희귀 진세노사이드 Rg6, Rg4, Rk3 및 Rh4의 효능 연구

정규진, 이지현, 조수현, 송규용 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

The research on the efficacy of rare ginsenosides in comparison to that of major ginsenosides has not been performed systematìcally and is insufficient, Therefore, with based on the literature survey, the efficacy of the rare ginsenosides, such as Rg6, Rg4, Rk3, and Rh4, is reviewed, and the direction for further research is presented. Sìnce ginsenosides Rg6, Rg4, Rk3, and Rh4 show very diverse and strong activities in various disease models, such as antioxidant activity, anticancer activity, immunity enhancing activity, antì-microbial activity, etc., it can be strong potential candidates as new materials derived from natural materials for pharmaceuticals, cosmetics. and food industry. However, most research is limited to the in-vitro efficacy. Therefore, to systematically investigate the in-vivo effìcacy of individual ginsenosides is required for the application of the ingredients. To do that, it is essential to establish standardized mass production and iso-lation method for individual rare ginsenosides

STD-11 와이어 컷 방전가공시 가공조건에 따른 북현상 고찰

조규재,김선진,조상현,김훈희 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.2

From the experimental study of W-EDM for alloyed steel STD-11, the characteristics such as Hand Drum Form and surface roughness have been observed and evaluated for various conditions. In square hole, the increase of IP as to made condition, the calculate high value of surface roughness. Also compare dimensionless square hole with circle hole' graph. In circle hole, if a value of surface roughness IP 6 in a side of circle it show a 0.4㎛ and in IP 8, 0.6㎛, in IP 10, 0.7㎛, in IP 12, 0.8㎛ higher than before. This figure show the surface roughness is higher than before, because a table move in either X-axis or Y-axis in square hole, on the contrary, in circle there table move in X-axis and Y-axis at the same time, hand drum form getting small when wire tension increase 1000gf to 1500gf, at the same working conditions, the smaller of off time, the maller of hand drum form in same condition and same wire tension. but if you compare square hole with circle hole' graph, hand drum form displayed in maintained term of working condision, on the contrary, in case of square hole variation of hand drum form is more increase than a grow of IP

SVD 알고리즘 및 HMM을 이용한 얼굴 및 눈 패턴 검출

진경찬,김명남,신장규,손병기,조진호 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

The studies about automatic pattern detection of the eye and face from the human image acquired by the CCD image sensor have good applicabilities in the industry, home automation, and data communication field. In general, pattern detection method consists of feature based matching and template matching. In feature based matching, the feature vector is extracted with DLM(dynamic linking matching), EBGM(elastic bunch graph matching), HMM(hidden markov model) matching and knowledge based matching using statistical characteristics. In template matching, in general, the template vector is extracted with PCA(principal component analysis). When these method applied in the face and eye detection, each method has its own merits and some disadvantage. Therefore, by combined utilization of SVD(singular value decomposition) and HMM algorithm, is expected that we can selectively make use of each methods advantage and it result in improved detection accuracy. In this paper, we proposed the method for face and eye detection, which was combined by the two algorithms, to be suitable for the high speed image processing using DSP chip or microprocessor. In the beginning, template matching was followed by a template extraction using batch SVD algorithm and then face pattern was classified and recognized by HMM algorithm which is one of feature based matching technique. Finally, eye pattern detection was performed by pattern search neural network utilizing eigeneye image.

오스템퍼링한 구상흑연주철(ADI)의 드릴 가공시 경도 및 현미경조직변화에 관한 연구

조규재,장우양,심재기,홍성오,김선진 한국공작기계학회 1999 한국생산제조학회지 Vol.8 No.1

This paper was carried out to know the influence of advanced austempered ductile cast iron (ADI) on the tool life and mechanical properties of drilling machinability. For manufactured method of ADI, the spheroidal graphite cast iron were austenized at 900℃ for 1 hour and then austempered for 2 hour at 370℃ in the salt bath. And interrelationship has been investigated between tool life and mechanical characteristics of specimen material on drilling condition when the ordinary and step-feed drilling are carried out to drill holes of specimens. Tensile strength and hardness of ADI decrease and elongation of ADI increases with the increase austempered temperature. It is known that about 2 times of tool life in the case of step-feed decreases compared with ordinary feed due to the high hardness of ADI and hardness ascribed to the fact that retained austenite beame to martensite state due to cutting heat in drilling. Under the constant feed rate 0.1㎜/rev relation between hardness and length of end tip after drilling can be formularized to Hv=788.46L^-0.096 for the cutting speed 6.1m/min.

역전파 신경회로망을 이용한 가공조건에 따른 STD-11 절단면의 신뢰성 평가

김선진,성백섭,조규재,김하식,반제삼 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.5

The purpose of this study was to present the method to choose the optimum machining condition for the wire EDM. This was completed by examining the ever-changing quality of the material and by improving the function of the wire electric discharge machine. Precision metal mold products and the unmanned wire electric discharge machining system were used and then applied in industrial fields. This experiment uses the wire electric discharge machine with brass wire electrode of 0.25mm. To measure the precision of the machining surface, average values are obtained from 3 samples of measures of center-line average roughness by using a third dimension gauge and a stylus surface roughness gauge.

