http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lee, Myong-Min,Kim, Hyeong-Geug,Lee, Sung-Bae,Lee, Jin-Seok,Kim, Won-Yong,Choi, Seung-Hoon,Lee, Sam-Keun,Byun, Chang-Kyu,Hyun, Pung-Mi,Son, Chang-Gue Elsevier 2018 Phytomedicine Vol.41 No.-
<P>Conclusion: Our data present experimental evidence for the potential of CGplus as an herbal therapeutic against NAFLD and NASH. Its underlying mechanisms may involve the modulations of pro- and anti-inflammatory cytokines, but further study is required especially for the actions of CGplus on lipid metabolisms.</P>
Kim, Hyo-Seon,Kim, Hyeong-Geug,Im, Hwi-Jin,Lee, Jin-Seok,Lee, Sung-Bae,Kim, Won-Yong,Lee, Hye-Won,Lee, Sam-Keun,Byun, Chang Kyu,Son, Chang-Gue Hindawi Publishing Corporation 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P><I>Rhus verniciflua</I> Stoke has been commonly used in traditional medicine to treat gastrointestinal (GI) dysfunction diseases. In order to investigate pharmacological properties of<I> Rhus verniciflua</I> Stoke water extract (RVX) on cisplatin-induced amnesia, RVX (0, 25, 50, or 100 mg/kg) was orally administrated for five consecutive days after a single intraperitoneal injection of cisplatin (6 mg/kg) to SD rat. Cisplatin injection significantly increased the kaolin intake (emesis) but reduced the normal diet intake (anorexia) whereas the RVX treatment significantly improved these abnormal diet behaviors at both the acute and delayed phase. The serotonin concentration and the related gene expressions (5-HT3 receptors and SERT) in small intestine tissue were abnormally altered by cisplatin injection, which were significantly attenuated by the RVX treatment. Histological findings of gastrointestinal tracts, as well as the proteins level of proinflammatory cytokines (TNF-<I>α</I>, IL-6, and IL-1<I>β</I>), revealed the beneficial effect of RVX on cisplatin-induced gastrointestinal inflammation. In addition, RVX significantly improved cisplatin-induced myelosuppression, as evidenced by the observation of leukopenia and by histological examinations in bone marrow. Our findings collectively indicated<I> Rhus verniciflua</I> Stoke improved the resistance of rats to chemotherapy-related adverse effects in the gastrointestinal track and bone marrow.</P>
Lee, Jin-Seok,Kim, Won-Yong,Jeon, Yoo-Jin,Lee, Sam-Keun,Son, Chang-Gue Elsevier 2018 BIOMEDICINE AND PHARMACOTHERAPY Vol.106 No.-
<P><B>Abstract</B></P> <P>An imbalance between excitatory and inhibitory neurotransmitters is known to induce neuronal excitotoxicity which is a major cause of neurodegenerative disorders. Excessive glutamate concentration leads to the neuronal death by increasing oxidative stress and affecting the apoptotic signaling pathway. We investigated the anti-excitotoxic effects and associated working mechanisms of 30% ethanol extract of <I>Aquilariae Lignum</I> (ALE) against hippocampal neuronal death by glutamate. HT22 cells were treated with glutamate (20 mM) for 24 h following pretreatment with ALE (5, 10, 25 μg/mL). Cell viability, biochemical analysis, flow chemistry, and Western blotting assays were performed.</P> <P>Glutamate treatment substantially increased the intracellular level of reactive oxygen species (ROS) and Ca<SUP>2+</SUP> influx into the cell, which were followed by apoptosis. ALE pretreatment, however, significantly attenuated these excitotoxicity-related features according to the results of Annexin V analysis and the lactate dehydrogenase assay, in which the calpain pathway (in a caspase 3-independent manner) may be involved. ALE pretreatment also significantly attenuated the glutamate-induced activation of both inflammation-associated molecules (extracellular signal–regulated kinase, c-Jun N-terminal kinases and p38) and death-related molecules (p53, apoptosis-inducing factor). The inactivation of brain-derived neurotrophic factor (BDNF) was restored by ALE pretreatment.