Mechanisms of Motility Change on Trinitrobenzenesulfonic Acid- Induced Colonic Inflammation in Mice

Gab Jin Cheon,Yuan Cui,Dong-Soo Yeon,권성춘,박병곤 대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.6

Ulcerative colitis is an inflammatory bowel disease (IBD) characterized by recurrent episodes of colonic inflammation and tissue degeneration in human or animal models. The contractile force generated by the smooth muscle is significantly attenuated, resulting in altered motility leading to diarrhea or constipation in IBD. The aim of this study is to clarify the altered contractility of circular and longitudinal smooth muscle layers in proximal colon of trinitrobenzen sulfonic acid (TNBS)-induced colitis mouse. Colitis was induced by direct injection of TNBS (120 mg/kg, 50% ethanol) in proximal colon of ICR mouse using a 30 G needle anesthetized with ketamin (50 mg/kg), whereas animals in the control group were injected of 50% ethanol alone. In TNBS-induced colitis, the wall of the proximal colon is diffusely thickened with loss of haustration, and showed mucosal and mucular edema with inflammatory infiltration. The colonic inflammation is significantly induced the reduction of colonic contractile activity including spontaneous contractile activity, depolarization-induced contractility, and muscarinic acetylcholine receptor-mediated contractile response in circular muscle layer compared to the longitudinal muscle layer. The inward rectification of currents, especially, important to Ca2+ and Na+ influx-induced depolarization and contraction, was markedly reduced in the TNBS-induced colitis compared to the control. The muscarinic acetylcholine-mediated contractile responses were significantly attenuated in the circular and longitudinal smooth muscle strips induced by the reduction of membrane expression of canonical transient receptor potential (TRPC) channel isoforms from the proximal colon of the TNBS-induced colitis mouse than the control.

Mechanisms of Motility Change on Trinitrobenzenesulfonic Acid-Induced Colonic Inflammation in Mice

Cheon, Gab Jin,Cui, Yuan,Yeon, Dong-Soo,Kwon, Seong-Chun,Park, Byong-Gon The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.6

Ulcerative colitis is an inflammatory bowel disease (IBD) characterized by recurrent episodes of colonic inflammation and tissue degeneration in human or animal models. The contractile force generated by the smooth muscle is significantly attenuated, resulting in altered motility leading to diarrhea or constipation in IBD. The aim of this study is to clarify the altered contractility of circular and longitudinal smooth muscle layers in proximal colon of trinitrobenzen sulfonic acid (TNBS)-induced colitis mouse. Colitis was induced by direct injection of TNBS (120 mg/kg, 50% ethanol) in proximal colon of ICR mouse using a 30 G needle anesthetized with ketamin (50 mg/kg), whereas animals in the control group were injected of 50% ethanol alone. In TNBS-induced colitis, the wall of the proximal colon is diffusely thickened with loss of haustration, and showed mucosal and mucular edema with inflammatory infiltration. The colonic inflammation is significantly induced the reduction of colonic contractile activity including spontaneous contractile activity, depolarization-induced contractility, and muscarinic acetylcholine receptor-mediated contractile response in circular muscle layer compared to the longitudinal muscle layer. The inward rectification of currents, especially, important to $Ca^{2+}$ and $Na^+$ influx-induced depolarization and contraction, was markedly reduced in the TNBS-induced colitis compared to the control. The muscarinic acetylcholine-mediated contractile responses were significantly attenuated in the circular and longitudinal smooth muscle strips induced by the reduction of membrane expression of canonical transient receptor potential (TRPC) channel isoforms from the proximal colon of the TNBS-induced colitis mouse than the control.

A Clinical Analysis of Gastrointestinal Stromal Tumors in Small Intestine: Comparison of Bleeding and Non-bleeding Group

( Sang Jin Lee ),( Jong Kyu Park ),( Hyun Il Seo ),( Koon Hee Han ),( Young Don Kim ),( Woo Jin Jeong ),( Gab Jin Cheon ),( Jae Seok Song ) 대한장연구학회 2013 Intestinal Research Vol.11 No.2

Background/Aims: Gastrointestinal stromal tumors (GIST) in the small intestine are rare and can cause bleeding. The study investigated the clinical characteristics of GIST in the small intestine and to determine the factors related to gastrointestinal bleeding. Methods: We retrospectively evaluated the clinical outcomes of 22 patients with small bowel GIST who were pathologically diagnosed at Gangneung Asan Hospital between March 1997 and August 2012. Results: The median age was 63.5 (38-82) years. Nine patients (40.9%) had gastrointestinal bleeding, five patients (22.7%) had abdominal pain, two patients (9%) had palpable mass. The site of tumor was the duodenum in nine cases (40.9%), jejunum in 7 cases (31.8%), and ileum in six cases (27.3%). Most patients underwent small bowel resection or wedge resection but three patients underwent pancreaticoduodenectomy. Tumor size ranged from 1.6 to 19 cm (median 6.5 cm). The median mitotic rate was 2 (0-50)/50 high power fields (HPF). The median mitotic rate was 2 (0-50)/50 HPF. Five patients (25%) showed recurrence. Gender, aspirin or warfarin use, size and mitotic index of tumor, hospital stay, recurrence and survival were not significantly different between bleeding and non-bleeding group. Bleeding group showed older age, proximal location in small intestine and mucosal ulceration significantly. Conclusions: Small bowel GISTs with bleeding were marked by older age, mucosal ulceration and location of proximal small bowel (duodenum and jejunum) rather than distal small bowel (ileum). (Intest Res 2013;11:113-119)

