http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Graciella Wahjoepramono ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
( Graciella Wahjoepramono ),( Franxicus Clinton ),( Shirley Ivone Moningkey ),( Wahyuni Lukita Atmodjo ),( George Mathew ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Hepatitis B viral infection is estimated more than one third of the world`s population and 5% of all carriers develop cirrhosis, and primary hepatocellular carcinoma. Our previous epidemiology study of prevalence Hepatitis B infection in rural areas of Tangerang regency showed about 3. 96% were positive to HBsAg test. Serologic test used for the diagnosis of Hepatitis B virus infection involves of distinct HBV-specifi c antigens and host antibody react to these antigens, however the interpretation of these tests was complicated and refi ects multiple possibilities. Methods: five hundred patients visited Rural Health Community Centers were recruited with inclusion criteria age 15 - 60 years old male or female, they do not drink alcohol and they have no history of jaundice. Their plasma was screened for HbsAg using ELISA and Rapid Diagnostic tests; then those blood demonstrated positive to HbsAg, subsequently tested for anti-HBs, anti-HBc, HBeAg, anti-HBe and HBV DNA viral load. Results: The blood of nineteen (19) patients showed positive to HBsAg. Serologic test for anti-HBs was negative, but all of 19 showed positive to anti-HBc. Only 2 patients were detected HBeAg-positive but anti-HBe react either positive or negative. Measurement viral load of HBV-DNA demonstrated the number < 1, 000 IU/ml for 16 patients and 3 patients the number > 10, 000 IU/ml. Conclusions: Serologic profi les of 19 patients with HBsAg-pos are consistent with carrier state or chronic hepatitis B infection, however only 3 patients with higher HBV DNA levels (>10. 000 IU/ml) were diagnosed as Chronic Hepatitis B infection. Mostly patients were diagnosed as carrier state due to their serologic profi le of HBeAg-negative and anti Hbe positive or negative with viral load less than 1000 IU/ml.
-
( Wahyuni Lukita Atmodjo ),( Darti Isbandiati Wibisono ),( Stella Marleen Damai ),( Graciella Wahjoepramono ),( Franxicus Clinton ),( George Mathew ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Curcuminoids that exert a strong anti-inflammatory effect has shown to inhibit multiplicity of tumor nodules in liver carcinogenesis. However its efficacy to inhibit the progression of cellular transformation in liver carcinogenesis has not yet been evaluated clearly. Methods: Forty of 5 weeks old male Balb/C mice were divided randomly into 15 weeks and 20 weeks scarifying groups. Each of that group divided into 2 control groups, injected with sterile saline and fed either with basal diet (1), or fed with 0.2% curcuminoids- containing diet (2); and 2 treated groups, injected intra peritoneal with DEN 75mg/kg BW for 3 weeks, continued with 100mg/kg BW for 3 continuous weeks, fed with basal diet (3) or fed with 0.2% curcuminoid-containing diet (4). They were sacrificed at 15 weeks (n=20) and 20 weeks (n=20) after the first injection of DEN. The liver sections were stained with H&E and monoclonal antibody anti-Ki 67. The number of transformed-hepatocytes and Ki 67-positive cells were counted in high-powered fields (X400) surrounding central vein randomly. The results were analyzed statistically using t-test with considered significant at p<0.05. Results: Histologically, liver sections of the treated groups showed disruption of hepatic architecture with dilated sinusoids and degeneration of hepatocytes. Abundant transformed-hepatocytes characterized with enlargement nuclei, hyperchromatin nuclei and prominent nucleoli were scattered within liver parenchyma (fig.1,2). The numbers of transformed-hepatoctes were reduced significantly (p<0.05) when they fed with curcuminoids either in 15 or 20 weeks. Increasing number of Ki 67-positive cells were shown after injections of DEN (fig 2). Conclusions: We suggested that one of the mechanism by which curcuminoids-containing diets inhibit the progression of liver carcinogenesis is possibly through suppressing proliferation of transformed-hepatocytes.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