</P> <P>Our results verified that <I>A. Lignum</I> has potential neuroprotective effects on glutamate-induced excitotoxicity in hippocampal neuron cells, and its underlying mechanism may involve the regulation of ROS-mediated cell death pathways.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Glutamate leads to neuroexcitotoxicity in HT22 cells, hippocampal neuron cell line. </LI> <LI> ALE notably prevented the glutamate-induced neuronal cell death. </LI> <LI> ALE inhibited the glutamate-induced intracellular ROS generation and Ca<SUP>2+</SUP> influx. </LI> <LI> ALE remarkably prevented the glutamate-induced depletion of BDNF. </LI> <LI> ALE exerts inhibitory property against neuroexcitotoxicity via calpain pathway. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
폐결핵 진단에서 Amplified Mycobacterium Tuberculosis Direct Test의 임상적 유용성
박삼석 ( Sam Seok Park ),곽경록 ( Kyung Rok Kwak ),황지윤 ( Ji Yun Hwang ),윤상명 ( Sang Myeong Yun ),류기찬 ( Chi Chan Ryue ),장철훈 ( Chul Hun Chang ),이민기 ( Min Gi Lee ),박순규 ( Sun Gue Park ) 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.6
Herbal Transformation by Fermentation
Chang-Gue Son,Sam-Keun Lee,In-Kyu Choi,Eun-Su Jang,Kee-Jung Bang 사단법인약침학회 2020 Journal of Acupuncture & Meridian Studies Vol.13 No.5
We herein show a dramatic change of herbal properties of the composition as well as function via fermentation of Cynanchi atrati Radix (family Asclepiadaceae). Cynanchi atrati Radix showed a high cytotoxicity against B16-F10 melanoma cell line, but the function of Cynanchi atrati Radix was completely changed into anti-melanin activity at very low concentration after Lactobacillus -fermentation. In addition, the compounds were drastically changed as shown in HPLC-based profile. Furthermore, this transformation has been achieved by only Lactobacillus -fermentation. This study proposes an strategy which we need to consider in the herb-derived material researches including pharmacopuncture.
Microsurgical Replantation of A Partial Ear with Arteriole Anastomosis
Ahn, Ho-Beom,Cho, Gue-Seung,Kim, Dae-Young,Lee, Sam-Yoong,Cho, Bek-Hyun The Korean Society for Microsurgery 1999 Archives of reconstructive microsurgery Vol.8 No.1
Ear reconstruction is very difficult to perform and often results in a devastating deformity. The use of microsurgical replantation techniques has allowed very favorable anesthetic results. We report a case of a partial ear replantation without venous repair with the use of medicinal leeches to decompress the acute venous congestion during the postoperative care. The medicinal leech therapy can be very useful in a partial ear replantation in cases with no venous repair.
Application of Perfluoropolymethylisopropyl Ether to Long Wearing Lipstick
( Sang-je Kim ),( Dong-uk Shin ),( Phan-gu Cho ),( Jae-gak Han ),( Jae-hyung Lim ),( Baek-sun Ahn ),( Chul-hee Jung ),( Gue-sam Lee ),( Won-sun Oh ),( Hyun-kwan Jung ),( Iio-yeun Kim ) 대한화장품학회 1997 대한화장품학회지 Vol.23 No.3
lt has been used chat fluorinated compounds could be applied to Make-up products. lt is that fluorinated compounds are hydropliobiciry, lipopliobiciry and lioinophobicitv. These fluorinated compounds are reported ro form a highly prorecrive and effective film againsr most aggressive chemical and physical agents. In this study we made a success to formulate the new type of lipstick using perfluoropolymerhylisopropylether (PPIH, MW- 650. commercial name - Fomblin HC/01 by Ausimont Co.) with low-molecular weight which is long wearing and comfortable (excellent) to use. This PPIE was adsorbed more than 90% in this experinient and formed the well-balanced gei nerworks even if the selected PP1E is 100% volutile ar room remperarure. On the basis of the adsorprion of FPIE, we developed rlie new type lipstick, whicli was highly-lip feeling and had long wearing and non coloration. And these cliaracreristics were verified by acrual consumer test.