CCA 처리재로부터 방부제 유효성분의 용제추출

김규혁,공일곤,나종범,조재성,김재진 한국목재공학회 2003 목재공학 Vol.31 No.4

본 연구는 CCA 처리재로부터 방부제 유효성분을 추출하기 위한 적정 용제를 선정하고, 선정된 용제의 최적추출조건을 평가하기 위 해 수행되었다. 추출수율과 용제의 사용 및 환경 안전성을 고려할 때, 과산화수소가 CCA유효성분을 추출하는 데 가장 적절한 용제로 선정되었다. 과산화수소를 이용한 추출 결과. 추출온도, 추출용제농도, 추출시간 간에 상호작용이 존재하였으나 추출온도와 추출용제의 농도가 높을수록, 그리고 추출시간이 연장될수록 CCA유효성분의 추출수율은 증가되었다. 경제적인 측면을 고려할 때 가능하면 낮은 농도의 추출용제를 사용하여 저온에서 추출하여야 하나, 이 경우에는 필요한 추출수율을 달성하기 위한 추출시간이 상당히 길어지기 때문에 40℃ 이상의 온도에서 추출이 바람직하며 사용할 추출용제의 농도는 추출시간을 고려하여 최종적으로 결정하여야 된다고 사료된다. This research was performed to select an appropriate agent to extract preservative components from CCA-treated wood, and then to evaluate the effect of reagent concentration, extracting temperature, and CCA-treated wood, and then to evaluate the effect of reagent concentration, extracting temperature, and extracting time on the removal of chrome, copper, and arsenic from treated wood. Hydrogen peroxide was selected as the best extracting agent when considered extraction yield as well as use and environmental safety. Its extraction yield was dependent on extracting variables (temperature, concentration, and time), and a highly significant interaction existed among variables. It should be possible to optimize extraction by manipulating these extracting variables. The results may suggest that the required temperature conditions for the reasonable removal of CCA components are at least above 40℃ because extracting time is too long at low temperature (20℃). Reagent concentrations for extracting at above 40℃ should be decided by considering the extracting time.

응급실을 통한 정신과 입원환자에 대한 임상적 고찰

정영조,김진규 인제대학교 1992 仁濟醫學 Vol.13 No.4

본 연구는 1987년 1월 1일 부터 1989년 12월 31일까지 서울백병원 응급실을 통해 신경정신과에 입원한 환자 170례를 대상으로 병력지를 분석정리하여 응급실 및 외래를 통한 입원환자의 재입원 환자수의 비교, 평균재원일수의 비교, 진단별 분류, 응급실 내원 동기, 퇴원시 치료 반응 등을 분석, 연구하였다. The authors investigated the clinical characteristics of 170 neuropsychiatric patients admitted to Seoul Paik Hospital via the E.R. from January 1, 1987 to Decemenber 31, 1989. The results were as follows : 1.The proportion of patients admitted via the E.R. was 23.7% of total neuropsychiatric admissions. 2.The readmission proportin of patients admitted via the E.R. was 32.4% which was higher than the readmission proportion of 24.7% of patients admitted 1 via the O.P.D 3.The average duration of hospitalization of neuropsychiatric patients admitted via the E.R. was 39.4 days which was shorter than the average duration of 48.6 days for patients admitted via the O.P.D. 4.53% of the emergency admission patients were in their twenties or thirties in age. Male to female ratio was 1.02:1. 5.25.9% of the emergency admission patients is were diagnosed as shizophrenia, which was the most frequent diagnosis in all patients. 6.40% of the energency admission patients were discharged within 2 weeks. 7.Presenting porblems, in the order of frequency, were paralysis or numbness of extremities and somatic symptoms, hallucination of paranoid idea, anxiety or panic state. Neurotic symptoms are prominant over psychotic symptoms in chief complaints. 8.17.4% of the emergency admission patients were discharged A.M.A. without satisfactory improvement of symptoms.

