회 1997 제3의학 Vol.2 No.1

DFSS에 의한 FPD용 높이 조절기구 설계

정선환,최성대,조규열 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

This study was carried out to minimize the lifting force and to design the slim sized frame of a height adjustment mechanism. This unit is designed for the display devices in order to enhance the ergonomics for effective height adjustment as well as to achieve much slimmer frame for the pedestal. A tolerance analysis of 6 sigma was applied to achieve smooth lift at design stage not to change the tolerance specification of gap several times in a roller type of lifting mechanism at mass production stage. The specification of minimum gap and the target of production yield ratio were agreed with a quality team before tooling. A DFSS simulation on drawings had been done with reasonable tolerance and achievable standard deviation(σ) several times until the target spec of gap and yield ratio was met. Once tolerance and deviation(σ) were fixed tooling start was done successfully. A CAE method was applied to achieve a slim design. Design parameters were frozen when those parameters matched the reference strength data of standard model. Through those tolerance analysis and CAE simulation the number of tool modification was reduced and production yield ratio was raised up without arguing quality specification at production stage in the end.

감초(Glycyrrhiza uralensis Fisch) 추출물이 밀가루 물성 및 빵의 품질에 미치는 영향

조남지,최영주,조규성 안성산업대학교 1995 論文集 Vol.27 No.-

甘味 添加劑로서 甘草 엑기스를 제빵제조시 添加했을 때 반죽물성과 제품품질에 미치는 影響을 측정하기 위하여 farinograh, Extensograph, Amylograph를 측정하였고, 발효팽창력, 내상, 비용적, 관능검사 등을 조사하였다. 1. 사용한 甘草의 일반성분으로는 수분 73.7%, 조단백 4.1%, 조지방 2.8%, 조회분 1.4%였다. 2. 甘草 추출물의 添加量이 많을수록 Farinogram 측정에 있어서 수분 흡수율, 도착시간, 반죽 형성시간과 기계내성지수의 값은 커졌으며 안정도는 낮아졌다. 바로리메타값은 크게 영향을 받지 않았다. 3. Extensograph 측정에 있어서는 甘草 추출물의 添加量이 증가함에 따라 신장저항도는 증가되고 신장도는 줄어들었다. 4. Amylograph 측정에 있어서는, 호화개시온도나 최고점도시 온도는 농도의 변화에 큰 차이가 없었으나, 최고점도는 甘草 추출물이 1.0% 이상시 크게 떨어지는 현상을 보였다. 5. 발효 팽창은 添加劑 증가시 감소되는 경향을 보였으며 비용적도 감소하였다. 6. 빵의 내관은 添加劑 증가시 더욱 거칠어지고, 조밀해졌으며 firmness의 증가가 뚜렷하였다. 7. 관능검사는 添加劑의 증가시 낮은 점수를 받았다. This study is to investigate the effect on the quality and properties of bread affected by licorice extract addition. The measurements of the farinograph, extensograph and amylograph on dough are cried out. And the evaluations of volumetric changes during fermentation, shape of bread crumb, sensory test, firmness are obtained results are as follows. 1. Proximate compositions of licorice extract are as follows : moisture 73.7%, crude protein 4.1%, crude lipid 2.8%, crude ash 1.4%. 2. Water absorption, arrival time, dough development time, mechanical tolerance index and valorimeter value are increased but stability is decreased with the addition of licorice extract. 3. The resistance to extension is increased but extensibility is decreased with the addition of licorice extract. 4. The initial pasting and highest viscosity temperatures are not affected but the highest viscosity is steeply decreased over 1.0% addition of licorice extract. 5. The volume of dough during fermentation and specific volume of bread is decreased with the addition of licorice extract. 6. The grain of bread is to be rough and irregular and the firmness is increased with the addition of licorice extract. 7. The records of sensory test are decreased with the addition of licorice extract.

