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전자 현미경상 Epinephrine 과립이 관찰된 Zuckerkandl 기관에 발생한 Norepinephrine 분비성 갈색세포종 1예
이원석,김의숙,이강룡,이정아,장지정,선우인철,김대하,이광섭,백영주 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.2
Extraadrenal pheochromocytomas developed from the paraganglia other than adrenal medulla are uncommon tumors. Such lesions have been reported that as much as 10% of retroperitoneal paragliomas arise outside the adrenal gland. But their incidence and prognosis are changing partly as a result of progression in developmental mechanism, diagnostic tools and concepts including ultrastructure, immunohistochemistry. The ultrastructure of chromaffine neoplasm from adrenal and extraadrenal tissues has been studied with chrornaffine granule specificity and type of catecholamine content. With rare exceptions, extraadrenal chrornaffine tumor mainly has high concentration of norepinephrine which is suggested as dict relationship to numoruos electrone dense granular bodies in the cell cytoplasrm. High or intermediate level of epinephrine in tissue is associated with cytoplasmic granular bodies of much less density. Recently we experienced the exception, a case of norepinephrine secreting pheochrom-ocytoma in the organ of Zuckerkandl with epinephrine granules in cytoplasm and this discrepancy probably due to the plasticity - the differences in developmental process and local factors between adrenal medulla and extraadrenal tissues(J Kor Soc Endocrinol 11:233 ~239, 1996).
진균구로 오인된 낭포내 응혈을 보인 23세 여자에서의 선천성 낭포성 유선종 폐기형 1례
이강룡 ( Gang Ryong Lee ),이군순 ( Kun Sun Lee ),주인규 ( In Kyu Joo ),박준옥 ( June Ock Park ),최승준 ( Seung Jun Choi ),이원석 ( Won Seok Lee ),김의숙 ( Eui Sook Kim ),이규현,김대하 ( Dae Ha Kim ),이광섭 ( Gwang Seob Lee ),한영숙 ( 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.46 No.1
Development of traditional wine using biomass from alcoholic fermentation by Phellinus sp. mycelium
Hak-Seob Lim,Gang-Young Lee,Eun-Jung Jung,Won-Su Lee,Young-Kwang Ju,Min-Jeong Seo,Ji-Eun Kim,Tae-Yeon Kim,Hey-Rin Lee,Kyung Tae Chung,Byung Tae Choi,Young Hee Kim,Yong Kee Jeong 한국생명과학회 2006 한국생명과학회 심포지움 Vol.47 No.-
Expression analysis and COG classification of seed developmental genes in Oryza sativa L.
Jung Sook Lee,Yong Hwan Kim,Tae Ho Lee,Kyung Hwan Kim,Jang Ho Hahn,Seok Cheol Suh,Moo Young Eun,Gang Seob Lee,Ung Han Yoon,Hee Won Yang,Chang Kug Kim,Shoshi Kikuchi,Kouji Satoh 한국육종학회 2007 한국육종학회 학술발표회 발표요지 Vol.2007 No.6
Up-dating of new dCAPS markers for mapping yield-related traits using MGRIL
Ye-Ji Lee,Hyun-Ju Lee,In-Seon Jeong,Seon-Hwa Bae,Hyeon-So Ji,Gang-Seob Lee,Ung-Han Yoon,Jang-Ho Hahn,Tae-Ho Kim 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
The next-generation sequencing(NGS) technology is being used for more effective genetic mapping. In previous study, we obtained 60x coverage of sequence from Milyang23 and Gihobyeo on average comparing with Nipponbare reference genome. Also, we developed new derived cleaved amplified polymorphic sequence(dCAPS) markers based on the single nucleotide polymorphisms(SNPs) in coding region sequence(CDS) between these varieties. Totally, 1,726,798 SNPs between Milyang23 and Gihobyeo were detected. Among them, 146 SNP were selected for making dCAPS markers and located on genetic map with previously reported 219 PCR-based DNA markers. The map was applied to the detection of quantitative trait loci(QTLs) for stem internode diameters, culm length and panicle length within MGRIL population, and six QTLs with relatively high LOD score were found at three chromosomes; culm length and stem diameter including the first internode diameter, third and fourth internode diameter. This study showed that the NGS allowed the rapid discovery of a large number of SNPs for dCAPS marker. So, we tried to find out more single nucleotide polymorphisms(SNPs) which were located on the whole genome sequence, such as un-translated region(UTR), intron, Inter-region and coding region sequence(CDS) between Milyang23 and Gihobyeo varieties. And we collected phenotypic information about culm length, panicle length, four stem internode diameters and panicle number in rice MGRIL population for QTLs. Furthermore, results of QTL analysis described above will shows relevance of molecular markers in mapping genes for useful breeding.
Map-based cloning of SUI4 gene which controls internode elongation in rice
Hyeonso Ji,Gang-Seob Lee,Doh-Won Yun,Seung-Bum Lee,Seok-Chul Suh,Moo-Young Eun 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Internode elongation is an important agronomic trait in rice that is associated with lodging, yield, and flooding adaptation. We identified a novel rice mutant line showing shortened uppermost internode among the rice Ac/Ds insertional mutant population and named it shortened uppermost internode 4 (sui4). The phenotypes of F1 plants and F2 plants from the cross of sui4 with its original variety, Dongjin, indicated that the SUI4 gene shows incomplete dominance or semidominance. Because the Ds genotypes did not co-segregate with the sui4 phenotypes, we performed mapping of this gene with 273 F2 plants from a cross between sui4 and Milyang23. Primary mapping revealed that the SUI4 locus was located between the S07012 and S07015 markers on rice chromosome 7. Further fine mapping narrowed down the location of SUI4 to the 1.1-Mbp interval of RM1253-S07015. Using re-sequencing data of this mutant along with its original variety, Dongjin, and five other varieties, we found six sui4 specific SNPs occurred within the genic region of five genes in the fine-mapped interval. Among them, one SNP is in exon, while the other five SNPs are in intron. This SNP in exon occurred in the miR172 binding site of a gene encoding AP2 domain transcription factor, which seems to interrupt suppression of this gene activity by miR172. We isolated the genomic region of this gene from sui4 and transformed the wild type variety, Dongjin. The transgenic plants showed remarkably shortened internodes, which indicates that this AP2 domain transcription factor gene is the SUI4 gene.