0.5% Timolol과 2% Dorzolamide의 병용투여군과 cosopt®단독 투여군에서의 안압 하강 효과비교

서정성,최광주,나경수,조남수 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

ackground and Objective: This study was designed to compare the IOP decreasing effect between the IOP decreasing effect of patients who were treated with 0.5% Timolol and 2% of Dorzolamide and that of patients who were treated with Cosopt® only being the patients who couldn't be controlled by Timolol adequately. Materials and Method: Twenty eight open angle glaucoma patients, 40 eyes, who weren't able to reach desirable IOP when treated with 0.5% Timolol, were tested. The patients were divided into two groups. In group A 13 patients, 20 eyes, were treated with Timolol and 2% Dorzolamide. In group B 15 patients, 20 eyes, were treated with Cosopt® only. The IOP and side effects were recorded after The 1st week, the 1st month and the 3rd month. Results: After 3 months, the IOP in group A was decreased by 20.5% (4.0mmHg) from 19.5mmHg to 15.5mmHg and the IOP in group B was decreased by 23.7% (4.7mmHg) from 19.8mmHg to 15.1mmHg. There was no statistical significance between the two groups. Conclusion Cosopt® has a similar IOP decreasing effect with that of 0.5% Timolol and 2% Dorzolamide combined. It may increase adaptation of patients by decreasing the number of dispensions.

Phage Display 기법을 이용한 B형 간염 바이러스 Polymerase의 Rnase H 활성을 억제하는 인간 단세포군 항체의개발

이성락,송은경,정영주,이영이,김익중,최인학,박세광 Official Journal of the Korean society for immunol 2004 Immune Network Vol.4 No.1

전치부의 경미한 공간부조화 개선을 위한 가철성 장치의 적용 예

곽아람,최영철,박재홍,최성철,김광철 大韓小兒齒科學會 2007 大韓小兒齒科學會誌 Vol.34 No.4

골격성 부조화가 없는 I급 부정교합은 치아-악궁 간의 크기 차이에 의한 총생(crowding)이나 공극(spacing)이 주된 문제점이다. 이와 같은 경미한 공간 부조화를 개선시키고자 할 때,치열의 종류,치아-악궁크기 부조화의 양,환자의 협조도,또는 환자의 요구 등에 따라 치료 방법은 다양할 수 있다. 본 증례보고에서는 I급 구치부 관계를 지니면서 전치부의 치아-악궁크기 부조화의 양이 크지 않은 영구치열에서 상하 악 전치부의 경미한 총생이나 공극이 관찰되는 경우에 사용할 수 있는 clear aligner와 spring aligner 장치의 이용에 관하여 보고하고자 한다. 이와 같은 장치들의 임상 적용에는 몇 가지 제한적인 조건이 있기는 하지만,잘 선택된 증례에서는 매우 유용하며 편리하게 이용될 수 있다. 특히 총생이 존재하는 경우에는 이를 해소시킬 공간이 치열 내에서 확보되어야 하므로,확실한 분석과 진단으로 치아 인접면 삭제의 양을 정확히 결정하여 각 치아들의 근심면과 원심면에서의 삭제의 양이 균등히 이루어질 수 있도록 하는 것이 바람직하다. 또한 치간에 공극이 존재하는 경우에는 배열 후 치열궁 둘레의 감소와 함께 상하악 전치부 간의 over-jet 문제가 생길 수 있어 대합치열과의 교합관계에 신중을 기하여야 한다. Class I malocclusion without skeletal problem results from tooth size/arch-size discrepancies, either evidenced by crowding, or spacing problems. Treatment method can be chosen according to dentition, the amount of arch discrepancy, patient compliance, or patient demands. We report of clear aligner and spring aligner that can be applicated in cases of permanent dentition with minimal arch discrepancy in anterior segment. There are some limits of application, but these are very useful appliances in the selective case. When crowding exists, definitive analysis and diagnosis should be made before starting treatment because certain amount of space must be obtained somewhere in the dentition to resolve the crowding. Therefore, appliance should be applied when lacking space is small. Also, in cases with spacing arch circumference is reduced after alignment so no problem in intermaxilla occlusal relationship must be confirmed. In case with crowding, judicious removal of interproximal enamel is indicated.