할로아세틸시코닌 유도체의 합성 및 항암성 평가 : Synthesis and Evaluation of Antitumor Activity

鄭相國,金光洙,송규용,조훈,안병준 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

The secondary hydroxy group at side chain of shikonin structure was selectively acylated with various haloacetic acids in presence of dicyclohexylcarbodiimide and 4-dimethylaminopyridine to produce haloacetylshikonin derivatives. The cytotoxicity of monohaloacetylshikonin derivatives against L1210 cells increased in the following order: monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖) nonobromoacetylshikonin (ED_50, 0.158㎍/㎖)>monoiodoacetylshikonin (ED_50, 0.173 ㎍/㎖). Introduction of larger halogen atoms decreased the cytotoxic activity, presumably due to steric hinderance. The cytotoxicity of chloroacetylshikonin derivatives was dependent on the number of chlorine atom, thus increasing in the following order : trichloroacetylshikonin (0.032 ㎍/㎖)>dichloroacetylshikonin (0.059 ㎍/㎖)> monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖). Thus, the electron-withdrawing effect seems to be important for the cytotoxicity of chloracetylshikonin derivatives. Consistent with the above, dichloracetylshikonin (T/C, 182%) and trifluoroacetylshikonin (195%) showed higher T/C values than monochloroacetyl-(T/C, 122%), monobromoacetyl-(T/C, 154%) and monoiodoacetylshikonin (T/C, 117%) derivatives. Haloacetylshikonin derivatives showing lower cytotoxic activities against L1210 cells exhibited lower T/C values. It seems that there is a relationship between the cytotoxicity of haloacetylshikonin and their antitumor activity.

도플러지수를 이용한 급성 심근경색증의 진단에 있어 노인 환자의 특징

김원,조규종,오세현,이영수,이은주,홍진숙,김영득,현석천,임경수 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.4

연구보문 : 식물환경 ; 폐가축사체의 농업적 재활용을 위한 가축사체 액상부산물의 액비화 조건 구명

서영진 ( Young Jin Seo ),서동철 ( Dong Cheol Seo ),강세원 ( Se Won Kang ),이상규 ( Sang Gyu Lee ),박주왕 ( Ju Wang Park ),최익원 ( Ik Won Choi ),성환후 ( Hwan Hoo Sung ),강석진 ( Seog Jin Kang ),조주식 ( Ju Sik Cho1 ) 한국환경농학회 2013 한국환경농학회지 Vol.32 No.4

가축사체 액상부산물을 이용하여 액비의 최적조건(미생물, pH, 미생물 주입량)을 조사하였고, 이들 최적 조건하에서 112일간 부숙하여 액비의 품질을 평가하였다. 가축사체 액상 부산물 액비 부숙시 최적 LP 미생물의 주입량은 0.5 mL/100mL이었으며, pH는 7 조건에서 각각 50점으로 완숙판정을 받았다. 최적조건하에서 112일 동안 부숙시킨 액비의 부숙도 는 부숙 후 28일에 50점을 받아 완숙판정을 받았으며, 부숙기 간이 길어짐에 따라 부숙 56일에는 온도가 60℃를 넘어 최고 점인 55점을 받았고, 이후 온도가 조금씩 낮아져 부숙 후 112 일에는 실온조건에 이르렀다. 완숙된 가축사체 액상부산물 액 비의 품질을 평가해본 결과, 최적조건하에서 부숙시킨 액비의 경우에는 T-N, P2O5 및 K2O의 함량이 28일에 가장 높았으며, 시간이 경과함에 따라 약간 감소하는 경향이었다. 또한, 유해성분(As, Cd, Cu, Cr, Hg, Ni, Pb 및 Zn)의 함량은 28일, 56일 및 112일 부숙시킨 액비에서 모두 비료공정규격 기 준치에 적합하였다. 이상의 결과를 미루어 볼 때 가축사체 액상부산물을 농업적 재활용을 위한 액비화 조건은 pH 7조건 에서 LP 미생물을 0.5 mL/100 mL 주입한 경우이다. 하지 만 본 연구에서 비교된 가축분뇨 발효액은 공시재료(가축사체)가 상이하여 향후 가축사체를 이용한 액비의 부숙도 기준이 개선되어야 할 것으로 판단된다. BACKGROUND: Globally, concern about emerging infectious diseases of livestock is growing. For the disposal of the animal carcass, it is necessary to recycle the carcass into an agriculturally usable product. The objective of this study was to investigate the composting conditions of liquid by-product obtained from degradation of animal carcass. METHODS AND RESULTS: Optimum conditions of liquid fertilizer were investigated using different microorganisms, pHs, and volumes of microorganisms (Lactobacillus rhamnosus + Pichia deserticola). Based on the results from the optimum conditions, compost maturity and quality of liquid fertilizer were evaluated for 112 days. The compost maturity of liquid fertilizer were higher in the order of LP(Lactobacillus rhamnosus + Pichia deserticola) > BC(Bacillus cereus) > BS (Bacillus subtilis). The optimum condition under different volumes of LP was injection of 0.5 mL/100 mL. The compost maturity under different pHs were higher in the order of pH 7 > 5 ≥ 9 ÷ 11. The liquid by-product at 56 days after composting was completely decomposed. The concentrations of T-N, T-P and K2O in liquid fertilizer at 56 days were 0.94, 0.17 and 3.78%, respectively, and the sum of those concentrations was 4.89%. CONCLUSION(S): Liquid fertilizer of by-product using pig carcass was decomposed with optimum conditions(LP, pH 7, injection of 0.5 mL/100 mL) in 56 days after composting, and was suitable for official standard of commercial fertilizer.