2009년 유럽간학회 하이라이트 : 간경변증 관련 분야(복수)

천갑진 ( Gab Jin Cheon ) 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.2

전이 증례 경동맥화학색전술 후 폐전이가 소실된 간세포암의 증례

천갑진 ( Gab Jin Cheon ),김연수 ( Yun Soo Kim ),정준성 ( Joon Seong Jung ),김영석 ( Young Seok Kim ),문종호 ( Jong Ho Moon ),조영덕 ( Young Deok Cho ),이문성 ( Moon Sung Lee ),심찬섭 ( Chan Sup Shim ),김부성 ( Boo Sung Kim ) 대한간암학회 2001 대한간암학회지 Vol.1 No.-

비알콜성지방간 질환의 약물치료: 제한점

천갑진 ( Gab Jin Cheon ),김영돈 ( Young Don Kim ) 대한내과학회 2018 대한내과학회 춘계학술대회 Vol.2018 No.-

Nonalcoholic fatty liver disease (NAFLD) is an increasingly common cause of chronic liver disease in Korea. This is due to westernized diet, changes in lifestyle, lack of exercise, and an increase in obesity & diabetes. NAFLD is associated with increased liver-related mortality and hepatocellular carcinoma. So Appropriate treatment is needed. But the natural history and pathogenesis of NAFLD remains unclear. The prognosis of NAFLD depends on the histological subtype. The more than 60% patients had disease remission or remained the same. There is no definitive non-invasive diagnostic method. At present there are no approved pharmacologic therapies. The weight reduction proved to be the only effective. So diet and lifestyle modification remain the mainstay of treatment. For patients with NASH (Nonalcoholic steatohepatitis) and advanced fibrosis, current liver- directed pharmacotherapy with vitamin E and pioglitazone offer some benefits in selected cases. However, the beneficial effects of these therapies must be balanced with the potential adverse effects, limiting their widespread use. Coexisting comorbidity must be diagnosed and treated because cardiovascular disease remains primary cause of death in these patients. New drugs currently in clinical trials are expected to become effective and targeted drug therapies in this area. But, at present, pharmacologic treatment of NAFLD is controversial.

만성 B형 간염 치료에 있어 항바이러스 약제 이외의 치료

천갑진 ( Gab Jin Cheon ),김영돈 ( Young Don Kim ) 대한간학회 2015 Postgraduate Courses (PG) Vol.2015 No.1

The goals of chronic hepatitis B treatment are to decrease the mortality rate and increase the survival rate by alleviating hepatic inflammation and preventing the development of fibrosis, which ultimately decrease the progression of hepatitis to liver cirrhosis or HCC. Host, viral and environmental factors contribute to an HBsAg-positive patients`` risk of cirrhosis and HCC. The main risk factors for HCC are not only chronic hepatitis viruses (hepatitis B and C), but also alcohol drinking, tobacco smoking, and aflatoxin exposure. Oral contraceptive usage, iron overload, overweight, and diabetes are also known or suspected as risk factors of HCC. Currently, treatment of hepatitis B concentrates on antiviral agents mainly. Although Peginterferon and nucleos(t)ide analogues are effective, both therapies have limitations such aslow response rate, side effects, long term use and drug resistance. In contrast with viral factors, there are a few effort and study to improve the host and environmental factors. Considering the synergistic effects of host and environmental factors and HBV infection on the risk of HCC, efforts should be focused not only on abstinence but also on promoting and modifying generally healthy lifestyles. To maximize the effects of treatment for chronic hepatitis B, personalized approach should be conducted according to disease characteristics, individual preferences, medical comorbidities and social circumstances. And proper education should be considered

간암에 대한 고주파 열치료 후 발생된 담관누공 1 예

천갑진(Gab Jin Cheon),김연수(Yun Soo Kim),김영석(Young Seok Kim),천영국(Young Koog Cheon),문종호(Jong Ho Moon),조영덕(Young Deok Cho),이문성(Moon Sung Lee),심찬섭(Chan Sup Shim),김부성(Boo Sung Kim) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.6

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소화성 궤양에서 Helicobacter pylori 박멸의 장기적 효과에 대한 후향적 관찰