Space Supervision을 이용한 치성 정중선 변위의 교정

김수연,최영철,박재홍,최성철,김광철 大韓小兒齒科學會 2007 大韓小兒齒科學會誌 Vol.34 No.4

상하악 중절치 간의 정중선 변위는 골격성 변위,치성 변위 및 골격성과 치성의 복합적 변위 등으로 구분된다. 그 중 치성 정중선 변위는 치열의 발육시기에 따라 다양한 방법으로 치료 방법을 선택할 수 있다. 특히 혼합치열의 초기에는 치열 내에 존재하는 공간의 조건,인접 영구치의 맹출 시기 또는 맹출 방향에 따라 영구 절치들의 위치가 자발적으로 변화,개선될 수 있다. 따라서 이러한 치아의 생리적 이동을 이용하여 특별한 교정장치의 이용 없이 치열 내에서 치아의 배열을 개선시킬 수 있다. 본 증례보고에서는 특히 유견치의 발거 시기 및 좌우 유치의 발거 순서 등을 이용하여 치성 정중선 불일치를 개선시킨 증례틀을 보고하고자 한다. A midline deviation is divided into three types, such as a skeletal midline deviation, a dental midline deviation, and a combination. Among them, the midline deviation which appear in the early mixed dentition without any skeletal problem can be managed differently by the stage of dental development. The location of the permanent incisors can be improved without using artificial force in consideration of the condition of the space, the eruption timing or the eruption path of the adjacent permanent teeth in early mixed dentition, especially when the permanent incisors are erupting. Therefore. the space supervision technique, which can have the teeth align themselves utilizing physiologic events such as sequence or timing of the eruption of permanent teeth, can be an alternative to orthodontic movement. This case report describes midline deviation improvement by space supervision.

구순구개열 환아에서의 치조골이식

조해성,박재홍,김광철,최성철,이긍호,최영철 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

치조파열 및 구개열과 같은 선천성 기형은 이환된 환자에게 기능적, 심미적으로 많은 문제점을 야기하므로 정상으로 회복시켜 주는 것은 중요한 문제이다. 장기간 방치될 경우 영양장애, 구강위생 불량, 호흡기 간염, 언어 장애, 악안면 변형, 그리고 정신적인 문제 등이 복합적으로 발생할 수 있다. 따라서 구순구개열 환자의 치료는 여러 전문 치료 분야의 복합적인 접근이 필요하다. 골이식은 구순구개열 환자에 있어 중요한 치과치료 단계이다. 치아의 맹출과 치열의 안정화를 위해 치열궁은 골격손이 없이 완전해져야 한다. 또한 치열궁의 파열이 있는 부위로는 정상적인 교정적 치아이동이 곤란하다. 따라서 구순구개열 환자에 있어 골이식은 광범위하게 적용되고 있는 외과적 술식이다. 치조골을 이식함으로써 치조열은 안정화되고, 견치 또는 절치가 이식부위로 이동할 수 있게 된다. 그리고 골 이식 후, 교정을 통해 치조열 부위의 공간을 폐쇄함으로써 보철 치료 없이 치열을 재형성할 수 있다. 골이식술에는 다양한 이식재료가 사용되었다. 자가골을 이식할 경우 장골이 가장 선호되며, 그 밖에 경골, 늑골, 두개골, 하악골을 이용하기도 한다. 그리고 골이식은 골이식 시기에 따라 일차골이식, 조기 이차골이식, 이차골이식, 만기 이차골이식으로 구분할 수 있다. 이차골이식은 혼합치열기 말경에 시행되는 것을 말하며 가장 좋은 것으로 받아들여지고 있다. 영구 견치가 맹출되기 전에 이차골이식을 시행하면 인접치아의 맹출과 보존에 도움이 된다. 본 증례에서는 치조구개파열 환자의 장골에서 골을 채취하여 골 이식을 시행한 후, 골이 채워진 이식 부위에 인접 치아가 성공적으로 이동하거나 치축이 개선되고 교정치료를 통해 치열궁 배열의 만족스러운 결과를 얻었기에 이를 보고하는 바이다 Cleft lip and palate are congenital craniofacial malformation. Reconstruction of dental arch in patient with alveolo-palatal clefts is very important, because they have many problems in functions and esthetics. Malnutrition, poor oral hygiene, respiratory infections, speech malfunctions, maxillofacial deformity, and psychological problems may be occured without proper treatment during the long period of management of the cleft lip and palate. So the treatment should be managed with a multidisciplinary approach. Bone grafting is a consequential step in the dental rehabilitation of the cleft lip and palate patient. A complete alveolar arch should be achieved of the teeth to erupt in and to form a stable dentition. And the presence of the cleft complicate the orthodontic treatment. Therefore bone grafting in patients with cleft lip and palate is a widely adopted surgical procedure. Grafted bone stabilizes the alveolar process and allows the canine or incisor to move into the graft site. After the bone grafting, orthodontic closure of the maxillary arch has become a common practice for achieving dental reconstruction without any prosthodontic treatment. Various grafting materials have been used in alveolar clefts. Iliac bone is most widely fovoured, but tibia, rib, cranial bone, mandible have also been used. And according to its time of occurrence, the bone graft may be divided into primary, early secondary, secondary, late secondary. Bone grafting is called secondary when performed later, at the end of the mixed dentition. It is the most accepted procedure and has become part of treatment of protocol. A secondary bone graft is performed preferably before the eruption of the permanent canine in order to provide adequate periodontal support for the eruption and preservation of the teeth adjacent to the cleft. In this report, we report here on a patient with unilateral cleft lip and palate, who underwent iliac bone graft. The cleft was fully obliterated by grafted bone in the region of the alveolar process. The presence of bone permitted physiologic tooth movement and the orthodontic movement of adjacent tooth into the former cleft area. Satisfactory arch alignment could be achieved in by subsequent orthodontic treatment.