초내열합금 B1900의 미세조직과 인장특성에 미치는 고온노출의 영향

김인수,최백규,서성문,조창용 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.7

Influence of thermal exposure on microstructural evolution and tensile properties of Ni-base superalloy B1900 has been investigated. Phase transformations during thermal exposure and their effects on tensile behavior of the alloy have been analyzed by microstructural observations. Considerable amount of acicular type M_(6)C carbide precipitated in the interdendritic regions (including γ/γ' eutectic) and in the vicinity of MC carbide as a result of thermal exposure above 871°C. Thermal exposure also assisted precipitation of small discrete M_(23)C_(6) carbide which is hard to be found in the alloy. Thermal exposure deteriorated tensile properties of the alloy. The effect of M_(6)C precipitation on the tensile properties of the alloy is not clear. However, degradation of tensile properties of the alloy is primarily attributed to the coarsening of y' phase during thermal exposure. While the localized deformation bands were observed in the as-cast tensile specimen due to shearing of γ' particle, dislocation network formed at γ/γ'interface in the thermally exposed tensile specimen.

표면근전도와 적외선체열촬영을 이용한 요통의 평가

이강진,최인성,이소영,한재영,이삼규,채홍재,이성과,문재동 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.3

목적 : 요통환자에서 요통의 유무와 강도를 평가하고자 표면근전도를 이용하여 근육 활동성의 차이를 검증하였고 적외선체열촬영을 이용하여 제표면 온도의 변화를 측정하였다. 방법 : 요통환자군 16명과 대조군 16명에 대하여 요부에 부착한 표면전극에서 얻은 근전도 신호와 적외선체열촬영 결과를 비교하였다. 교란요인의 영향을 배제하기 위하여 연령과 성별 그리고 비만도에 따라 정상 대조군과 요통환자군을 짝짓기하여 각각 16명씩 선정하였다. 결과 : 정적표면근전도 실시 결과 우측의 경우 중앙값이 요통환자군에서 198.1 ㎶, 정상대조군에서는 161.3 ㎶로 통계적으로 유의한 차이가 있었고(p<0.01), 좌측은 요통환자군에서 194.2 ㎶, 정상대조군에서 180.5 ㎶로 유의한 차이는 없었다. 동적표면근전도 실시 결과 재신전시와 굴곡시 근전위의 비가 우측의 경우 요통환자군에서 중앙값이 1.12였고 정상 대조군은 1.39로서 두 군간에 유의한 차이가 있었고(p=0.027), 좌측의 경우도 요통환자군에서는 1.08이었고 정상 대조군에서는 1.21로 유의한 차이가 있었다(p=0.036). 적외선체열촬영결과 ΔT가 0.5 ℃ 이상의 차이가 있을 때 이상이 있는 것으로 정하면, 요통환자군에서는 16명 모두 이상자로 판정되었고, 정상 대조군에서는 16명중 3명이 이상자로 판정되어 민감도는 100 %, 특이도는 81.3 % 였다. 표면근전도를 이용한 요통의 진단은 민감도가 78.6 %이고 특이도가 72.2 %였으며, 적외선체열촬영은 민감도가 100 %였고 특이도가 87.5 %였다. 결론 : 이러한 결과로 볼 때 표면근전도 검사법과 적외선체열촬영은 요통을 간접적으로 평가하는데 도움이 되는 검사법이며, 적외선체열촬영이 표면근전도검사법에 비하여 보다 정확한 검사법으로 판단된다. Objectives : We studied the efficacy of surface electromyography(SEMG) and digital infrared theimographic imaging (DITI) in the assessment of low back pain both(LBP) Methods : We compared electromygraphic signals from electrodes placed in the lumbar area and the digital theimographic images in 16 LBPpatients and 16 control subjects. The LBP patients and the control subjects were matched for age, gender, and body mass index(BMI) to adjust for any confounding effects Results : In the static analyses of SEMG, median value was 198.1 ㎶ for the controls on the right side, and they were 194.2 ㎶ and 180.5㎶ on left side respectively. There was a statistically significant difference between the two groups on the right side(p<0.01), but not on the left side. In the dynamic analyses of the SEMG, the median values of the extension per flexion ratio of right side were 1.12 for LBP patients and 1.39 for controls. and those on the left side were 1.08 and 1.21 respectively. There were statistically significant differences in both sodes(p<0.05). The sensitivity and specificity were 100% and 81.3% in DITI, 78.6% and 72.2% in SEMG. Conclusions : These results indicate that SEMG and DITI are useful methods for indirect assessments of LBP, and that DITI is more sensitive and specific than SEMG.