홍수진(Su Jin Hong),은수훈(Soo Hoon Eun),정준성(Joon Seong Jung),류권호(Kwon Ho Ryu),차상우(Sang Woo Cha),천갑진(Gab Jin Cheon),김진오(Jin Oh Kim),조주영(Joo Young Cho),이준성(Joon Seong Lee),이문성(Moon Sung Lee),심찬섭(Chan Sup Shi 대한내과학회 2002 대한내과학회지 Vol.63 No.1

목적: 소화성 궤양 환자에 있어 H. pylori 박멸은 재발 억제를 위해 시행되고 있으나 박멸 후 장기간 추적에 대한 국내 보고는 드문 실정이다. 본 연구에서는 소화성 궤양으로 H. pylori 박멸요법을 시행받고 박멸이 확인되었던 환자에서 H. pylori 재감염율, 궤양의 재발을 장기간 고찰하고자 하였다. 방법: 상부소화관 내시경검사상 H. pylori 양성인 소화성 궤양 환자 중 H. pylori 박멸요법을 시행하고 6주 이후에 박멸을 확인한 환자 763명 중 4년간 장기간 추적이 가능했던 환자 32명을 대상으로 상부소화관 내시경검사 소견, 13C-요소호기검사를 통한 H. pylori 감염 여부를 확인하여 기록하였다. 결과: 32명 중 남성은 22명, 여성은 10명이었고, 평균 연령은 51.7세 (29∼69세)였으며 내시경적 진단은 위 궤양 9명, 십이지장 궤양 12명, 위 궤양 및 십이지장 궤양 11명이었다. 4년간의 추적 기간 동안 H. pylori 재감염은 2명에서 있었고, 연간 재감염율은 1.6%였다. 32명의 환자 중 3명에서 궤양의 재발이 있어 9.4%의 재발율을 보였다. 결론: H. pylori의 연간 재감염율은 선진국의 재감염율과 유사한 1.6%였으며, H. pylori 박멸치료는 소화성 궤양의 재발 방지에 효과적인 유용한 치료방법으로 생각된다. Background: Eradication therapy for H. pylori infection is known to decrease the recurrence rate of peptic ulcer disease. The aim of this study was to evaluate longterm effect of H. pylori eradication on the recurrence of peptic ulcer disease and the reinfection rate after treatment in Korea. Methods: Between July 1996 and February 1997, 763 patients who were diagnosed peptic ulcer diseases and H. pylori infection after upper endoscopies in Soonchunhyang university hospital. Among those patients, we reviewed 32 patients who achieved eradication of H. pylori after eradication therapy and could be followed for up to 4 years by 13C-urea breath test or endoscopy. Results: The mean age of the patients was 51.7 years (range: 29∼68). Nine patients had gastric ulcer, 12 had duodenal ulcer and 11 had duodenal and gastric ulcer. An annual reinfection rate of H. pylori was 1.6% in our study. After H. pylori eradication, recurrence of peptic ulcer was detected in three patients (9.4%). Conclusion: In our study, the reinfection rate was similar to rates observed in developed countries. H. pylori eradication was effective for preventing recurrent peptic ulcers.(Korean J Med 63:23-28, 2002)

13C-요소호기검사와 Helicobacter pylori의 균량 및 조직학적 소견과의 관계

조주영,이준성,김진오,이문성,심찬섭,송상훈,진소영,홍수진,천갑진 대한소화기학회 2001 대한소화기학회지 Vol.37 No.2

Background/Aims: ^(13)C-urea breath test (UBT) is an useful diagnostic test for Helicobacter pylori (H. pylori) infection. This study was aimed at clarifying the relationship between the UBT and gastric histological findings. Methods: Forty-nine patients with H. pylori infection identified by UBT and histological findings were selected. For biopsy specimens obtained endoscopically from gastric antrum and body, the number of H. pylori, gastritis activity, atrophy and intestinal metaplasia were inverstigated. Their gastritis activities were graded according to the updated Sydney system. UBT results were expressed delta over baseline at 30 min (DOB30). Results: The grades of gastritis activity were classified histologically into scores of 0, 1, 2, and 3. The DOB30 values were positively correlated with the grades of gastritis activity (r=0.35, p$lt;0.05). However, there was a negative correlation between the DOB30 values and the grades of gastric mucosal atrophy (r=-0.39, p$lt;0.05). In concerning with existence of intestinal metaplasia, the DOB30 values were 29.0±25.3‰, 55.1±38.9‰, 42.1±26.8‰ in none, focal, broad existence of intestinal metaplasia, respectively (r=0.01, p$gt;0.05). A significant positive correlation was observed between the DOB30 values and intragastric H. pylori load (r=0.52, p$lt;0.01). Conclusions: 13C-UBT can be used to evaluate intragastric H. pylori load, grades of gastritis activity and atrophy.