Examination

( Gwang Seong Choi ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3

Efficacy and safety of dutasteride in the treatment of androgenetic alopecia

( Gwang Seong Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Dutasteride inhibits both type 1 and 2 5-alpha reductases, eventually suppressing DHT in circulation and the target organ. Dutastride was firstly approved for male patten hair loss in Korea since 2009. A. Efficacy - In phase II clinical trial, dutasteride 0.5 mg suppressed DHT concentrations in serum by 92% and in scalp by 51%, while finasteride 5 mg in serum by 73% and in scalp by 41%. Dutasteride 0.5 mg significantly increased hair count versus placebo at 12 and 24 weeks. - In phase III Korean study, dutasteride 0.5 mg showed significantly higher efficacy than placebo group by subject self-assessment and by investigator and panel photographic assessment. There was no major difference in adverse events between two groups. - Recent phase III study with bigger number of subjects (917 men) showed the close dose response in hair count increase across dutasteride 0.02 mg, 0.1 mg and 0.5 mg and added that dutasteride 0.1 mg was non-inferior to finasteride 1 mg and dutasteride 0.5 mg was superior to finasteride 1 mg. B. Safety - It is believed that the adverse events(AE) is related to the DHT suppression. As a result, physicians perceive that the more potent DHT suppression by dutasteride, the more hair growth but the more AEs. - In In phase III Korean study, sexually related AE was not different between dutasteride 0.5 mg group (4.1%) and placebo group (4.0%). - Recent phase III study reported sexual AEs in all active groups (including dutasteride 0.02 mg, 0.1 mg, 0.5 mg and finasteride 1mg) comparing placebo group showed no dose response relationship in dutasteride doses. This study also showed that decreased libido was reported by 9 subjects (4.9%) in dutasteride 0.5 mg group and by 12 subjects (6.7%) in finasteride 1 mg group. - Open label, multi-center, non-interventional observational study in Korea was done from 2009 to 2013. During study period, 712 subjects were enrolled. The subjects of 29.3±6.0 years old exposed to dutasteride for 204.7±161.5 days. Most frequent adverse drug reaction(ADR)s were libido decreased (9, 1.3%), dyspepsia (8, 1.1%), impotence (7, 1.0%), and fatigue (5, 0.7%). Other interested ADRs were sexual function abnormality (4, 0.6%), gynecomastia (2, 0.3%), and ejaculation disorder (1, 0.1%). Most subjects (78.6%) showed overall improvement after treatment of dutasteride in the effectiveness. The sexually related AE in this study is relatively lower than other controlled studies. Like other studies for AGA with dutasteride, this study showed no reports of prostate cancer, breast cancer, or cardiovascular AEs of special interest. The reports on the prognosis of the AEs in alopecia subjects are not found. In the 4-year follow-up of the phase III trials in benign prostate hyperplasia (BPH), the incidence of the sexual AEs was low and tended to decrease over time. Conclusion - Dutasteride increased hair and was relatively well tolerated for the treatment of male pattern hair loss.

Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia

( Gwang Seong Choi ),( Joon Hyung Kim ),( Shin Young Oh ),( Jung Min Park ),( Ji Soo Hong ),( Yil Seob Lee ),( Won Soo Lee ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.4

Background: After the approval of dutastride for androgenic alopecia (AGA) in 2009, Korean authority required a post-marketing surveillance to obtain further data on its safety profile. Objective: The objective was to monitor adverse events (AEs) of dutasteride 0.5 mg in Korean AGA male patients in a clinical practice environment. Methods: Open label, multi-center, non-interventional observational study was done from July 2009 to July 2013. AGA subjects (18∼41 years of age) with no experience of dutasteride were enrolled. Dosage regimen was recommended according to the prescribing information. The incidences of any AEs, serious adverse events (SAEs), and adverse drug reactions (ADRs) were evaluated. Multiple logistic regression method was used to identify risk factors related to ADRs. Effectiveness was generally evaluated by physicians. Results: During study period, 712 subjects were enrolled. The subjects of 29.3±6.0 years old exposed to dutasteride for 204.7±161.5 days. One hundred and ten (15.4%) of sub-jects reported 138 AEs. Four subjects (0.6%) reported 5 SAEs (right radius fracture, 2 events of chronic follicular tonsillitis, influenza infection, and acute appendicitis). Sixty-six subjects (9.3%) reported 80 ADRs. Most frequent ADRs were libido decreased (9 subjects, 1.3%), dyspepsia (8 subjects, 1.1%), impotence (7 subjects, 1.0%), and fatigue (5 subjects, 0.7%). Other interested ADRs were sexual function abnormality (4 subjects, 0.6%), gynecomastia (2 subjects, 0.3%), and ejaculation disorder (1 subject, 0.1%). Most subjects (78.6%) showed overall improvement after treatment of dutasteride in the effectiveness. Conclusion: Dutasteride 0.5 mg is to be well-tolerated in 18 to 41 years old AGA patients in a clinical practice environment. (Ann Dermatol 28(4) 444∼ 450, 2016)

Effect of Different Severities of Summer Pruning on Fruit Characteristics and Tree Growth in Young ‘Fuyu’ and ‘Nishimurawase’ Persimmon

Seong-Tae Choi(최성태),Seong-Mo Kang(강성모),Doo-Sang Park(박두상),Won-Doo Song(송원두),Gwang-Hwan Ahn(안광환) 한국원예학회 2003 Horticulture, Environment, and Biotechnology Vol.44 No.5

Tree Responses of ‘Fuyu’ Persimmon to Different Degrees of Early Defoliation on Fruit Characteristics at Harvest and Tree Development the Next Season

Seong-Tae Choi,Seong-Mo Kang,Doo-Sang Park,Young-Whang Yoon,Gwang-Hwan Ahn 한국원예학회 2005 Horticulture, Environment, and Biotechnology Vol.46 No.2

This study was conducted to understand the responses of persimmon trees to early defoliation by typhoons. In 9- and 6-year-old ‘Fuyu’ persimmon trees, 0 (control), 25, 50, and 75% of the leaves were defoliated on September 4 in 1998 and 0 (control), 75, and 100% on October 9 in 2002. Fruit fresh weight and soluble solids tended to decrease as defoliation percentages increased. However, fruit diameter continued to increase in the absence of any leaves, and a 50% defoliation in early September did not significantly affect fruit weight at harvest. Starch concentration in dormant shoots significantly decreased to 1.9% by 75% defoliation from 3.6% for the control in the 1998 experiment, and to 3.2 and 3.1% by 75 and 100% defoliation, respectively, from 4.0% for the control in the 2002 experiment. Shoot growth, number of flower buds, and fruit set the following year were not consistently affected by different degrees of defoliation the previous year. However, a 75% defoliation resulted in a 7.8- and 4.4-fold increase in winter-shoot mortality in 1999 and 2003, respectively. Although not significant, only fruit weight the following year tended to decrease with increasing degrees of defoliation in both experiments. Soluble solids were significantly low in the fruits of 75%- and 100%-defoliated trees in 2003, but not in 1999. The results indicated that measures to enhance fruit quality and carbohydrate reserve of the tree should be practiced after a severe defoliation by typhoons.